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Aliases for IFFO1 Gene

Aliases for IFFO1 Gene

  • Intermediate Filament Family Orphan 1 2 3 4 5
  • IFFO 3 4
  • Intermediate Filament-Like MGC:2625 3
  • Intermediate Filament Family Orphan 2
  • Tumor Antigen HOM-TES-103 4
  • HOM-TES-103 3

External Ids for IFFO1 Gene

Previous HGNC Symbols for IFFO1 Gene

  • IFFO

Previous GeneCards Identifiers for IFFO1 Gene

  • GC12M006521
  • GC12M006648

Summaries for IFFO1 Gene

Entrez Gene Summary for IFFO1 Gene

  • This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IFFO1 Gene

IFFO1 (Intermediate Filament Family Orphan 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO2.

Additional gene information for IFFO1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFFO1 Gene

Genomics for IFFO1 Gene

GeneHancer (GH) Regulatory Elements for IFFO1 Gene

Promoters and enhancers for IFFO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006546 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 610.8 +4.2 4168 10.3 SP1 CTCF ELF3 POLR2A ZNF687 ZSCAN21 FOS TFE3 YY1 SP7 IFFO1 CHD4 ENSG00000247853 ENSG00000219410 TAPBPL VAMP1 ZNF384 SCARNA11 SCARNA10 NCAPD2
GH12J006557 Enhancer 0.9 ENCODE dbSUPER 600.7 -2.0 -1983 0.5 ZNF384 CTCF PRDM10 PHF21A TRIM22 GABPA BCL11A RAD21 GABPB1 ZBTB11 IFFO1 VAMP1 NOP2 ENSG00000285238
GH12J006602 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -49.6 -49645 7.4 SP1 CC2D1A ZKSCAN8 ZNF148 NKRF POLR2A MLLT1 CSDE1 ZNF687 ZSCAN21 CHD4 ENSG00000285238 ZNF384 ENSG00000219410 ENSG00000247853 NCAPD2 NOP2 EMG1 ING4 SPSB2
GH12J006382 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +171.9 171910 3.3 ZNF652 ZFX ELF3 CEBPG RERE GTF2F1 AHR MYC TFE3 TRIM24 LTBR TNFRSF1A PLEKHG6 TAPBPL CD27-AS1 IFFO1 ENSG00000256433 SCNN1A LOC105369628
GH12J006530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +19.0 18987 12.8 HDGF ZNF652 SP1 ZFX ELF3 CC2D1A CTCF ZNF148 NKRF POLR2A GAPDH ENSG00000269968 GPR162 ZNF384 CHD4 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ATN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFFO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFFO1 gene promoter:
  • c-Ets-1
  • C/EBPbeta
  • Elk-1
  • FOXO4
  • NF-1
  • Zic3

Genomic Locations for IFFO1 Gene

Genomic Locations for IFFO1 Gene
17,709 bases
Minus strand
17,709 bases
Minus strand

Genomic View for IFFO1 Gene

Genes around IFFO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFFO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFFO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO1 Gene

Proteins for IFFO1 Gene

  • Protein details for IFFO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intermediate filament family orphan 1
    Protein Accession:
    Secondary Accessions:
    • Q24JT6
    • Q7L5J9
    • Q7Z5X4
    • Q9BQ46

    Protein attributes for IFFO1 Gene

    559 amino acids
    Molecular mass:
    61979 Da
    Quaternary structure:
    No Data Available
    • Sequence=AF124432; Type=Frameshift; Positions=119, 226, 384; Evidence={ECO:0000305}; Sequence=AF124432; Type=Frameshift; Positions=121, 227, 385; Evidence={ECO:0000305};

    Alternative splice isoforms for IFFO1 Gene

neXtProt entry for IFFO1 Gene

Post-translational modifications for IFFO1 Gene

  • Ubiquitination at posLast=103103, posLast=7878, and posLast=113113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IFFO1 Gene

Domains & Families for IFFO1 Gene

Gene Families for IFFO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFFO1 Gene


