This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of ot... See more...

Aliases for IDE Gene

Aliases for IDE Gene

  • Insulin Degrading Enzyme 2 3 5
  • Insulin-Degrading Enzyme 2 3 4
  • Abeta-Degrading Protease 3 4
  • Insulin Protease 3 4
  • EC 3.4.24.56 4 50
  • Insulinase 3 4
  • Insulysin 2 4
  • INSULYSIN 3
  • EC 3.4.24 50
  • IDE 5

External Ids for IDE Gene

Previous GeneCards Identifiers for IDE Gene

  • GC10M093095
  • GC10M093435
  • GC10M094342
  • GC10M093878
  • GC10M094201
  • GC10M087837
  • GC10M094211

Summaries for IDE Gene

Entrez Gene Summary for IDE Gene

  • This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

GeneCards Summary for IDE Gene

IDE (Insulin Degrading Enzyme) is a Protein Coding gene. Diseases associated with IDE include Type 2 Diabetes Mellitus and Glucose Intolerance. Among its related pathways are A-beta Pathways: Uptake and Degradation and Deubiquitination. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is NRDC.

UniProtKB/Swiss-Prot Summary for IDE Gene

  • Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:2293021, PubMed:10684867, PubMed:26968463, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:29596046, PubMed:21098034). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
  • (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).

Gene Wiki entry for IDE Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IDE Gene

Genomics for IDE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IDE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J092572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 264.9 +0.5 495 4 BCLAF1 SP1 ZNF654 MYC IKZF1 ZNF600 ZNF580 KLF9 ZNF223 ZNF10 IDE KIF11 BTAF1 RPL17P34 MYOF TNKS2 MARK2P9 EIF2S2P3 lnc-CPEB3-2 CPEB3
GH10J092688 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.9 -119.2 -119235 10.7 NCOR1 MYC ZNF600 IKZF1 ZNF592 ZMYM3 KLF9 CEBPA ATF3 ZSCAN16 HHEX BTAF1 RPL17P34 KIF11 PDE6C IDE TNKS2 EIF2S2P3 lnc-IDE-3 HSALNG0079722
GH10J092833 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -260.7 -260723 2.8 USF2 THRAP3 ATF4 ATF3 DACH1 FOS CEBPG EXOC6 IDE KIF11 MARCHF5 HSALNG0079727 ENSG00000225118 CYP26C1
GH10J092644 Enhancer 0.9 Ensembl ENCODE 11.5 -70.7 -70705 2 ZNF654 REST MNT CTCF MAX MAFF SAP130 RAD21 SMC3 ZNF316 HHEX IDE KIF11 MN309194 lnc-KIF11-2
GH10J092544 Enhancer 0.8 Ensembl ENCODE 12.5 +29.6 29596 3 REST EBF1 SPI1 EHMT2 ZNF189 MAX ZNF384 IKZF1 ZNF664 IKZF2 KIF11 IDE MARK2P9 EIF2S2P3 HHEX lnc-CPEB3-2 FJ601666-010 CPEB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IDE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IDE

Top Transcription factor binding sites by QIAGEN in the IDE gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • E2F-4
  • E2F-5
  • NF-Y
  • NF-YC

Genomic Locations for IDE Gene

Latest Assembly
chr10:92,451,684-92,574,096
(GRCh38/hg38)
Size:
122,413 bases
Orientation:
Minus strand

Previous Assembly
chr10:94,211,441-94,333,850
(GRCh37/hg19 by Entrez Gene)
Size:
122,410 bases
Orientation:
Minus strand

chr10:94,211,441-94,333,833
(GRCh37/hg19 by Ensembl)
Size:
122,393 bases
Orientation:
Minus strand

Genomic View for IDE Gene

Genes around IDE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDE Gene

Proteins for IDE Gene

  • Protein details for IDE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14735-IDE_HUMAN
    Recommended name:
    Insulin-degrading enzyme
    Protein Accession:
    P14735
    Secondary Accessions:
    • B2R721
    • B7ZAU2
    • D3DR35
    • Q5T5N2

    Protein attributes for IDE Gene

    Size:
    1019 amino acids
    Molecular mass:
    117968 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer (PubMed:17051221, PubMed:19321446, PubMed:23922390, PubMed:26394692, PubMed:29596046) (Probable). Can also form homotetramers (By similarity).
    • (Microbial infection) Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus (PubMed:17055432, PubMed:17553876).
    Miscellaneous:
    • ATP-binding induces a conformation change.

