Aliases for IER2 Gene
Aliases for IER2 Gene
External Ids for IER2 Gene
- HGNC: 28871
- Entrez Gene: 9592
- Ensembl: ENSG00000160888
- UniProtKB: Q9BTL4
Previous GeneCards Identifiers for IER2 Gene
- GC19P013124
- GC19P013122
- GC19P013261
- GC19P012833
Summaries for IER2 Gene
GeneCards Summary for IER2 Gene
IER2 (Immediate Early Response 2) is a Protein Coding gene. An important paralog of this gene is IER5.
UniProtKB/Swiss-Prot for IER2 Gene
-
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER2 Gene
Genomics for IER2 Gene
GeneHancer (GH) Regulatory Elements for IER2 Gene
Promoters and enhancers for IER2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IER2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IER2 gene promoter:
-
- deltaCREB
- CREB
- NF-kappaB1
- NF-kappaB
- c-Ets-1
- ATF-2
- CRE-BP1
- c-Myb
- En-1
Regulatory Element Products
Genomic Locations for IER2 Gene
Genomic Locations for IER2 Gene
- chr19:13,150,415-13,154,908
- (GRCh38/hg38)
- Size:
- 4,494 bases
- Orientation:
- Plus strand
- chr19:13,261,229-13,265,722
- (GRCh37/hg19)
- Size:
- 4,494 bases
- Orientation:
- Plus strand
Genomic View for IER2 Gene
Genes around IER2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.13 by Entrez Gene
- 19p13.13 by HGNC
- 19p13.13 by Ensembl
IER2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IER2 Gene
Proteins for IER2 Gene
-
Protein details for IER2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BTL4-IER2_HUMAN
- Recommended name:
- Immediate early response gene 2 protein
- Protein Accession:
- Q9BTL4
- Q03827
- Q2TAZ2
Protein attributes for IER2 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 24196 Da
- Quaternary structure:
- No Data Available
Protein Expression for IER2 Gene
Post-translational modifications for IER2 Gene
Other Protein References for IER2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for IER2
- Novus Biologicals Antibodies for IER2
- Invitrogen Antibodies for IER2 (AFLGC-IER2)
- antibodies-online: Search results for available IER2 related products ranked by validation data
- Search GeneTex for Antibodies for IER2
-
Boster Bio Antibodies for IER2
Protein Products
-
OriGene Purified Proteins for IER2
- Search Origene for MassSpec and Protein Over-expression Lysates for IER2
- Origene Custom Protein Services for IER2
- antibodies-online: Search results for available IER2 related products ranked by validation data
- Search GeneTex for Proteins for IER2
-
Abcam proteins for IER2
Assay Products
- antibodies-online: Search results for available IER2 related products ranked by validation data
No data available for DME Specific Peptides for IER2 Gene
Domains & Families for IER2 Gene
Gene Families for IER2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for IER2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BTL4- Family:
-
- Belongs to the IER family.
Function for IER2 Gene
Molecular function for IER2 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).
- UniProtKB/Swiss-Prot Induction:
- By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).
Phenotypes From GWAS Catalog for IER2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 19584537 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 19584537 |
| GO:0003677 | DNA binding | IDA,IEA | 19584537 |
Phenotypes for IER2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IER2
-
CRISPR Products
-
OriGene CRISPR knockouts for IER2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER2
- genomics-online: gRNA clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
- Applied Biological Materials CRISPR for IER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IER2
- GenScript: Design CRISPR guide RNA sequences for IER2
miRNA for IER2 Gene
- miRTarBase miRNAs that target IER2
-
- hsa-mir-18a-3p (MIRT040855)
- hsa-mir-15a-5p (MIRT150354)
- hsa-mir-16-5p (MIRT150355)
- hsa-mir-15b-5p (MIRT150357)
- hsa-mir-195-5p (MIRT150358)
- hsa-mir-580-3p (MIRT234999)
- hsa-mir-8066 (MIRT235001)
- hsa-mir-548j-3p (MIRT399350)
- hsa-mir-548x-3p (MIRT399353)
- hsa-mir-548ae-3p (MIRT399356)
- hsa-mir-548ah-3p (MIRT399357)
- hsa-mir-548aj-3p (MIRT399358)
- hsa-mir-548am-3p (MIRT399359)
- hsa-mir-548aq-3p (MIRT399360)
- hsa-mir-5582-3p (MIRT399362)
- hsa-mir-539-5p (MIRT484232)
- hsa-mir-1910-5p (MIRT484233)
- hsa-mir-455-3p (MIRT484234)
- hsa-mir-5694 (MIRT484235)
- hsa-mir-1245b-3p (MIRT484236)
- hsa-mir-383-5p (MIRT484237)
- hsa-mir-5700 (MIRT484238)
- hsa-mir-30c-5p (MIRT733929)
- hsa-mir-3186-3p (MIRT740904)
- hsa-mir-424-5p (MIRT743302)
- hsa-mir-4530 (MIRT745965)
- hsa-mir-4787-5p (MIRT748892)
- hsa-mir-497-5p (MIRT749283)
- hsa-mir-510-5p (MIRT749731)
- hsa-mir-548ao-5p (MIRT750558)
- hsa-mir-548ax (MIRT750634)
- hsa-mir-5585-5p (MIRT750980)
- hsa-mir-634 (MIRT752667)
- hsa-mir-6750-3p (MIRT754568)
- hsa-mir-6752-5p (MIRT754638)
- hsa-mir-6838-5p (MIRT757284)
- hsa-mir-6842-5p (MIRT757372)
- hsa-mir-7110-5p (MIRT758998)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IER2
- Browse OriGene Inhibitory RNA Products For IER2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER2
- genomics-online: shRNA clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IER2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IER2
- Applied Biological Materials Clones for IER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IER2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IER2 Gene
Localization for IER2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IER2 Gene
- Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. {ECO:0000269 PubMed:22120713}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 22120713 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 22120713 |
Pathways & Interactions for IER2 Gene
No Data Available
Interacting Proteins for IER2 Gene
GPS-Prot Interaction Network for IER2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0030182 | neuron differentiation | ISS | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 19584537 |
| GO:0048870 | cell motility | IMP | 22120713 |