Suggested Antigen Peptide Sequences for IFFO1 Gene

GenScript: Design optimal peptide antigens:
  • Tumor antigen HOM-TES-103 (IFFO1_HUMAN)
  • IFFO1 protein (Q6P593_HUMAN)
  • cDNA FLJ20703 fis, clone KAIA1965 (Q9NWP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO1: view

Function for IFFO1 Gene

Phenotypes From GWAS Catalog for IFFO1 Gene

genes like me logo Genes that share phenotypes with IFFO1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IFFO1 - Now 50% OFF >
  • * IFFO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IFFO1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFFO1 Gene

Localization for IFFO1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFFO1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IFFO1 Gene

Pathways & Interactions for IFFO1 Gene

PathCards logo

SuperPathways for IFFO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFFO1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IFFO1 Gene

Drugs & Compounds for IFFO1 Gene

No Compound Related Data Available

Transcripts for IFFO1 Gene

Unigene Clusters for IFFO1 Gene

Intermediate filament family orphan 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IFFO1 - Now 50% OFF >
  • * IFFO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IFFO1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP4: - - -
SP5: - -

Relevant External Links for IFFO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFFO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFFO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFFO1 Gene

This gene is overexpressed in Heart (49.2), Milk (9.1), and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFFO1 Gene

Protein tissue co-expression partners for IFFO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFFO1 Gene:


SOURCE GeneReport for Unigene cluster for IFFO1 Gene:


mRNA Expression by UniProt/SwissProt for IFFO1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for IFFO1 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with IFFO1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFFO1 Gene

Orthologs for IFFO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IFFO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFFO1 35 34
  • 99.77 (n)
(Bos Taurus)
Mammalia IFFO1 35
  • 94 (a)
(Canis familiaris)
Mammalia IFFO1 35 34
  • 92.96 (n)
(Mus musculus)
Mammalia Iffo1 17 35 34
  • 89.32 (n)
(Rattus norvegicus)
Mammalia Iffo1 34
  • 88.66 (n)
(Monodelphis domestica)
Mammalia IFFO1 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia IFFO1 35
  • 85 (a)
(Gallus gallus)
Aves IFFO1 35
  • 81 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
-- 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo1 34
  • 70.57 (n)
Str.2744 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22282 34
(Danio rerio)
Actinopterygii LOC563794 34
  • 64.18 (n)
iffo1a 35
  • 50 (a)
iffo1b 35
  • 50 (a)
sbcb164 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2490 34
(Oryza sativa)
Liliopsida Os.16852 34
(Hordeum vulgare)
Liliopsida Hv.5144 34
(Zea mays)
Liliopsida Zm.731 34
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1551 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1551 34
Species where no ortholog for IFFO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO1 Gene

Gene Tree for IFFO1 (if available)
Gene Tree for IFFO1 (if available)
Evolutionary constrained regions (ECRs) for IFFO1: view image

Paralogs for IFFO1 Gene

Paralogs for IFFO1 Gene

(5) SIMAP similar genes for IFFO1 Gene using alignment to 4 proteins:

  • F8W8H2_HUMAN
  • Q6P593_HUMAN
genes like me logo Genes that share paralogs with IFFO1: view

Variants for IFFO1 Gene

Sequence variations from dbSNP and Humsavar for IFFO1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000043749 -- 6,545,838(-) G/A intron_variant
rs1000108220 -- 6,543,285(-) G/A intron_variant
rs1000335740 -- 6,553,504(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000398238 -- 6,556,825(-) AAA/AAAA upstream_transcript_variant
rs1000453804 -- 6,553,332(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFFO1 Gene

Variant ID Type Subtype PubMed ID
esv2759876 CNV gain 17122850
esv3628408 CNV gain 21293372

Variation tolerance for IFFO1 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFFO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFFO1 Gene

Disorders for IFFO1 Gene

Additional Disease Information for IFFO1

No disorders were found for IFFO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFFO1 Gene

Publications for IFFO1 Gene

  1. Intermediate filament proteins. (PMID: 8771189) Quinlan R … Lane B (Protein profile 1995) 2 3 58
  2. Molecular and cellular biology of intermediate filaments. (PMID: 3052284) Steinert PM … Roop DR (Annual review of biochemistry 1988) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for IFFO1 Gene

Sources for IFFO1 Gene

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