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This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008] See more...
Aliases for IER5 Gene
Aliases for IER5 Gene
External Ids for IER5 Gene
- HGNC: 5393
- Entrez Gene: 51278
- Ensembl: ENSG00000162783
- OMIM: 607177
- UniProtKB: Q5VY09
Previous GeneCards Identifiers for IER5 Gene
- GC01P178581
- GC01P176486
- GC01P177578
- GC01P178297
- GC01P177789
- GC01P179324
- GC01P181057
- GC01P152288
Summaries for IER5 Gene
-
This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
GeneCards Summary for IER5 Gene
IER5 (Immediate Early Response 5) is a Protein Coding gene. An important paralog of this gene is IER5L.
UniProtKB/Swiss-Prot Summary for IER5 Gene
-
Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).
Additional gene information for IER5 Gene
- HGNC(5393)
- Entrez Gene(51278)
- Ensembl(ENSG00000162783)
- OMIM(607177)
- UniProtKB(Q5VY09)
- Open Targets Platform(ENSG00000162783)
- Search for IER5 at DataMed
- Search for IER5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IER5 Gene
Genomics for IER5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IER5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IER5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IER5
- Top Transcription factor binding sites by QIAGEN in the IER5 gene promoter:
-
- GATA-1
- NF-kappaB
- NF-kappaB1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- STAT1
- STAT1alpha
- STAT1beta
- STAT3
Genomic Locations for IER5 Gene
Genomic Locations for IER5 Gene
- chr1:181,088,700-181,092,900
- (GRCh38/hg38)
- Size:
- 4,201 bases
- Orientation:
- Plus strand
- chr1:181,057,638-181,059,979
- (GRCh37/hg19)
- Size:
- 2,342 bases
- Orientation:
- Plus strand
Genomic View for IER5 Gene
Genes around IER5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by HGNC
- 1q25.3 by Entrez Gene
- 1q25.3 by Ensembl
IER5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IER5 Gene
Proteins for IER5 Gene
-
Protein details for IER5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VY09-IER5_HUMAN
- Recommended name:
- Immediate early response gene 5 protein
- Protein Accession:
- Q5VY09
- B2RBV3
- Q8WY68
- Q9NY49
- Q9NZP9
Protein attributes for IER5 Gene
- Size:
- 327 amino acids
- Molecular mass:
- 33704 Da
- Quaternary structure:
-
- Monomer (PubMed:26496226). Homodimer (PubMed:26496226). Associates with the catalytic subunit of protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Interacts (via N- and C-terminal regions) with PPP2R2B (PubMed:25816751, PubMed:26496226). Interacts with PPP2R2A, PPP2R2C and PPP2R2D (PubMed:25816751). Interacts (via N-terminus) with RPS6KB1 (PubMed:26496226). Interacts (via central region) with HSF1; this interaction promotes PPP2CA-induced HSF1 dephosphorylation, leading to enhanced HSF1 transcriptional activity (PubMed:25816751, PubMed:26496226, PubMed:26754925).
Protein Expression for IER5 Gene
Post-translational modifications for IER5 Gene
Other Protein References for IER5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IER5
-
Abcam antibodies for IER5
- Invitrogen Antibodies for IER5 (AFLGC-IER5)
- Sino Biological Antibodies for IER5
Protein Products
-
OriGene Purified Proteins for IER5
- Search Origene for MassSpec and Protein Over-expression Lysates for IER5
- Origene Custom Protein Services for IER5
- antibodies-online: Show 4 available IER5 Proteins ranked by validation data
- Compare Top IER5 Proteins
-
Quality Products:
-
Abcam proteins for IER5
Assay Products
- antibodies-online: Show 1 available IER5 Elisa Kits ranked by validation data
- Compare Top IER5 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for IER5 Gene
Domains & Families for IER5 Gene
Gene Families for IER5 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for IER5 Gene
- GenScript: Design optimal peptide antigens:
-
- Immediate early response gene 5 protein (IER5_HUMAN)
- Immediate early response 5 (Q32P56_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5VY09- Family:
-
- Belongs to the IER family.
Function for IER5 Gene
Molecular function for IER5 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by heat shock in a heat shock HSF1-dependent manner (PubMed:25355627). Up-regulated by ionizing radiation (PubMed:19238419).