| GO:0071774 | response to fibroblast growth factor | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for IER2 Gene
Transcripts for IER2 Gene
mRNA/cDNA for IER2 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (447) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000587885 1291 bps (uc060uid.1)
- ENST00000292433 2085 bps (uc002mwr.4)
- ENST00000588173 2934 bps (uc021upr.3)
Unigene Clusters for IER2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IER2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER2
- genomics-online: gRNA clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
- Applied Biological Materials CRISPR for IER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IER2
- GenScript: Design CRISPR guide RNA sequences for IER2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IER2
- Browse OriGene Inhibitory RNA Products For IER2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IER2
- genomics-online: shRNA clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IER2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IER2
- Applied Biological Materials Clones for IER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: |
Expression for IER2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- AII Amacrine Cells Inner Nuclear Layer
-
Neurons
- AII Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for IER2 Gene
This gene is overexpressed in Fallopian Tube (x4.5) and Whole Blood (x4.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IER2 Gene
NURSA nuclear receptor signaling pathways regulating expression of IER2 Gene:
IER2SOURCE GeneReport for Unigene cluster for IER2 Gene:
Hs.501629mRNA Expression by UniProt/SwissProt for IER2 Gene:
Q9BTL4-IER2_HUMAN
Tissue specificity:
Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).
Evidence on tissue expression from TISSUES for IER2 Gene
- Nervous system(4.5)
- Intestine(4.4)
- Kidney(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for IER2
-
OriGene qPCR primer pairs and template standards for IER2
- genomics-online: primer clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IER2 Gene
Orthologs for IER2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IER2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | IER2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IER2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ier2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ier2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IER2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IER2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | IER2 34 |
|
OneToOne |
- Species where no ortholog for IER2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IER2 Gene
- ENSEMBL:
- Gene Tree for IER2 (if available)
- TreeFam:
- Gene Tree for IER2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IER2: view image
Paralogs for IER2 Gene
Variants for IER2 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000264223 | -- | 13,151,707(+) | G/A | intron_variant | |
| rs1000314104 | -- | 13,152,715(+) | A/T | intron_variant | |
| rs1000698409 | -- | 13,151,415(+) | G/T | intron_variant | |
| rs1001019889 | -- | 13,155,325(+) | C/T | downstream_transcript_variant | |
| rs1001054108 | -- | 13,155,181(+) | C/G | downstream_transcript_variant |
Residual Variation Intolerance Score:
50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.24;
62.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IER2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IER2 Gene
Disorders for IER2 Gene
Additional Disease Information for IER2
No disorders were found for IER2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IER2 Gene
Publications for IER2 Gene
- Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. (PMID: 2061303) Shimizu N … Utiyama H (The Journal of biological chemistry 1991) 2 3 4 22 58
- The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients. (PMID: 22120713) Neeb A … Sleeman JP (Oncogene 2012) 3 4 58
- Functional analyses of immediate early gene ETR101 expressed in yeast. (PMID: 19584537) Takaya T … Nikawa J (Bioscience, biotechnology, and biochemistry 2009) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Immediate early response protein 2 regulates hepatocellular carcinoma cell adhesion and motility via integrin β1-mediated signaling pathway. (PMID: 27840969) Xu Z … Shen W (Oncology reports 2017) 3 58
Products for IER2 Gene
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- Custom Antibody ServicesOriGene Antibodies for IER2
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- OriGene qPCR primer pairs for IER2
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- GenScript: Design CRISPR guide RNA sequences for IER2
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- Novus Biologicals
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- Invitrogen Antibodies for IER2 (AFLGC-IER2)
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- antibodies-online: Search results for available IER2 related products ranked by validation data
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- Search GeneTex for Antibodies for IER2
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- Horizon Cell Lines for IER2
- genomics-online: cdna clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
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- Overview of 108 available IER2 gene related products
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- Overview of 108 available IER2 gene related products
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- Overview of 108 available IER2 gene related products
- genomics-online: shRNA clones - Search results for 108 available IER2 gene related products
- Overview of 108 available IER2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IER2
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- Boster Bio Antibodies for IER2
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Sources for IER2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
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