Aliases for IER3 Gene
External Ids for IER3 Gene
Previous GeneCards Identifiers for IER3 Gene
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for IER3 Gene
IER3 (Immediate Early Response 3) is a Protein Coding gene. Diseases associated with IER3 include Cortical Dysplasia, Complex, With Other Brain Malformations 6 and Gilles De La Tourette Syndrome. Among its related pathways are RET signaling and Signaling by GPCR.
UniProtKB/Swiss-Prot Summary for IER3 Gene
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.