Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NAD... See more...

Aliases for IDH3A Gene

Aliases for IDH3A Gene

  • Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha 2 3 5
  • Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial 2 3 4
  • NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2 3
  • Isocitrate Dehydrogenase (NAD+) Alpha Chain 2 3
  • Isocitrate Dehydrogenase (NAD(+)) 3 Alpha 2 3
  • Isocitrate Dehydrogenase 3 (NAD+) Alpha 2 3
  • Isocitric Dehydrogenase Subunit Alpha 3 4
  • NAD(+)-Specific ICDH Subunit Alpha 3 4
  • NAD+-Specific ICDH 2 3
  • H-IDH Alpha 2 3
  • EC 1.1.1.41 4 50
  • Isocitrate Dehydrogenase 3 (NAD(+)) Alpha 3
  • Isocitric Dehydrogenase 2
  • EC 1.1.1 50
  • IDH3A 5
  • RP90 3

External Ids for IDH3A Gene

Previous GeneCards Identifiers for IDH3A Gene

  • GC15P074520
  • GC15P071531
  • GC15P076017
  • GC15P076157
  • GC15P076228
  • GC15P078441
  • GC15P055199
  • GC15P078423

Summaries for IDH3A Gene

Entrez Gene Summary for IDH3A Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3A Gene

IDH3A (Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with IDH3A include Retinitis Pigmentosa 90 and Retinitis Pigmentosa. Among its related pathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3G.

UniProtKB/Swiss-Prot Summary for IDH3A Gene

  • Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Gene Wiki entry for IDH3A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IDH3A Gene

Genomics for IDH3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IDH3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IDH3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IDH3A

Top Transcription factor binding sites by QIAGEN in the IDH3A gene promoter:
  • AP-2gamma
  • GCNF
  • GCNF-1
  • GCNF-2
  • NF-1
  • NF-1/L
  • STAT1
  • STAT1alpha
  • STAT1beta
  • YY1

Genomic Locations for IDH3A Gene

Latest Assembly
chr15:78,131,498-78,171,945
(GRCh38/hg38)
Size:
40,448 bases
Orientation:
Plus strand

Previous Assembly
chr15:78,441,704-78,464,287
(GRCh37/hg19 by Entrez Gene)
Size:
22,584 bases
Orientation:
Plus strand

chr15:78,423,840-78,464,291
(GRCh37/hg19 by Ensembl)
Size:
40,452 bases
Orientation:
Plus strand

Genomic View for IDH3A Gene

Genes around IDH3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3A Gene

Proteins for IDH3A Gene

  • Protein details for IDH3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50213-IDH3A_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Protein Accession:
    P50213
    Secondary Accessions:
    • D3DW83
    • Q9H3X0

    Protein attributes for IDH3A Gene

    Size:
    366 amino acids
    Molecular mass:
    39592 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.

    Three dimensional structures from OCA and Proteopedia for IDH3A Gene

    Alternative splice isoforms for IDH3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3A Gene

Selected DME Specific Peptides for IDH3A Gene

P50213:
  • SKVSRLLGAFHN
  • RENTEGEYS
  • ANPTALLLS
  • APDIAGKD
  • GDGIGPEI
  • KCSDFTEEICR
  • ACFATIKDGKSLTKDLGGN
  • LLSAVMMLR
  • ANVRPCVSI
  • VMPNLYG
  • KFNEMYLDTVCLN
  • AGLIGGLG
  • VTAVHKAN
  • VTAVHKANI
  • PGDGIGPE
  • VHKANIM
  • GVVQSIKLIT

Post-translational modifications for IDH3A Gene

  • Ubiquitination at Lys100, Lys58, and Lys77
  • Modification sites at PhosphoSitePlus

Domains & Families for IDH3A Gene

Gene Families for IDH3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IDH3A Gene

InterPro:
Blocks:
  • Isocitrate/isopropylmalate dehydrogenase

Suggested Antigen Peptide Sequences for IDH3A Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78950, highly similar to Isocitrate dehydrogenase (B7Z9J8_HUMAN)
  • NAD(+)-specific ICDH subunit alpha (IDH3A_HUMAN)
  • NAD+-dependent isocitrate dehydrogenase 3 alpha subunit (Q9H326_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50213

UniProtKB/Swiss-Prot:

IDH3A_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3A: view

Function for IDH3A Gene

Molecular function for IDH3A Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH; Xref=Rhea:RHEA:23632, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.41; Evidence={ECO:0000269|PubMed:28098230, ECO:0000269|PubMed:28139779};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=20.0 umol/min/mg enzyme with isocitrate as substrate (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=10.9 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=7.29 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=20.7 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=10.0 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=22.1 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=9.42 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=21.3 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.9 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=13.1 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=17.7 umol/min/mg enzyme with isocitrate as substrate in the presence of ATP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=6.62 umol/min/mg enzyme with isocitrate as substrate in the presence ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=17.6 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=8.94 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Note=kcat is 26.7 sec(-1) for the heterotetramer with isocitrate as substrate. kcat is 14.6 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate. kcat is 9.72 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate. kcat is 23.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ATP. kcat is 11.9 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ATP. kcat is 28.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ADP. kcat is 15.8 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate in the presence of citrate and ADP. kcat is 17.6 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ADP. {ECO:0000269|PubMed:28139779};
UniProtKB/Swiss-Prot EnzymeRegulation:
The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
GENATLAS Biochemistry:
isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric acid cycle

Enzyme Numbers (IUBMB) for IDH3A Gene

Phenotypes From GWAS Catalog for IDH3A Gene

Gene Ontology (GO) - Molecular Function for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 28098230
GO:0004449 isocitrate dehydrogenase (NAD+) activity IBA,IDA 28098230
GO:0005515 protein binding IPI 14555658
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with IDH3A: view
genes like me logo Genes that share phenotypes with IDH3A: view

Human Phenotype Ontology for IDH3A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3A Gene

Localization for IDH3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDH3A gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
peroxisome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with IDH3A: view

Pathways & Interactions for IDH3A Gene

genes like me logo Genes that share pathways with IDH3A: view

Gene Ontology (GO) - Biological Process for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 8833160
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006102 isocitrate metabolic process IBA 21873635
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3A: view

No data available for SIGNOR curated interactions for IDH3A Gene

Drugs & Compounds for IDH3A Gene

(9) Drugs for IDH3A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 65
NADH Approved Nutra Target 0
Copper Approved, Investigational Pharma Target 276
Xanthinol Approved, Withdrawn Pharma Target, cofactor 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0

(1) Additional Compounds for IDH3A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton
genes like me logo Genes that share compounds with IDH3A: view

Transcripts for IDH3A Gene

mRNA/cDNA for IDH3A Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -
SP20:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for IDH3A Gene

GeneLoc Exon Structure for
IDH3A

Expression for IDH3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDH3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDH3A Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for IDH3A Gene

This gene is overexpressed in Brain (8.6) and Nasal epithelium (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDH3A Gene



Protein tissue co-expression partners for IDH3A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IDH3A

SOURCE GeneReport for Unigene cluster for IDH3A Gene:

Hs.591110

Evidence on tissue expression from TISSUES for IDH3A Gene

  • Nervous system(5)
  • Heart(4.6)
  • Muscle(3.1)
  • Intestine(2.9)
  • Kidney(2.8)
  • Skin(2.6)
  • Liver(2.4)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with IDH3A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3A Gene

Orthologs for IDH3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IDH3A 29 30
  • 99.64 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IDH3A 30
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IDH3A 30
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia IDH3A 29 30
  • 92.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IDH3A 29 30
  • 91.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Idh3a 29 16 30
  • 89.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Idh3a 29
  • 88.98 (n)
Chicken
(Gallus gallus)
Aves IDH3A 29 30
  • 80.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IDH3A 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia idh3a 29
  • 76.5 (n)
MGC76128 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.15952 29
Zebrafish
(Danio rerio)
Actinopterygii idh3a 29 30
  • 75.78 (n)
OneToOne
zgc56380 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9912 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG12233 31
  • 71 (a)
l(1)G0156 29 30
  • 64.6 (n)
OneToMany
CG3483 30 31
  • 35 (a)
OneToMany
CG32026 30
  • 30 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002728 29
  • 63.81 (n)
Worm
(Caenorhabditis elegans)
Secernentea F43G9.1 31
  • 65 (a)
idha-1 29 30
  • 63.57 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03125g 29
  • 55.59 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH2 29 30 32
  • 54.48 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR137C 29
  • 53.92 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons IDH-V 29
  • 58.24 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6781 29
Soybean
(Glycine max)
eudicotyledons Gma.7251 29
Rice
(Oryza sativa)
Liliopsida Os01g0276100 29
  • 58.91 (n)
Os.207 29
Barley
(Hordeum vulgare)
Liliopsida Hv.620 29
Wheat
(Triticum aestivum)
Liliopsida Ta.24979 29
Corn
(Zea mays)
Liliopsida Zm.3035 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 73 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU07697 29
  • 58.28 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes idh2 29
  • 58.23 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8758 29
Species where no ortholog for IDH3A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IDH3A Gene

ENSEMBL:
Gene Tree for IDH3A (if available)
TreeFam:
Gene Tree for IDH3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IDH3A: view image
Alliance of Genome Resources:
Additional Orthologs for IDH3A

Paralogs for IDH3A Gene

Paralogs for IDH3A Gene

(3) SIMAP similar genes for IDH3A Gene using alignment to 14 proteins:

  • IDH3A_HUMAN
  • B7Z9J8_HUMAN
  • H0YKD0_HUMAN
  • H0YL05_HUMAN
  • H0YL72_HUMAN
  • H0YLF8_HUMAN
  • H0YLI6_HUMAN
  • H0YM46_HUMAN
  • H0YM64_HUMAN
  • H0YMU3_HUMAN
  • H0YMY5_HUMAN
  • H0YNF5_HUMAN
  • H0YNF8_HUMAN
  • Q9H326_HUMAN
genes like me logo Genes that share paralogs with IDH3A: view

Variants for IDH3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IDH3A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
1001202 Uncertain Significance: not provided 78,165,065(+) A/G
NM_005530.3(IDH3A):c.853A>G (p.Ile285Val)
MISSENSE
1003741 Uncertain Significance: not provided 78,162,289(+) G/A
NM_005530.3(IDH3A):c.533G>A (p.Arg178His)
MISSENSE
1003946 Uncertain Significance: not provided 78,162,381(+) G/A
NM_005530.3(IDH3A):c.611+14G>A
INTRON
1006368 Uncertain Significance: not provided 78,165,056(+) G/A
NM_005530.3(IDH3A):c.844G>A (p.Gly282Arg)
MISSENSE
1007116 Uncertain Significance: not provided 78,157,613(+) G/T
NM_005530.3(IDH3A):c.156G>T (p.Lys52Asn)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IDH3A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IDH3A Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259

Variation tolerance for IDH3A Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDH3A Gene

Human Gene Mutation Database (HGMD)
IDH3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDH3A
Leiden Open Variation Database (LOVD)
IDH3A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3A Gene

Disorders for IDH3A Gene

MalaCards: The human disease database

(8) MalaCards diseases for IDH3A Gene - From: OMI, CVR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search IDH3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IDH3A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IDH3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IDH3A Gene

Publications for IDH3A Gene

  1. Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PMID: 8833160) Huh TL … Inazawa J (Genomics 1996) 2 3 22
  2. Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PMID: 7755589) Kim YO … Huh TL (The Biochemical journal 1995) 3 4 22
  3. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for IDH3A Gene

Sources for IDH3A Gene