Aliases for IDUA Gene
External Ids for IDUA Gene
Previous GeneCards Identifiers for IDUA Gene
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
GeneCards Summary for IDUA Gene
IDUA (Alpha-L-Iduronidase) is a Protein Coding gene. Diseases associated with IDUA include Hurler Syndrome and Scheie Syndrome. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and L-iduronidase activity.