Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFI44L Gene

Aliases for IFI44L Gene

  • Interferon Induced Protein 44 Like 2 3 5
  • Interferon-Induced Protein 44-Like 2 3
  • C1orf29 3 4
  • Chromosome 1 Open Reading Frame 29 2
  • GS3686 3

External Ids for IFI44L Gene

Previous HGNC Symbols for IFI44L Gene

  • C1orf29

Previous GeneCards Identifiers for IFI44L Gene

  • GC01P078799
  • GC01P078858
  • GC01P079085
  • GC01P077217

Summaries for IFI44L Gene

GeneCards Summary for IFI44L Gene

IFI44L (Interferon Induced Protein 44 Like) is a Protein Coding gene. An important paralog of this gene is IFI44.

UniProtKB/Swiss-Prot for IFI44L Gene

  • Exhibits a low antiviral activity against hepatitis C virus.

Additional gene information for IFI44L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44L Gene

Genomics for IFI44L Gene

GeneHancer (GH) Regulatory Elements for IFI44L Gene

Promoters and enhancers for IFI44L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I078619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.0 1030 3.8 PKNOX1 SMAD1 NFIB ZNF529 ZNF195 ZNF366 ZNF350 ETV6 BCLAF1 IKZF2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 FUBP1 USP33 IFI44
GH01I078625 Promoter 0.5 EPDnew 550.4 +6.1 6104 0.1 IFI44L IFI44
GH01I078617 Enhancer 1 Ensembl ENCODE 0.8 -2.2 -2165 0.5 CTCF USF1 MAX RAD21 RFX5 YY1 ZNF335 SMC3 ZNF143 RCOR1 IFI44L PIR50856
GH01I078645 Enhancer 0.2 Ensembl 0.3 +25.8 25779 0.2 NSRP1P1 IFI44 IFI44L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFI44L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFI44L gene promoter:

Genomic Locations for IFI44L Gene

Genomic Locations for IFI44L Gene
chr1:78,619,922-78,646,145
(GRCh38/hg38)
Size:
26,224 bases
Orientation:
Plus strand
chr1:79,085,607-79,111,830
(GRCh37/hg19)

Genomic View for IFI44L Gene

Genes around IFI44L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44L Gene

Proteins for IFI44L Gene

  • Protein details for IFI44L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53G44-IF44L_HUMAN
    Recommended name:
    Interferon-induced protein 44-like
    Protein Accession:
    Q53G44
    Secondary Accessions:
    • Q86TE1
    • Q96B64
    • Q99984

    Protein attributes for IFI44L Gene

    Size:
    452 amino acids
    Molecular mass:
    51322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA19056.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAD96807.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI44L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44L Gene

Post-translational modifications for IFI44L Gene

No Post-translational modifications

No data available for DME Specific Peptides for IFI44L Gene

Domains & Families for IFI44L Gene

Gene Families for IFI44L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI44L Gene

Graphical View of Domain Structure for InterPro Entry

Q53G44

UniProtKB/Swiss-Prot:

IF44L_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44L: view

Function for IFI44L Gene

Molecular function for IFI44L Gene

UniProtKB/Swiss-Prot Function:
Exhibits a low antiviral activity against hepatitis C virus.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Phenotypes From GWAS Catalog for IFI44L Gene

Gene Ontology (GO) - Molecular Function for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IFI44L: view
genes like me logo Genes that share phenotypes with IFI44L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI44L Gene

Localization for IFI44L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI44L gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44L: view

Pathways & Interactions for IFI44L Gene

SuperPathways for IFI44L Gene

No Data Available

Interacting Proteins for IFI44L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359787%0d%0a9606.ENSP00000259555%0d%0a
Selected Interacting proteins: Q53G44-IF44L_HUMAN ENSP00000359787 for IFI44L Gene via IID STRING

Gene Ontology (GO) - Biological Process for IFI44L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IDA,IEA 21478870
genes like me logo Genes that share ontologies with IFI44L: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44L Gene

Drugs & Compounds for IFI44L Gene

No Compound Related Data Available

Transcripts for IFI44L Gene

Unigene Clusters for IFI44L Gene

Interferon-induced protein 44-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: -
SP11: - -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for IFI44L Gene

