Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011] See more...

Aliases for IDO2 Gene

Aliases for IDO2 Gene

  • GeneCards Symbol: IDO2 2
  • Indoleamine 2,3-Dioxygenase 2 2 3 4 5
  • INDOL1 3 4 5
  • Indoleamine-Pyrrole 2,3-Dioxygenase-Like Protein 1 3 4
  • Indoleamine-Pyrrole 2,3 Dioxygenase-Like 1 2 3
  • Indoleamine 2,3-Dioxygenase-Like Protein 1 3 4
  • Indoleamine 2,3-Dioxygenase-Like 1 Protein 3
  • EC 1.13.11.- 4
  • IDO-2 4

External Ids for IDO2 Gene

Previous HGNC Symbols for IDO2 Gene

  • INDOL1

Previous GeneCards Identifiers for IDO2 Gene

  • GC08P039913
  • GC08P039792
  • GC08P038325
  • GC08P039935
  • GC08P039949
  • GC08P039965
  • GC08P039936
  • GC08P039940
  • GC08P039944

Summaries for IDO2 Gene

Entrez Gene Summary for IDO2 Gene

  • Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

GeneCards Summary for IDO2 Gene

IDO2 (Indoleamine 2,3-Dioxygenase 2) is a Protein Coding gene. Among its related pathways are NAD de novo biosynthesis II (from tryptophan) and L-tryptophan degradation XI (mammalian, via kynurenine). Gene Ontology (GO) annotations related to this gene include heme binding and indoleamine 2,3-dioxygenase activity.

UniProtKB/Swiss-Prot Summary for IDO2 Gene

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). ( I23O2_HUMAN,Q6ZQW0 )

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB Summary , Rfam classification and piRNA Summary for IDO2 Gene

Genomics for IDO2 Gene

GeneHancer (GH) Regulatory Elements (see citations)

Promoters and enhancers for IDO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J039936 Enhancer 0.6 FANTOM5 Ensembl 250.70 153.67 +1.8 1 0.8 ZNF592 IRF9 TEAD2 ZNF354B ZNF740 LOC100420480 IDO2 ENSG00000253939 ENSG00000253790 piR-30876-103 TCIM
GH08J039933 Enhancer 0.3 Ensembl 250.70 64.02 -0.2 0 2.4 FOXA2 LOC100420480 IDO2 ENSG00000253939 ENSG00000253790 IDO1 RF00017-6574
GH08J039948 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.44 0.53 +9.7 1 0.6 ZNF592 IRF9 CAVIN1 TAF7 MEIS2 CEBPB TEAD2 SPI1 ZBTB17 PKNOX1 IDO1 ENSG00000254287 ENSG00000253939 ENSG00000253790 piR-30876-103 LOC100420480 IDO2 TCIM
GH08J039947 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.37 0.53 +15.8 4 4.8 DPF2 NCOR1 CEBPG YY1 ZNF592 TBP IRF2 RXRA EBF1 TAL1 IDO1 ENSG00000253939 ENSG00000253790 ENSG00000254287 piR-57460-673 piR-41652-006 IDO2 TCIM
GH08J039945 Enhancer 1 FANTOM5 ENCODE dbSUPER 0.41 0.43 +11.1 1 1.0 DPF2 NCOR1 NFIC TAF9B ZNF316 NBN NFE2 HDAC2 EP400 SMARCA4 piR-30791-090 piR-30876-103 ENSG00000254287 IDO1 ENSG00000253939 ENSG00000253790 LOC100420480 IDO2 TCIM

GeneHancers around IDO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IDO2

Top Transcription factor binding sites by QIAGEN in the IDO2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FOXO1
  • FOXO1a
  • GR
  • GR-alpha
  • GR-beta
  • LUN-1
  • NF-kappaB1
  • POU3F2

Genomic Locations for IDO2 Gene

Latest Assembly
chr8:39,934,614-40,016,392
(GRCh38/hg38)
Size:
81,779 bases
Orientation:
Plus strand

Previous Assembly
chr8:39,792,474-39,873,910
(GRCh37/hg19 by Entrez Gene)
Size:
81,437 bases
Orientation:
Plus strand

chr8:39,792,133-39,873,910
(GRCh37/hg19 by Ensembl)
Size:
81,778 bases
Orientation:
Plus strand

Genomic View for IDO2 Gene

Genes around IDO2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Cytogenetic band:
IDO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDO2 Gene
Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDO2 Gene

Proteins for IDO2 Gene

  • Protein details for IDO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQW0-I23O2_HUMAN
    Recommended name:
    Indoleamine 2,3-dioxygenase 2
    Protein Accession:
    Q6ZQW0
    Secondary Accessions:
    • A4UD41
    • F5H5G0

    Protein attributes for IDO2 Gene

    Size:
    420 amino acids
    Molecular mass:
    47075 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:

    • IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction.
      IDO2 affinity for tryptophan is much lower than that of IDO1.
      50 % of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity.
      IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598).
      IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548).
      Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090).
      IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.

    Predicted three dimensional structure from AlphaFold

    Q6ZQW0

    Alternative splice isoforms for IDO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDO2 Gene

Post-translational modifications for IDO2 Gene

  • Modification sites at PhosphoSitePlus
    Q6ZQW0
  • Modification sites at neXtProt
    NX_Q6ZQW0

Other Protein References for IDO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Protein products for research

  • Novus Biologicals lysates for IDO2
  • Abcam proteins for IDO2

No data available for DME Specific Peptides for IDO2 Gene

Domains & Families for IDO2 Gene

Gene Families for IDO2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Metabolic proteins
  • Predicted intracellular proteins

Protein Domains for IDO2 Gene

Suggested Antigen Peptide Sequences for IDO2 Gene

GenScript: Design optimal peptide antigens:
  • Indoleamine-pyrrole 2,3-dioxygenase-like protein 1 (I23O2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZQW0

UniProtKB/Swiss-Prot:

I23O2_HUMAN :
  • Belongs to the indoleamine 2,3-dioxygenase family.
Family:
  • Belongs to the indoleamine 2,3-dioxygenase family.
Genes that share domains with IDO2: view

Function for IDO2 Gene

Molecular function for IDO2 Gene according to UniProtKB/Swiss-Prot

Function:
  • Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).
    Involved in immune regulation.
    May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). I23O2_HUMAN,Q6ZQW0
CatalyticActivity:
EnzymeRegulation:
  • Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). I23O2_HUMAN,Q6ZQW0

Enzyme Numbers (IUBMB) for IDO2 Gene

Phenotypes From GWAS Catalog for IDO2 Gene

Phenotype Gene Relation Best Score Mean Score # of Snps # of Studies SNP IDs
kynurenine measurement 26.5 26.52288 1 1
blood protein measurement 19.5 19.52288 1 1
blood metabolite measurement
  • GWAS
10.2 10.1549 1 1
body height
  • GWAS
7.2 7.221849 1 1
schizophreniasex interaction measurement 5.7 5.5 1 1

Gene Ontology (GO) - Molecular Function for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004833 3 5 enables tryptophan 2,3-dioxygenase activity IBA 21873635
GO:0016491 5 oxidoreductase activity IEA
GO:0016702 5 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
GO:0020037 3 5 enables heme binding IEA
GO:0033754 3 5 enables indoleamine 2,3-dioxygenase activity IDA, ISS, IBA, IEA 17499941
Genes that share ontologies with IDO2: view
Genes that share phenotypes with IDO2: view

Animal Models for IDO2 Gene

MGI Knock Outs for IDO2:
  • Ido2 Ido2<tm1.2Gcp>

miRNA products for research

No data available for Human Phenotype Ontology , miRNA , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for IDO2 Gene

Localization for IDO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDO2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 2
cytoskeleton 2
extracellular 2
plasma membrane 2
lysosome 1
endosome 1
endoplasmic reticulum 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 3 5 located_in cytoplasm ISS, IBA, IEA 17499941
GO:0005829 3 5 located_in cytosol TAS
Genes that share ontologies with IDO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IDO2 Gene

Pathways & Interactions for IDO2 Gene

Genes that share pathways with IDO2: view

UniProtKB/Swiss-Prot Q6ZQW0-I23O2_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Additional Pathway Information for IDO2 Gene

