Aliases for IFI44L Gene

Aliases for IFI44L Gene

  • Interferon Induced Protein 44 Like 2 3 5
  • Interferon-Induced Protein 44-Like 2 3 4
  • C1orf29 3 4
  • GS3686 2 3
  • Chromosome 1 Open Reading Frame 29 2
  • IFI44L 5

External Ids for IFI44L Gene

Previous HGNC Symbols for IFI44L Gene

  • C1orf29

Previous GeneCards Identifiers for IFI44L Gene

  • GC01P078799
  • GC01P078858
  • GC01P079085
  • GC01P077217

Summaries for IFI44L Gene

GeneCards Summary for IFI44L Gene

IFI44L (Interferon Induced Protein 44 Like) is a Protein Coding gene. Diseases associated with IFI44L include Lymph Node Tuberculosis and Immunodeficiency 38 With Basal Ganglia Calcification. An important paralog of this gene is IFI44.

UniProtKB/Swiss-Prot Summary for IFI44L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFI44L Gene

Genomics for IFI44L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFI44L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J078619 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +1.3 1319 4.4 CEBPB TRIM22 ZNF148 ZNF132 PRDM6 CBFB ZNF571 ZNF624 TAF1 NFE2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 IFI44 USP33 lnc-ADGRL4-6
GH01J078617 Enhancer 0.9 Ensembl ENCODE 250.7 -1.9 -1902 1.2 DEK CTCF MAX TRIM22 PRDM1 SMC3 RAD21 RFX5 YY1 ZFP91 IFI44L HSALNG0004629 lnc-ADGRL4-6 PTGFR
GH01J078625 Promoter 0.3 EPDnew 250.4 +6.1 6124 0.1 IFI44L IFI44 lnc-ADGRL4-6
GH01J078607 Enhancer 0.7 Ensembl 0.4 -11.7 -11701 0.4 FOXA2 SMAD4 SAP130 GABPB1 TEAD3 DRAP1 ZNF48 MIER2 GATAD1 ELF3 IFI44L HSALNG0004629 lnc-ADGRL4-6 PTGFR
GH01J078490 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.1 -128.6 -128601 2.6 ZBTB10 ZBTB48 GLIS1 L3MBTL2 ZNF366 EZH2 ZBTB17 GLIS2 PKNOX1 CEBPB PTGFR piR-43106-007 HSALNG0004624 IFI44L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI44L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFI44L

Top Transcription factor binding sites by QIAGEN in the IFI44L gene promoter:
  • C/EBPbeta
  • Hlf
  • Lhx3a
  • LHX3b
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for IFI44L Gene

Latest Assembly
chr1:78,619,902-78,646,145
(GRCh38/hg38)
Size:
26,244 bases
Orientation:
Plus strand

Previous Assembly
chr1:79,086,133-79,111,830
(GRCh37/hg19 by Entrez Gene)
Size:
25,698 bases
Orientation:
Plus strand

chr1:79,085,607-79,111,830
(GRCh37/hg19 by Ensembl)
Size:
26,224 bases
Orientation:
Plus strand

Genomic View for IFI44L Gene

Genes around IFI44L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44L Gene

Proteins for IFI44L Gene

  • Protein details for IFI44L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53G44-IF44L_HUMAN
    Recommended name:
    Interferon-induced protein 44-like
    Protein Accession:
    Q53G44
    Secondary Accessions:
    • Q86TE1
    • Q96B64
    • Q99984

    Protein attributes for IFI44L Gene

    Size:
    452 amino acids
    Molecular mass:
    51322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA19056.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAD96807.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI44L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44L Gene

Post-translational modifications for IFI44L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI44L Gene

Domains & Families for IFI44L Gene

Gene Families for IFI44L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI44L Gene

Suggested Antigen Peptide Sequences for IFI44L Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79131, highly similar to Homo sapiens interferon-induced protein 44-like (IFI44L), mRNA (B4E019_HUMAN)
  • Interferon-induced protein 44-like (IF44L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53G44

UniProtKB/Swiss-Prot:

IF44L_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44L: view

Function for IFI44L Gene

Molecular function for IFI44L Gene

UniProtKB/Swiss-Prot Function:
Exhibits a low antiviral activity against hepatitis C virus.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Phenotypes From GWAS Catalog for IFI44L Gene

Gene Ontology (GO) - Molecular Function for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IFI44L: view
genes like me logo Genes that share phenotypes with IFI44L: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI44L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI44L Gene

Localization for IFI44L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI44L gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44L: view

Pathways & Interactions for IFI44L Gene

PathCards logo

SuperPathways for IFI44L Gene

No Data Available

Interacting Proteins for IFI44L Gene

Gene Ontology (GO) - Biological Process for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA 21873635
GO:0051607 defense response to virus IEA,IDA 21478870
genes like me logo Genes that share ontologies with IFI44L: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44L Gene

Drugs & Compounds for IFI44L Gene

No Compound Related Data Available

Transcripts for IFI44L Gene

mRNA/cDNA for IFI44L Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI44L

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: -
SP11: - -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IFI44L Gene