Phenotypes From GWAS Catalog for IER5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25816751 |
| GO:0042802 | identical protein binding | IPI | 26496226 |
Phenotypes for IER5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IER5 - Select products 50% OFF >
- * IER5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IER5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER5
-
Santa Cruz Biotechnology (SCBT) CRISPR for IER5
miRNA for IER5 Gene
- miRTarBase miRNAs that target IER5
-
- hsa-miR-744-5p (MIRT016089)
- hsa-miR-33a-5p (MIRT028187)
- hsa-miR-26b-5p (MIRT029804)
- hsa-miR-147b (MIRT054217)
- hsa-miR-30a-5p (MIRT131850)
- hsa-miR-92a-2-5p (MIRT131851)
- hsa-miR-30c-5p (MIRT131857)
- hsa-miR-30d-5p (MIRT131859)
- hsa-miR-30b-5p (MIRT131864)
- hsa-miR-149-3p (MIRT131869)
- hsa-miR-30e-5p (MIRT131874)
- hsa-miR-491-5p (MIRT131882)
- hsa-miR-1249-5p (MIRT131910)
- hsa-miR-1252-5p (MIRT131917)
- hsa-miR-3126-5p (MIRT131924)
- hsa-miR-3150a-3p (MIRT131931)
- hsa-miR-3691-3p (MIRT131953)
- hsa-miR-4728-5p (MIRT131979)
- hsa-miR-6763-5p (MIRT132012)
- hsa-miR-6785-5p (MIRT132016)
- hsa-miR-6797-5p (MIRT132019)
- hsa-miR-6825-5p (MIRT132027)
- hsa-miR-6830-3p (MIRT132029)
- hsa-miR-6875-5p (MIRT132033)
- hsa-miR-6883-5p (MIRT132034)
- hsa-miR-7845-5p (MIRT132041)
- hsa-miR-939-5p (MIRT536732)
- hsa-miR-1343-5p (MIRT536733)
- hsa-miR-3175 (MIRT536734)
- hsa-miR-1827 (MIRT567215)
- hsa-miR-6088 (MIRT567216)
- hsa-miR-4770 (MIRT567217)
- hsa-miR-143-3p (MIRT567218)
- hsa-miR-5585-5p (MIRT567219)
- hsa-miR-548ax (MIRT567220)
- hsa-miR-548ao-5p (MIRT567221)
- hsa-miR-4649-3p (MIRT567222)
- hsa-miR-544b (MIRT567223)
- hsa-miR-5582-5p (MIRT567224)
- hsa-miR-7977 (MIRT638569)
- hsa-miR-486-3p (MIRT638570)
- hsa-miR-24-3p (MIRT638571)
- hsa-miR-4284 (MIRT638572)
- hsa-miR-449b-5p (MIRT638573)
- hsa-miR-449a (MIRT638574)
- hsa-miR-34c-5p (MIRT638575)
- hsa-miR-34a-5p (MIRT638576)
- hsa-miR-5693 (MIRT638577)
- hsa-miR-335-3p (MIRT642060)
- hsa-miR-1305 (MIRT642061)
- hsa-miR-524-5p (MIRT642062)
- hsa-miR-4275 (MIRT642063)
- hsa-miR-520d-5p (MIRT642064)
- hsa-miR-4659b-3p (MIRT657226)
- hsa-miR-4659a-3p (MIRT657227)
- hsa-miR-6875-3p (MIRT657228)
- hsa-miR-511-5p (MIRT657229)
- hsa-miR-4713-5p (MIRT657230)
- hsa-miR-676-5p (MIRT657231)
- hsa-miR-6845-3p (MIRT657232)
- hsa-miR-2116-3p (MIRT657233)
- hsa-miR-532-3p (MIRT657234)
- hsa-miR-216b-5p (MIRT657235)
- hsa-miR-101-3p (MIRT761073)
- hsa-miR-1321 (MIRT762513)
- hsa-miR-1910-3p (MIRT763295)
- hsa-miR-2467-3p (MIRT764089)
- hsa-miR-3160-3p (MIRT765121)
- hsa-miR-3162-5p (MIRT765164)
- hsa-miR-340-3p (MIRT765720)
- hsa-miR-3612 (MIRT765912)
- hsa-miR-4257 (MIRT768128)
- hsa-miR-4487 (MIRT769658)
- hsa-miR-4684-5p (MIRT770999)
- hsa-miR-4739 (MIRT771839)
- hsa-miR-4756-5p (MIRT771978)
- hsa-miR-548c-3p (MIRT774314)
- hsa-miR-558 (MIRT774833)
- hsa-miR-582-5p (MIRT775324)
- hsa-miR-650 (MIRT776670)
- hsa-miR-6511a-5p (MIRT776793)
- hsa-miR-655-5p (MIRT777306)
- hsa-miR-6760-5p (MIRT778452)
- hsa-miR-6771-3p (MIRT778626)
- hsa-miR-6827-3p (MIRT779918)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IER5
- Browse OriGene Inhibitory RNA Products For IER5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER5
Clone Products
- Applied Biological Materials (abm): Clones for IER5 - Select products 50% OFF >
- * IER5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IER5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IER5
Cell Line Products
-
Horizon Cell Lines for IER5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER5 Gene
Localization for IER5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IER5 Gene
- Nucleus. Cytoplasm. Note=Predominantly cytoplasmic (PubMed:25816751). Translocated in the nucleus during heat shock (PubMed:25816751). {ECO:0000269 PubMed:25816751}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | colocalizes_with protein phosphatase type 2A complex | IDA | 25816751 |
| GO:0005634 | nucleus | IEA,IDA | 25816751 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 25816751 |
Pathways & Interactions for IER5 Gene
Interacting Proteins for IER5 Gene
Selected Interacting proteins:
Q5VY09-IER5_HUMAN
ENSP00000356549
for IER5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IER5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0034605 | cellular response to heat | IDA | 25816751 |
| GO:0042127 | regulation of cell proliferation | IMP | 26496226 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 25816751 |
| GO:1900036 | positive regulation of cellular response to heat | IMP | 26496226 |
No data available for Pathways by source and SIGNOR curated interactions for IER5 Gene
Transcripts for IER5 Gene
mRNA/cDNA for IER5 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367577 4201 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IER5 - Select products 50% OFF >
- * IER5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IER5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER5
