This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological proc... See more...

Aliases for IDO1 Gene

Aliases for IDO1 Gene

  • Indoleamine 2,3-Dioxygenase 1 2 3 4 5
  • Indoleamine-Pyrrole 2,3-Dioxygenase 3 4
  • IDO-1 3 4
  • INDO 3 4
  • IDO 3 4
  • Indoleamine-Pyrrole 2,3 Dioxygenase 2
  • Indolamine 2,3 Dioxygenase 3
  • Indole 2,3-Dioxygenase 3
  • EC 1.13.11.52 4
  • IDO1 5

External Ids for IDO1 Gene

Previous HGNC Symbols for IDO1 Gene

  • IDO
  • INDO

Previous GeneCards Identifiers for IDO1 Gene

  • GC08P039771
  • GC08P038304

Summaries for IDO1 Gene

Entrez Gene Summary for IDO1 Gene

  • This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

GeneCards Summary for IDO1 Gene

IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include Listeriosis and Trypanosomiasis. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include heme binding and tryptophan 2,3-dioxygenase activity.

UniProtKB/Swiss-Prot Summary for IDO1 Gene

  • Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).

Gene Wiki entry for IDO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IDO1 Gene

Genomics for IDO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IDO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J039912 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.4 +11.3 11325 2 IKZF2 ARID3A RUNX3 BCL11A ARNT IKZF1 CEBPG JUNB STAT1 TBX21 ENSG00000253838 IDO1 ENSG00000253790 ENSG00000253939 TCIM piR-50437-624 IDO2
GH08J039901 Promoter/Enhancer 0.9 Ensembl ENCODE 600.7 +1.5 1505 3.6 POLR2A JUNB BATF SIN3A NANOG TBP POU5F1 SPI1 IDO1 piR-50437-624 IDO2 ENSG00000253939
GH08J039900 Enhancer 0.2 Ensembl 600.7 -1.6 -1574 0.6 IDO1 piR-42613-091 ADAM2
GH08J039947 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +48.1 48124 4.8 IKZF1 IKZF2 DPF2 HDAC1 SOX6 PKNOX1 TCF12 RELB RUNX3 GATAD2B IDO1 ENSG00000253939 ENSG00000253790 ENSG00000254287 piR-30791-090 piR-41652-006 IDO2 TCIM
GH08J039948 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +42.0 42033 0.6 PKNOX1 ZNF740 CEBPB MEF2D ZBTB17 GTF2A2 ZNF592 MEIS2 IRF9 TAF7 IDO1 ENSG00000254287 ENSG00000253790 ENSG00000253939 piR-30876-103 IDO2 LOC100420480 TCIM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IDO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IDO1

Top Transcription factor binding sites by QIAGEN in the IDO1 gene promoter:
  • AML1a
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • LUN-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for IDO1 Gene

Genomic Locations for IDO1 Gene
chr8:39,902,275-39,928,790
(GRCh38/hg38)
Size:
26,516 bases
Orientation:
Plus strand
chr8:39,759,794-39,786,309
(GRCh37/hg19)
Size:
26,516 bases
Orientation:
Plus strand

Genomic View for IDO1 Gene

Genes around IDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDO1 Gene

Proteins for IDO1 Gene

  • Protein details for IDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14902-I23O1_HUMAN
    Recommended name:
    Indoleamine 2,3-dioxygenase 1
    Protein Accession:
    P14902
    Secondary Accessions:
    • E5RGR8
    • F6M9T7
    • Q540B4

    Protein attributes for IDO1 Gene

    Size:
    403 amino acids
    Molecular mass:
    45326 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AC007991; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
    • IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50% of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598). IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548). Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090). IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.
    • Elevated IDO1 expression is a hallmark of major viral infections including HIV, HBV, HCV or influenza and also of major bacteria infections, such as Tb, CAP, listeriosis and sepsis. Depletion of tryptophan and production of tryptophan metabolites with bactericidal activity are important as direct anti-pathogen mechanisms. Pathogens are able to highjack the immunosuppressive effects of IDO1 and make use of them to facilitate their own life cycle.

    Three dimensional structures from OCA and Proteopedia for IDO1 Gene

neXtProt entry for IDO1 Gene

Post-translational modifications for IDO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IDO1 Gene

Antibody Products

No data available for DME Specific Peptides for IDO1 Gene

Domains & Families for IDO1 Gene

Gene Families for IDO1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IDO1 Gene

InterPro:
Blocks:
  • Indoleamine 2,3-dioxygenase
ProtoNet:

Suggested Antigen Peptide Sequences for IDO1 Gene

GenScript: Design optimal peptide antigens:
  • Indolamine 2,3 dioxygenase (F6M9T7_HUMAN)
  • Indoleamine-pyrrole 2,3-dioxygenase (I23O1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14902

UniProtKB/Swiss-Prot:

I23O1_HUMAN :
  • Belongs to the indoleamine 2,3-dioxygenase family.
Family:
  • Belongs to the indoleamine 2,3-dioxygenase family.
genes like me logo Genes that share domains with IDO1: view

Function for IDO1 Gene

Molecular function for IDO1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-tryptophan + O2 = N-formyl-D-kynurenine; Xref=Rhea:RHEA:14189, ChEBI:CHEBI:15379, ChEBI:CHEBI:57719, ChEBI:CHEBI:60051; EC=1.13.11.52; Evidence={ECO:0000269|PubMed:17671174};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.52; Evidence={ECO:0000269|PubMed:17671174};.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in most cells (PubMed:2109605, PubMed:1907934). Exogenous inflammatory stimuli induce the expression of IDO1 in antigen-presenting cells such as dendritic cells, macrophages and B-cells (PubMed:25157255).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21.23 uM for L-tryptophan {ECO:0000269|PubMed:18026683}; KM=4.6 mM for D-tryptophan {ECO:0000269|PubMed:18026683}; Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan).

Enzyme Numbers (IUBMB) for IDO1 Gene

Phenotypes From GWAS Catalog for IDO1 Gene

Gene Ontology (GO) - Molecular Function for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004833 tryptophan 2,3-dioxygenase activity IBA 21873635
GO:0009055 electron transfer activity TAS 2109605
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IEA --
GO:0033754 indoleamine 2,3-dioxygenase activity IBA,IMP 25310899
genes like me logo Genes that share ontologies with IDO1: view
genes like me logo Genes that share phenotypes with IDO1: view

Animal Models for IDO1 Gene

MGI Knock Outs for IDO1:
  • Ido1 Ido1<tm1Alm>
  • Ido1 Ido1<tm1.1Mkks>

Animal Model Products

CRISPR Products

miRNA for IDO1 Gene

miRTarBase miRNAs that target IDO1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDO1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IDO1 Gene

Localization for IDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDO1 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 3
cytoskeleton 3
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0030485 smooth muscle contractile fiber IEA --
GO:0032421 stereocilium bundle IEA --
genes like me logo Genes that share ontologies with IDO1: view

Pathways & Interactions for IDO1 Gene

genes like me logo Genes that share pathways with IDO1: view

Pathways by source for IDO1 Gene

UniProtKB/Swiss-Prot P14902-I23O1_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Gene Ontology (GO) - Biological Process for IDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002534 cytokine production involved in inflammatory response IEA --
GO:0002666 positive regulation of T cell tolerance induction IEA --
GO:0002678 positive regulation of chronic inflammatory response IEA --
GO:0002830 positive regulation of type 2 immune response IEA --
genes like me logo Genes that share ontologies with IDO1: view

No data available for SIGNOR curated interactions for IDO1 Gene

Drugs & Compounds for IDO1 Gene

(44) Drugs for IDO1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tryptophan Approved, Withdrawn Nutra Allosteric regulator, Positive, Inhibitor, Inhibition, Enzyme, substrate 96
Melatonin Approved, Vet_approved Nutra Antagonist, Agonist, Full agonist, Enzyme, substrate Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 398
Nitric Oxide Approved Pharma Target 771
Oxygen Approved, Vet_approved Pharma 0
cannabidiol Approved, Investigational Pharma Agonist, Partial agonist, Antagonist, Channel blocker, Activator, Target, inhibitor 0

(32) Additional Compounds for IDO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxy-N-formylkynurenine
Acetyl-N-formyl-5-methoxykynurenamine
  • AFMK
  • Formyl-N-acetyl-5-methoxykynurenamine
  • N-Acetyl-N-formyl-5-methoxykynurenamine
  • N-[3-(2-formamido-5-Methoxy-phenyl)-3-oxo-propyl]acetamide
  • N1-Acetyl-N2-formyl-5-methoxykynurenine
52450-38-1
Formyl-5-hydroxykynurenamine
  • 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole
  • N-(2(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide
  • N-(2-(6-Hydroxy-5-methoxyindol-3-yl)ethyl)-acetamide
  • N-(2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl)-acetamide
  • N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide
958733-17-0
L-Formylkynurenine
  • 3-(2-Formamidobenzoyl)-L-alanine
  • N'-formylkynurenine
  • N-Formylkynurenine
N'-Formylkynurenine
  • 3-(2-Formamidobenzoyl)alanine
  • Formylkynurenine
  • 3-(N-Formylanthraniloyl)-alanine
  • alpha-amino-2-(formylamino)-gamma-oxo-Benzenebutanoate
  • alpha-amino-2-(formylamino)-gamma-oxo-Benzenebutanoic acid
1022-31-7

