Aliases for IFFO2 Gene

Aliases for IFFO2 Gene

  • Intermediate Filament Family Orphan 2 2 3 4 5
  • IFFO2 5

External Ids for IFFO2 Gene

Previous GeneCards Identifiers for IFFO2 Gene

  • GC01M019106
  • GC01M019230
  • GC01M017474

Summaries for IFFO2 Gene

GeneCards Summary for IFFO2 Gene

IFFO2 (Intermediate Filament Family Orphan 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFFO2 Gene

Genomics for IFFO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFFO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J018946 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.8 +4.4 4418 11.1 SP1 HNRNPL GATAD2A TEAD4 ZNF629 TFE3 NFKBIZ KDM1A ZNF692 RCOR2 IFFO2 EMC1 ALDH4A1 AKR7A3 UBR4 AKR7A2 lnc-PAX7-7 AB372591
GH01J018901 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +53.8 53824 3.6 BRCA1 RNF2 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 ZNF629 REST ALDH4A1 HSALNG0001341 UBR4 IFFO2 MN308687
GH01J019007 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.5 -50.5 -50541 2.8 HNRNPL GATAD2A KDM1A RCOR2 REST SP1 ZNF24 CEBPA SOX13 ZSCAN5C IFFO2 EMC1 lnc-IFFO2-1 piR-42491-002 LOC105376815 UBR4
GH01J018925 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +28.5 28493 4.4 ZBTB33 IKZF1 POLR2A JUND ZNF24 SMAD5 IKZF2 RELA ZNF747 ZNF600 EMC1 UBR4 IFFO2 AB372591 MN308687 ALDH4A1
GH01J018936 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 13.2 +16.7 16728 7.5 GATAD2A PRDM10 ZNF629 TFE3 SOX13 KDM1A ZNF692 RCOR2 ZIC2 ZNF600 IFFO2 EMC1 AKR7A3 AB372591 ALDH4A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFFO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFFO2

Top Transcription factor binding sites by QIAGEN in the IFFO2 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • FosB
  • FOXJ2
  • Fra-1
  • JunB
  • JunD
  • Nkx2-5

Genomic Locations for IFFO2 Gene

Genomic Locations for IFFO2 Gene
chr1:18,904,280-18,956,676
(GRCh38/hg38)
Size:
52,397 bases
Orientation:
Minus strand
chr1:19,230,774-19,283,180
(GRCh37/hg19)
Size:
52,407 bases
Orientation:
Minus strand

Genomic View for IFFO2 Gene

Genes around IFFO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFFO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFFO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO2 Gene

Proteins for IFFO2 Gene

  • Protein details for IFFO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TF58-IFFO2_HUMAN
    Recommended name:
    Intermediate filament family orphan 2
    Protein Accession:
    Q5TF58
    Secondary Accessions:
    • Q9H7K0

    Protein attributes for IFFO2 Gene

    Size:
    517 amino acids
    Molecular mass:
    57328 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFFO2 Gene

Post-translational modifications for IFFO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFFO2 Gene

No data available for DME Specific Peptides for IFFO2 Gene

Domains & Families for IFFO2 Gene

Gene Families for IFFO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFFO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFFO2 Gene

GenScript: Design optimal peptide antigens:
  • Intermediate filament family orphan 2 (IFFO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5TF58

UniProtKB/Swiss-Prot:

IFFO2_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO2: view

Function for IFFO2 Gene

Phenotypes From GWAS Catalog for IFFO2 Gene

Animal Model Products

CRISPR Products

miRNA for IFFO2 Gene

miRTarBase miRNAs that target IFFO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFFO2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFFO2 Gene

Localization for IFFO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFFO2 gene
Compartment Confidence
cytoskeleton 3
extracellular 1
peroxisome 1
nucleus 1
cytosol 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IFFO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IFFO2 Gene

Pathways & Interactions for IFFO2 Gene

PathCards logo

SuperPathways for IFFO2 Gene

No Data Available

Interacting Proteins for IFFO2 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000387941 Q5TF58-IFFO2_HUMAN for IFFO2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IFFO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFFO2 Gene

Drugs & Compounds for IFFO2 Gene

No Compound Related Data Available

Transcripts for IFFO2 Gene

mRNA/cDNA for IFFO2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFFO2

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO2 Gene

No ASD Table

Relevant External Links for IFFO2 Gene

GeneLoc Exon Structure for
IFFO2

Expression for IFFO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFFO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFFO2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.5), Skin - Sun Exposed (Lower leg) (x8.9), and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for IFFO2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFFO2 Gene



Protein tissue co-expression partners for IFFO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFFO2

SOURCE GeneReport for Unigene cluster for IFFO2 Gene:

Hs.466625

Evidence on tissue expression from TISSUES for IFFO2 Gene

  • Spleen(4.1)
genes like me logo Genes that share expression patterns with IFFO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFFO2 Gene

Orthologs for IFFO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFFO2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFFO2 30 31
  • 98.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IFFO2 30
  • 95.29 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 94 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Iffo2 30
  • 93.03 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 91 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Iffo2 30 17 31
  • 90.17 (n)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 85 (a)
OneToMany
IFFO2 30
  • 79.5 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 83 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia iffo2 30
  • 78.72 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100150502 30
  • 69.08 (n)
CABZ01030889.1 31
  • 65 (a)
ManyToMany
iffo2a 31
  • 64 (a)
ManyToMany
Species where no ortholog for IFFO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFFO2 Gene

ENSEMBL:
Gene Tree for IFFO2 (if available)
TreeFam:
Gene Tree for IFFO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFFO2: view image

Paralogs for IFFO2 Gene

Paralogs for IFFO2 Gene

(4) SIMAP similar genes for IFFO2 Gene using alignment to 3 proteins:

  • IFFO2_HUMAN
  • H0Y4W3_HUMAN
  • J3KNZ4_HUMAN
genes like me logo Genes that share paralogs with IFFO2: view

Variants for IFFO2 Gene

Additional dbSNP identifiers (rs#s) for IFFO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFFO2 Gene

Variant ID Type Subtype PubMed ID
nsv1142751 CNV deletion 24896259
nsv512722 CNV insertion 21212237
nsv834347 CNV gain 17160897

Variation tolerance for IFFO2 Gene

Gene Damage Index Score: 3.43; 54.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFFO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFFO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFFO2 Gene

Disorders for IFFO2 Gene

Additional Disease Information for IFFO2

No disorders were found for IFFO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFFO2 Gene

Publications for IFFO2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays. (PMID: 29560723) Masschaele D … Tavernier J (Journal of proteome research 2018) 3
  4. The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for IFFO2 Gene

Sources for IFFO2 Gene