Aliases for IER5L Gene

Aliases for IER5L Gene

  • Immediate Early Response 5 Like 2 3 5
  • Immediate Early Response Gene 5-Like Protein 3 4
  • BA247A12.2 2 3
  • IER5L 5

External Ids for IER5L Gene

Previous GeneCards Identifiers for IER5L Gene

  • GC09M129018
  • GC09M130977
  • GC09M131937
  • GC09M101545

Summaries for IER5L Gene

GeneCards Summary for IER5L Gene

IER5L (Immediate Early Response 5 Like) is a Protein Coding gene. Diseases associated with IER5L include Spinal Muscular Atrophy, Type Iv and Retinitis Pigmentosa 7. An important paralog of this gene is IER5.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IER5L Gene

Genomics for IER5L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IER5L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IER5L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IER5L

Top Transcription factor binding sites by QIAGEN in the IER5L gene promoter:
  • aMEF-2
  • Egr-1
  • Egr-2
  • GATA-2
  • MEF-2A
  • NF-1
  • NF-1/L
  • p300
  • Pax-5
  • YY1

Genomic Locations for IER5L Gene

Latest Assembly
2,710 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,710 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,706 bases
Minus strand

Genomic View for IER5L Gene

Genes around IER5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5L Gene

Proteins for IER5L Gene

  • Protein details for IER5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immediate early response gene 5-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6P3E2

    Protein attributes for IER5L Gene

    404 amino acids
    Molecular mass:
    42109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IER5L Gene


neXtProt entry for IER5L Gene

Post-translational modifications for IER5L Gene

No Post-translational modifications

Other Protein References for IER5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5L Gene

Domains & Families for IER5L Gene

Gene Families for IER5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IER5L Gene


Suggested Antigen Peptide Sequences for IER5L Gene

GenScript: Design optimal peptide antigens:
  • Immediate early response gene 5-like protein (IER5L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IER family.
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5L: view

Function for IER5L Gene

Phenotypes From GWAS Catalog for IER5L Gene

genes like me logo Genes that share phenotypes with IER5L: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER5L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IER5L Gene

Localization for IER5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER5L gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5L Gene

Pathways & Interactions for IER5L Gene

PathCards logo

SuperPathways for IER5L Gene

No Data Available

Interacting Proteins for IER5L Gene

Gene Ontology (GO) - Biological Process for IER5L Gene


No data available for Pathways by source and SIGNOR curated interactions for IER5L Gene

Drugs & Compounds for IER5L Gene

No Compound Related Data Available

Transcripts for IER5L Gene

mRNA/cDNA for IER5L Gene

7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER5L

Alternative Splicing Database (ASD) splice patterns (SP) for IER5L Gene

No ASD Table

Relevant External Links for IER5L Gene

GeneLoc Exon Structure for

Expression for IER5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IER5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5L Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IER5L Gene

Protein tissue co-expression partners for IER5L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IER5L

SOURCE GeneReport for Unigene cluster for IER5L Gene:

genes like me logo Genes that share expression patterns with IER5L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER5L Gene

Orthologs for IER5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IER5L 29 30
  • 93.23 (n)
(Bos Taurus)
Mammalia IER5L 29 30
  • 92.93 (n)
(Rattus norvegicus)
Mammalia Ier5l 29
  • 92.58 (n)
(Mus musculus)
Mammalia Ier5l 29 16 30
  • 92.56 (n)
(Monodelphis domestica)
Mammalia IER5L 30
  • 48 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ier5l 29
  • 74.83 (n)
MGC75980 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.33398 29
(Danio rerio)
Actinopterygii ier5l 29 30
  • 68.46 (n)
wufe50b07 29
Species where no ortholog for IER5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IER5L Gene

Gene Tree for IER5L (if available)
Gene Tree for IER5L (if available)
Evolutionary constrained regions (ECRs) for IER5L: view image
Alliance of Genome Resources:
Additional Orthologs for IER5L

Paralogs for IER5L Gene

Paralogs for IER5L Gene

genes like me logo Genes that share paralogs with IER5L: view

Variants for IER5L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IER5L Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs192335853 Benign: not provided 129,177,372(-) C/A
NM_203434.3(IER5L):c.681G>T (p.Pro227=)
rs60193826 Benign: not provided 129,177,273(-) G/A
NM_203434.3(IER5L):c.780C>T (p.Asp260=)
rs184457 -- p.Pro105Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IER5L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IER5L Gene

Variant ID Type Subtype PubMed ID
esv2675916 CNV deletion 23128226
nsv1137668 CNV deletion 24896259
nsv1144292 CNV deletion 24896259
nsv466578 CNV loss 19166990
nsv615417 CNV loss 21841781
nsv615418 CNV loss 21841781
nsv818725 CNV gain 17921354
nsv825108 CNV gain 20364138
nsv825110 CNV gain 20364138
nsv825111 CNV gain 20364138

Variation tolerance for IER5L Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IER5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5L Gene

Disorders for IER5L Gene

MalaCards: The human disease database

(3) MalaCards diseases for IER5L Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search IER5L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IER5L

genes like me logo Genes that share disorders with IER5L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IER5L Gene

Publications for IER5L Gene

  1. IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A. (PMID: 30599213) Ueda T … Sakurai H (Cellular signalling 2019) 3
  2. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3

Products for IER5L Gene

Sources for IER5L Gene