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Aliases for IFFO2 Gene

Aliases for IFFO2 Gene

  • Intermediate Filament Family Orphan 2 2 3 4 5

External Ids for IFFO2 Gene

Previous GeneCards Identifiers for IFFO2 Gene

  • GC01M019106
  • GC01M019230
  • GC01M017474

Summaries for IFFO2 Gene

GeneCards Summary for IFFO2 Gene

IFFO2 (Intermediate Filament Family Orphan 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO1.

Additional gene information for IFFO2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFFO2 Gene

Genomics for IFFO2 Gene

GeneHancer (GH) Regulatory Elements for IFFO2 Gene

Promoters and enhancers for IFFO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J018946 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +4.2 4218 11.5 SP1 ZFX ELF3 ZNF148 NKRF POLR2A ZNF121 CEBPG RERE ZNF687 IFFO2 EMC1 ALDH4A1 AKR7A3 UBR4 AKR7A2 ENSG00000255275
GH01J018901 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +53.8 53838 3.7 HDGF ZNF652 CC2D1A ZFX SP1 ELF3 MNT SIX5 CBFA2T2 ZNF148 ALDH4A1 UBR4 IFFO2 ENSG00000255275
GH01J019006 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.5 -51.1 -51141 2.4 ELF3 SP1 ZNF644 RXRA CEBPA GATAD2A REST RCOR2 ZNF24 SOX13 GC01P019006 IFFO2 EMC1 GC01P019027 LOC105376815
GH01J018925 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +28.5 28479 4.3 ZNF148 ZNF687 SP7 CREM MLLT1 RELA IKZF1 POLR2A ZBTB33 ZNF600 UBR4 EMC1 IFFO2 ENSG00000255275
GH01J018936 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 13.2 +16.7 16728 7.5 ZNF652 MNT ZNF121 CEBPG RERE TFE3 SP1 PPARG SP5 ZNF384 UBR4 IFFO2 EMC1 AKR7A3 ENSG00000255275
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFFO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFFO2 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • FosB
  • FOXJ2
  • Fra-1
  • JunB
  • JunD
  • Nkx2-5

Genomic Locations for IFFO2 Gene

Genomic Locations for IFFO2 Gene
chr1:18,904,280-18,956,676
(GRCh38/hg38)
Size:
52,397 bases
Orientation:
Minus strand
chr1:19,230,774-19,283,180
(GRCh37/hg19)
Size:
52,407 bases
Orientation:
Minus strand

Genomic View for IFFO2 Gene

Genes around IFFO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFFO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFFO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO2 Gene

Proteins for IFFO2 Gene

  • Protein details for IFFO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TF58-IFFO2_HUMAN
    Recommended name:
    Intermediate filament family orphan 2
    Protein Accession:
    Q5TF58
    Secondary Accessions:
    • Q9H7K0

    Protein attributes for IFFO2 Gene

    Size:
    517 amino acids
    Molecular mass:
    57328 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFFO2 Gene

Post-translational modifications for IFFO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFFO2 Gene

No data available for DME Specific Peptides for IFFO2 Gene

Domains & Families for IFFO2 Gene

Gene Families for IFFO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFFO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFFO2 Gene

GenScript: Design optimal peptide antigens:
  • Intermediate filament family orphan 2 (IFFO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5TF58

UniProtKB/Swiss-Prot:

IFFO2_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO2: view

Function for IFFO2 Gene

Phenotypes From GWAS Catalog for IFFO2 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IFFO2 - Now 50% OFF >
  • * IFFO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IFFO2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFFO2 Gene

Localization for IFFO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFFO2 gene
Compartment Confidence
cytoskeleton 3
peroxisome 1
nucleus 1
cytosol 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFFO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFFO2 Gene

Pathways & Interactions for IFFO2 Gene

PathCards logo

SuperPathways for IFFO2 Gene

No Data Available

Interacting Proteins for IFFO2 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000387941%0d9606.ENSP00000421491%0d9606.ENSP00000410294%0d
Selected Interacting proteins: Q5TF58-IFFO2_HUMAN ENSP00000387941 for IFFO2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for IFFO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFFO2 Gene

Drugs & Compounds for IFFO2 Gene

No Compound Related Data Available

Transcripts for IFFO2 Gene

mRNA/cDNA for IFFO2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for IFFO2 Gene

Intermediate filament family orphan 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IFFO2 - Now 50% OFF >
  • * IFFO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IFFO2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO2 Gene

No ASD Table

Relevant External Links for IFFO2 Gene

GeneLoc Exon Structure for
IFFO2
ECgene alternative splicing isoforms for
IFFO2

Expression for IFFO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFFO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFFO2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.5), Skin - Sun Exposed (Lower leg) (x8.9), and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for IFFO2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFFO2 Gene



Protein tissue co-expression partners for IFFO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFFO2 Gene:

IFFO2

SOURCE GeneReport for Unigene cluster for IFFO2 Gene:

Hs.466625

Evidence on tissue expression from TISSUES for IFFO2 Gene

  • Spleen(4.1)
genes like me logo Genes that share expression patterns with IFFO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFFO2 Gene

Orthologs for IFFO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFFO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFFO2 35 34
  • 98.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IFFO2 34
  • 95.29 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Iffo2 34
  • 93.03 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Iffo2 17 35 34
  • 90.17 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 85 (a)
OneToMany
IFFO2 34
  • 79.5 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo2 34
  • 78.72 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150502 34
  • 69.08 (n)
CABZ01030889.1 35
  • 65 (a)
ManyToMany
iffo2a 35
  • 64 (a)
ManyToMany
Species where no ortholog for IFFO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO2 Gene

ENSEMBL:
Gene Tree for IFFO2 (if available)
TreeFam:
Gene Tree for IFFO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFFO2: view image

Paralogs for IFFO2 Gene

Paralogs for IFFO2 Gene

(4) SIMAP similar genes for IFFO2 Gene using alignment to 3 proteins:

  • IFFO2_HUMAN
  • H0Y4W3_HUMAN
  • J3KNZ4_HUMAN
genes like me logo Genes that share paralogs with IFFO2: view

Variants for IFFO2 Gene

Sequence variations from dbSNP and Humsavar for IFFO2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000081390 -- 18,924,853(-) G/A intron_variant
rs1000190922 -- 18,949,035(-) G/A intron_variant
rs1000196463 -- 18,955,887(-) G/A coding_sequence_variant, missense_variant
rs1000244050 -- 18,943,013(-) C/A intron_variant
rs1000249566 -- 18,916,197(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IFFO2 Gene

Variant ID Type Subtype PubMed ID
nsv1142751 CNV deletion 24896259
nsv512722 CNV insertion 21212237
nsv834347 CNV gain 17160897

Variation tolerance for IFFO2 Gene

Gene Damage Index Score: 3.43; 54.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFFO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFFO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFFO2 Gene

Disorders for IFFO2 Gene

Additional Disease Information for IFFO2

No disorders were found for IFFO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFFO2 Gene

Publications for IFFO2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays. (PMID: 29560723) Masschaele D … Tavernier J (Journal of proteome research 2018) 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan LC … Rothenberg ME (Nature genetics 2014) 3 58

Products for IFFO2 Gene

Sources for IFFO2 Gene

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