Aliases for ID3 Gene
External Ids for ID3 Gene
Previous GeneCards Identifiers for ID3 Gene
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
GeneCards Summary for ID3 Gene
ID3 (Inhibitor Of DNA Binding 3, HLH Protein) is a Protein Coding gene. Diseases associated with ID3 include Fibrodysplasia Ossificans Progressiva and Lujo Hemorrhagic Fever. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is ID4.
UniProtKB/Swiss-Prot Summary for ID3 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.