Gene Ontology (GO) - Biological Process for IDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 3 5 involved_in immune system process IEA
GO:0006569 5 tryptophan catabolic process IEA
GO:0019441 3 5 involved_in tryptophan catabolic process to kynurenine IDA, ISS, IBA, IEA, IBA 17499941
GO:0034354 3 5 involved_in 'de novo' NAD biosynthetic process from tryptophan IBA 21873635
Genes that share ontologies with IDO2: view

No data available for SIGNOR curated interactions for IDO2 Gene

Drugs & Compounds for IDO2 Gene

(9) Drugs for IDO2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen 24 Approved, Vet_approved 23 Pharma
Melatonin 24 Approved, Vet_approved Nutra Melatonin receptors MT inhibitor, Small Molecule, Hypnotics And Sedatives, Endogenous hormone; agonist at MT1 and MT2
Oxitriptan 24 Approved, Investigational Nutra
Tryptophan 24 Approved, Withdrawn Nutra
Indoximod 81 Investigational 23 Pharma Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor Potent and selective HDAC6 inhibitor, Indoleamine 2,3-dioxygenase (IDO) inhibitor

(7) Additional Compounds for IDO2 Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tryptanthrin 5i
  • compound 5i [PMID: 24099220]
5-Hydroxy-N-formylkynurenine
Acetyl-N-formyl-5-methoxykynurenamine
  • AFMK
  • Formyl-N-acetyl-5-methoxykynurenamine
  • K1
  • N-[3-(2-Formamido-5-methoxy-phenyl)-3-oxo-propyl]acetamide
  • N1-Acetyl-N2-formyl-5-methoxykynurenine
52450-38-1
Formyl-5-hydroxykynurenamine
  • 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole
  • N-(2(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide
  • N-(2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)-acetamide
  • N-(2-(6-Hydroxy-5-methoxyindol-3-yl)ethyl)-acetamide
  • N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide
958733-17-0
heme
  • [3,7,12,17-Tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(II)
  • [Fe(ppix)]
  • Fe(ppix)
  • ferroheme|haem
  • Ferroprotoheme
14875-96-8

(4) ApexBio Compounds for IDO2 Gene

Compound Action Cas Number
IDO inhibitor 1 Indoleamine-2,3-dioxygenase inhibitor 1204669-37-3
INCB024360 Potent IDO1 inhibitor 914471-09-3
Indoximod (NLG-8189) Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor Potent and selective HDAC6 inhibitor 110117-83-4
NLG919 Potent IDO pathway inhibitor 1402836-58-1
Genes that share compounds with IDO2: view

Drug products for research

Transcripts for IDO2 Gene

mRNA/cDNA for IDO2 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

miRNA products for research

Alternative Splicing Database (ASD) splice patterns (SP) for IDO2 Gene

No ASD Table

Relevant External Links for IDO2 Gene

GeneLoc Exon Structure for
IDO2

Expression for IDO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDO2 Gene

This gene is overexpressed in Liver (x28.7), Thyroid (x7.7), and Testis (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IDO2 Gene



Protein tissue co-expression partners for IDO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IDO2

SOURCE GeneReport for Unigene cluster for IDO2 Gene:

Hs.676257

mRNA Expression by UniProt/SwissProt for IDO2 Gene:

Q6ZQW0-I23O2_HUMAN
Tissue specificity: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).

Evidence on tissue expression from TISSUES for IDO2 Gene

  • Blood(2.4)
  • Spleen(2.3)
  • Lymph node(2.3)
  • Liver(2.2)
  • Nervous system(2)

Bgee gene expression patterns for IDO2 gene:

  • Expressed in right lobe of liver, placenta, left lobe of thyroid gland and 53 other tissues.
Genes that share expression patterns with IDO2: view

Primer products for research

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDO2 Gene

Orthologs for IDO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IDO2 28 29
  • 99.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IDO2 28 29
  • 83.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IDO2 28 29
  • 79.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ido2 28
  • 78.45 (n)
Mouse
(Mus musculus)
Mammalia Ido2 28 16 29
  • 76.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IDO2 29
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IDO2 29
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves INDOL1 28
  • 64.43 (n)
IDO2 29
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IDO2 29
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ido1 28
  • 57.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1465 28
Zebrafish
(Danio rerio)
Actinopterygii ido1 28 29
  • 59.01 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA2 29
  • 29 (a)
OneToMany
Species where no ortholog for IDO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IDO2 Gene

