Aliases for IFI27 Gene

Aliases for IFI27 Gene

  • Interferon Alpha Inducible Protein 27 2 3 5
  • Interferon Alpha-Inducible Protein 27, Mitochondrial 3 4
  • Interferon Alpha-Induced 11.5 KDa Protein 3 4
  • Interferon-Stimulated Gene 12a Protein 3 4
  • ISG12(A) 3 4
  • ISG12A 3 4
  • P27 3 4
  • 2310061N23Rik 3
  • FAM14D 3
  • ISG12 3

External Ids for IFI27 Gene

Previous GeneCards Identifiers for IFI27 Gene

  • GC14P092084
  • GC14P088393
  • GC14P092567
  • GC14P093646
  • GC14P094577
  • GC14P074756

Summaries for IFI27 Gene

GeneCards Summary for IFI27 Gene

IFI27 (Interferon Alpha Inducible Protein 27) is a Protein Coding gene. Diseases associated with IFI27 include Hepatitis C Virus and Oral Leukoplakia. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include RNA polymerase II activating transcription factor binding and lamin binding. An important paralog of this gene is IFI27L2.

UniProtKB/Swiss-Prot Summary for IFI27 Gene

  • Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).

Gene Wiki entry for IFI27 Gene

Additional gene information for IFI27 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFI27 Gene

Genomics for IFI27 Gene

GeneHancer (GH) Regulatory Elements for IFI27 Gene

Promoters and enhancers for IFI27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J094109 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.4 +7.7 7732 6.3 NRF1 ZIC2 POLR2A HINFP NR2F2 RELA NFIC ZFP36 USF1 IRF1 KY994058 NONHSAG015771.2 IFI27 IFI27L1 PPP4R4 DDX24 IFI27L2
GH14J094102 Enhancer 0.4 ENCODE 500.7 -1.8 -1826 0.2 ZBTB26 FOXA2 FOXA1 IFI27 piR-33712 IFI27L1
GH14J094104 Enhancer 0.2 Ensembl 500.7 -1.3 -1335 0.6 IFI27 piR-33712 IFI27L1
GH14J094077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -25.4 -25436 6.8 ZBTB40 ZSCAN5C SIN3A NRF1 POLR2G SP1 PHF8 ZFX ZNF639 POLR2A DDX24 IFI27L1 NONHSAG015770.2 piR-35837 BTBD7 IFI27 PPP4R4
GH14J094025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 -76.9 -76894 4.3 ZBTB40 ZNF217 CTCF TCF12 USF1 SP1 JUND ZNF639 ZIC2 ZBTB10 OTUB2 DDX24 CCDC197 ASB2 BTBD7 IFI27L2 IFI27L1 IFI27 lnc-IFI27L2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFI27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFI27

Top Transcription factor binding sites by QIAGEN in the IFI27 gene promoter:
  • HOXA5
  • IRF-1
  • IRF-7A
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5A

Genomic Locations for IFI27 Gene

Genomic Locations for IFI27 Gene
chr14:94,104,836-94,116,699
(GRCh38/hg38)
Size:
11,864 bases
Orientation:
Plus strand
chr14:94,571,182-94,583,033
(GRCh37/hg19)
Size:
11,852 bases
Orientation:
Plus strand

Genomic View for IFI27 Gene

Genes around IFI27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27 Gene

Proteins for IFI27 Gene

  • Protein details for IFI27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40305-IFI27_HUMAN
    Recommended name:
    Interferon alpha-inducible protein 27, mitochondrial
    Protein Accession:
    P40305
    Secondary Accessions:
    • A0A087WZF8
    • A8K0H0
    • Q53YA6
    • Q6IEC1
    • Q7Z5R0
    • Q7Z5R1
    • Q7Z5R2
    • Q96BK3
    • Q9H4B1

    Protein attributes for IFI27 Gene

    Size:
    122 amino acids
    Molecular mass:
    11542 Da
    Quaternary structure:
    • Homodimer (PubMed:27673746). Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with SKP2; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with NR4A1 (PubMed:22427340). May interact with BCL2 (PubMed:27673746).
    Miscellaneous:
    • [Isoform 3]: Major isoform in blood and cervix.

    Alternative splice isoforms for IFI27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI27 Gene

Post-translational modifications for IFI27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI27 Gene

Domains & Families for IFI27 Gene

Gene Families for IFI27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IFI27 Gene

Blocks:
  • Interferon-induced 6-16
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFI27 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92370, highly similar to Homo sapiens interferon, alpha-inducible protein 27 (IFI27), mRNA (A8K0H0_HUMAN)
  • Interferon-stimulated gene 12a protein (IFI27_HUMAN)
  • Interferon-induced ISG12-S short isoform (Q7Z5R0_HUMAN)
  • Interferon-induced ISG12-S short isoform (Q7Z5R1_HUMAN)
  • Interferon-induced ISG12c delta isoform (Q7Z5R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40305

UniProtKB/Swiss-Prot:

IFI27_HUMAN :
  • Belongs to the IFI6/IFI27 family.
Family:
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27: view

Function for IFI27 Gene

Molecular function for IFI27 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).
UniProtKB/Swiss-Prot Induction:
Up-regulated by type-I and type-II interferons.
GENATLAS Biochemistry:
interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma

Phenotypes From GWAS Catalog for IFI27 Gene

Gene Ontology (GO) - Molecular Function for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 22427340
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 27194766
GO:0005521 lamin binding IDA 22427340
GO:0042802 identical protein binding IDA 27673746
genes like me logo Genes that share ontologies with IFI27: view
genes like me logo Genes that share phenotypes with IFI27: view

Animal Model Products

CRISPR Products

miRNA for IFI27 Gene

miRTarBase miRNAs that target IFI27

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI27 Gene

Localization for IFI27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27 Gene

Mitochondrion membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported. {ECO:0000269 PubMed:22427340, ECO:0000269 PubMed:27673746}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFI27 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 3
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 11722583
GO:0005637 nuclear inner membrane IDA 22427340
GO:0005739 mitochondrion IBA 21873635
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with IFI27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFI27 Gene

Pathways & Interactions for IFI27 Gene

genes like me logo Genes that share pathways with IFI27: view

Pathways by source for IFI27 Gene

Gene Ontology (GO) - Biological Process for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IGI 22427340
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IDA,IEA 18330707
GO:0016032 viral process IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 27194766
genes like me logo Genes that share ontologies with IFI27: view

No data available for SIGNOR curated interactions for IFI27 Gene

Drugs & Compounds for IFI27 Gene

(41) Drugs for IFI27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(31) Additional Compounds for IFI27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFI27: view

Transcripts for IFI27 Gene

mRNA/cDNA for IFI27 Gene

12 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFI27

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for IFI27 Gene

GeneLoc Exon Structure for
IFI27

Expression for IFI27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFI27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI27 Gene

This gene is overexpressed in Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for IFI27 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI27 Gene



Protein tissue co-expression partners for IFI27 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFI27

SOURCE GeneReport for Unigene cluster for IFI27 Gene:

Hs.532634

Evidence on tissue expression from TISSUES for IFI27 Gene

  • Intestine(3.5)
  • Liver(2.8)
  • Lung(2.7)
  • Stomach(2.7)
  • Gall bladder(2.5)
  • Spleen(2.5)
  • Nervous system(2.5)
  • Kidney(2.2)
  • Pancreas(2.1)
  • Heart(2)
  • Muscle(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with IFI27: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFI27 Gene

Orthologs for IFI27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI27 31 30
  • 98.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifi27l2a 31
  • 59 (a)
ManyToMany
Ifi27l2b 31
  • 19 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia IFI27 31
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFI27L2 31
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:152791 31
  • 49 (a)
ManyToMany
zgc:123068 31
  • 42 (a)
ManyToMany
si:dkey-188i13.11 31
  • 41 (a)
ManyToMany
si:dkey-188i13.10 31
  • 38 (a)
ManyToMany
si:dkey-188i13.9 31
  • 31 (a)
ManyToMany
si:dkey-188i13.7 31
  • 30 (a)
ManyToMany
si:dkey-188i13.6 31
  • 30 (a)
ManyToMany
Species where no ortholog for IFI27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27 Gene

ENSEMBL:
Gene Tree for IFI27 (if available)
TreeFam:
Gene Tree for IFI27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFI27: view image

Paralogs for IFI27 Gene

Paralogs for IFI27 Gene

(3) SIMAP similar genes for IFI27 Gene using alignment to 10 proteins:

  • IFI27_HUMAN
  • A8K0H0_HUMAN
  • C9JX49_HUMAN
  • E7EQA7_HUMAN
  • G3V2M7_HUMAN
  • G3V3Q7_HUMAN
  • G3V4L7_HUMAN
  • G3V4U3_HUMAN
  • G3V5W8_HUMAN
  • H0YJR6_HUMAN
genes like me logo Genes that share paralogs with IFI27: view

Variants for IFI27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFI27 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
768677 Benign: not provided 94,115,784(+) T/TGGCCATGGC INITIATIOR_CODON_VARIANT,INFRAME_INSERTION,FIVE_PRIME_UTR_VARIANT
rs2227974 - p.Ser109Phe

Additional dbSNP identifiers (rs#s) for IFI27 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFI27 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV loss 18971310
esv3635373 CNV gain 21293372
esv3892577 CNV gain 25118596
nsv565621 CNV gain 21841781

Variation tolerance for IFI27 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFI27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFI27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27 Gene

Disorders for IFI27 Gene

MalaCards: The human disease database

(23) MalaCards diseases for IFI27 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
oral leukoplakia
  • leukoplakia oral
hepatitis c
  • chronic hepatitis c
hepatitis
  • hepatitis a
newcastle disease
  • newcastle's disease
- elite association - COSMIC cancer census association via MalaCards
Search IFI27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFI27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFI27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI27 Gene

Publications for IFI27 Gene

  1. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PMID: 8358738) Rasmussen UB … Basset P (Cancer research 1993) 2 3 4 23 54
  2. Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins. (PMID: 27673746) Gytz H … Martensen PM (Biology of the cell 2017) 3 4 54
  3. ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis. (PMID: 27777077) Chen Y … Chen L (Virus research 2017) 3 4 54
  4. ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. (PMID: 27194766) Xue B … Zhu H (Journal of virology 2016) 3 4 54
  5. miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT. (PMID: 24970806) Liu N … Zhu H (Oncotarget 2014) 3 4 54

Products for IFI27 Gene

Sources for IFI27 Gene