Aliases for ID4 Gene
External Ids for ID4 Gene
Previous GeneCards Identifiers for ID4 Gene
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]
GeneCards Summary for ID4 Gene
ID4 (Inhibitor Of DNA Binding 4, HLH Protein) is a Protein Coding gene. Diseases associated with ID4 include Mesomelic Dysplasia, Savarirayan Type and Aplastic Anemia. Among its related pathways are TGF-beta signaling pathway (KEGG) and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II transcription factor binding. An important paralog of this gene is ID2.
UniProtKB/Swiss-Prot for ID4 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).