Aliases for IDH3A Gene
- Isocitrate Dehydrogenase 3 (NAD(+)) Alpha 2 3 5
- EC 126.96.36.199 4 56
- Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial 2
- NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2
- Isocitrate Dehydrogenase (NAD+) Alpha Chain 2
- Isocitrate Dehydrogenase 3 (NAD+) Alpha 2
- Isocitric Dehydrogenase Subunit Alpha 4
External Ids for IDH3A Gene
Previous GeneCards Identifiers for IDH3A Gene
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDH3A Gene
IDH3A (Isocitrate Dehydrogenase 3 (NAD(+)) Alpha) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
UniProtKB/Swiss-Prot for IDH3A Gene
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.