Aliases for IFI27L1 Gene

Aliases for IFI27L1 Gene

  • Interferon Alpha Inducible Protein 27 Like 1 2 3 5
  • Interferon Alpha-Inducible Protein 27-Like Protein 1 3 4
  • Family With Sequence Similarity 14, Member B 2 3
  • Interferon-Stimulated Gene 12c Protein 3 4
  • FAM14B 3 4
  • ISG12C 3 4
  • ISG12(C) Protein 3
  • ISG12(C) 4
  • IFI27L1 5

External Ids for IFI27L1 Gene

Previous HGNC Symbols for IFI27L1 Gene

  • FAM14B

Previous GeneCards Identifiers for IFI27L1 Gene

  • GC14P093618
  • GC14P094547
  • GC14P074727

Summaries for IFI27L1 Gene

GeneCards Summary for IFI27L1 Gene

IFI27L1 (Interferon Alpha Inducible Protein 27 Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for IFI27L1 Gene

  • Plays a role in the apoptotic process and has a pro-apoptotic activity.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFI27L1 Gene

Genomics for IFI27L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFI27L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J094077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 257 -1.1 -1101 5.2 TBP ZBTB10 SP1 NR2C1 MNT IKZF1 SMAD5 MBD2 POLR2A BHLHE40 DDX24 IFI27L1 NONHSAG015770.2 piR-35837 BTBD7 IFI27 PPP4R4 OTUB2
GH14J094109 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 43.3 +31.3 31267 6.3 TBP IKZF1 IRF2 ZIC2 RFX5 RELA NFE2 IRF9 ZBTB48 NRF1 KY994058 NONHSAG015771.2 IFI27 IFI27L1 PPP4R4 DDX24 IFI27L2
GH14J094025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -53.4 -53359 4.3 ZBTB10 SP1 MNT MBD2 ZNF217 ZBTB7B ZIC2 HOMEZ ZNF610 THAP11 OTUB2 HSALNG0103342 BTBD7 DDX24 CCDC197 ASB2 IFI27L2 IFI27L1 IFI27 lnc-IFI27L2-3
GH14J094173 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 +93.4 93400 3 ZBTB10 FEZF1 ZIC2 SIN3A VEZF1 SAP130 ZNF341 KLF9 ZNF146 BCL11B PPP4R4 HSALNG0103356 IFI27L2 DDX24 IFI27L1 LOC105370634 SERPINA10
GH14J094097 Enhancer 0.4 Ensembl ENCODE 39.9 +17.2 17208 1 ZFHX2 HSALNG0103345 HSALNG0103346 IFI27L1 IFI27L2 OTUB2 IFI27 RF00994-345 NONHSAG015770.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI27L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFI27L1

Top Transcription factor binding sites by QIAGEN in the IFI27L1 gene promoter:
  • AML1a
  • ATF6
  • CUTL1
  • E47
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Tal-1beta

Genomic Locations for IFI27L1 Gene

Latest Assembly
22,546 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
21,400 bases
Plus strand

(GRCh37/hg19 by Ensembl)
22,565 bases
Plus strand

Genomic View for IFI27L1 Gene

Genes around IFI27L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27L1 Gene

Proteins for IFI27L1 Gene

  • Protein details for IFI27L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-inducible protein 27-like protein 1
    Protein Accession:

    Protein attributes for IFI27L1 Gene

    104 amino acids
    Molecular mass:
    9549 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFI27L1 Gene

neXtProt entry for IFI27L1 Gene

Post-translational modifications for IFI27L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI27L1 Gene

Domains & Families for IFI27L1 Gene

Gene Families for IFI27L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFI27L1 Gene

  • Interferon-induced 6-16

Suggested Antigen Peptide Sequences for IFI27L1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-stimulated gene 12c protein (I27L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IFI6/IFI27 family.
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27L1: view

Function for IFI27L1 Gene

Molecular function for IFI27L1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the apoptotic process and has a pro-apoptotic activity.
UniProtKB/Swiss-Prot Induction:
Not up-regulated by type-I interferon.

Phenotypes From GWAS Catalog for IFI27L1 Gene

Gene Ontology (GO) - Molecular Function for IFI27L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFI27L1: view
genes like me logo Genes that share phenotypes with IFI27L1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI27L1 Gene

Localization for IFI27L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27L1 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27L1 gene
Compartment Confidence
extracellular 3
mitochondrion 3
plasma membrane 1
nucleus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for IFI27L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFI27L1 Gene

Pathways & Interactions for IFI27L1 Gene

PathCards logo

SuperPathways for IFI27L1 Gene

No Data Available

Interacting Proteins for IFI27L1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96BM0-I27L1_HUMAN ENSP00000451851 for IFI27L1 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for IFI27L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,IMP 27673746
GO:0097190 apoptotic signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with IFI27L1: view

No data available for Pathways by source and SIGNOR curated interactions for IFI27L1 Gene

Drugs & Compounds for IFI27L1 Gene

No Compound Related Data Available

Transcripts for IFI27L1 Gene

mRNA/cDNA for IFI27L1 Gene

4 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27L1

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27L1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - -

Relevant External Links for IFI27L1 Gene

GeneLoc Exon Structure for

Expression for IFI27L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI27L1 Gene

mRNA differential expression in normal tissues according to GTEx for IFI27L1 Gene

This gene is overexpressed in Testis (x6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI27L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFI27L1

SOURCE GeneReport for Unigene cluster for IFI27L1 Gene:


Evidence on tissue expression from TISSUES for IFI27L1 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with IFI27L1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27L1 Gene

Orthologs for IFI27L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFI27L1 31
  • 99 (a)
(Canis familiaris)
Mammalia -- 31
  • 67 (a)
(Mus musculus)
Mammalia Ifi27l2a 31
  • 60 (a)
Ifi27l2b 31
  • 19 (a)
(Bos Taurus)
Mammalia IFI27 31
  • 27 (a)
(Gallus gallus)
Aves IFI27L2 31
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
-- 31
  • 23 (a)
(Danio rerio)
Actinopterygii zgc:152791 31
  • 48 (a)
si:dkey-188i13.11 31
  • 47 (a)
zgc:123068 31
  • 45 (a)
si:dkey-188i13.10 31
  • 44 (a)
si:dkey-188i13.6 31
  • 37 (a)
si:dkey-188i13.7 31
  • 33 (a)
si:dkey-188i13.9 31
  • 33 (a)
Species where no ortholog for IFI27L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFI27L1 Gene

Gene Tree for IFI27L1 (if available)
Gene Tree for IFI27L1 (if available)
Evolutionary constrained regions (ECRs) for IFI27L1: view image

Paralogs for IFI27L1 Gene

(2) SIMAP similar genes for IFI27L1 Gene using alignment to 8 proteins:

  • I27L1_HUMAN
  • G3V248_HUMAN
  • G3V2F0_HUMAN
  • G3V349_HUMAN
  • G3V3W3_HUMAN
  • G3V460_HUMAN
  • G3V4A1_HUMAN
  • G3V585_HUMAN
genes like me logo Genes that share paralogs with IFI27L1: view

No data available for Paralogs for IFI27L1 Gene

Variants for IFI27L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFI27L1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs57677258 - p.Gly35Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFI27L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFI27L1 Gene

Variant ID Type Subtype PubMed ID
esv2669953 CNV deletion 23128226
esv34067 CNV loss 18971310
esv3635373 CNV gain 21293372
esv3892577 CNV gain 25118596
nsv565621 CNV gain 21841781

Variation tolerance for IFI27L1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI27L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27L1 Gene

Disorders for IFI27L1 Gene

Additional Disease Information for IFI27L1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for IFI27L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFI27L1 Gene

Publications for IFI27L1 Gene

  1. Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins. (PMID: 27673746) Gytz H … Martensen PM (Biology of the cell 2017) 3 4
  2. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PMID: 19260139) Polasek O … Rudan I (Croatian medical journal 2009) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12. (PMID: 14728724) Parker N … Porter AC (BMC genomics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for IFI27L1 Gene

Sources for IFI27L1 Gene