Aliases for IDI1 Gene
External Ids for IDI1 Gene
Previous GeneCards Identifiers for IDI1 Gene
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDI1 Gene
IDI1 (Isopentenyl-Diphosphate Delta Isomerase 1) is a Protein Coding gene. Diseases associated with IDI1 include Zellweger Syndrome and Pelizaeus-Merzbacher Disease. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include hydrolase activity and manganese ion binding. An important paralog of this gene is IDI2.
UniProtKB/Swiss-Prot Summary for IDI1 Gene
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).