Aliases for IFI27L2 Gene

Aliases for IFI27L2 Gene

  • Interferon Alpha Inducible Protein 27 Like 2 2 3 5
  • TLH29 2 3 4
  • Interferon Alpha-Inducible Protein 27-Like Protein 2 3 4
  • Family With Sequence Similarity 14, Member A 2 3
  • Interferon-Stimulated Gene 12b Protein 3 4
  • PIFI27-Like Protein 3 4
  • FAM14A 3 4
  • ISG12B 3 4
  • ISG12(B) Protein 3
  • Protein TLH29 4
  • ISG12(B) 4
  • IFI27L2 5

External Ids for IFI27L2 Gene

Previous HGNC Symbols for IFI27L2 Gene

  • FAM14A

Previous GeneCards Identifiers for IFI27L2 Gene

  • GC14M093664
  • GC14M094594
  • GC14M074773

Summaries for IFI27L2 Gene

GeneCards Summary for IFI27L2 Gene

IFI27L2 (Interferon Alpha Inducible Protein 27 Like 2) is a Protein Coding gene. Diseases associated with IFI27L2 include Ileum Cancer. An important paralog of this gene is IFI27.

UniProtKB/Swiss-Prot Summary for IFI27L2 Gene

  • Plays a role in the apoptotic process and has a pro-apoptotic activity.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFI27L2 Gene

Genomics for IFI27L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFI27L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI27L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFI27L2

Top Transcription factor binding sites by QIAGEN in the IFI27L2 gene promoter:
  • C/EBPalpha
  • CUTL1
  • NF-1
  • Pbx1a
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2

Genomic Locations for IFI27L2 Gene

Latest Assembly
2,475 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,824 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,475 bases
Minus strand

Genomic View for IFI27L2 Gene

Genes around IFI27L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27L2 Gene

Proteins for IFI27L2 Gene

  • Protein details for IFI27L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 27-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TBD7
    • Q9NYL0

    Protein attributes for IFI27L2 Gene

    130 amino acids
    Molecular mass:
    12410 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF65760.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for IFI27L2 Gene

Post-translational modifications for IFI27L2 Gene

No Post-translational modifications

Other Protein References for IFI27L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI27L2 Gene

Domains & Families for IFI27L2 Gene

Gene Families for IFI27L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI27L2 Gene

  • Interferon-induced 6-16

Suggested Antigen Peptide Sequences for IFI27L2 Gene

GenScript: Design optimal peptide antigens:
  • pIFI27-like protein (I27L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFI6/IFI27 family.
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27L2: view

Function for IFI27L2 Gene

Molecular function for IFI27L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the apoptotic process and has a pro-apoptotic activity.
UniProtKB/Swiss-Prot Induction:
Not up-regulated by type-I interferon.

Phenotypes From GWAS Catalog for IFI27L2 Gene

genes like me logo Genes that share phenotypes with IFI27L2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27L2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI27L2 Gene

Localization for IFI27L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27L2 Gene

Mitochondrion membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27L2 gene
Compartment Confidence
mitochondrion 5
extracellular 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFI27L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA,IDA 27673746
genes like me logo Genes that share ontologies with IFI27L2: view

Pathways & Interactions for IFI27L2 Gene

PathCards logo

SuperPathways for IFI27L2 Gene

No Data Available

Interacting Proteins for IFI27L2 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000238609 Q9H2X8-I27L2_HUMAN for IFI27L2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IFI27L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,IMP 27673746
GO:0097190 apoptotic signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with IFI27L2: view

No data available for Pathways by source and SIGNOR curated interactions for IFI27L2 Gene

Drugs & Compounds for IFI27L2 Gene

No Compound Related Data Available

Transcripts for IFI27L2 Gene

mRNA/cDNA for IFI27L2 Gene

6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27L2

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for IFI27L2 Gene

GeneLoc Exon Structure for

Expression for IFI27L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI27L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFI27L2

SOURCE GeneReport for Unigene cluster for IFI27L2 Gene:


Evidence on tissue expression from TISSUES for IFI27L2 Gene

  • Pancreas(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with IFI27L2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27L2 Gene

Orthologs for IFI27L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI27L2 30 31
  • 99.04 (n)
(Bos Taurus)
Mammalia IFI27L2 30 31
  • 77.24 (n)
-- 31
  • 36 (a)
ISG12(B) 31
  • 29 (a)
(Mus musculus)
Mammalia Ifi27 31
  • 22 (a)
(Gallus gallus)
Aves IFI27L2 31
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
-- 31
  • 25 (a)
(Danio rerio)
Actinopterygii zgc:152791 31
  • 51 (a)
zgc:123068 31
  • 48 (a)
si:dkey-188i13.10 31
  • 47 (a)
si:dkey-188i13.11 31
  • 47 (a)
si:dkey-188i13.7 31
  • 38 (a)
si:dkey-188i13.6 31
  • 37 (a)
si:dkey-188i13.9 31
  • 34 (a)
Species where no ortholog for IFI27L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFI27L2 Gene

Gene Tree for IFI27L2 (if available)
Gene Tree for IFI27L2 (if available)
Evolutionary constrained regions (ECRs) for IFI27L2: view image

Paralogs for IFI27L2 Gene

Paralogs for IFI27L2 Gene

(3) SIMAP similar genes for IFI27L2 Gene using alignment to 1 proteins:

  • I27L2_HUMAN
genes like me logo Genes that share paralogs with IFI27L2: view

Variants for IFI27L2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFI27L2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFI27L2 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV loss 18971310
esv3635373 CNV gain 21293372

Variation tolerance for IFI27L2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI27L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFI27L2 Gene

Disorders for IFI27L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFI27L2 Gene - From: COP

Disorder Aliases PubMed IDs
ileum cancer
  • ileal neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFI27L2

genes like me logo Genes that share disorders with IFI27L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI27L2 Gene

Publications for IFI27L2 Gene

  1. Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins. (PMID: 27673746) Gytz H … Martensen PM (Biology of the cell 2017) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4
  4. ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis. (PMID: 27777077) Chen Y … Chen L (Virus research 2017) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for IFI27L2 Gene

Sources for IFI27L2 Gene