Aliases for IDH3A Gene
Aliases for IDH3A Gene
- Isocitrate Dehydrogenase 3 (NAD(+)) Alpha 2 3 5
- Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial 2 3
- NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2 3
- Isocitrate Dehydrogenase (NAD+) Alpha Chain 2 3
- Isocitrate Dehydrogenase 3 (NAD+) Alpha 2 3
- Isocitric Dehydrogenase Subunit Alpha 3 4
External Ids for IDH3A Gene
- HGNC: 5384
- Entrez Gene: 3419
- Ensembl: ENSG00000166411
- OMIM: 601149
- UniProtKB: P50213
Previous GeneCards Identifiers for IDH3A Gene
- GC15P074520
- GC15P071531
- GC15P076017
- GC15P076157
- GC15P076228
- GC15P078441
- GC15P055199
- GC15P078423
Summaries for IDH3A Gene
-
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDH3A Gene
IDH3A (Isocitrate Dehydrogenase 3 (NAD(+)) Alpha) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
UniProtKB/Swiss-Prot for IDH3A Gene
-
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3A Gene
Genomics for IDH3A Gene
GeneHancer (GH) Regulatory Elements for IDH3A Gene
Promoters and enhancers for IDH3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IDH3A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IDH3A gene promoter:
-
- STAT1beta
- STAT1alpha
- STAT1
- NF-1/L
- NF-1
- AP-2gamma
- YY1
- GCNF
- GCNF-2
- GCNF-1
Regulatory Element Products
Genomic Locations for IDH3A Gene
Genomic Locations for IDH3A Gene
- chr15:78,131,498-78,171,949
- (GRCh38/hg38)
- Size:
- 40,452 bases
- Orientation:
- Plus strand
- chr15:78,423,840-78,464,291
- (GRCh37/hg19)
- Size:
- 40,452 bases
- Orientation:
- Plus strand
Genomic View for IDH3A Gene
Genes around IDH3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q25.1 by Entrez Gene
- 15q25.1 by HGNC
- 15q25.1 by Ensembl
IDH3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IDH3A Gene
Proteins for IDH3A Gene
-
Protein details for IDH3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50213-IDH3A_HUMAN
- Recommended name:
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- Protein Accession:
- P50213
- D3DW83
- Q9H3X0
Protein attributes for IDH3A Gene
- Size:
- 366 amino acids
- Molecular mass:
- 39592 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
Three dimensional structures from OCA and Proteopedia for IDH3A Gene
Protein Expression for IDH3A Gene
Post-translational modifications for IDH3A Gene
Other Protein References for IDH3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IDH3A
-
Abcam antibodies for IDH3A
- Invitrogen Antibodies for IDH3A (AFLGC-IDH3A)
- GeneTex IDH3A Antibody for IDH3A
-
Boster Bio Antibodies for IDH3A
-
Santa Cruz Biotechnology (SCBT) Antibodies for IDH3A
Protein Products
-
OriGene Purified Proteins for IDH3A
- Search Origene for MassSpec and Protein Over-expression Lysates for IDH3A
- Origene Custom Protein Services for IDH3A
- Search GeneTex for Proteins for IDH3A
-
Abcam proteins for IDH3A
Assay Products
- antibodies-online: Search results for 2 available IDH3A Elisa Kits ranked by validation data
- Compare Top IDH3A Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for IDH3A Gene
Domains & Families for IDH3A Gene
Gene Families for IDH3A Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IDH3A Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IDH3A Gene
Graphical View of Domain Structure for InterPro Entry
P50213UniProtKB/Swiss-Prot:
IDH3A_HUMAN :- Belongs to the isocitrate and isopropylmalate dehydrogenases family.
- Family:
-
- Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Function for IDH3A Gene
Molecular function for IDH3A Gene
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=20.0 umol/min/mg enzyme with isocitrate as substrate (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=10.9 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=7.29 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=20.7 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=10.0 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=22.1 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=9.42 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=21.3 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=11.9 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269 PubMed:28139779}; Vmax=13.1 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=17.7 umol/min/mg enzyme with isocitrate as substrate in the presence of ATP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=6.62 umol/min/mg enzyme with isocitrate as substrate in the presence ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Vmax=17.6 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterotetramer) {ECO:0000269 PubMed:28139779}; Vmax=8.94 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269 PubMed:28139779}; Note=kcat is 26.7 sec(-1) for the heterotetramer with isocitrate as substrate. kcat is 14.6 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate. kcat is 9.72 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate. kcat is 23.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ATP. kcat is 11.9 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ATP. kcat is 28.4 sec(- 1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ADP. kcat is 15.8 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate in the presence of citrate and ADP. kcat is 17.6 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ADP. {ECO:0000269 PubMed:28139779};
- GENATLAS Biochemistry:
- isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric acid cycle
Enzyme Numbers (IUBMB) for IDH3A Gene
Phenotypes From GWAS Catalog for IDH3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 28098230 |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | IDA | 28098230 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for IDH3A Gene
- MGI mutant phenotypes for IDH3A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IDH3A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IDH3A
-
CRISPR Products
-
OriGene CRISPR knockouts for IDH3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IDH3A
- genomics-online: gRNA clones - Search results for available IDH3A gene related products
- Applied Biological Materials CRISPR for IDH3A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
- GenScript: Design CRISPR guide RNA sequences for IDH3A
miRNA for IDH3A Gene
- miRTarBase miRNAs that target IDH3A
-
- hsa-mir-16-5p (MIRT031744)
- hsa-mir-8085 (MIRT459765)
- hsa-mir-6731-5p (MIRT459766)
- hsa-mir-5703 (MIRT459767)
- hsa-mir-4516 (MIRT459768)
- hsa-mir-4434 (MIRT459769)
- hsa-mir-7-5p (MIRT459770)
- hsa-mir-107 (MIRT459771)
- hsa-mir-4784 (MIRT459772)
- hsa-mir-103a-3p (MIRT459773)
- hsa-mir-3150b-3p (MIRT459774)
- hsa-mir-6770-5p (MIRT459775)
- hsa-mir-7515 (MIRT459776)
- hsa-mir-1184 (MIRT459777)
- hsa-mir-922 (MIRT459778)
- hsa-mir-6847-5p (MIRT459779)
- hsa-mir-6760-5p (MIRT459780)
- hsa-mir-6859-5p (MIRT459781)
- hsa-mir-3916 (MIRT459782)
- hsa-mir-3125 (MIRT459783)
- hsa-mir-4524b-3p (MIRT459784)
- hsa-mir-3154 (MIRT459786)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IDH3A
- Browse OriGene Inhibitory RNA Products For IDH3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A
- genomics-online: shRNA clones - Search results for available IDH3A gene related products
Clone Products
- Sino Biological Human cDNA Clone for IDH3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IDH3A
- genomics-online: cdna clones - Search results for available IDH3A gene related products
- orf clones - Search results for available IDH3A gene related products
- Applied Biological Materials Clones for IDH3A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IDH3A
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3A Gene
Localization for IDH3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for IDH3A Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 3 |
| peroxisome | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0043209 | myelin sheath | IEA | -- |
Pathways & Interactions for IDH3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Citrate cycle (TCA cycle) |
.01
|
|
| 2 | Carbon metabolism | ||
| 3 | Pyruvate metabolism and Citric Acid (TCA) cycle |
.01
|
|
| 4 | Metabolism |
.37
|
|
| 5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
Pathways by source for IDH3A Gene
4 BioSystems pathways for IDH3A Gene
4 Reactome pathways for IDH3A Gene
5 KEGG pathways for IDH3A Gene
Interacting Proteins for IDH3A Gene
GPS-Prot Interaction Network for IDH3A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | NAS | 8833160 |
| GO:0006099 | tricarboxylic acid cycle | TAS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for IDH3A Gene
Drugs & Compounds for IDH3A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 37 | ||
| NADH | Approved | Nutra | Target | 0 | ||
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Xanthinol | Approved, Withdrawn | Pharma | Target, cofactor | 0 | ||
| Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Hydrogen Ion |
|
|
Drug Products
Transcripts for IDH3A Gene
mRNA/cDNA for IDH3A Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (340) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000558605 573 bps (uc059mbh.1)
- ENST00000299518 4128 bps (uc002bdd.4)
- ENST00000558933 878 bps (uc059mbj.1)
- ENST00000558554 1595 bps (uc010umt.3)
- ENST00000560667 2110 bps (uc059mbk.1)
Unigene Clusters for IDH3A Gene
CRISPR Products
-
OriGene CRISPR knockouts for IDH3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IDH3A
- genomics-online: gRNA clones - Search results for available IDH3A gene related products
- Applied Biological Materials CRISPR for IDH3A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
- GenScript: Design CRISPR guide RNA sequences for IDH3A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IDH3A
- Browse OriGene Inhibitory RNA Products For IDH3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A
- genomics-online: shRNA clones - Search results for available IDH3A gene related products
Clone Products
- Sino Biological Human cDNA Clone for IDH3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IDH3A
- genomics-online: cdna clones - Search results for available IDH3A gene related products
- orf clones - Search results for available IDH3A gene related products
- Applied Biological Materials Clones for IDH3A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: |
| ExUns: | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: | |||||||||||
| SP19: | |||||||||||
| SP20: |
Expression for IDH3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Adipose (Muscoskeletal System)
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Brain (Nervous System)
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IDH3A Gene
This gene is overexpressed in Heart - Left Ventricle (x4.1).