    Three dimensional structures from OCA and Proteopedia for IDE Gene

    Alternative splice isoforms for IDE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDE Gene

Selected DME Specific Peptides for IDE Gene

P14735:
  • KVLLISDP
  • EDKREYRGLELANGIKVLL
  • EHMLFLGT
  • GALDRFAQFF
  • YYSSNLM
  • HLIGHEGPGSLLSELK
  • KIVPIKDIR

Post-translational modifications for IDE Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys192, Lys308, Lys884, Lys929, Lys938, and Lys1018
  • Modification sites at PhosphoSitePlus

Antibodies for research

Domains & Families for IDE Gene

Gene Families for IDE Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IDE Gene

InterPro:
Blocks:
  • Insulinase-like peptidase, family M16

Suggested Antigen Peptide Sequences for IDE Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79306, highly similar to Insulin-degrading enzyme (EC 3.4.24.56) (B7ZAU2_HUMAN)
  • Insulysin (IDE_HUMAN)
  • Insulin-degrading enzyme (Q5T5N3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14735

UniProtKB/Swiss-Prot:

IDE_HUMAN :
  • The SlyX motif may be involved in the non-conventional secretion of the protein.
  • Belongs to the peptidase M16 family.
Domain:
  • The SlyX motif may be involved in the non-conventional secretion of the protein.
Family:
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with IDE: view

Function for IDE Gene

Molecular function for IDE Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:2293021, PubMed:10684867, PubMed:26968463, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:29596046, PubMed:21098034). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
UniProtKB/Swiss-Prot Function:
(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Degradation of insulin, glucagon and other polypeptides. No action on proteins.; EC=3.4.24.56; Evidence={ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0000269|PubMed:21098034, ECO:0000269|PubMed:2293021, ECO:0000269|PubMed:23922390, ECO:0000269|PubMed:24847884, ECO:0000269|PubMed:26394692, ECO:0000269|PubMed:29596046};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by small peptides (By similarity). Activated by ATP and GTP, and to a lesser extent by CTP, TTP and PPPi (PubMed:17613531). Inhibited by bacitracin (PubMed:17055432, PubMed:17613531). In vitro modification of Cys residues impairs enzyme activity (PubMed:18986166).
GENATLAS Biochemistry:
insulin degrading enzyme,cytosolic metalloproteinase (110kDa)

Enzyme Numbers (IUBMB) for IDE Gene

Phenotypes From GWAS Catalog for IDE Gene

Gene Ontology (GO) - Molecular Function for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001540 amyloid-beta binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0003824 catalytic activity IEA --
GO:0004175 endopeptidase activity IDA 20364150
genes like me logo Genes that share ontologies with IDE: view
genes like me logo Genes that share phenotypes with IDE: view

Animal Models for IDE Gene

MGI Knock Outs for IDE:
  • Ide Ide<tm1a(EUCOMM)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for IDE

miRNA for IDE Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IDE Gene

Localization for IDE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDE Gene

Cytoplasm, cytosol. Cell membrane. Secreted. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDE gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
peroxisome 5
nucleus 5
cytosol 5
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,TAS 10684867
GO:0005634 NOT nucleus IDA 18226493
GO:0005737 cytoplasm IEA,IDA 9231799
GO:0005739 mitochondrion IBA,IDA 15285718
genes like me logo Genes that share ontologies with IDE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IDE Gene

Pathways & Interactions for IDE Gene

genes like me logo Genes that share pathways with IDE: view

Pathways by source for IDE Gene

1 BioSystems pathway for IDE Gene
1 KEGG pathway for IDE Gene
1 Qiagen pathway for IDE Gene
  • DHA Signaling

SIGNOR curated interactions for IDE Gene

Inactivates:

Gene Ontology (GO) - Biological Process for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 18602473
GO:0006625 protein targeting to peroxisome TAS --
GO:0008152 metabolic process IEA --
GO:0008286 insulin receptor signaling pathway NAS 3059494
GO:0008340 determination of adult lifespan IDA 18448515
genes like me logo Genes that share ontologies with IDE: view

Drugs & Compounds for IDE Gene

(23) Drugs for IDE Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bacitracin Approved, Vet_approved Pharma Target, inhibitor 43
Zinc Approved, Investigational Pharma 1706
Insulin beef Approved Pharma Enzyme, substrate 0
Insulin human Approved, Investigational Pharma Enzyme, substrate, cleavage 0
Insulin lispro Approved Pharma Enzyme, substrate 324

(10) Additional Compounds for IDE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IDE: view

Transcripts for IDE Gene

mRNA/cDNA for IDE Gene

7 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
38 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDE

Alternative Splicing Database (ASD) splice patterns (SP) for IDE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: - -
SP2: -
SP3:

ExUns: 27 ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:

Relevant External Links for IDE Gene

GeneLoc Exon Structure for
IDE

Expression for IDE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IDE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDE Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for IDE Gene

This gene is overexpressed in Lymph node (9.0) and Stomach (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDE Gene



Protein tissue co-expression partners for IDE Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IDE

SOURCE GeneReport for Unigene cluster for IDE Gene:

Hs.500546

mRNA Expression by UniProt/SwissProt for IDE Gene:

P14735-IDE_HUMAN
Tissue specificity: Detected in brain and in cerebrospinal fluid (at protein level).

