Aliases for ICOSLG Gene

Aliases for ICOSLG Gene

  • Inducible T Cell Costimulator Ligand 2 3 5
  • B7-Related Protein 1 2 3 4
  • B7 Homolog 2 2 3 4
  • B7RP-1 2 3 4
  • B7-H2 2 3 4
  • B7RP1 2 3 4
  • B7H2 2 3 4
  • B7-Like Protein Gl50 3 4
  • B7 Homologue 2 2 3
  • ICOS Ligand 3 4
  • KIAA0653 2 4
  • ICOS-L 2 3
  • CD275 2 3
  • ICOSL 3 4
  • GL50 2 3
  • B7h 2 3
  • Transmembrane Protein B7-H2 ICOS Ligand 3
  • Inducible T-Cell Costimulator Ligand 2
  • CD275 Antigen 4
  • ICOSLG 5
  • LICOS 3

External Ids for ICOSLG Gene

Previous HGNC Symbols for ICOSLG Gene

  • ICOSL

Previous GeneCards Identifiers for ICOSLG Gene

  • GC21M044468
  • GC21M045642
  • GC21M031016

Summaries for ICOSLG Gene

GeneCards Summary for ICOSLG Gene

ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Autoimmune Disease Of Exocrine System and Immune System Disease. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LOC102723996.

UniProtKB/Swiss-Prot Summary for ICOSLG Gene

  • Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Gene Wiki entry for ICOSLG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICOSLG Gene

Genomics for ICOSLG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ICOSLG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICOSLG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICOSLG

Top Transcription factor binding sites by QIAGEN in the ICOSLG gene promoter:
  • ATF-2
  • CRE-BP1
  • CREB
  • deltaCREB
  • Pax-2
  • Pax-2a
  • Pax-5
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for ICOSLG Gene

Genomic Locations for ICOSLG Gene
chr21:44,216,979-44,240,966
(GRCh38/hg38)
Size:
23,988 bases
Orientation:
Minus strand
chr21:45,642,874-45,660,849
(GRCh37/hg19)
Size:
17,976 bases
Orientation:
Minus strand

Genomic View for ICOSLG Gene

Genes around ICOSLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICOSLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICOSLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOSLG Gene

Proteins for ICOSLG Gene

  • Protein details for ICOSLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75144-ICOSL_HUMAN
    Recommended name:
    ICOS ligand
    Protein Accession:
    O75144
    Secondary Accessions:
    • A8MUZ1
    • Q9HD18
    • Q9NRQ1

    Protein attributes for ICOSLG Gene

    Size:
    302 amino acids
    Molecular mass:
    33349 Da
    Quaternary structure:
    • Interacts with CTLA4 (in vitro).
    SequenceCaution:
    • Sequence=BAA31628.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICOSLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOSLG Gene

Post-translational modifications for ICOSLG Gene

  • Glycosylation at Asn137, Asn173, Asn186, Asn70, Asn102, and Asn225
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICOSL_HUMAN (740)

Antibody Products

No data available for DME Specific Peptides for ICOSLG Gene

Domains & Families for ICOSLG Gene

Gene Families for ICOSLG Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICOSLG Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for ICOSLG Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95137, Homo sapiens B7-like protein (B7H2), mRNA (A0N0L8_HUMAN)
  • cDNA FLJ33173 fis, clone ADRGL2002191, highly similar to ICOS ligand (A8MUZ1_HUMAN)
  • B7-related protein 1 (ICOSL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75144

UniProtKB/Swiss-Prot:

ICOSL_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with ICOSLG: view

Function for ICOSLG Gene

Molecular function for ICOSLG Gene

UniProtKB/Swiss-Prot Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
UniProtKB/Swiss-Prot Induction:
Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

Phenotypes From GWAS Catalog for ICOSLG Gene

Gene Ontology (GO) - Molecular Function for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA,TAS 11429535
GO:0005515 protein binding IPI 11956294
GO:0042802 identical protein binding IPI 16951355
genes like me logo Genes that share ontologies with ICOSLG: view
genes like me logo Genes that share phenotypes with ICOSLG: view

Animal Model Products

CRISPR Products

miRNA for ICOSLG Gene

miRTarBase miRNAs that target ICOSLG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOSLG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICOSLG Gene

Localization for ICOSLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOSLG Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICOSLG gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 3
nucleus 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12145647
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with ICOSLG: view

Pathways & Interactions for ICOSLG Gene

genes like me logo Genes that share pathways with ICOSLG: view

Pathways by source for ICOSLG Gene

1 GeneGo (Thomson Reuters) pathway for ICOSLG Gene
  • Immune response ICOS pathway in T-helper cell
1 Qiagen pathway for ICOSLG Gene
  • ICos-ICosL Pathway in T-Helper Cell

Gene Ontology (GO) - Biological Process for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA 21873635
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response NAS 11983910
GO:0006972 hyperosmotic response NAS 12145647
genes like me logo Genes that share ontologies with ICOSLG: view

No data available for SIGNOR curated interactions for ICOSLG Gene

Drugs & Compounds for ICOSLG Gene

No Compound Related Data Available

Transcripts for ICOSLG Gene

mRNA/cDNA for ICOSLG Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOSLG

Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for ICOSLG Gene

GeneLoc Exon Structure for
ICOSLG

Expression for ICOSLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICOSLG Gene

Protein differential expression in normal tissues from HIPED for ICOSLG Gene

This gene is overexpressed in Urine (28.5) and Serum (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ICOSLG Gene



Protein tissue co-expression partners for ICOSLG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICOSLG

SOURCE GeneReport for Unigene cluster for ICOSLG Gene:

Hs.14155

mRNA Expression by UniProt/SwissProt for ICOSLG Gene:

O75144-ICOSL_HUMAN
Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

Evidence on tissue expression from TISSUES for ICOSLG Gene

  • Nervous system(4.8)
  • Lymph node(4.7)
  • Spleen(4.7)
  • Blood(4.6)
  • Bone marrow(4.6)
  • Intestine(4.5)
  • Lung(2.5)
  • Kidney(2.3)
  • Pancreas(2.3)
  • Skin(2.3)
  • Heart(2.2)
  • Liver(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ICOSLG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICOSLG Gene

Orthologs for ICOSLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOSLG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ICOSLG 30 31
  • 98.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ICOSLG 30 31
  • 73.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ICOSLG 30 31
  • 73.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Icoslg 30
  • 63.04 (n)
Mouse
(Mus musculus)
Mammalia Icosl 30 31
  • 61.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ICOSLG 31
  • 44 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ICOSLG 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ICOSLG 30
  • 47.51 (n)
LICOS 31
  • 32 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ICOSLG 31
  • 25 (a)
OneToOne
Species where no ortholog for ICOSLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ICOSLG Gene

ENSEMBL:
Gene Tree for ICOSLG (if available)
TreeFam:
Gene Tree for ICOSLG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICOSLG: view image

Paralogs for ICOSLG Gene

genes like me logo Genes that share paralogs with ICOSLG: view

Variants for ICOSLG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICOSLG Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
777641 Benign: not provided 44,237,037(-) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
783880 Benign: not provided 44,236,977(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
rs1165558487 Likely Pathogenic: Inborn genetic diseases 44,238,447(-) C/A SPLICE_DONOR_VARIANT
rs11558819 - p.Val128Ile

Additional dbSNP identifiers (rs#s) for ICOSLG Gene

Structural Variations from Database of Genomic Variants (DGV) for ICOSLG Gene

Variant ID Type Subtype PubMed ID
esv1737771 CNV insertion 17803354
esv33817 CNV loss 17666407
esv3647125 CNV gain 21293372
nsv1117313 CNV tandem duplication 24896259
nsv470906 CNV loss 18288195
nsv587740 CNV loss 21841781
nsv953645 CNV deletion 24416366

Variation tolerance for ICOSLG Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICOSLG Gene

Human Gene Mutation Database (HGMD)
ICOSLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICOSLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOSLG Gene

Disorders for ICOSLG Gene

MalaCards: The human disease database

(245) MalaCards diseases for ICOSLG Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ICOSLG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ICOSLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICOSLG Gene

Publications for ICOSLG Gene

  1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PMID: 11007762) Yoshinaga SK … Coccia MA (International immunology 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  3. Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (PMID: 20217071) Pan F … Deng HW (Immunogenetics 2010) 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41

Products for ICOSLG Gene

Sources for ICOSLG Gene