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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NAD... See more...
Aliases for IDH3A Gene
Aliases for IDH3A Gene
- Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha 2 3 5
- Isocitrate Dehydrogenase [NAD] Subunit Alpha, Mitochondrial 2 3 4
- NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2 3
- Isocitrate Dehydrogenase (NAD+) Alpha Chain 2 3
- Isocitrate Dehydrogenase (NAD(+)) 3 Alpha 2 3
- Isocitrate Dehydrogenase 3 (NAD+) Alpha 2 3
- Isocitric Dehydrogenase Subunit Alpha 3 4
- NAD(+)-Specific ICDH Subunit Alpha 3 4
External Ids for IDH3A Gene
- HGNC: 5384
- NCBI Entrez Gene: 3419
- Ensembl: ENSG00000166411
- OMIM®: 601149
- UniProtKB/Swiss-Prot: P50213
Previous GeneCards Identifiers for IDH3A Gene
- GC15P074520
- GC15P071531
- GC15P076017
- GC15P076157
- GC15P076228
- GC15P078441
- GC15P055199
- GC15P078423
Summaries for IDH3A Gene
-
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDH3A Gene
IDH3A (Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with IDH3A include Retinitis Pigmentosa 90 and Retinitis Pigmentosa. Among its related pathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3G.
UniProtKB/Swiss-Prot Summary for IDH3A Gene
-
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Additional gene information for IDH3A Gene
- HGNC (5384)
- NCBI Entrez Gene (3419)
- Ensembl (ENSG00000166411)
- OMIM® (601149)
- UniProtKB/Swiss-Prot (P50213)
- Open Targets Platform(ENSG00000166411)
- Alliance of Genome Resources
- Search for IDH3A at DataMed
- Search for IDH3A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IDH3A Gene
Genomics for IDH3A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IDH3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IDH3A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IDH3A
- Top Transcription factor binding sites by QIAGEN in the IDH3A gene promoter:
-
- AP-2gamma
- GCNF
- GCNF-1
- GCNF-2
- NF-1
- NF-1/L
- STAT1
- STAT1alpha
- STAT1beta
- YY1
Genomic Locations for IDH3A Gene
Latest Assembly
- chr15:78,131,498-78,171,945
- (GRCh38/hg38)
- Size:
- 40,448 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:78,441,704-78,464,287
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 22,584 bases
- Orientation:
- Plus strand
Genomic View for IDH3A Gene
Genes around IDH3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q25.1 by HGNC
- 15q25.1 by Entrez Gene
- 15q25.1 by Ensembl
IDH3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IDH3A Gene
Proteins for IDH3A Gene
-
Protein details for IDH3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50213-IDH3A_HUMAN
- Recommended name:
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- Protein Accession:
- P50213
- D3DW83
- Q9H3X0
Protein attributes for IDH3A Gene
- Size:
- 366 amino acids
- Molecular mass:
- 39592 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
Three dimensional structures from OCA and Proteopedia for IDH3A Gene
Protein Expression for IDH3A Gene
Selected DME Specific Peptides for IDH3A Gene
- P50213:
-
- SKVSRLLGAFHN
- RENTEGEYS
- ANPTALLLS
- APDIAGKD
- GDGIGPEI
- KCSDFTEEICR
- ACFATIKDGKSLTKDLGGN
- LLSAVMMLR
- ANVRPCVSI
- VMPNLYG
- KFNEMYLDTVCLN
- AGLIGGLG
- VTAVHKAN
- VTAVHKANI
- PGDGIGPE
- VHKANIM
- GVVQSIKLIT
Post-translational modifications for IDH3A Gene
Other Protein References for IDH3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IDH3A Antibody (LS-B8365) and IDH3A Antibody (LS-B11128)
- Novus Biologicals Antibodies for IDH3A
-
Abcam antibodies for IDH3A
- Invitrogen Antibodies for IDH3A (AFLGC-IDH3A)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IDH3A
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for IDH3A
- Origene Custom Protein Services for IDH3A
-
Abcam proteins for IDH3A
Assay products for research
- antibodies-online: Show 3 available IDH3A Elisa Kits ranked by validation data
- Compare Top IDH3A Elisa Kits
-
Quality Products:
Domains & Families for IDH3A Gene
Gene Families for IDH3A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IDH3A Gene
- InterPro:
- Blocks:
-
- Isocitrate/isopropylmalate dehydrogenase
Suggested Antigen Peptide Sequences for IDH3A Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ78950, highly similar to Isocitrate dehydrogenase (B7Z9J8_HUMAN)
- NAD(+)-specific ICDH subunit alpha (IDH3A_HUMAN)
- NAD+-dependent isocitrate dehydrogenase 3 alpha subunit (Q9H326_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P50213UniProtKB/Swiss-Prot:
IDH3A_HUMAN :- Belongs to the isocitrate and isopropylmalate dehydrogenases family.
- Family:
-
- Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Function for IDH3A Gene
Molecular function for IDH3A Gene
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH; Xref=Rhea:RHEA:23632, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.41; Evidence={ECO:0000269|PubMed:28098230, ECO:0000269|PubMed:28139779};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=20.0 umol/min/mg enzyme with isocitrate as substrate (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=10.9 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=7.29 umol/min/mg enzyme with isocitrate as substrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=20.7 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=10.0 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=22.1 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.2 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=9.42 umol/min/mg enzyme with isocitrate as substrate in the presence of ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=21.3 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=11.9 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3B subunits) {ECO:0000269|PubMed:28139779}; Vmax=13.1 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ADP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=17.7 umol/min/mg enzyme with isocitrate as substrate in the presence of ATP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=6.62 umol/min/mg enzyme with isocitrate as substrate in the presence ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Vmax=17.6 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterotetramer) {ECO:0000269|PubMed:28139779}; Vmax=8.94 umol/min/mg enzyme with isocitrate as substrate in the presence of citrate and ATP (heterodimer composed of IDH3A and IDH3G subunits) {ECO:0000269|PubMed:28139779}; Note=kcat is 26.7 sec(-1) for the heterotetramer with isocitrate as substrate. kcat is 14.6 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate. kcat is 9.72 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate. kcat is 23.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ATP. kcat is 11.9 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ATP. kcat is 28.4 sec(-1) for the heterotetramer with isocitrate as substrate in the presence of citrate and ADP. kcat is 15.8 sec(-1) for the heterodimer composed of IDH3A and IDH3B subunits with isocitrate as substrate in the presence of citrate and ADP. kcat is 17.6 sec(-1) for the heterodimer composed of IDH3A and IDH3G subunits with isocitrate as substrate in the presence of citrate and ADP. {ECO:0000269|PubMed:28139779};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
- GENATLAS Biochemistry:
- isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric acid cycle
Enzyme Numbers (IUBMB) for IDH3A Gene
Phenotypes From GWAS Catalog for IDH3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 28098230 |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | IBA,IDA | 28098230 |
| GO:0005515 | protein binding | IPI | 14555658 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | -- |
Phenotypes for IDH3A Gene
- MGI mutant phenotypes for IDH3A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IDH3A:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IDH3A - Starting at $85 >
- * IDH3A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IDH3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IDH3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
miRNA for IDH3A Gene
- miRTarBase miRNAs that target IDH3A
-
- hsa-miR-16-5p (MIRT031744)
- hsa-miR-8085 (MIRT459765)
- hsa-miR-6731-5p (MIRT459766)
- hsa-miR-5703 (MIRT459767)
- hsa-miR-4516 (MIRT459768)
- hsa-miR-4434 (MIRT459769)
- hsa-miR-7-5p (MIRT459770)
- hsa-miR-107 (MIRT459771)
