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Aliases for ID2 Gene

Aliases for ID2 Gene

  • Inhibitor Of DNA Binding 2 2 3 4 5
  • Inhibitor Of Differentiation 2 2 3 4
  • Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 26 3 4
  • Cell Growth-Inhibiting Gene 8 2 3
  • BHLHb26 3 4
  • Inhibitor Of DNA Binding 2, HLH Protein 3
  • DNA-Binding Protein Inhibitor ID-2 3
  • DNA-Binding Protein Inhibitor ID2 3
  • Helix-Loop-Helix Protein ID2 3
  • GIG8 3
  • ID2A 3
  • ID2H 3

External Ids for ID2 Gene

Previous GeneCards Identifiers for ID2 Gene

  • GC02P008605
  • GC02P008873
  • GC02P008843
  • GC02P008818

Summaries for ID2 Gene

Entrez Gene Summary for ID2 Gene

  • The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID2 Gene

ID2 (Inhibitor Of DNA Binding 2) is a Protein Coding gene. Diseases associated with ID2 include Ewing Sarcoma and Diamond-Blackfan Anemia. Among its related pathways are miRs in Muscle Cell Differentiation and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and ion channel binding. An important paralog of this gene is ID4.

UniProtKB/Swiss-Prot for ID2 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Wiki entry for ID2 Gene

Additional gene information for ID2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID2 Gene

Genomics for ID2 Gene

GeneHancer (GH) Regulatory Elements for ID2 Gene

Promoters and enhancers for ID2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I008675 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +2.2 2158 10.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 ID2-AS1 ID2 LOC105373412 ENSG00000239300 CPSF3
GH02I008300 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -376.2 -376210 3.4 PKNOX1 ATF1 SMAD1 IRF4 TCF12 GATA2 ZNF207 ZNF143 ATF7 FOS ID2 ID2-AS1 LINC00298 LINC00299
GH02I008312 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -365.6 -365649 2 PKNOX1 ATF1 SMAD1 YBX1 IRF4 YY1 TCF12 ZNF207 ZNF143 FOS ID2 ID2-AS1 LINC00298 LINC00299
GH02I008533 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -141.4 -141353 7.1 PKNOX1 FOXA2 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF48 YY1 TCF12 ID2 ID2-AS1 KIDINS220 ENSG00000231435 LINC00299
GH02I008499 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.7 -178.1 -178072 1.7 FOXA2 MLX ARID4B RAD21 RARA ZEB1 FOS RXRA CEBPB ZEB2 ID2 ID2-AS1 ENSG00000231435 LINC00299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ID2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ID2 gene promoter:

Genomic Locations for ID2 Gene

Genomic Locations for ID2 Gene
chr2:8,678,845-8,684,453
(GRCh38/hg38)
Size:
5,609 bases
Orientation:
Plus strand
chr2:8,818,975-8,824,583
(GRCh37/hg19)

Genomic View for ID2 Gene

Genes around ID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID2 Gene

Proteins for ID2 Gene

  • Protein details for ID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02363-ID2_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-2
    Protein Accession:
    Q02363

    Protein attributes for ID2 Gene

    Size:
    134 amino acids
    Molecular mass:
    14917 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. Interacts with CLOCK and ARNTL/BMAL1.

    Three dimensional structures from OCA and Proteopedia for ID2 Gene

neXtProt entry for ID2 Gene

Post-translational modifications for ID2 Gene

  • Ubiquitination at isoforms=12
  • Modification sites at PhosphoSitePlus

Other Protein References for ID2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ID2

No data available for DME Specific Peptides for ID2 Gene

Domains & Families for ID2 Gene

Gene Families for ID2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q02363

UniProtKB/Swiss-Prot:

ID2_HUMAN :
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
Domain:
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
genes like me logo Genes that share domains with ID2: view

Function for ID2 Gene

Molecular function for ID2 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription factors of the basic helix loop helix family
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Phenotypes From GWAS Catalog for ID2 Gene

Gene Ontology (GO) - Molecular Function for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10915743
GO:0044325 ion channel binding IPI 16311606
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ID2: view
genes like me logo Genes that share phenotypes with ID2: view

