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Aliases for IDNK Gene

Aliases for IDNK Gene

  • IDNK, Gluconokinase 2 3 5
  • Gluconate Kinase 3 4
  • C9orf103 3 4
  • IdnK, Gluconokinase Homolog (E. Coli) 2
  • Chromosome 9 Open Reading Frame 103 2
  • IdnK, Gluconokinase Homolog 3
  • Gluconokinase-Like Protein 3
  • Glucokinase-Like Protein 3
  • Probable Gluconokinase 3
  • EC 4
  • BA522I20.2 3
  • HGntK 3

External Ids for IDNK Gene

Previous HGNC Symbols for IDNK Gene

  • C9orf103

Previous GeneCards Identifiers for IDNK Gene

  • GC09P086238

Summaries for IDNK Gene

GeneCards Summary for IDNK Gene

IDNK (IDNK, Gluconokinase) is a Protein Coding gene. Among its related pathways are Pentose phosphate pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and gluconokinase activity.

Additional gene information for IDNK Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDNK Gene

Genomics for IDNK Gene

GeneHancer (GH) Regulatory Elements for IDNK Gene

Promoters and enhancers for IDNK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I083620 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.3 +0.4 369 5.3 HDGF FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B SP3 SP5 IDNK LOC105376114 KIF27 UBQLN1 GKAP1 GC09M083666
GH09I083705 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +84.4 84434 3.9 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LOC105376114 UBQLN1 HNRNPK KIF27 IDNK GC09M083666
GH09I083977 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.3 +357.0 357008 5.5 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B IRF4 HNRNPK RMI1 KIF27 C9orf64 LOC105376116 IDNK GKAP1 ENSG00000235298
GH09I083628 Enhancer 1.1 ENCODE dbSUPER 12.4 +7.3 7252 3.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 RXRA SP5 MXD4 LOC105376114 IDNK GC09M083666
GH09I083334 Enhancer 0.8 ENCODE 10.6 -288.6 -288618 0.2 ELF3 IRF4 THRB RAD21 ZNF143 RCOR1 ATF7 MIXL1 SMARCA5 ZNF654 IDNK ENSG00000237529 GC09M083455 FRMD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IDNK on UCSC Golden Path with GeneCards custom track

Genomic Locations for IDNK Gene

Genomic Locations for IDNK Gene
21,082 bases
Plus strand

Genomic View for IDNK Gene

Genes around IDNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDNK Gene

Proteins for IDNK Gene

  • Protein details for IDNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable gluconokinase
    Protein Accession:
    Secondary Accessions:
    • A5PLN6
    • Q5T6J6

    Protein attributes for IDNK Gene

    187 amino acids
    Molecular mass:
    20578 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IDNK Gene


neXtProt entry for IDNK Gene

Post-translational modifications for IDNK Gene

No Post-translational modifications

No data available for DME Specific Peptides for IDNK Gene

Domains & Families for IDNK Gene

Gene Families for IDNK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IDNK Gene

Suggested Antigen Peptide Sequences for IDNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gluconokinase GntK/GntV family.
  • Belongs to the gluconokinase GntK/GntV family.
genes like me logo Genes that share domains with IDNK: view

Function for IDNK Gene

Molecular function for IDNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Enzyme Numbers (IUBMB) for IDNK Gene

Gene Ontology (GO) - Molecular Function for IDNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046316 gluconokinase activity IEA --
genes like me logo Genes that share ontologies with IDNK: view
genes like me logo Genes that share phenotypes with IDNK: view

Animal Models for IDNK Gene

MGI Knock Outs for IDNK:

Animal Model Products

CRISPR Products

miRNA for IDNK Gene

miRTarBase miRNAs that target IDNK

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IDNK Gene

Localization for IDNK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDNK gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IDNK Gene

Pathways & Interactions for IDNK Gene

genes like me logo Genes that share pathways with IDNK: view

Pathways by source for IDNK Gene

UniProtKB/Swiss-Prot Q5T6J7-GNTK_HUMAN

  • Pathway: Carbohydrate acid metabolism; D-gluconate degradation.

Gene Ontology (GO) - Biological Process for IDNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
GO:0046177 D-gluconate catabolic process IEA --
genes like me logo Genes that share ontologies with IDNK: view

No data available for SIGNOR curated interactions for IDNK Gene

Drugs & Compounds for IDNK Gene

(3) Drugs for IDNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gluconic acid Approved Pharma 0
6-Phosphogluconic acid Experimental Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for IDNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with IDNK: view

Transcripts for IDNK Gene

Unigene Clusters for IDNK Gene

IdnK, gluconokinase homolog (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDNK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for IDNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IDNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IDNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IDNK Gene

This gene is overexpressed in Liver (18.7) and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IDNK Gene

NURSA nuclear receptor signaling pathways regulating expression of IDNK Gene:


SOURCE GeneReport for Unigene cluster for IDNK Gene:


Evidence on tissue expression from TISSUES for IDNK Gene

  • Liver(4.3)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with IDNK: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDNK Gene

Orthologs for IDNK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDNK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IDNK 33 34
  • 97.3 (n)
(Canis familiaris)
Mammalia IDNK 33 34
  • 88.29 (n)
(Bos Taurus)
Mammalia LOC100297815 33
  • 87.03 (n)
  • 80 (a)
(Mus musculus)
Mammalia Idnk 33 16 34
  • 80.07 (n)
(Rattus norvegicus)
Mammalia Idnk 33
  • 78.92 (n)
(Monodelphis domestica)
Mammalia IDNK 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia IDNK 34
  • 67 (a)
(Gallus gallus)
Aves CZH9ORF103 33
  • 66.28 (n)
  • 52 (a)
(Anolis carolinensis)
Reptilia IDNK 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia idnk 33
  • 61.79 (n)
(Caenorhabditis elegans)
Secernentea F26D11.1 33 34
  • 49.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDR248C 33
  • 50.47 (n)
-- 34
  • 30 (a)
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR164C 33
  • 49.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12078g 33
  • 46.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G16790 33
  • 56.09 (n)
(Oryza sativa)
Liliopsida Os06g0114650 33
  • 49.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02702 33
  • 48.95 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4G9.12 33
  • 45.56 (n)
Species where no ortholog for IDNK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IDNK Gene

Gene Tree for IDNK (if available)
Gene Tree for IDNK (if available)

Paralogs for IDNK Gene

No data available for Paralogs for IDNK Gene

Variants for IDNK Gene

Sequence variations from dbSNP and Humsavar for IDNK Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000281322 -- 83,640,994(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs1000364827 -- 83,641,180(+) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000745193 -- 83,625,306(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000986153 -- 83,623,609(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001060517 -- 83,629,716(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IDNK Gene

Variant ID Type Subtype PubMed ID
nsv516587 CNV loss 19592680

Variation tolerance for IDNK Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDNK Gene

Disorders for IDNK Gene

Additional Disease Information for IDNK

No disorders were found for IDNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDNK Gene

Publications for IDNK Gene

  1. Kinetic analysis of gluconate phosphorylation by human gluconokinase using isothermal titration calorimetry. (PMID: 26505675) Rohatgi N … Rolfsson Ó (FEBS letters 2015) 2 3 58
  2. Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysis. (PMID: 24896608) Rohatgi N … Rolfsson Ó (PloS one 2014) 2 3 58
  3. Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity. (PMID: 23067238) Rolfsson Ó … Thiele I (The Biochemical journal 2013) 2 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for IDNK Gene

Sources for IDNK Gene

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