- hsa-miR-4784 (MIRT459772)
- hsa-miR-103a-3p (MIRT459773)
- hsa-miR-3150b-3p (MIRT459774)
- hsa-miR-6770-5p (MIRT459775)
- hsa-miR-7515 (MIRT459776)
- hsa-miR-1184 (MIRT459777)
- hsa-miR-922 (MIRT459778)
- hsa-miR-6847-5p (MIRT459779)
- hsa-miR-6760-5p (MIRT459780)
- hsa-miR-6859-5p (MIRT459781)
- hsa-miR-3916 (MIRT459782)
- hsa-miR-3125 (MIRT459783)
- hsa-miR-4524b-3p (MIRT459784)
- hsa-miR-3154 (MIRT459786)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IDH3A
- Browse OriGene Inhibitory RNA Products For IDH3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A
Clone products for research
- Applied Biological Materials (abm): Clones for IDH3A - Starting at $45 >
- * IDH3A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IDH3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IDH3A
Cell Lines for research
-
Horizon Cell Lines for IDH3A
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3A Gene
Localization for IDH3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for IDH3A Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 3 |
| peroxisome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
Pathways & Interactions for IDH3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Citrate cycle (TCA cycle) |
.01
|
|
| 2 | Carbon metabolism | ||
| 3 | Pyruvate metabolism and Citric Acid (TCA) cycle |
.01
|
|
| 4 | Metabolism |
.40
|
|
| 5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
Pathways by source for IDH3A Gene
4 BioSystems pathways for IDH3A Gene
4 Reactome pathways for IDH3A Gene
5 KEGG pathways for IDH3A Gene
Interacting Proteins for IDH3A Gene
Selected Interacting proteins:
P50213-IDH3A_HUMAN
ENSP00000299518
for IDH3A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IDH3A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | NAS | 8833160 |
| GO:0006099 | tricarboxylic acid cycle | IEA,TAS | -- |
| GO:0006102 | isocitrate metabolic process | IBA | 21873635 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for IDH3A Gene
Drugs & Compounds for IDH3A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 65 | ||
| NADH | Approved | Nutra | Target | 0 | ||
| Copper | Approved, Investigational | Pharma | Target | 276 | ||
| Xanthinol | Approved, Withdrawn | Pharma | Target, cofactor | 0 | ||
| Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Hydrogen Ion |
|
|
Transcripts for IDH3A Gene
mRNA/cDNA for IDH3A Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000299518 4083 nts (view in UCSC)
- ENST00000557826 587 nts (view in UCSC)
- ENST00000557960 424 nts (view in UCSC)
- ENST00000558016 535 nts (view in UCSC)
- ENST00000558509 617 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IDH3A - Starting at $85 >
- * IDH3A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IDH3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IDH3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IDH3A
- Browse OriGene Inhibitory RNA Products For IDH3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3A
Clone products for research
- Applied Biological Materials (abm): Clones for IDH3A - Starting at $45 >
- * IDH3A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IDH3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IDH3A
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: |
| ExUns: | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: | |||||||||||
| SP19: | |||||||||||
| SP20: |
Relevant External Links for IDH3A Gene
- GeneLoc Exon Structure for
- IDH3A
Expression for IDH3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Adipose (Muscoskeletal System)
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Brain (Nervous System)
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IDH3A Gene
This gene is overexpressed in Heart - Left Ventricle (x4.1).
This gene is overexpressed in Brain (8.6) and Nasal epithelium (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDH3A Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IDH3A
SOURCE GeneReport for Unigene cluster for IDH3A Gene:
Hs.591110Evidence on tissue expression from TISSUES for IDH3A Gene
- Nervous system(5)
- Heart(4.6)
- Muscle(3.1)
- Intestine(2.9)
- Kidney(2.8)
- Skin(2.6)
- Liver(2.4)
- Pancreas(2)
Primer products for research
-
OriGene qPCR primer pairs for IDH3A
-
OriGene qPCR primer pairs and template standards for IDH3A
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3A Gene
Orthologs for IDH3A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IDH3A 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IDH3A 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IDH3A 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IDH3A 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IDH3A 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Idh3a 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Idh3a 29 |
|
||
| Chicken (Gallus gallus) |
Aves | IDH3A 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IDH3A 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | idh3a 29 |
|
||
| MGC76128 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15952 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | idh3a 29 30 |
|
OneToOne | |
| zgc56380 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9912 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG12233 31 |
|
|
|
| l(1)G0156 29 30 |
|
OneToMany | |||
| CG3483 30 31 |
|
OneToMany | |||
| CG32026 30 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002728 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F43G9.1 31 |
|
|
|
| idha-1 29 30 |
|
OneToOne | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E03125g 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IDH2 29 30 32 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR137C 29 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | IDH-V 29 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6781 29 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.7251 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0276100 29 |
|
||
| Os.207 29 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.620 29 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.24979 29 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.3035 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07697 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | idh2 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8758 29 |
|
- Species where no ortholog for IDH3A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for IDH3A Gene
- ENSEMBL:
- Gene Tree for IDH3A (if available)
- TreeFam:
- Gene Tree for IDH3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IDH3A: view image
- Alliance of Genome Resources:
- Additional Orthologs for IDH3A
Paralogs for IDH3A Gene
(3) SIMAP similar genes for IDH3A Gene using alignment to 14 proteins:
- IDH3A_HUMAN
- B7Z9J8_HUMAN
- H0YKD0_HUMAN
- H0YL05_HUMAN
- H0YL72_HUMAN
- H0YLF8_HUMAN
- H0YLI6_HUMAN
- H0YM46_HUMAN
- H0YM64_HUMAN
- H0YMU3_HUMAN
- H0YMY5_HUMAN
- H0YNF5_HUMAN
- H0YNF8_HUMAN
- Q9H326_HUMAN
Variants for IDH3A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IDH3A Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1001202 | Uncertain Significance: not provided | 78,165,065(+) |
A/G NM_005530.3(IDH3A):c.853A>G (p.Ile285Val) |
MISSENSE | |
| 1003741 | Uncertain Significance: not provided | 78,162,289(+) |
G/A NM_005530.3(IDH3A):c.533G>A (p.Arg178His) |
MISSENSE | |
| 1003946 | Uncertain Significance: not provided | 78,162,381(+) |
G/A NM_005530.3(IDH3A):c.611+14G>A |
INTRON | |
| 1006368 | Uncertain Significance: not provided | 78,165,056(+) |
G/A NM_005530.3(IDH3A):c.844G>A (p.Gly282Arg) |
MISSENSE | |
| 1007116 | Uncertain Significance: not provided | 78,157,613(+) |
G/T NM_005530.3(IDH3A):c.156G>T (p.Lys52Asn) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1116464 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IDH3A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3A Gene
Disorders for IDH3A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 90 |
|
|
| retinitis pigmentosa |
|
|
| cone-rod dystrophy 2 |
|
|
| inhibited female orgasm |
|
|
| infantile cerebellar-retinal degeneration |
|
|
Search IDH3A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IDH3A
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IDH3A Gene
Publications for IDH3A Gene
- Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PMID: 8833160) Huh TL … Inazawa J (Genomics 1996) 2 3 22
- Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PMID: 7755589) Kim YO … Huh TL (The Biochemical journal 1995) 3 4 22
- Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for IDH3A Gene
- Custom Antibody ServicesOriGene Antibodies for IDH3A
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- Novus Biologicals proteins and lysates for IDH3A
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- VectorBuilder Custom and pre-made DNA vectors for IDH3A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IDH3A (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 13 available IDH3A Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) CRISPR for IDH3A
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- Search for IDH3A Proteins at ProSci
- Horizon Cell Lines for IDH3A
- Browse GeneCopoeia Cell Lines
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Sources for IDH3A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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