Animal Models for ID2 Gene

MGI Knock Outs for ID2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID2 Gene

Localization for ID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IDA 16311606
GO:0005737 colocalizes_with cytoplasm IDA,IEA 16311606
GO:0005829 cytosol IDA 16311606
GO:0043234 protein complex ISS --
genes like me logo Genes that share ontologies with ID2: view

Pathways & Interactions for ID2 Gene

genes like me logo Genes that share pathways with ID2: view

SIGNOR curated interactions for ID2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001656 metanephros development IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001966 thigmotaxis IEA --
GO:0002521 leukocyte differentiation IEA --
genes like me logo Genes that share ontologies with ID2: view

Drugs & Compounds for ID2 Gene

(4) Drugs for ID2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for ID2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID2: view

Transcripts for ID2 Gene

Unigene Clusters for ID2 Gene

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID2

Alternative Splicing Database (ASD) splice patterns (SP) for ID2 Gene

No ASD Table

Relevant External Links for ID2 Gene

GeneLoc Exon Structure for
ID2
ECgene alternative splicing isoforms for
ID2

Expression for ID2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID2 Gene

This gene is overexpressed in Artery - Tibial (x6.6) and Liver (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ID2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ID2 Gene:

ID2

SOURCE GeneReport for Unigene cluster for ID2 Gene:

Hs.180919

mRNA Expression by UniProt/SwissProt for ID2 Gene:

Q02363-ID2_HUMAN
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system.

Evidence on tissue expression from TISSUES for ID2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.7)
  • Thyroid gland(3.2)
  • Bone marrow(2.9)
  • Blood(2.6)
  • Lymph node(2.6)
  • Muscle(2.6)
  • Spleen(2.6)
  • Intestine(2.5)
  • Kidney(2.4)
  • Heart(2.2)
  • Skin(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ID2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID2 Gene

Orthologs for ID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID2 33 34
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ID2 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Id2 33 16 34
  • 95.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ID2 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ID2 33 34
  • 94.53 (n)
rat
(Rattus norvegicus)
Mammalia Id2 33
  • 94.03 (n)
chicken
(Gallus gallus)
Aves ID2 33 34
  • 86.32 (n)
lizard
(Anolis carolinensis)
Reptilia ID2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia id2 33
  • 79.13 (n)
MGC75823 33
African clawed frog
(Xenopus laevis)
Amphibia id2 33
zebrafish
(Danio rerio)
Actinopterygii id2a 33 34
  • 77.61 (n)
id2b 34
  • 60 (a)
OneToMany
id2 33
fruit fly
(Drosophila melanogaster)
Insecta emc 34
  • 7 (a)
OneToMany
Species where no ortholog for ID2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID2 Gene

ENSEMBL:
Gene Tree for ID2 (if available)
TreeFam:
Gene Tree for ID2 (if available)

Paralogs for ID2 Gene

Paralogs for ID2 Gene

(4) SIMAP similar genes for ID2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ID2 Gene

genes like me logo Genes that share paralogs with ID2: view

Variants for ID2 Gene

Sequence variations from dbSNP and Humsavar for ID2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000021926 -- 8,684,237(+) C/T 3_prime_UTR_variant
rs1000098881 -- 8,680,330(+) G/T upstream_transcript_variant
rs1000154781 -- 8,680,184(+) A/G upstream_transcript_variant
rs1000207077 -- 8,680,023(+) G/A upstream_transcript_variant
rs1000553136 -- 8,683,470(+) G/T intron_variant

Variation tolerance for ID2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ID2 Gene

Disorders for ID2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ID2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ID2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ID2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ID2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID2 Gene

Publications for ID2 Gene

  1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E … Oda K (The Journal of biological chemistry 1994) 2 3 4 58
  2. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward SM … Duffield GE (The Journal of biological chemistry 2010) 3 4 58
  3. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (PMID: 20388805) Coma S … Klagsbrun M (Cancer research 2010) 3 22 58
  4. Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. (PMID: 20483740) Schotte R … Blom B (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 58
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58

Products for ID2 Gene

  • Addgene plasmids for ID2

Sources for ID2 Gene

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