This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively splice... See more...

Aliases for IFFO1 Gene

Aliases for IFFO1 Gene

  • Intermediate Filament Family Orphan 1 2 3 4 5
  • IFFO 3 4
  • Intermediate Filament-Like MGC:2625 3
  • Intermediate Filament Family Orphan 2
  • Tumor Antigen HOM-TES-103 4
  • HOM-TES-103 3

External Ids for IFFO1 Gene

Previous HGNC Symbols for IFFO1 Gene

  • IFFO

Previous GeneCards Identifiers for IFFO1 Gene

  • GC12M006521
  • GC12M006648

Summaries for IFFO1 Gene

Entrez Gene Summary for IFFO1 Gene

  • This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IFFO1 Gene

IFFO1 (Intermediate Filament Family Orphan 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is IFFO2.

Additional gene information for IFFO1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFFO1 Gene

Genomics for IFFO1 Gene

GeneHancer (GH) Regulatory Elements for IFFO1 Gene

Promoters and enhancers for IFFO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFFO1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFFO1

Top Transcription factor binding sites by QIAGEN in the IFFO1 gene promoter:
  • c-Ets-1
  • C/EBPbeta
  • Elk-1
  • FOXO4
  • NF-1
  • Zic3

Genomic Locations for IFFO1 Gene

Genomic Locations for IFFO1 Gene
chr12:6,538,375-6,556,083
(GRCh38/hg38)
Size:
17,709 bases
Orientation:
Minus strand
chr12:6,647,541-6,665,249
(GRCh37/hg19)
Size:
17,709 bases
Orientation:
Minus strand

Genomic View for IFFO1 Gene

Genes around IFFO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFFO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFFO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFFO1 Gene

Proteins for IFFO1 Gene

  • Protein details for IFFO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0D2I5-IFFO1_HUMAN
    Recommended name:
    Intermediate filament family orphan 1
    Protein Accession:
    Q0D2I5
    Secondary Accessions:
    • Q24JT6
    • Q7L5J9
    • Q7Z5X4
    • Q9BQ46

    Protein attributes for IFFO1 Gene

    Size:
    559 amino acids
    Molecular mass:
    61979 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AF124432; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFFO1 Gene

    Alternative splice isoforms for IFFO1 Gene

neXtProt entry for IFFO1 Gene

Post-translational modifications for IFFO1 Gene

  • Ubiquitination at Lys78, Lys103, and Lys113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IFFO1 Gene

Domains & Families for IFFO1 Gene

Gene Families for IFFO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IFFO1 Gene

Blocks:
  • Intermediate filament protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFFO1 Gene

GenScript: Design optimal peptide antigens:
  • Tumor antigen HOM-TES-103 (IFFO1_HUMAN)
  • IFFO1 protein (Q6P593_HUMAN)
  • cDNA FLJ20703 fis, clone KAIA1965 (Q9NWP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q0D2I5

UniProtKB/Swiss-Prot:

IFFO1_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with IFFO1: view

Function for IFFO1 Gene

Phenotypes From GWAS Catalog for IFFO1 Gene

genes like me logo Genes that share phenotypes with IFFO1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFFO1 Gene

Localization for IFFO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFFO1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for IFFO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with IFFO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IFFO1 Gene

Pathways & Interactions for IFFO1 Gene

PathCards logo

SuperPathways for IFFO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IFFO1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFFO1 Gene

Drugs & Compounds for IFFO1 Gene

No Compound Related Data Available

Transcripts for IFFO1 Gene

mRNA/cDNA for IFFO1 Gene

8 REFSEQ mRNAs :
33 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFFO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3:
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for IFFO1 Gene

GeneLoc Exon Structure for
IFFO1

Expression for IFFO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFFO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFFO1 Gene

This gene is overexpressed in Heart (49.2), Milk (9.1), and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFFO1 Gene



Protein tissue co-expression partners for IFFO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFFO1

SOURCE GeneReport for Unigene cluster for IFFO1 Gene:

Hs.15243

mRNA Expression by UniProt/SwissProt for IFFO1 Gene:

Q0D2I5-IFFO1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for IFFO1 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with IFFO1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFFO1 Gene

Orthologs for IFFO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IFFO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFFO1 31 30
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IFFO1 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFFO1 31 30
  • 92.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Iffo1 17 31 30
  • 89.32 (n)
rat
(Rattus norvegicus)
Mammalia Iffo1 30
  • 88.66 (n)
oppossum
(Monodelphis domestica)
Mammalia IFFO1 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFFO1 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFFO1 31
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 92 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iffo1 30
  • 70.57 (n)
Str.2744 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22282 30
zebrafish
(Danio rerio)
Actinopterygii LOC563794 30
  • 64.18 (n)
iffo1a 31
  • 50 (a)
OneToMany
iffo1b 31
  • 50 (a)
OneToMany
sbcb164 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2490 30
corn
(Zea mays)
Liliopsida Zm.731 30
rice
(Oryza sativa)
Liliopsida Os.16852 30
barley
(Hordeum vulgare)
Liliopsida Hv.5144 30
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1551 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1551 30
Species where no ortholog for IFFO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFFO1 Gene

ENSEMBL:
Gene Tree for IFFO1 (if available)
TreeFam:
Gene Tree for IFFO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFFO1: view image

Paralogs for IFFO1 Gene

Paralogs for IFFO1 Gene

(5) SIMAP similar genes for IFFO1 Gene using alignment to 4 proteins:

  • IFFO1_HUMAN
  • E9PPX7_HUMAN
  • F8W8H2_HUMAN
  • Q6P593_HUMAN
genes like me logo Genes that share paralogs with IFFO1: view

Variants for IFFO1 Gene

Additional dbSNP identifiers (rs#s) for IFFO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFFO1 Gene

Variant ID Type Subtype PubMed ID
esv2759876 CNV gain 17122850
esv3628408 CNV gain 21293372

Variation tolerance for IFFO1 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFFO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFFO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFFO1 Gene

Disorders for IFFO1 Gene

Additional Disease Information for IFFO1

No disorders were found for IFFO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFFO1 Gene

Publications for IFFO1 Gene

  1. Intermediate filament proteins. (PMID: 8771189) Quinlan R … Lane B (Protein profile 1995) 2 3 54
  2. Molecular and cellular biology of intermediate filaments. (PMID: 3052284) Steinert PM … Roop DR (Annual review of biochemistry 1988) 2 3 54
  3. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. (PMID: 31548606) Li W … Xu D (Nature cell biology 2019) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3 54

Products for IFFO1 Gene

Sources for IFFO1 Gene