Aliases for IFI30 Gene
External Ids for IFI30 Gene
Previous GeneCards Identifiers for IFI30 Gene
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
GeneCards Summary for IFI30 Gene
IFI30 (IFI30 Lysosomal Thiol Reductase) is a Protein Coding gene. Diseases associated with IFI30 include Lassa Fever and Eunuchism. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors.
UniProtKB/Swiss-Prot Summary for IFI30 Gene
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).