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Aliases for IER5L Gene

Aliases for IER5L Gene

  • Immediate Early Response 5 Like 2 3 5
  • Immediate Early Response Gene 5-Like Protein 3
  • BA247A12.2 3

External Ids for IER5L Gene

Previous GeneCards Identifiers for IER5L Gene

  • GC09M129018
  • GC09M130977
  • GC09M131937
  • GC09M101545

Summaries for IER5L Gene

GeneCards Summary for IER5L Gene

IER5L (Immediate Early Response 5 Like) is a Protein Coding gene. An important paralog of this gene is IER5.

Additional gene information for IER5L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER5L Gene

Genomics for IER5L Gene

GeneHancer (GH) Regulatory Elements for IER5L Gene

Promoters and enhancers for IER5L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I129172 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.1 +2.5 2502 7.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC PPARGC1A SSRP1 IER5L ENSG00000268050 LOC105376289 CRAT NUP188 CIZ1 ODF2 GLE1 TOR1A SPOUT1
GH09I129179 Enhancer 0.7 ENCODE dbSUPER 550.8 -1.9 -1852 0.4 E2F1 ZBTB33 ZNF18 ZBTB17 IER5L CRAT LOC105376289 GC09M129195
GH09I129317 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 11.6 -142.6 -142560 7.2 FOXA2 PKNOX1 ARID4B SIN3A ZNF48 YY1 ETS1 GATA2 ZNF207 ZNF143 C9orf106 IER5L LOC105376289 ENSG00000273186 SH3GLB2 LOC101929331
GH09I129330 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.7 -156.3 -156281 7.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IER5L LOC105376289 LINC01503 C9orf50 NTMT1 RN7SL159P
GH09I129555 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -379.7 -379680 4.1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 PAF1 NTMT1 C9orf50 IER5L LOC105376289 PKN3 DOLPP1 LOC105376292 LINC00963
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IER5L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IER5L gene promoter:

Genomic Locations for IER5L Gene

Genomic Locations for IER5L Gene
chr9:129,175,552-129,178,262
(GRCh38/hg38)
Size:
2,711 bases
Orientation:
Minus strand
chr9:131,937,831-131,940,540
(GRCh37/hg19)

Genomic View for IER5L Gene

Genes around IER5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IER5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IER5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IER5L Gene

Proteins for IER5L Gene

  • Protein details for IER5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T953-IER5L_HUMAN
    Recommended name:
    Immediate early response gene 5-like protein
    Protein Accession:
    Q5T953
    Secondary Accessions:
    • Q6P3E2

    Protein attributes for IER5L Gene

    Size:
    404 amino acids
    Molecular mass:
    42109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IER5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IER5L Gene

Post-translational modifications for IER5L Gene

No Post-translational modifications

Other Protein References for IER5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER5L Gene

Domains & Families for IER5L Gene

Gene Families for IER5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IER5L Gene

Suggested Antigen Peptide Sequences for IER5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T953

UniProtKB/Swiss-Prot:

IER5L_HUMAN :
  • Belongs to the IER family.
Family:
  • Belongs to the IER family.
genes like me logo Genes that share domains with IER5L: view

Function for IER5L Gene

Phenotypes From GWAS Catalog for IER5L Gene

Phenotypes for IER5L Gene

GenomeRNAi human phenotypes for IER5L:
genes like me logo Genes that share phenotypes with IER5L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IER5L Gene

Localization for IER5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IER5L gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IER5L Gene

Pathways & Interactions for IER5L Gene

SuperPathways for IER5L Gene

No Data Available

Interacting Proteins for IER5L Gene

Gene Ontology (GO) - Biological Process for IER5L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IER5L Gene

Drugs & Compounds for IER5L Gene

No Compound Related Data Available

Transcripts for IER5L Gene

mRNA/cDNA for IER5L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(123) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER5L Gene

Immediate early response 5-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IER5L Gene

No ASD Table

Relevant External Links for IER5L Gene

GeneLoc Exon Structure for
IER5L
ECgene alternative splicing isoforms for
IER5L

Expression for IER5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IER5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IER5L Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IER5L Gene



Protein tissue co-expression partners for IER5L Gene

NURSA nuclear receptor signaling pathways regulating expression of IER5L Gene:

IER5L

SOURCE GeneReport for Unigene cluster for IER5L Gene:

Hs.529857
genes like me logo Genes that share expression patterns with IER5L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER5L Gene

Orthologs for IER5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER5L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IER5L 33 34
  • 93.23 (n)
cow
(Bos Taurus)
Mammalia IER5L 33 34
  • 92.93 (n)
rat
(Rattus norvegicus)
Mammalia Ier5l 33
  • 92.58 (n)
mouse
(Mus musculus)
Mammalia Ier5l 33 16 34
  • 92.56 (n)
oppossum
(Monodelphis domestica)
Mammalia IER5L 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ier5l 33
  • 74.83 (n)
MGC75980 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33398 33
zebrafish
(Danio rerio)
Actinopterygii ier5l 33 34
  • 68.46 (n)
wufe50b07 33
Species where no ortholog for IER5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IER5L Gene

ENSEMBL:
Gene Tree for IER5L (if available)
TreeFam:
Gene Tree for IER5L (if available)

Paralogs for IER5L Gene

Paralogs for IER5L Gene

genes like me logo Genes that share paralogs with IER5L: view

Variants for IER5L Gene

Sequence variations from dbSNP and Humsavar for IER5L Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000239133 -- 129,177,641(-) C/T coding_sequence_variant, missense_variant
rs1000489864 -- 129,178,070(-) G/C 5_prime_UTR_variant
rs1001110391 -- 129,177,020(-) C/A coding_sequence_variant, missense_variant
rs1001190649 -- 129,178,576(-) C/T upstream_transcript_variant
rs1001567367 -- 129,178,271(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IER5L Gene

Variant ID Type Subtype PubMed ID
esv2675916 CNV deletion 23128226
nsv1137668 CNV deletion 24896259
nsv1144292 CNV deletion 24896259
nsv466578 CNV loss 19166990
nsv615417 CNV loss 21841781
nsv615418 CNV loss 21841781
nsv818725 CNV gain 17921354
nsv825108 CNV gain 20364138
nsv825110 CNV gain 20364138
nsv825111 CNV gain 20364138

Variation tolerance for IER5L Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IER5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IER5L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5L Gene

Disorders for IER5L Gene

Additional Disease Information for IER5L

No disorders were found for IER5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5L Gene

Publications for IER5L Gene

  1. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for IER5L Gene

Sources for IER5L Gene

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