GeneLoc Exon Structure for
IFI44L

Expression for IFI44L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI44L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44L Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI44L Gene



Protein tissue co-expression partners for IFI44L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFI44L

SOURCE GeneReport for Unigene cluster for IFI44L Gene:

Hs.744918

Evidence on tissue expression from TISSUES for IFI44L Gene

  • Nervous system(4.7)
  • Bone(4.1)
  • Spleen(2.6)
  • Lymph node(2.2)
  • Blood(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with IFI44L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI44L Gene

Orthologs for IFI44L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFI44L 30 31
  • 98.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IFI44L 30 31
  • 77.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IFI44L 30 31
  • 73.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ifi44l 30
  • 68.56 (n)
Mouse
(Mus musculus)
Mammalia Ifi44l 30 17 31
  • 65.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CR855320.1 31
  • 36 (a)
ManyToMany
zgc:153654 31
  • 34 (a)
ManyToMany
si:ch211-197g15.8 31
  • 33 (a)
ManyToMany
si:ch211-197g15.9 31
  • 33 (a)
ManyToMany
si:dkey-193b15.5 31
  • 33 (a)
ManyToMany
si:ch211-197g15.7 31
  • 31 (a)
ManyToMany
si:ch211-197g15.6 31 31
  • 31 (a)
ManyToMany
si:ch211-197g15.10 31
  • 30 (a)
ManyToMany
si:dkey-79f11.7 31
  • 28 (a)
ManyToMany
si:dkeyp-9d4.2 31
  • 28 (a)
ManyToMany
si:dkey-79f11.9 31
  • 27 (a)
ManyToMany
si:dkey-79f11.5 31
  • 27 (a)
ManyToMany
si:ch211-208g24.8 31
  • 27 (a)
ManyToMany
si:dkey-79f11.4 31
  • 26 (a)
ManyToMany
CABZ01073795.1 31
  • 26 (a)
ManyToMany
si:dkey-79f11.8 31
  • 25 (a)
ManyToMany
CABZ01045230.1 31
  • 25 (a)
ManyToMany
si:dkey-79f11.10 31
  • 25 (a)
ManyToMany
si:dkeyp-75b4.9 31
  • 25 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToMany
Species where no ortholog for IFI44L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFI44L Gene

ENSEMBL:
Gene Tree for IFI44L (if available)
TreeFam:
Gene Tree for IFI44L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFI44L: view image

Paralogs for IFI44L Gene

Paralogs for IFI44L Gene

(1) SIMAP similar genes for IFI44L Gene using alignment to 4 proteins:

  • IF44L_HUMAN
  • B4E019_HUMAN
  • C9JPJ0_HUMAN
  • H7C1K6_HUMAN
genes like me logo Genes that share paralogs with IFI44L: view

Variants for IFI44L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFI44L Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs143077503 Likely Benign: not provided 78,628,091(+) A/G
NM_006820.4(IFI44L):c.176A>G (p.Asn59Ser)
MISSENSE_VARIANT,INTRON
rs273258 Benign: not provided. - 78,628,357(+) C/Tp.Arg148Cys
NM_006820.4(IFI44L):c.442C>T (p.Arg148Cys)
MISSENSE_VARIANT,INTRON
rs34615115 Benign: not provided 78,641,602(+) G/A
NM_006820.4(IFI44L):c.1317G>A (p.Glu439=)
SYNONYMOUS
rs61729831 Benign: not provided 78,637,042(+) G/A
NM_006820.4(IFI44L):c.887G>A (p.Arg296His)
MISSENSE
rs761700063 Likely Benign: not provided 78,629,710(+) A/G
NM_006820.4(IFI44L):c.528-10A>G
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFI44L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFI44L Gene

Variant ID Type Subtype PubMed ID
esv2661424 CNV deletion 23128226
esv2750218 CNV deletion 23290073
esv3303563 CNV mobile element insertion 20981092
esv3309841 CNV mobile element insertion 20981092
esv3386975 CNV insertion 20981092
esv3406252 CNV insertion 20981092
esv3431836 CNV insertion 20981092
esv3586552 CNV loss 21293372
nsv1001291 CNV loss 25217958
nsv830315 CNV gain 17160897

Variation tolerance for IFI44L Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI44L Gene

Human Gene Mutation Database (HGMD)
IFI44L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44L Gene

Disorders for IFI44L Gene

MalaCards: The human disease database

(4) MalaCards diseases for IFI44L Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFI44L

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IFI44L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI44L Gene

Publications for IFI44L Gene

  1. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 4
  2. Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus. (PMID: 32611756) Busse DC … Tregoning JS (Journal of virology 2020) 3
  3. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3
  4. A qPCR expression assay of IFI44L gene differentiates viral from bacterial infections in febrile children. (PMID: 31409879) Gómez-Carballa A … Salas A (Scientific reports 2019) 3
  5. IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway. (PMID: 29848298) Huang WC … Chu PY (BMC cancer 2018) 3

Products for IFI44L Gene

Sources for IFI44L Gene