Aliases for IFI44 Gene

Aliases for IFI44 Gene

  • Interferon Induced Protein 44 2 3 5
  • Interferon-Induced Protein 44 2 3 4
  • MTAP44 2 3 4
  • P44 2 3 4
  • TBC/LysM-Associated Domain Containing 5 2 3
  • Microtubule-Associated Protein 44 3 4
  • TLDC5 2 3
  • Interferon-Induced, Hepatitis C-Associated Microtubular Aggregate Protein (44kD) 3
  • IFI44 5

External Ids for IFI44 Gene

Previous GeneCards Identifiers for IFI44 Gene

  • GC01P079275
  • GC01P078014
  • GC01P078506
  • GC01P078538
  • GC01P078827
  • GC01P078888
  • GC01P079115
  • GC01P077247

Summaries for IFI44 Gene

GeneCards Summary for IFI44 Gene

IFI44 (Interferon Induced Protein 44) is a Protein Coding gene. Diseases associated with IFI44 include Hepatitis D and Potocki-Shaffer Syndrome. An important paralog of this gene is IFI44L.

UniProtKB/Swiss-Prot Summary for IFI44 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFI44 Gene

Genomics for IFI44 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFI44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J078649 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +2.1 2056 3.6 POLR2A SIN3A IRF4 EBF1 TBP TAF1 REST IKZF1 YY1 NBN IFI44 MN308954 lnc-ADGRL4-6 ADGRL4
GH01J078619 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 -27.7 -27722 4.4 CEBPB TRIM22 ZNF148 ZNF132 PRDM6 CBFB ZNF571 ZNF624 TAF1 NFE2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 IFI44 USP33 lnc-ADGRL4-6
GH01J077886 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.1 -758.8 -758786 6.5 ZBTB10 IKZF1 ZIC2 ZNF610 CEBPB ZNF513 SIN3A REST ZNF341 KMT2B NEXN NEXN-AS1 NONHSAG001877.2 USP33 GIPC2 FUBP1 IFI44 MN309174-007 DNAJB4
GH01J078099 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -546.3 -546306 5.3 MAX JUND USF2 MAFK RAD21 POLR2A PKNOX1 ZSCAN4 HLF NFE2L2 GIPC2 IFI44 RNA5SP22 RF00001-007 HSALNG0004616 PTGFR
GH01J077829 Enhancer 1 Ensembl ENCODE dbSUPER 5.2 -816.3 -816302 6.7 IKZF1 ZNF217 RUNX1 FOXA2 PRDM6 NFE2 GATA3 TCF7L2 FOXA1 JUND MIGA1 RNA5SP21 ACTG1P21 USP33 IFI44 NEXN FUBP1 NSRP1P1 RF00017-253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI44 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFI44

Top Transcription factor binding sites by QIAGEN in the IFI44 gene promoter:
  • Bach1
  • Bach2
  • CUTL1
  • IRF-1
  • Pbx1a
  • STAT5A
  • Tal-1
  • TBP
  • TFIID

Genomic Locations for IFI44 Gene

Latest Assembly
chr1:78,648,943-78,664,078
(GRCh38/hg38)
Size:
15,136 bases
Orientation:
Plus strand

Previous Assembly
chr1:79,115,474-79,129,763
(GRCh37/hg19 by Entrez Gene)
Size:
14,290 bases
Orientation:
Plus strand

chr1:79,115,481-79,129,763
(GRCh37/hg19 by Ensembl)
Size:
14,283 bases
Orientation:
Plus strand

Genomic View for IFI44 Gene

Genes around IFI44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI44 Gene

Proteins for IFI44 Gene

  • Protein details for IFI44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB0-IFI44_HUMAN
    Recommended name:
    Interferon-induced protein 44
    Protein Accession:
    Q8TCB0
    Secondary Accessions:
    • B7ZAG3
    • D3DQ80
    • Q14496

    Protein attributes for IFI44 Gene

    Size:
    444 amino acids
    Molecular mass:
    50491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44 Gene

Post-translational modifications for IFI44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI44 Gene

Antibodies for research

  • Abcam antibodies for IFI44
  • Boster Bio Antibodies for IFI44

No data available for DME Specific Peptides for IFI44 Gene

Domains & Families for IFI44 Gene

Gene Families for IFI44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI44 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFI44 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79177, moderately similar to Interferon-induced protein 44 (B7ZAG3_HUMAN)
  • Microtubule-associated protein 44 (IFI44_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCB0

UniProtKB/Swiss-Prot:

IFI44_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44: view

Function for IFI44 Gene

Molecular function for IFI44 Gene

UniProtKB/Swiss-Prot Function:
This protein aggregates to form microtubular structures.
UniProtKB/Swiss-Prot Induction:
By alpha and beta interferons, but not by gamma interferons.

Phenotypes From GWAS Catalog for IFI44 Gene

Gene Ontology (GO) - Molecular Function for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFI44: view
genes like me logo Genes that share phenotypes with IFI44: view

Animal Models for IFI44 Gene

MGI Knock Outs for IFI44:
  • Ifi44 Ifi44<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFI44 Gene

Localization for IFI44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI44 gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44: view

Pathways & Interactions for IFI44 Gene

PathCards logo

SuperPathways for IFI44 Gene

No Data Available

Interacting Proteins for IFI44 Gene

Gene Ontology (GO) - Biological Process for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA 21873635
GO:0009615 response to virus TAS 7925411
GO:0009617 response to bacterium IEA --
genes like me logo Genes that share ontologies with IFI44: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44 Gene

Drugs & Compounds for IFI44 Gene

No Compound Related Data Available

Transcripts for IFI44 Gene

mRNA/cDNA for IFI44 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI44

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3: - - - - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for IFI44 Gene

GeneLoc Exon Structure for
IFI44

Expression for IFI44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44 Gene

This gene is overexpressed in NK cells (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFI44 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFI44

SOURCE GeneReport for Unigene cluster for IFI44 Gene:

Hs.82316

Evidence on tissue expression from TISSUES for IFI44 Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Spleen(2.8)
  • Lymph node(2.5)
  • Bone marrow(2.4)
  • Blood(2.3)
  • Intestine(2.3)
  • Heart(2.1)
  • Liver(2.1)
  • Kidney(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with IFI44: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI44 Gene

Orthologs for IFI44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFI44 30 31
  • 98.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IFI44 30 31
  • 75.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IFI44 30 31
  • 75.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ifi44 30 17 31
  • 69.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ifi44 30
  • 68.65 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-197g15.6 30
  • 47.82 (n)
CR855320.1 31
  • 35 (a)
ManyToMany
si:dkey-79f11.7 31
  • 31 (a)
ManyToMany
CABZ01073795.1 31
  • 30 (a)
ManyToMany
si:dkey-79f11.9 31
  • 30 (a)
ManyToMany
si:dkey-79f11.5 31
  • 29 (a)
ManyToMany
si:dkeyp-9d4.2 31
  • 28 (a)
ManyToMany
si:dkey-79f11.8 31
  • 27 (a)
ManyToMany
si:dkey-79f11.4 31
  • 27 (a)
ManyToMany
si:dkeyp-75b4.9 31
  • 26 (a)
ManyToMany
si:ch211-208g24.8 31
  • 26 (a)
ManyToMany
si:dkey-79f11.10 31
  • 26 (a)
ManyToMany
CABZ01045230.1 31
  • 26 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Species where no ortholog for IFI44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFI44 Gene

ENSEMBL:
Gene Tree for IFI44 (if available)
TreeFam:
Gene Tree for IFI44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFI44: view image

Paralogs for IFI44 Gene

Paralogs for IFI44 Gene

(1) SIMAP similar genes for IFI44 Gene using alignment to 4 proteins:

  • IFI44_HUMAN
  • B7ZAG3_HUMAN
  • C9JUM8_HUMAN
  • H7C1F3_HUMAN
genes like me logo Genes that share paralogs with IFI44: view

Variants for IFI44 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFI44 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs115638974 Benign: not provided 78,650,276(+) C/G
NM_006417.5(IFI44):c.81C>G (p.Leu27=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs2070123 - p.Trp9Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFI44 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFI44 Gene

Variant ID Type Subtype PubMed ID
esv2677291 CNV deletion 23128226
esv3586554 CNV loss 21293372
nsv1001291 CNV loss 25217958
nsv830315 CNV gain 17160897

Variation tolerance for IFI44 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44 Gene

Disorders for IFI44 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IFI44 Gene - From: COP

Disorder Aliases PubMed IDs
hepatitis d
  • delta hepatitis
potocki-shaffer syndrome
  • pss
limited scleroderma
  • limited cutaneous systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search IFI44 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFI44

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IFI44: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI44 Gene

Publications for IFI44 Gene

  1. Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. (PMID: 7925411) Kitamura A … Kitamura N (European journal of biochemistry 1994) 2 3 4 23
  2. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 23 41
  3. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PMID: 18953482) Mailaparambil B … Heinzmann A (Archives of virology 2008) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for IFI44 Gene

Sources for IFI44 Gene