-
Santa Cruz Biotechnology (SCBT) CRISPR for IER5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IER5
- Browse OriGene Inhibitory RNA Products For IER5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER5
Clone Products
- Applied Biological Materials (abm): Clones for IER5 - Select products 50% OFF >
- * IER5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IER5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IER5
Relevant External Links for IER5 Gene
- GeneLoc Exon Structure for
- IER5
Expression for IER5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Bone (Muscoskeletal System)
This gene is overexpressed in Placenta (42.4) and Adipocyte (26.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IER5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IER5
SOURCE GeneReport for Unigene cluster for IER5 Gene:
Hs.15725mRNA Expression by UniProt/SwissProt for IER5 Gene:
Q5VY09-IER5_HUMAN
Tissue specificity:
Expressed in acute myeloid leukemia (AML) cells.
Evidence on tissue expression from TISSUES for IER5 Gene
- Blood(4.4)
- Spleen(4.4)
- Lymph node(4.2)
- Muscle(2.7)
- Nervous system(2.6)
- Heart(2.3)
- Stomach(2.2)
- Liver(2.2)
- Intestine(2.2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for IER5
-
OriGene qPCR primer pairs and template standards for IER5
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER5 Gene
Orthologs for IER5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IER5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IER5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ier5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ier5 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | IER5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IER5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IER5 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.7086 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ier5 30 31 |
|
OneToOne | |
| wufb04b03 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9060 30 |
|
- Species where no ortholog for IER5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IER5 Gene
- ENSEMBL:
- Gene Tree for IER5 (if available)
- TreeFam:
- Gene Tree for IER5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IER5: view image
Paralogs for IER5 Gene
Variants for IER5 Gene
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.85;
86.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IER5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IER5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER5 Gene
Disorders for IER5 Gene
Additional Disease Information for IER5
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for IER5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER5 Gene
Publications for IER5 Gene
- IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. (PMID: 26754925) Asano Y … Ohki R (Scientific reports 2016) 3 4
- HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y … Sakurai H (FEBS letters 2015) 3 4
- Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells. (PMID: 25355627) Ishikawa Y … Sakurai H (The FEBS journal 2015) 3 4
- Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1. (PMID: 26496226) Kawabata S … Sakurai H (FEBS letters 2015) 3 4
- Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia. (PMID: 22132193) Nakamura S … Yamashita M (PloS one 2011) 3 4
ExternalLinks
Products for IER5 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for IER5
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- Browse OriGene Inhibitory RNA Products For IER5
- OriGene qPCR primer pairs for IER5
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- OriGene CRISPR knockouts for IER5
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- Sino Biological Antibodies for IER5
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IER5
- Novus Biologicals proteins and lysates for IER5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IER5
- Abcam proteins for IER5
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for IER5 (AFLGC-IER5)
- VectorBuilder Custom and pre-made DNA vectors for IER5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IER5 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for IER5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IER5
- antibodies-online: Show 15 available IER5 Antibodies ranked by validation data
- Compare Top IER5 Antibodies
- antibodies-online: Show 1 available IER5 Elisa Kits ranked by validation data
- Compare Top IER5 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available IER5 Proteins ranked by validation data
- Compare Top IER5 Proteins
- Quality Products:
- Horizon Cell Lines for IER5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IER5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IER5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER5
Sources for IER5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB