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IFI44 Gene(Protein Coding)

Interferon Induced Protein 44

GCID:
GC01P078649
GIFtS:
42
Genes Participants
UDN Logo

Aliases for IFI44 Gene

Aliases for IFI44 Gene

  • Interferon Induced Protein 44 2 3 5
  • TBC/LysM-Associated Domain Containing 5 2 3
  • Microtubule-Associated Protein 44 3 4
  • Interferon-Induced Protein 44 2 3
  • MTAP44 3 4
  • P44 3 4
  • Interferon-Induced, Hepatitis C-Associated Microtubular Aggregate Protein (44kD) 3
  • TLDC5 3

External Ids for IFI44 Gene

Previous GeneCards Identifiers for IFI44 Gene

  • GC01P079275
  • GC01P078014
  • GC01P078506
  • GC01P078538
  • GC01P078827
  • GC01P078888
  • GC01P079115
  • GC01P077247

Summaries for IFI44 Gene

GeneCards Summary for IFI44 Gene

IFI44 (Interferon Induced Protein 44) is a Protein Coding gene. An important paralog of this gene is IFI44L.

UniProtKB/Swiss-Prot for IFI44 Gene

  • This protein aggregates to form microtubular structures.

Additional gene information for IFI44 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI44 Gene

Genomics for IFI44 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IFI44 Gene

Promoters and enhancers for IFI44 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I078649 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +1.7 1717 2.9 SMAD1 TAF1 CHD1 EBF1 REST IRF4 YY1 RELA POLR2A IKZF1 IFI44 RPL23P3
GH01I078619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.5 -28.0 -27991 3.8 PKNOX1 SMAD1 NFIB ZNF529 ZNF195 ZNF366 ZNF350 ETV6 BCLAF1 IKZF2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 FUBP1 USP33 IFI44
GH01I077886 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 5.1 -759.5 -759543 5 HDGF SIN3A DMAP1 ZNF2 ZNF121 GLIS2 FOS KLF13 YY2 REST NEXN-AS1 NEXN USP33 GIPC2 FUBP1 IFI44
GH01I078070 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.3 -577.6 -577595 2.1 PKNOX1 ARNT JUN FEZF1 YY1 POLR2A FOSL2 FOS RXRA JUNB GIPC2 ACTG1P21 MIGA1 RNA5SP21 IFI44 RNU6-1102P LOC100131495
GH01I078625 Promoter 0.5 EPDnew 12.5 -22.9 -22917 0.1 IFI44L IFI44
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFI44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFI44 gene promoter:

Genomic Locations for IFI44 Gene

Genomic Locations for IFI44 Gene
chr1:78,648,943-78,664,078
(GRCh38/hg38)
Size:
15,136 bases
Orientation:
Plus strand
chr1:79,115,477-79,129,763
(GRCh37/hg19)

Genomic View for IFI44 Gene

Genes around IFI44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI44 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFI44 Gene

Proteins for IFI44 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFI44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB0-IFI44_HUMAN
    Recommended name:
    Interferon-induced protein 44
    Protein Accession:
    Q8TCB0
    Secondary Accessions:
    • B7ZAG3
    • D3DQ80
    • Q14496

    Protein attributes for IFI44 Gene

    Size:
    444 amino acids
    Molecular mass:
    50491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IFI44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI44 Gene

Protein Expression for IFI44 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IFI44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFI44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI44 Gene

Domains & Families for IFI44 Gene

Gene Families for IFI44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI44 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFI44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCB0

UniProtKB/Swiss-Prot:

IFI44_HUMAN :
  • Belongs to the IFI44 family.
Family:
  • Belongs to the IFI44 family.
genes like me logo Genes that share domains with IFI44: view

Function for IFI44 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IFI44 Gene

UniProtKB/Swiss-Prot Function:
This protein aggregates to form microtubular structures.
UniProtKB/Swiss-Prot Induction:
By alpha and beta interferons, but not by gamma interferons.
genes like me logo Genes that share phenotypes with IFI44: view

Animal Models for IFI44 Gene

MGI Knock Outs for IFI44:

Animal Model Products

miRNA for IFI44 Gene

miRTarBase miRNAs that target IFI44

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFI44 Gene

Localization for IFI44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI44 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI44 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IFI44: view

