The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, ... See more...

Aliases for ID1 Gene

Aliases for ID1 Gene

  • Inhibitor Of DNA Binding 1, HLH Protein 2 3 5
  • DNA-Binding Protein Inhibitor ID-1 2 3 4
  • Inhibitor Of Differentiation 1 2 3 4
  • Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 24 3 4
  • BHLHb24 3 4
  • ID 3 4
  • DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein) 3
  • Inhibitor Of DNA Binding 1 4
  • BHLHB24 4

External Ids for ID1 Gene

Previous GeneCards Identifiers for ID1 Gene

  • GC20P029981
  • GC20P030891
  • GC20P030938
  • GC20P029656
  • GC20P030193
  • GC20P026981

Summaries for ID1 Gene

Entrez Gene Summary for ID1 Gene

  • The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ID1 Gene

ID1 (Inhibitor Of DNA Binding 1, HLH Protein) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is ID2.

UniProtKB/Swiss-Prot Summary for ID1 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Wiki entry for ID1 Gene

Additional gene information for ID1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ID1 Gene

Genomics for ID1 Gene

GeneHancer (GH) Regulatory Elements for ID1 Gene

Promoters and enhancers for ID1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ID1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ID1 gene promoter:
  • Nkx2-5

Genomic Locations for ID1 Gene

Genomic Locations for ID1 Gene
chr20:31,605,283-31,606,515
(GRCh38/hg38)
Size:
1,233 bases
Orientation:
Plus strand
chr20:30,193,086-30,194,318
(GRCh37/hg19)
Size:
1,233 bases
Orientation:
Plus strand

Genomic View for ID1 Gene

Genes around ID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID1 Gene

Proteins for ID1 Gene

  • Protein details for ID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41134-ID1_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-1
    Protein Accession:
    P41134
    Secondary Accessions:
    • A8K537
    • E1P5L4
    • O00651
    • O00652
    • Q16371
    • Q16377
    • Q5TE66
    • Q5TE67
    • Q969Z7
    • Q9H0Z5
    • Q9H109

    Protein attributes for ID1 Gene

    Size:
    155 amino acids
    Molecular mass:
    16133 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.

    Alternative splice isoforms for ID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ID1 Gene

Post-translational modifications for ID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ID1
  • Biorbyt antibodies for ID1
  • Boster Bio Antibodies for ID1

No data available for DME Specific Peptides for ID1 Gene

Domains & Families for ID1 Gene

Gene Families for ID1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ID1 Gene

Suggested Antigen Peptide Sequences for ID1 Gene

GenScript: Design optimal peptide antigens:
  • Inhibitor of DNA binding 1 (ID1_HUMAN)
genes like me logo Genes that share domains with ID1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ID1 Gene

Function for ID1 Gene

Molecular function for ID1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
GENATLAS Biochemistry:
inhibitor of DNA binding 1,putative transcription regulator,expressed during early development and in adult tissues,inhibiting transcription factors of the basic helix loop helix family,controlling growth and/or differentiation of several cell types,potentially required for neurogenesis and angiogenesis

Phenotypes From GWAS Catalog for ID1 Gene

Gene Ontology (GO) - Molecular Function for ID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001085 RNA polymerase II transcription factor binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 15694377
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with ID1: view
genes like me logo Genes that share phenotypes with ID1: view

Animal Models for ID1 Gene

MGI Knock Outs for ID1:
  • Id1 Id1<tm1Zhu>
  • Id1 Id1<tm1Xhsu>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for ID1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID1 Gene

Localization for ID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytoskeleton 3
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 colocalizes_with cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IEA --
genes like me logo Genes that share ontologies with ID1: view

Pathways & Interactions for ID1 Gene

genes like me logo Genes that share pathways with ID1: view

SIGNOR curated interactions for ID1 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for ID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis TAS 14522471
GO:0001886 endothelial cell morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 14522471
genes like me logo Genes that share ontologies with ID1: view

Drugs & Compounds for ID1 Gene

(3) Drugs for ID1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for ID1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID1: view

Transcripts for ID1 Gene

mRNA/cDNA for ID1 Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(765) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ID1

Alternative Splicing Database (ASD) splice patterns (SP) for ID1 Gene

No ASD Table

Relevant External Links for ID1 Gene

GeneLoc Exon Structure for
ID1
ECgene alternative splicing isoforms for
ID1

Expression for ID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID1 Gene

This gene is overexpressed in Bladder (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ID1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ID1 Gene:

ID1

SOURCE GeneReport for Unigene cluster for ID1 Gene:

Hs.504609

Evidence on tissue expression from TISSUES for ID1 Gene

  • Lung(4.8)
  • Skin(4.4)
  • Nervous system(4.3)
  • Stomach(3.9)
  • Intestine(3.3)
  • Liver(3.3)
  • Pancreas(3.2)
  • Bone(3)
  • Thyroid gland(2.8)
  • Heart(2.7)
  • Muscle(2.7)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ID1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID1 Gene

Orthologs for ID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID1 33 32
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ID1 32
  • 93.38 (n)
cow
(Bos Taurus)
Mammalia ID1 33 32
  • 90.31 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Id1 17 33 32
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia Id1 32
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ID1 33
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID1 32
  • 68.13 (n)
zebrafish
(Danio rerio)
Actinopterygii id1 33 32
  • 66.94 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta emc 33
  • 18 (a)
OneToMany
Species where no ortholog for ID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID1 Gene

ENSEMBL:
Gene Tree for ID1 (if available)
TreeFam:
Gene Tree for ID1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ID1: view image

Paralogs for ID1 Gene

Paralogs for ID1 Gene

(3) SIMAP similar genes for ID1 Gene using alignment to 1 proteins:

  • ID1_HUMAN
genes like me logo Genes that share paralogs with ID1: view

Variants for ID1 Gene

Sequence variations from dbSNP and Humsavar for ID1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000147063 -- 31,606,366(+) A/T 3_prime_UTR_variant
rs1000215198 -- 31,605,492(+) G/C coding_sequence_variant, synonymous_variant
rs1002226519 -- 31,606,951(+) G/A downstream_transcript_variant
rs1002325758 -- 31,603,841(+) G/A/T upstream_transcript_variant
rs1002495331 -- 31,606,816(+) C/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ID1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
esv2763228 CNV gain 21179565
nsv458961 CNV gain 19166990
nsv470546 CNV gain 18288195
nsv585911 CNV gain 21841781

Variation tolerance for ID1 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID1 Gene

Disorders for ID1 Gene

Additional Disease Information for ID1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ID1 Gene

Publications for ID1 Gene

  1. Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. (PMID: 9070860) Nehlin JO … Campisi J (Biochemical and biophysical research communications 1997) 3 4 23 56
  2. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E … Oda K (The Journal of biological chemistry 1994) 2 3 4 56
  3. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward SM … Duffield GE (The Journal of biological chemistry 2010) 3 4 56
  4. Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. (PMID: 20515335) Phi JH … Kim SK (Journal of neurosurgery. Pediatrics 2010) 3 23 56
  5. ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. (PMID: 20388787) Geng H … Qian DZ (Cancer research 2010) 3 23 56

Products for ID1 Gene