GeneLoc Exon Structure for
IFI44L
ECgene alternative splicing isoforms for
IFI44L

Expression for IFI44L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI44L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44L Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI44L Gene



Protein tissue co-expression partners for IFI44L Gene

NURSA nuclear receptor signaling pathways regulating expression of IFI44L Gene:

IFI44L

SOURCE GeneReport for Unigene cluster for IFI44L Gene:

Hs.744918

Evidence on tissue expression from TISSUES for IFI44L Gene

  • Nervous system(4.5)
  • Bone(4)
genes like me logo Genes that share expression patterns with IFI44L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI44L Gene

Orthologs for IFI44L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI44L 33 34
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia IFI44L 33 34
  • 77.7 (n)
dog
(Canis familiaris)
Mammalia IFI44L 33 34
  • 73.7 (n)
rat
(Rattus norvegicus)
Mammalia Ifi44l 33
  • 68.56 (n)
mouse
(Mus musculus)
Mammalia Ifi44l 33 16 34
  • 65.98 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR855320.1 34
  • 36 (a)
ManyToMany
zgc:153654 34
  • 34 (a)
ManyToMany
si:ch211-197g15.8 34
  • 33 (a)
ManyToMany
si:ch211-197g15.9 34
  • 33 (a)
ManyToMany
si:dkey-193b15.5 34
  • 33 (a)
ManyToMany
si:ch211-197g15.6 34 34
  • 31 (a)
ManyToMany
si:ch211-197g15.7 34
  • 31 (a)
ManyToMany
si:ch211-197g15.10 34
  • 30 (a)
ManyToMany
si:dkey-79f11.7 34
  • 28 (a)
ManyToMany
si:dkeyp-9d4.2 34
  • 28 (a)
ManyToMany
si:ch211-208g24.8 34
  • 27 (a)
ManyToMany
si:dkey-79f11.5 34
  • 27 (a)
ManyToMany
si:dkey-79f11.9 34
  • 27 (a)
ManyToMany
CABZ01073795.1 34
  • 26 (a)
ManyToMany
si:dkey-79f11.4 34
  • 26 (a)
ManyToMany
CABZ01045230.1 34
  • 25 (a)
ManyToMany
si:dkey-79f11.10 34
  • 25 (a)
ManyToMany
si:dkey-79f11.8 34
  • 25 (a)
ManyToMany
si:dkeyp-75b4.9 34
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
Species where no ortholog for IFI44L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44L Gene

ENSEMBL:
Gene Tree for IFI44L (if available)
TreeFam:
Gene Tree for IFI44L (if available)

Paralogs for IFI44L Gene

Paralogs for IFI44L Gene

(1) SIMAP similar genes for IFI44L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44L: view

Variants for IFI44L Gene

Sequence variations from dbSNP and Humsavar for IFI44L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018323 -- 78,623,571(+) G/A intron_variant
rs1000232270 -- 78,633,904(+) A/C intron_variant
rs1000407360 -- 78,622,319(+) C/T intron_variant
rs1000476201 -- 78,639,858(+) GCCG/G intron_variant
rs1000484208 -- 78,623,368(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IFI44L Gene

Variant ID Type Subtype PubMed ID
nsv830315 CNV gain 17160897
nsv1001291 CNV loss 25217958
esv3586552 CNV loss 21293372
esv3431836 CNV insertion 20981092
esv3406252 CNV insertion 20981092
esv3386975 CNV insertion 20981092
esv3309841 CNV mobile element insertion 20981092
esv3303563 CNV mobile element insertion 20981092
esv2750218 CNV deletion 23290073
esv2661424 CNV deletion 23128226

Variation tolerance for IFI44L Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI44L Gene

Human Gene Mutation Database (HGMD)
IFI44L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44L Gene

Disorders for IFI44L Gene

Additional Disease Information for IFI44L

No disorders were found for IFI44L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44L Gene

Publications for IFI44L Gene

  1. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine. (PMID: 28289848) Haralambieva IH … Poland GA (Human genetics 2017) 3 58
  4. Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. (PMID: 26116899) Zahoor MA … Aida Y (Virus research 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for IFI44L Gene

Sources for IFI44L Gene

Content
Loading form....