(5) ApexBio Compounds for IDO1 Gene

Compound Action Cas Number
IDO inhibitor 1 Indoleamine-2,3-dioxygenase inhibitor 1204669-37-3
INCB024360 Potent IDO1 inhibitor 914471-09-3
INCB-024360 potent and selective inhibitor of IDO1 1204669-58-8
Indoximod (NLG-8189) Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor Potent and selective HDAC6 inhibitor 110117-83-4
NLG919 Potent IDO pathway inhibitor 1402836-58-1
genes like me logo Genes that share compounds with IDO1: view

Transcripts for IDO1 Gene

mRNA/cDNA for IDO1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDO1

Alternative Splicing Database (ASD) splice patterns (SP) for IDO1 Gene

No ASD Table

Relevant External Links for IDO1 Gene

GeneLoc Exon Structure for
IDO1

Expression for IDO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDO1 Gene

This gene is overexpressed in Lung (x10.6), Brain - Substantia nigra (x5.8), Adipose - Visceral (Omentum) (x5.2), Cervix - Endocervix (x4.3), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for IDO1 Gene

This gene is overexpressed in Nasopharynx (50.5) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IDO1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IDO1

SOURCE GeneReport for Unigene cluster for IDO1 Gene:

Hs.840

mRNA Expression by UniProt/SwissProt for IDO1 Gene:

P14902-I23O1_HUMAN
Tissue specificity: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).

Evidence on tissue expression from TISSUES for IDO1 Gene

  • Blood(4.7)
  • Lung(4.5)
  • Lymph node(3.6)
  • Spleen(3.4)
  • Intestine(3.2)
  • Liver(2.5)
  • Bone marrow(2.5)
  • Nervous system(2.5)
  • Heart(2.3)
  • Skin(2.3)
  • Muscle(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with IDO1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDO1 Gene

Orthologs for IDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IDO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IDO1 30 31
  • 99.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IDO1 30 31
  • 78.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IDO1 30 31
  • 78.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ido1 30
  • 72.41 (n)
Mouse
(Mus musculus)
Mammalia Ido1 30 17 31
  • 72.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IDO1 31
  • 57 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IDO1 31
  • 49 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA2 30 31 33
  • 45 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR188C 30
  • 44.79 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU05752 30
  • 45.38 (n)
Species where no ortholog for IDO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IDO1 Gene

ENSEMBL:
Gene Tree for IDO1 (if available)
TreeFam:
Gene Tree for IDO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IDO1: view image

Paralogs for IDO1 Gene

(1) SIMAP similar genes for IDO1 Gene using alignment to 6 proteins:

  • I23O1_HUMAN
  • E5RGR8_HUMAN
  • E5RH36_HUMAN
  • E5RIX2_HUMAN
  • F6M9T7_HUMAN
  • J3KN03_HUMAN
genes like me logo Genes that share paralogs with IDO1: view

No data available for Paralogs for IDO1 Gene

Variants for IDO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IDO1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
718318 Benign: not provided 39,927,927(+) G/A SYNONYMOUS_VARIANT
733967 Likely Benign: not provided 39,925,220(+) T/C INTRON_VARIANT
786116 Benign: not provided 39,913,932(+) G/A MISSENSE_VARIANT
786117 Benign: not provided 39,920,102(+) C/T MISSENSE_VARIANT
rs35059413 - p.Ala4Thr

Additional dbSNP identifiers (rs#s) for IDO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IDO1 Gene

Variant ID Type Subtype PubMed ID
esv2658388 CNV deletion 23128226
esv3616962 CNV loss 21293372
nsv508505 CNV deletion 20534489

Variation tolerance for IDO1 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDO1 Gene

Human Gene Mutation Database (HGMD)
IDO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDO1 Gene

Disorders for IDO1 Gene

MalaCards: The human disease database

(35) MalaCards diseases for IDO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
listeriosis
  • infection by listeria monocytogenes
trypanosomiasis
bladder disease
  • urinary bladder disease
chlamydia
  • chlamydia trachomatis infectious disease
eosinophilia-myalgia syndrome
  • eosinophilia myalgia syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IDO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IDO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IDO1 Gene

Publications for IDO1 Gene

  1. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PMID: 16477023) Sugimoto H … Shiro Y (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23
  2. Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. (PMID: 16842443) Cozzi A … Moroni F (Journal of viral hepatitis 2006) 3 23 26
  3. Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PMID: 2109605) Dai W … Gupta SL (Biochemical and biophysical research communications 1990) 2 3 4
  4. Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2. (PMID: 25394548) Lee YK … Choi EY (Experimental & molecular medicine 2014) 3 4
  5. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. (PMID: 19487045) Suzuki Y … Chida K (Lung cancer (Amsterdam, Netherlands) 2010) 3 23

Products for IDO1 Gene

Sources for IDO1 Gene