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Aliases for IFI35 Gene

Aliases for IFI35 Gene

  • Interferon Induced Protein 35 2 3 5
  • Ifi-35 3 4
  • IFP 35 3 4
  • IFP35 3 4
  • Interferon-Induced 35 KDa Protein 3
  • Interferon-Induced Protein 35 2

External Ids for IFI35 Gene

Previous GeneCards Identifiers for IFI35 Gene

  • GC17M062367
  • GC17P043320
  • GC17P041067
  • GC17P041532
  • GC17P041533
  • GC17P038412
  • GC17P041158
  • GC17P036924

Summaries for IFI35 Gene

GeneCards Summary for IFI35 Gene

IFI35 (Interferon Induced Protein 35) is a Protein Coding gene. Diseases associated with IFI35 include Stomatitis. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is NMI.

UniProtKB/Swiss-Prot for IFI35 Gene

  • Not yet known.

Gene Wiki entry for IFI35 Gene

Additional gene information for IFI35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI35 Gene

Genomics for IFI35 Gene

GeneHancer (GH) Regulatory Elements for IFI35 Gene

Promoters and enhancers for IFI35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J043006 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656.3 +0.3 274 1.7 HDGF SMAD1 ARID4B SIN3A DMAP1 IRF4 ZNF48 ETS1 YY1 GLIS2 IFI35 NBR2 VAT1
GH17J042110 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 6.9 -894.3 -894323 3.3 HDGF HDAC1 ARID4B IRF4 RAD21 YY1 ZNF335 ZNF207 BCLAF1 RUNX3 DHX58 GC17P042116 PIR51780 CNP KCNH4 HCRT RAB5C IFI35 AOC4P KAT2A
GH17J042979 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.3 -26.2 -26163 2.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 SP3 PTGES3L RUNDC1 PTGES3L-AARSD1 HMGN2P15 RPL27 IFI35 AARSD1 PIR51537
GH17J043033 Enhancer 0.9 ENCODE dbSUPER 12.1 +28.6 28640 4 BCOR SOX13 ZNF768 ZMYM3 CEBPG ZNF384 BMI1 POLR2A PATZ1 ZNF143 NBR2 IFI35 RPL27 GC17P043498 RPL21P4
GH17J043040 Enhancer 0.7 ENCODE 12.1 +33.9 33891 0.6 FOXA2 SAP130 MAX CEBPG RAD21 YY1 EGR1 ZSCAN5C GATAD2A SOX5 IFI35 RPL27 PTGES3L-AARSD1 CNTD1 COA3 GC17P043498 RPL21P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFI35 gene promoter:
  • IRF-7A
  • RREB-1
  • Meis-1a
  • Meis-1
  • HOXA9B
  • HOXA9
  • SRF (504 AA)
  • SRF
  • MyoD
  • C/EBPalpha

Genomic Locations for IFI35 Gene

Genomic Locations for IFI35 Gene
7,735 bases
Plus strand
7,735 bases
Plus strand

Genomic View for IFI35 Gene

Genes around IFI35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI35 Gene

Proteins for IFI35 Gene

  • Protein details for IFI35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-induced 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • C9JGX1
    • Q92984
    • Q99537
    • Q9BV98

    Protein attributes for IFI35 Gene

    286 amino acids
    Molecular mass:
    31546 Da
    Quaternary structure:
    • Homodimer. Also interacts with B-ATF.
    • Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI35 Gene


neXtProt entry for IFI35 Gene

Post-translational modifications for IFI35 Gene

  • Ubiquitination at Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for IFI35 Gene

No data available for DME Specific Peptides for IFI35 Gene

Domains & Families for IFI35 Gene

Gene Families for IFI35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI35 Gene

Suggested Antigen Peptide Sequences for IFI35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NMI family.
  • Belongs to the NMI family.
genes like me logo Genes that share domains with IFI35: view

Function for IFI35 Gene

Molecular function for IFI35 Gene

UniProtKB/Swiss-Prot Function:
Not yet known.
UniProtKB/Swiss-Prot Induction:
By interferon gamma.
GENATLAS Biochemistry:
interferon-induced leucine zipper protein IFI35,may be the same as APRF

