Aliases for IDO2 Gene
Aliases for IDO2 Gene
External Ids for IDO2 Gene
- HGNC: 27269
- NCBI Entrez Gene: 169355
- Ensembl: ENSG00000188676
- OMIM®: 612129
- UniProtKB/Swiss-Prot: Q6ZQW0
Previous HGNC Symbols for IDO2 Gene
- INDOL1
Previous GeneCards Identifiers for IDO2 Gene
- GC08P039913
- GC08P039792
- GC08P038325
- GC08P039935
- GC08P039949
- GC08P039965
- GC08P039936
- GC08P039940
- GC08P039944
Summaries for IDO2 Gene
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Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
GeneCards Summary for IDO2 Gene
IDO2 (Indoleamine 2,3-Dioxygenase 2) is a Protein Coding gene. Among its related pathways are NAD de novo biosynthesis II (from tryptophan) and L-tryptophan degradation XI (mammalian, via kynurenine). Gene Ontology (GO) annotations related to this gene include heme binding and indoleamine 2,3-dioxygenase activity.
UniProtKB/Swiss-Prot Summary for IDO2 Gene
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). ( I23O2_HUMAN,Q6ZQW0 )