Evidence on tissue expression from TISSUES for IDE Gene

  • Nervous system(3.3)
  • Skin(2.8)
  • Liver(2.7)
  • Muscle(2.7)
  • Adrenal gland(2.6)
  • Heart(2.5)
  • Pancreas(2.5)
  • Blood(2.5)
  • Kidney(2.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with IDE: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IDE Gene

Orthologs for IDE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IDE 29 30
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IDE 29 30
  • 94.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IDE 29 30
  • 94.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IDE 30
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IDE 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ide 29
  • 89.7 (n)
Mouse
(Mus musculus)
Mammalia Ide 29 16 30
  • 89.01 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 98 (a)
OneToMany
-- 30
  • 92 (a)
OneToMany
IDE 29
  • 82.7 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 88 (a)
OneToMany
-- 30
  • 87 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ide 29
  • 78.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii ide 29 30
  • 76.48 (n)
OneToOne
Dr.5554 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010351 29
  • 53.65 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Ide 29 30 31
  • 52.85 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F44E7.4 29 30
  • 49.98 (n)
OneToMany
C02G6.2 30 31
  • 40 (a)
OneToMany
Y70C5C.1 30 31
  • 39 (a)
OneToMany
C02G6.1 30 31
  • 38 (a)
OneToMany
C28F5.4 30 31
  • 37 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05105g 29
  • 49.37 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 29 30 32
  • 49.2 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER053C 29
  • 47.3 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G41790 29
  • 49.34 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0570300 29
  • 49.48 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 55 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU00481 29
  • 49.14 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug138 29
  • 47.94 (n)
Species where no ortholog for IDE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IDE Gene

ENSEMBL:
Gene Tree for IDE (if available)
TreeFam:
Gene Tree for IDE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IDE: view image
Alliance of Genome Resources:
Additional Orthologs for IDE

Paralogs for IDE Gene

Paralogs for IDE Gene

(1) SIMAP similar genes for IDE Gene using alignment to 3 proteins:

  • IDE_HUMAN
  • Q5T5N3_HUMAN
  • R4GN65_HUMAN
genes like me logo Genes that share paralogs with IDE: view

Variants for IDE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IDE Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs35640611 Benign: not provided 92,465,791(-) G/T
NM_004969.4(IDE):c.2373C>A (p.Ile791=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs367823775 Likely Benign: not provided 92,514,981(-) T/C
NM_004969.4(IDE):c.723A>G (p.Leu241=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs554481643 Benign: not provided 92,573,990(-) G/A
NM_004969.4(IDE):c.30C>T (p.His10=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs61736443 Benign: not provided 92,463,969(-) A/G
NM_004969.4(IDE):c.2523T>C (p.Asn841=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IDE Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IDE Gene

Variant ID Type Subtype PubMed ID
dgv1349n54 CNV loss 21841781
esv3431710 CNV insertion 20981092
esv3546688 CNV deletion 23714750
esv3624226 CNV loss 21293372
nsv1046258 CNV gain 25217958
nsv1122547 CNV deletion 24896259
nsv1127132 CNV deletion 24896259
nsv508600 CNV deletion 20534489

Variation tolerance for IDE Gene

Residual Variation Intolerance Score: 3.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDE Gene

Human Gene Mutation Database (HGMD)
IDE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDE
Leiden Open Variation Database (LOVD)
IDE

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDE Gene

Disorders for IDE Gene

MalaCards: The human disease database

(12) MalaCards diseases for IDE Gene - From: COP and GCD

Disorder Aliases PubMed IDs
type 2 diabetes mellitus
  • t2d
glucose intolerance
  • glucose: intolerance
alzheimer disease 6
  • ad6
alzheimer disease
  • ad
cerebral amyloid angiopathy, cst3-related
  • amyloidosis, cerebroarterial, icelandic type
- elite association - COSMIC cancer census association via MalaCards
Search IDE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IDE

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IDE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IDE Gene

Publications for IDE Gene

  1. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. (PMID: 2293021) Affholter JA … Roth RA (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 22
  2. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. (PMID: 20098734) Carrasquillo MM … Morgan K (PloS one 2010) 3 22 40
  3. Production of an antigenic peptide by insulin-degrading enzyme. (PMID: 20364150) Parmentier N … Van den Eynde BJ (Nature immunology 2010) 3 4 22
  4. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. (PMID: 18996360) Zuo X … Jia J (Brain research 2009) 3 22 40
  5. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. (PMID: 19321446) Manolopoulou M … Tang WJ (The Journal of biological chemistry 2009) 3 4 22

Products for IDE Gene

Sources for IDE Gene