Phenotypes From GWAS Catalog for IFI35 Gene

Gene Ontology (GO) - Molecular Function for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8954125
genes like me logo Genes that share ontologies with IFI35: view
genes like me logo Genes that share phenotypes with IFI35: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI35 Gene

Localization for IFI35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI35 Gene

Nucleus. Note=Nuclear following IFN treatment.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI35 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 8288566
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFI35: view

Pathways & Interactions for IFI35 Gene

genes like me logo Genes that share pathways with IFI35: view

Pathways by source for IFI35 Gene

Gene Ontology (GO) - Biological Process for IFI35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with IFI35: view

No data available for SIGNOR curated interactions for IFI35 Gene

Drugs & Compounds for IFI35 Gene

(1) Drugs for IFI35 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IFI35: view

Transcripts for IFI35 Gene

mRNA/cDNA for IFI35 Gene

Unigene Clusters for IFI35 Gene

Interferon-induced protein 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI35 Gene

No ASD Table

Relevant External Links for IFI35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFI35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI35 Gene

This gene is overexpressed in Monocytes (12.4) and Lymph node (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFI35 Gene

Protein tissue co-expression partners for IFI35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFI35 Gene:


SOURCE GeneReport for Unigene cluster for IFI35 Gene:


mRNA Expression by UniProt/SwissProt for IFI35 Gene:

Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

Evidence on tissue expression from TISSUES for IFI35 Gene

  • Skin(4.4)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with IFI35: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI35 Gene

Orthologs for IFI35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI35 34 33
  • 98.84 (n)
(Bos Taurus)
Mammalia IFI35 34 33
  • 80.97 (n)
(Canis familiaris)
Mammalia IFI35 34 33
  • 79 (n)
(Rattus norvegicus)
Mammalia Ifi35 33
  • 78.9 (n)
(Mus musculus)
Mammalia Ifi35 16 34 33
  • 78.32 (n)
(Monodelphis domestica)
Mammalia IFI35 34
  • 58 (a)
(Gallus gallus)
Aves IFI35 34 33
  • 53.06 (n)
(Anolis carolinensis)
Reptilia IFI35 34
  • 29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ifi35 33
  • 48.96 (n)
(Danio rerio)
Actinopterygii ifi35 34 33
  • 49.25 (n)
Species where no ortholog for IFI35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI35 Gene

Gene Tree for IFI35 (if available)
Gene Tree for IFI35 (if available)
Evolutionary constrained regions (ECRs) for IFI35: view image

Paralogs for IFI35 Gene

Paralogs for IFI35 Gene

genes like me logo Genes that share paralogs with IFI35: view

Variants for IFI35 Gene

Sequence variations from dbSNP and Humsavar for IFI35 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000057655 -- 43,014,740(+) T/A downstream_transcript_variant
rs1000529574 -- 43,014,481(+) T/C downstream_transcript_variant
rs1000581878 -- 43,014,940(+) T/C downstream_transcript_variant
rs1001071099 -- 43,009,558(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001216878 -- 43,005,936(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFI35 Gene

Variant ID Type Subtype PubMed ID
esv2662750 CNV deletion 23128226
esv2672649 CNV deletion 23128226
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
esv3640619 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv457742 CNV loss 19166990
nsv483009 CNV gain 15286789
nsv575052 CNV loss 21841781

Variation tolerance for IFI35 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI35 Gene

Disorders for IFI35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFI35 Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search IFI35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFI35

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFI35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI35 Gene

Publications for IFI35 Gene

  1. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith TM … King MC (Genome research 1996) 3 4 22 58
  2. IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PMID: 8954125) Wang X … Taparowsky EJ (Biochemical and biophysical research communications 1996) 3 4 22 58
  3. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PMID: 8288566) Bange FC … Böttger EC (The Journal of biological chemistry 1994) 3 4 22 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PMID: 17197158) Zhang L … He F (Cellular signalling 2007) 3 22 58

Products for IFI35 Gene

Sources for IFI35 Gene

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