Pathways & Interactions for IFI44 Gene

SuperPathways for IFI44 Gene

PathCards logo More details on SuperPathways for IFI44
No Data Available

Interacting Proteins for IFI44 Gene

Selected Interacting proteins: Q8TCB0-IFI44_HUMAN for IFI44 Gene via IID

Gene Ontology (GO) - Biological Process for IFI44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus TAS 7925411
genes like me logo Genes that share ontologies with IFI44: view

No data available for Pathways by source and SIGNOR curated interactions for IFI44 Gene

Drugs & Compounds for IFI44 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IFI44 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IFI44 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(116) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFI44 Gene

Interferon-induced protein 44:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3: - - - - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for IFI44 Gene

GeneLoc Exon Structure for
IFI44
ECgene alternative splicing isoforms for
IFI44

Expression for IFI44 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI44 Gene

mRNA expression in normal human tissues for IFI44 Gene
mRNA expression by GTEx for IFI44 GenemRNA expression by BioGPS for IFI44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI44 Gene

This gene is overexpressed in NK cells (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFI44 Gene



NURSA nuclear receptor signaling pathways regulating expression of IFI44 Gene:

IFI44

SOURCE GeneReport for Unigene cluster for IFI44 Gene:

Hs.82316

Evidence on tissue expression from TISSUES for IFI44 Gene

  • Nervous system(4.5)
  • Lung(4.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with IFI44: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI44 Gene

Orthologs for IFI44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IFI44 33 34
  • 98.72 (n)
cow
(Bos Taurus)
 Mammalia IFI44 33 34
  • 75.91 (n)
dog
(Canis familiaris)
 Mammalia IFI44 33 34
  • 75.15 (n)
mouse
(Mus musculus)
 Mammalia Ifi44 33 16 34
  • 69.76 (n)
rat
(Rattus norvegicus)
 Mammalia Ifi44 33
  • 68.65 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 58 (a)
 ManyToMany
-- 34
  • 39 (a)
 ManyToMany
-- 34
  • 33 (a)
 ManyToMany
-- 34
  • 32 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii si:ch211-197g15.6 33
  • 47.82 (n)
CR855320.1 34
  • 35 (a)
 ManyToMany
si:dkey-79f11.7 34
  • 31 (a)
 ManyToMany
CABZ01073795.1 34
  • 30 (a)
 ManyToMany
si:dkey-79f11.9 34
  • 30 (a)
 ManyToMany
si:dkey-79f11.5 34
  • 29 (a)
 ManyToMany
si:dkeyp-9d4.2 34
  • 28 (a)
 ManyToMany
si:dkey-79f11.8 34
  • 27 (a)
 ManyToMany
si:dkey-79f11.4 34
  • 27 (a)
 ManyToMany
si:ch211-208g24.8 34
  • 26 (a)
 ManyToMany
CABZ01045230.1 34
  • 26 (a)
 ManyToMany
si:dkeyp-75b4.9 34
  • 26 (a)
 ManyToMany
si:dkey-79f11.10 34
  • 26 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 36 (a)
 OneToMany
Species where no ortholog for IFI44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI44 Gene

ENSEMBL:
Gene Tree for IFI44 (if available)
TreeFam:
Gene Tree for IFI44 (if available)

Paralogs for IFI44 Gene

Paralogs for IFI44 Gene

(1) SIMAP similar genes for IFI44 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IFI44: view

Variants for IFI44 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for IFI44 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022351 -- 78,664,213(+) T/C downstream_transcript_variant
rs1000143527 -- 78,648,649(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000184362 -- 78,658,254(+) T/G intron_variant
rs1000378209 -- 78,651,825(+) T/C intron_variant
rs1000436283 -- 78,661,611(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFI44 Gene

Variant ID Type Subtype PubMed ID
esv2677291 CNV deletion 23128226
esv3586554 CNV loss 21293372
nsv1001291 CNV loss 25217958
nsv830315 CNV gain 17160897

Variation tolerance for IFI44 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI44 Gene

Disorders for IFI44 Gene

Additional Disease Information for IFI44

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFI44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI44 Gene

Publications for IFI44 Gene

  1. Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. (PMID: 7925411) Kitamura A … Kitamura N (European journal of biochemistry 1994) 2 3 4 22 58
  2. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 22 44 58
  3. Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. (PMID: 18953482) Mailaparambil B … Heinzmann A (Archives of virology 2008) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for IFI44 Gene

Sources for IFI44 Gene

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