The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimeriza... See more...

Aliases for ID2 Gene

Aliases for ID2 Gene

  • Inhibitor Of DNA Binding 2 2 3 4 5
  • Inhibitor Of Differentiation 2 2 3 4
  • BHLHb26 2 3 4
  • Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 26 3 4
  • DNA-Binding Protein Inhibitor ID-2 3 4
  • Cell Growth-Inhibiting Gene 8 2 3
  • GIG8 2 3
  • Inhibitor Of DNA Binding 2, HLH Protein 3
  • DNA-Binding Protein Inhibitor ID2 3
  • Helix-Loop-Helix Protein ID2 3
  • BHLHB26 4
  • ID2A 3
  • ID2H 3
  • ID2 5

External Ids for ID2 Gene

Previous GeneCards Identifiers for ID2 Gene

  • GC02P008605
  • GC02P008873
  • GC02P008843
  • GC02P008772
  • GC02P008818

Summaries for ID2 Gene

Entrez Gene Summary for ID2 Gene

  • The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID2 Gene

ID2 (Inhibitor Of DNA Binding 2) is a Protein Coding gene. Diseases associated with ID2 include Ewing Sarcoma and Hydronephrosis. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and ion channel binding. An important paralog of this gene is ID4.

UniProtKB/Swiss-Prot Summary for ID2 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Wiki entry for ID2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ID2 Gene

Genomics for ID2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ID2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ID2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ID2

Top Transcription factor binding sites by QIAGEN in the ID2 gene promoter:
  • Egr-1
  • FOXO4
  • IRF-2
  • Nkx2-5
  • p53
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ID2 Gene

Latest Assembly
chr2:8,678,845-8,684,461
(GRCh38/hg38)
Size:
5,617 bases
Orientation:
Plus strand

Previous Assembly
chr2:8,822,186-8,824,591
(GRCh37/hg19 by Entrez Gene)
Size:
2,406 bases
Orientation:
Plus strand

chr2:8,818,975-8,824,583
(GRCh37/hg19 by Ensembl)
Size:
5,609 bases
Orientation:
Plus strand

Genomic View for ID2 Gene

Genes around ID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID2 Gene

Proteins for ID2 Gene

  • Protein details for ID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02363-ID2_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-2
    Protein Accession:
    Q02363

    Protein attributes for ID2 Gene

    Size:
    134 amino acids
    Molecular mass:
    14917 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. Interacts with CLOCK and ARNTL/BMAL1.

    Three dimensional structures from OCA and Proteopedia for ID2 Gene

neXtProt entry for ID2 Gene

Post-translational modifications for ID2 Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for ID2 Gene

No data available for DME Specific Peptides for ID2 Gene

Domains & Families for ID2 Gene

Gene Families for ID2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ID2 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH

Suggested Antigen Peptide Sequences for ID2 Gene

GenScript: Design optimal peptide antigens:
  • Inhibitor of DNA binding 2 (ID2_HUMAN)
  • cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA (Q53T66_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02363

UniProtKB/Swiss-Prot:

ID2_HUMAN :
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
Domain:
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
genes like me logo Genes that share domains with ID2: view

Function for ID2 Gene

Molecular function for ID2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
GENATLAS Biochemistry:
inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription factors of the basic helix loop helix family

Phenotypes From GWAS Catalog for ID2 Gene

Gene Ontology (GO) - Molecular Function for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding ISS --
GO:0005515 protein binding IPI 10915743
GO:0044325 ion channel binding IPI 16311606
GO:0046983 protein dimerization activity IEA --
GO:0140110 transcription regulator activity IBA 21873635
genes like me logo Genes that share ontologies with ID2: view
genes like me logo Genes that share phenotypes with ID2: view

Animal Models for ID2 Gene

MGI Knock Outs for ID2:
  • Id2 Id2<tm1Mcha>
  • Id2 Id2<tm1Ago>
  • Id2 Id2<tm1Mais>
  • Id2 Id2<tm1Yyk>
  • Id2 Id2<tm2.1Ago>
  • Id2 Id2<tm2b(EUCOMM)Wtsi>
  • Id2 Id2<tm2.1Blh>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ID2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID2 Gene

