The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011] See more...

Aliases for ID3 Gene

Aliases for ID3 Gene

  • Inhibitor Of DNA Binding 3, HLH Protein 2 3 5
  • Inhibitor Of Differentiation 3 2 3 4
  • Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 25 3 4
  • DNA-Binding Protein Inhibitor ID-3 3 4
  • ID-Like Protein Inhibitor HLH 1R21 3 4
  • Helix-Loop-Helix Protein HEIR-1 3 4
  • BHLHb25 3 4
  • Inhibitor Of DNA Binding 3 4
  • BHLHB25 4
  • HEIR-1 3
  • HEIR1 4
  • 1R21 4

External Ids for ID3 Gene

Previous GeneCards Identifiers for ID3 Gene

  • GC01M023442
  • GC01M022955
  • GC01M023353
  • GC01M023629
  • GC01M023756
  • GC01M023884
  • GC01M022134

Summaries for ID3 Gene

Entrez Gene Summary for ID3 Gene

  • The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID3 Gene

ID3 (Inhibitor Of DNA Binding 3, HLH Protein) is a Protein Coding gene. Diseases associated with ID3 include Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and ID signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is ID2.

UniProtKB/Swiss-Prot Summary for ID3 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Wiki entry for ID3 Gene

Additional gene information for ID3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ID3 Gene

Genomics for ID3 Gene

GeneHancer (GH) Regulatory Elements for ID3 Gene

Promoters and enhancers for ID3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ID3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ID3 gene promoter:
  • AML1a
  • ATF-2
  • c-Jun

Genomic Locations for ID3 Gene

Genomic Locations for ID3 Gene
chr1:23,557,926-23,559,794
(GRCh38/hg38)
Size:
1,869 bases
Orientation:
Minus strand
chr1:23,884,409-23,886,322
(GRCh37/hg19)
Size:
1,914 bases
Orientation:
Minus strand

Genomic View for ID3 Gene

Genes around ID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID3 Gene

Proteins for ID3 Gene

  • Protein details for ID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02535-ID3_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-3
    Protein Accession:
    Q02535
    Secondary Accessions:
    • A8K1T8
    • O75641

    Protein attributes for ID3 Gene

    Size:
    119 amino acids
    Molecular mass:
    12999 Da
    Quaternary structure:
    • Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation (By similarity). Interacts with CLOCK and ARNTL/BMAL1.
    SequenceCaution:
    • Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ID3 Gene

neXtProt entry for ID3 Gene

Post-translational modifications for ID3 Gene

  • Ubiquitination at Lys30
  • Modification sites at PhosphoSitePlus

Other Protein References for ID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID3 Gene

Domains & Families for ID3 Gene

Gene Families for ID3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ID3 Gene

Suggested Antigen Peptide Sequences for ID3 Gene

GenScript: Design optimal peptide antigens:
  • Inhibitor of DNA binding 3 (ID3_HUMAN)
genes like me logo Genes that share domains with ID3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ID3 Gene

Function for ID3 Gene

Molecular function for ID3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
UniProtKB/Swiss-Prot Induction:
By phorbol 12-myristate 13-acetate (PMA).
GENATLAS Biochemistry:
inhibitor of DNA binding 3,mouse ld-3 related,expressed during early development and in adult tissues,inhibing transcription factors of the basic helix loop helix family, required for neurogenesis and angiogenesis

Phenotypes From GWAS Catalog for ID3 Gene

Gene Ontology (GO) - Molecular Function for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001085 RNA polymerase II transcription factor binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA,IEA 21873635
GO:0003714 transcription corepressor activity TAS 8437843
GO:0005515 protein binding IPI 20861012
genes like me logo Genes that share ontologies with ID3: view
genes like me logo Genes that share phenotypes with ID3: view

Animal Models for ID3 Gene

MGI Knock Outs for ID3:
  • Id3 Id3<tm1Zhu>
  • Id3 Id3<tm2.1Cmu>
  • Id3 Id3<tm1Pzg>
  • Id3 Id3<tm1Cmu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ID3

Clone Products

  • Addgene plasmids for ID3

Cell Line Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID3 Gene

Localization for ID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
plasma membrane 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IBA 21873635
GO:0005737 colocalizes_with cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with ID3: view

Pathways & Interactions for ID3 Gene

genes like me logo Genes that share pathways with ID3: view

Pathways by source for ID3 Gene

SIGNOR curated interactions for ID3 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001656 metanephros development IEA --
GO:0006275 regulation of DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 1628620
genes like me logo Genes that share ontologies with ID3: view

Drugs & Compounds for ID3 Gene

(3) Drugs for ID3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved, Investigational Nutra 160

(1) Additional Compounds for ID3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID3: view

Transcripts for ID3 Gene

mRNA/cDNA for ID3 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(562) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ID3

Clone Products

  • Addgene plasmids for ID3

Alternative Splicing Database (ASD) splice patterns (SP) for ID3 Gene

No ASD Table

Relevant External Links for ID3 Gene

GeneLoc Exon Structure for
ID3
ECgene alternative splicing isoforms for
ID3

Expression for ID3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID3 Gene

Protein differential expression in normal tissues from HIPED for ID3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ID3 Gene



Protein tissue co-expression partners for ID3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ID3 Gene:

ID3

SOURCE GeneReport for Unigene cluster for ID3 Gene:

Hs.76884

mRNA Expression by UniProt/SwissProt for ID3 Gene:

Q02535-ID3_HUMAN
Tissue specificity: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.

Evidence on tissue expression from TISSUES for ID3 Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Blood(4.3)
  • Thyroid gland(2.8)
  • Lung(2.6)
  • Muscle(2.5)
  • Heart(2.4)
  • Eye(2.3)
  • Intestine(2)
  • Kidney(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ID3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID3 Gene

Orthologs for ID3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID3 33 32
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ID3 33 32
  • 92.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ID3 33 32
  • 91.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Id3 17 33 32
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Id3 32
  • 87.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ID3 33
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID3 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID3 33 32
  • 69.49 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia id3 32
  • 64.04 (n)
zebrafish
(Danio rerio)
Actinopterygii id3 33 32
  • 60.66 (n)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta emc 33
  • 5 (a)
OneToMany
Species where no ortholog for ID3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID3 Gene

ENSEMBL:
Gene Tree for ID3 (if available)
TreeFam:
Gene Tree for ID3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ID3: view image

Paralogs for ID3 Gene

Paralogs for ID3 Gene

(3) SIMAP similar genes for ID3 Gene using alignment to 1 proteins:

  • ID3_HUMAN
genes like me logo Genes that share paralogs with ID3: view

Variants for ID3 Gene

Sequence variations from dbSNP and Humsavar for ID3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000046510 -- 23,560,623(-) C/T upstream_transcript_variant
rs1000949440 -- 23,557,873(-) G/A downstream_transcript_variant
rs1001053944 -- 23,557,477(-) T/C downstream_transcript_variant
rs1001497265 -- 23,559,821(-) C/T upstream_transcript_variant
rs1001716370 -- 23,559,700(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ID3 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV loss 17160897

Variation tolerance for ID3 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID3 Gene

Human Gene Mutation Database (HGMD)
ID3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID3 Gene

Disorders for ID3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ID3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
fibrodysplasia ossificans progressiva
  • fop
- elite association - COSMIC cancer census association via MalaCards
Search ID3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ID3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ID3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID3 Gene

Publications for ID3 Gene

  1. Structural organisation and chromosomal mapping of the human Id-3 gene. (PMID: 7828896) Deed RW … Norton JD (Gene 1994) 3 4 23 56
  2. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. (PMID: 1628620) Ellmeier W … Weith A (The EMBO journal 1992) 2 3 4 56
  3. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward SM … Duffield GE (The Journal of biological chemistry 2010) 3 4 56
  4. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. (PMID: 20185798) Doran AC … McNamara CA (Circulation research 2010) 3 43 56
  5. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 43 56

Products for ID3 Gene

Sources for ID3 Gene