ENSEMBL:
Gene Tree for IDO2 (if available)
TreeFam:
Gene Tree for IDO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IDO2: view image
Alliance of Genome Resources:
Additional Orthologs for IDO2

Paralogs for IDO2 Gene

(1) SIMAP similar genes for IDO2 Gene using alignment to 3 proteins:

  • I23O2_HUMAN
  • F5H5G0_HUMAN
  • L8E9C5_HUMAN
Genes that share paralogs with IDO2: view

No data available for Paralogs for IDO2 Gene

Variants for IDO2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IDO2 Gene

I23O2_HUMAN-Q6ZQW0
The variant Trp-248 (p.R248W) drastically reduces the enzymatic activity (PubMed:17671174, PubMed:18418598). The Del359-420 variant (p.Y359X) generates a truncated, enzymatically inactive protein (PubMed:17671174). The high prevalence of these polymorphic alleles results in a non-functional IDO2 enzyme in up to 50% of Caucasians (PubMed:18418598).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IDO2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1229251

Benign: not provided

40,015,416(+) T/ANM_194294.5(IDO2):c.1038T>A (p.Tyr346Ter)
NONSENSE
1265377

Benign: not provided

39,982,715(+) A/GNM_194294.5(IDO2):c.379A>G (p.Ile127Val)
MISSENSE
1275323

Benign: not provided

40,005,362(+) C/TNM_194294.5(IDO2):c.703C>T (p.Arg235Trp)
MISSENSE
rs10109853 5 4 p.Arg248Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IDO2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IDO2 Gene

Variant ID Type Subtype PubMed ID
nsv4161814 CNV deletion 32461652
esv3649348 CNV insertion 25597990
nsv4153969 CNV duplication 32461652
nsv4158519 CNV deletion 32461652
nsv4168002 CNV deletion 32461652
nsv4567901 OTHER sequence alteration 32461652
esv2736908 CNV deletion 23290073
nsv4155486 CNV duplication 32461652
esv3572695 CNV loss 25503493
nsv4486735 CNV alu insertion 32461652
esv3649349 CNV insertion 25597990
esv3616963 CNV loss 21293372
esv2663657 CNV deletion 23128226
nsv4155560 CNV deletion 32461652
nsv4558620 CNV sva insertion 32461652
nsv4157226 CNV deletion 32461652
nsv4493521 CNV alu insertion 32461652
esv1987205 CNV deletion 18987734
nsv4165946 CNV deletion 32461652
esv2677111 CNV deletion 23128226
nsv1020859 CNV gain 25217958
nsv611087 CNV loss 21841781
nsv611088 CNV loss 21841781
esv3616964 CNV loss 21293372
SVs/CNVs around IDO2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for IDO2 Gene

Gene Damage Index Score: 23.62; 99.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDO2 Gene

Human Gene Mutation Database (HGMD)
IDO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDO2
Leiden Open Variation Database (LOVD)
IDO2

SNP Genotyping and Copy Number Assays for research

Disorders for IDO2 Gene

Additional Disease Information for IDO2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
Cancer Target Discovery and Development
(CTD² Dashboard)
The FABRIC Cancer Portal
(FABRIC)

No disorders were found for IDO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and GENATLAS for IDO2 Gene

Publications for IDO2 Gene

  1. Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2. (PMID: 25394548) Lee YK … Choi EY (Experimental & molecular medicine 2014) 3 4
  2. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. (PMID: 19476837) Witkiewicz AK … Brody JR (Journal of the American College of Surgeons 2009) 3 39
  3. The human indoleamine 2,3-dioxygenase gene and related human genes. (PMID: 17430106) Murray MF (Current drug metabolism 2007) 3 21
  4. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. (PMID: 17671174) Metz R … Prendergast GC (Cancer research 2007) 3 4
  5. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. (PMID: 17499941) Ball HJ … Hunt NH (Gene 2007) 3 4

Products for IDO2 Gene

Sources for IDO2 Gene