Localization for ID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin ISS --
GO:0005634 nucleus IC,IDA 16311606
GO:0005737 colocalizes_with cytoplasm IDA 16311606
GO:0005829 cytosol IDA 16311606
GO:0032991 protein-containing complex ISS --
genes like me logo Genes that share ontologies with ID2: view

Pathways & Interactions for ID2 Gene

genes like me logo Genes that share pathways with ID2: view

SIGNOR curated interactions for ID2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0007275 multicellular organism development IEA --
GO:0010628 positive regulation of gene expression ISS --
GO:0010629 negative regulation of gene expression ISS --
GO:0019216 regulation of lipid metabolic process ISS --
genes like me logo Genes that share ontologies with ID2: view

Drugs & Compounds for ID2 Gene

(4) Drugs for ID2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for ID2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID2: view

Transcripts for ID2 Gene

mRNA/cDNA for ID2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ID2

Alternative Splicing Database (ASD) splice patterns (SP) for ID2 Gene

No ASD Table

Relevant External Links for ID2 Gene

GeneLoc Exon Structure for
ID2

Expression for ID2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID2 Gene

This gene is overexpressed in Artery - Tibial (x6.6) and Liver (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ID2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ID2

SOURCE GeneReport for Unigene cluster for ID2 Gene:

Hs.180919

mRNA Expression by UniProt/SwissProt for ID2 Gene:

Q02363-ID2_HUMAN
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system.

Evidence on tissue expression from TISSUES for ID2 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Lung(4.7)
  • Thyroid gland(3.7)
  • Bone marrow(3.3)
  • Spleen(3.1)
  • Intestine(3.1)
  • Lymph node(3)
  • Blood(3)
  • Kidney(2.9)
  • Muscle(2.9)
  • Skin(2.8)
  • Heart(2.8)
  • Adrenal gland(2.6)
  • Eye(2.4)
  • Stomach(2.3)
  • Pancreas(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with ID2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID2 Gene

Orthologs for ID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ID2 29 30
  • 99.54 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ID2 30
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Id2 29 16 30
  • 95.02 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ID2 30
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ID2 29 30
  • 94.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Id2 29
  • 94.03 (n)
Chicken
(Gallus gallus)
Aves ID2 29 30
  • 86.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ID2 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia id2 29
  • 79.13 (n)
MGC75823 29
African clawed frog
(Xenopus laevis)
Amphibia id2 29
Zebrafish
(Danio rerio)
Actinopterygii id2a 29 30
  • 77.61 (n)
OneToMany
id2b 30
  • 60 (a)
OneToMany
id2 29
Fruit Fly
(Drosophila melanogaster)
Insecta emc 30
  • 7 (a)
OneToMany
Species where no ortholog for ID2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ID2 Gene

ENSEMBL:
Gene Tree for ID2 (if available)
TreeFam:
Gene Tree for ID2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ID2: view image
Alliance of Genome Resources:
Additional Orthologs for ID2

Paralogs for ID2 Gene

Paralogs for ID2 Gene

(4) SIMAP similar genes for ID2 Gene using alignment to 2 proteins:

  • ID2_HUMAN
  • Q53T66_HUMAN

Pseudogenes.org Pseudogenes for ID2 Gene

genes like me logo Genes that share paralogs with ID2: view

Variants for ID2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ID2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs114406044 Benign: not provided 8,682,268(+) C/T
NM_002166.5(ID2):c.103C>T (p.Leu35=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ID2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ID2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID2
Leiden Open Variation Database (LOVD)
ID2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ID2 Gene

Disorders for ID2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ID2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
hydronephrosis
lujo hemorrhagic fever
  • zambian hemorrhagic fever
inner ear disease
  • labyrinthine disease
burkitt lymphoma
  • bl
- elite association - COSMIC cancer census association via MalaCards
Search ID2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ID2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ID2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID2 Gene

Publications for ID2 Gene

  1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E … Oda K (The Journal of biological chemistry 1994) 2 3 4
  2. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward SM … Duffield GE (The Journal of biological chemistry 2010) 3 4
  3. Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. (PMID: 20483740) Schotte R … Blom B (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22
  4. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (PMID: 20388805) Coma S … Klagsbrun M (Cancer research 2010) 3 22
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 40

Products for ID2 Gene

Sources for ID2 Gene