Aliases for IDS Gene
External Ids for IDS Gene
Previous HGNC Symbols for IDS Gene
Previous GeneCards Identifiers for IDS Gene
This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for IDS Gene
IDS (Iduronate 2-Sulfatase) is a Protein Coding gene. Diseases associated with IDS include Mucopolysaccharidosis, Type Ii and Lysosomal Storage Disease. Among its related pathways are Lysosome and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and iduronate-2-sulfatase activity. An important paralog of this gene is ENSG00000241489.
UniProtKB/Swiss-Prot Summary for IDS Gene
Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.