This gene is overexpressed in Brain (8.6) and Nasal epithelium (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDH3A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IDH3A Gene:
IDH3ASOURCE GeneReport for Unigene cluster for IDH3A Gene:
Hs.591110Evidence on tissue expression from TISSUES for IDH3A Gene
- Nervous system(5)
- Heart(4.5)
- Muscle(2.7)
- Intestine(2.4)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for IDH3A
-
OriGene qPCR primer pairs and template standards for IDH3A
- genomics-online: primer clones - Search results for available IDH3A gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3A Gene
Orthologs for IDH3A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IDH3A 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IDH3A 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IDH3A 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IDH3A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IDH3A 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Idh3a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Idh3a 33 |
|
||
| chicken (Gallus gallus) |
Aves | IDH3A 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IDH3A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | idh3a 33 |
|
||
| MGC76128 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15952 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | idh3a 34 33 |
|
OneToOne | |
| zgc56380 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9912 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG12233 35 |
|
|
|
| l(1)G0156 34 33 |
|
OneToMany | |||
| CG3483 34 35 |
|
OneToMany | |||
| CG32026 34 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002728 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F43G9.1 35 |
|
|
|
| idha-1 34 33 |
|
OneToOne | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E03125g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IDH2 36 34 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR137C 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | IDH-V 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.7251 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6781 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0276100 33 |
|
||
| Os.207 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.24979 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.620 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.3035 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.8758 33 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07697 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | idh2 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8758 33 |
|
- Species where no ortholog for IDH3A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for IDH3A Gene
- ENSEMBL:
- Gene Tree for IDH3A (if available)
- TreeFam:
- Gene Tree for IDH3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IDH3A: view image
Paralogs for IDH3A Gene
(3) SIMAP similar genes for IDH3A Gene using alignment to 14 proteins:
- IDH3A_HUMAN
- B7Z9J8_HUMAN
- H0YKD0_HUMAN
- H0YL05_HUMAN
- H0YL72_HUMAN
- H0YLF8_HUMAN
- H0YLI6_HUMAN
- H0YM46_HUMAN
- H0YM64_HUMAN
- H0YMU3_HUMAN
- H0YMY5_HUMAN
- H0YNF5_HUMAN
- H0YNF8_HUMAN
- Q9H326_HUMAN
No data available for Paralogs for IDH3A Gene
Variants for IDH3A Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028333 | -- | 78,164,828(+) | C/G/T | intron_variant | |
| rs1000370566 | -- | 78,158,216(+) | G/A | intron_variant | |
| rs1000667107 | -- | 78,157,887(+) | T/G | intron_variant | |
| rs1000996110 | -- | 78,157,457(+) | C/G | intron_variant | |
| rs1001039260 | -- | 78,162,639(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1116464 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IDH3A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3A Gene
Disorders for IDH3A Gene
Additional Disease Information for IDH3A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for IDH3A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3A Gene
Publications for IDH3A Gene
- Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PMID: 8833160) Huh TL … Inazawa J (Genomics 1996) 2 3 22 58
- Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PMID: 7755589) Kim YO … Huh TL (The Biochemical journal 1995) 3 4 22 58
- Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for IDH3A Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for IDH3A
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- Custom Assay Services
- OriGene Purified Proteins for IDH3A
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- OriGene qPCR primer pairs for IDH3A
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- OriGene ORF clones in human for IDH3A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IDH3A
- GenScript: Next-day shipping of latest version cDNA ORF clones for IDH3A in any vector
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- GenScript: Design CRISPR guide RNA sequences for IDH3A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for IDH3A
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IDH3A
- Novus Biologicals proteins and lysates for IDH3A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IDH3A
- Abcam proteins for IDH3A
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Invitrogen Antibodies for IDH3A (AFLGC-IDH3A)
- Cyagen custom Knockout/knockin (KOKI) mouse models for IDH3A
- antibodies-online: Search results for 51 available IDH3A Antibodies ranked by validation data
- Compare Top IDH3A Antibodies
- antibodies-online: Search results for 2 available IDH3A Elisa Kits ranked by validation data
- Compare Top IDH3A Elisa Kits
- Quality Products:
- antibodies-online: Search results for 10 available IDH3A Proteins ranked by validation data
- Compare Top IDH3A Proteins
- GeneTex IDH3A Antibody for IDH3A
- Search GeneTex for Proteins for IDH3A
- Santa Cruz Biotechnology (SCBT) Antibodies for IDH3A
- Search Santa Cruz Biotechnology (SCBT) for IDH3A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
- Horizon Cell Lines for IDH3A
- genomics-online: cdna clones - Search results for available IDH3A gene related products
- orf clones - Search results for available IDH3A gene related products
- genomics-online: gRNA clones - Search results for available IDH3A gene related products
- genomics-online: primer clones - Search results for available IDH3A gene related products
- genomics-online: shRNA clones - Search results for available IDH3A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IDH3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IDH3A
- GeneCopoeia miRNA 3'UTR Target clone products for IDH3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A
- Boster Bio Antibodies for IDH3A
- Browse Boster Bio ELISA Kits
Sources for IDH3A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt