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Aliases for ICOSLG Gene

Aliases for ICOSLG Gene

  • Inducible T Cell Costimulator Ligand 2 3 5
  • B7-Related Protein 1 2 3 4
  • B7 Homolog 2 2 3 4
  • B7-Like Protein Gl50 3 4
  • B7 Homologue 2 2 3
  • B7RP-1 3 4
  • ICOSL 3 4
  • B7-H2 3 4
  • B7RP1 3 4
  • B7H2 3 4
  • Transmembrane Protein B7-H2 ICOS Ligand 3
  • Inducible T-Cell Co-Stimulator Ligand 3
  • Inducible T-Cell Costimulator Ligand 2
  • CD275 Antigen 4
  • ICOS Ligand 3
  • KIAA0653 4
  • ICOS-L 3
  • CD275 3
  • LICOS 3
  • GL50 3

External Ids for ICOSLG Gene

Previous HGNC Symbols for ICOSLG Gene

  • ICOSL

Previous GeneCards Identifiers for ICOSLG Gene

  • GC21M044468
  • GC21M045642
  • GC21M031016

Summaries for ICOSLG Gene

GeneCards Summary for ICOSLG Gene

ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Immunodeficiency With Hyper-Igm, Type 2 and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immune response NFAT in immune response and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LOC102723996.

UniProtKB/Swiss-Prot for ICOSLG Gene

  • Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Gene Wiki entry for ICOSLG Gene

Additional gene information for ICOSLG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOSLG Gene

Genomics for ICOSLG Gene

GeneHancer (GH) Regulatory Elements for ICOSLG Gene

Promoters and enhancers for ICOSLG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J044239 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 684.6 -1.9 -1851 6.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ICOSLG ENSG00000275799 ENSG00000278158 ENSG00000184441 C21orf2 SIK1 UBE2G2 HSF2BP PWP2 TRAPPC10
GH21J044137 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26.3 +98.9 98922 11 HDGF HNRNPUL1 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B PWP2 ICOSLG TRAPPC10 UBE2G2 RRP1B MTND5P1 PFKL C21orf2 TRPM2 PDXK
GH21J044192 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +46.4 46396 5.8 HDGF PKNOX1 ARNT SIN3A ZBTB7B IRF4 ZNF766 E2F8 ZNF207 ZNF143 LOC105377139 UBE2G2 ICOSLG DNMT3L PWP2 RRP1B AIRE ENSG00000184441 TRAPPC10 TRPM2
GH21J044202 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +38.2 38228 2.9 PKNOX1 ATF1 ZNF766 GLIS2 ATF7 JUNB SMARCB1 MEF2D ATF4 SMARCA4 ICOSLG AIRE TRPM2 TRAPPC10 LOC105372832 LOC102725065 LOC105377139 GATD3A
GH21J044152 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +84.3 84264 8.7 HDGF PKNOX1 SMAD1 IRF4 GLIS2 ZNF207 ZNF143 ATF7 RUNX3 JUNB PWP2 ICOSLG ENSG00000184441 C21orf2 PFKL LINC01678 TRPM2 TRAPPC10 CSTB PDXK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICOSLG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ICOSLG gene promoter:
  • Sp1
  • deltaCREB
  • CREB
  • Pax-5
  • SRF (504 AA)
  • SRF
  • CRE-BP1
  • ATF-2
  • Pax-2
  • Pax-2a

Genomic Locations for ICOSLG Gene

Genomic Locations for ICOSLG Gene
chr21:44,216,971-44,241,447
(GRCh38/hg38)
Size:
24,477 bases
Orientation:
Minus strand
chr21:45,642,874-45,660,849
(GRCh37/hg19)
Size:
17,976 bases
Orientation:
Minus strand

Genomic View for ICOSLG Gene

Genes around ICOSLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICOSLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICOSLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOSLG Gene

Proteins for ICOSLG Gene

  • Protein details for ICOSLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75144-ICOSL_HUMAN
    Recommended name:
    ICOS ligand
    Protein Accession:
    O75144
    Secondary Accessions:
    • A8MUZ1
    • Q9HD18
    • Q9NRQ1

    Protein attributes for ICOSLG Gene

    Size:
    302 amino acids
    Molecular mass:
    33349 Da
    Quaternary structure:
    • Interacts with CTLA4 (in vitro).
    SequenceCaution:
    • Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICOSLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOSLG Gene

Post-translational modifications for ICOSLG Gene

  • Glycosylation at Asn225, Asn186, Asn173, isoforms=2, 3137, isoforms=2102, and isoforms=270
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICOSL_HUMAN (740)

No data available for DME Specific Peptides for ICOSLG Gene

Domains & Families for ICOSLG Gene

Gene Families for ICOSLG Gene

Graphical View of Domain Structure for InterPro Entry

O75144

UniProtKB/Swiss-Prot:

ICOSL_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with ICOSLG: view

Function for ICOSLG Gene

Molecular function for ICOSLG Gene

UniProtKB/Swiss-Prot Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
UniProtKB/Swiss-Prot Induction:
Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

Phenotypes From GWAS Catalog for ICOSLG Gene

Gene Ontology (GO) - Molecular Function for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 11429535
GO:0005515 protein binding IPI 11956294
genes like me logo Genes that share ontologies with ICOSLG: view
genes like me logo Genes that share phenotypes with ICOSLG: view

Animal Model Products

CRISPR Products

miRNA for ICOSLG Gene

miRTarBase miRNAs that target ICOSLG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOSLG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICOSLG Gene

Localization for ICOSLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOSLG Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICOSLG gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 3
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12145647
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with ICOSLG: view

Pathways & Interactions for ICOSLG Gene

genes like me logo Genes that share pathways with ICOSLG: view

Pathways by source for ICOSLG Gene

1 GeneGo (Thomson Reuters) pathway for ICOSLG Gene
1 R&D Systems pathway for ICOSLG Gene
1 Qiagen pathway for ICOSLG Gene

Gene Ontology (GO) - Biological Process for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response NAS 11983910
GO:0006972 hyperosmotic response NAS 12145647
genes like me logo Genes that share ontologies with ICOSLG: view

No data available for SIGNOR curated interactions for ICOSLG Gene

Drugs & Compounds for ICOSLG Gene

No Compound Related Data Available

Transcripts for ICOSLG Gene

Unigene Clusters for ICOSLG Gene

Inducible T-cell co-stimulator ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOSLG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for ICOSLG Gene

GeneLoc Exon Structure for
ICOSLG
ECgene alternative splicing isoforms for
ICOSLG

Expression for ICOSLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICOSLG Gene

Protein differential expression in normal tissues from HIPED for ICOSLG Gene

This gene is overexpressed in Urine (28.5) and Serum (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ICOSLG Gene



Protein tissue co-expression partners for ICOSLG Gene

NURSA nuclear receptor signaling pathways regulating expression of ICOSLG Gene:

ICOSLG

SOURCE GeneReport for Unigene cluster for ICOSLG Gene:

Hs.14155

mRNA Expression by UniProt/SwissProt for ICOSLG Gene:

O75144-ICOSL_HUMAN
Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

Evidence on tissue expression from TISSUES for ICOSLG Gene

  • Nervous system(4.7)
  • Lymph node(4.6)
  • Spleen(4.6)
  • Blood(4.5)
  • Bone marrow(4.4)
  • Intestine(4.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ICOSLG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICOSLG Gene

Orthologs for ICOSLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOSLG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICOSLG 34 33
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ICOSLG 34 33
  • 73.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ICOSLG 34 33
  • 73.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icoslg 33
  • 63.04 (n)
mouse
(Mus musculus)
Mammalia Icosl 34 33
  • 61.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICOSLG 34
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICOSLG 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICOSLG 33
  • 47.51 (n)
LICOS 34
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICOSLG 34
  • 25 (a)
OneToOne
Species where no ortholog for ICOSLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOSLG Gene

ENSEMBL:
Gene Tree for ICOSLG (if available)
TreeFam:
Gene Tree for ICOSLG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICOSLG: view image

Paralogs for ICOSLG Gene

Paralogs for ICOSLG Gene

genes like me logo Genes that share paralogs with ICOSLG: view

Variants for ICOSLG Gene

Sequence variations from dbSNP and Humsavar for ICOSLG Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000401044 -- 44,227,103(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000597347 -- 44,240,835(-) C/T 5_prime_UTR_variant
rs1000742298 -- 44,231,011(-) C/T intron_variant
rs1000931828 -- 44,241,060(-) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001270373 -- 44,238,567(-) G/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ICOSLG Gene

Variant ID Type Subtype PubMed ID
esv1737771 CNV insertion 17803354
esv33817 CNV loss 17666407
esv3647125 CNV gain 21293372
nsv1117313 CNV tandem duplication 24896259
nsv470906 CNV loss 18288195
nsv587740 CNV loss 21841781
nsv953645 CNV deletion 24416366

Variation tolerance for ICOSLG Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICOSLG Gene

Human Gene Mutation Database (HGMD)
ICOSLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICOSLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOSLG Gene

Disorders for ICOSLG Gene

MalaCards: The human disease database

(2) MalaCards diseases for ICOSLG Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency with hyper-igm, type 2
  • higm2
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ICOSLG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICOSLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICOSLG Gene

Publications for ICOSLG Gene

  1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PMID: 11007762) Yoshinaga SK … Coccia MA (International immunology 2000) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58

Products for ICOSLG Gene

Sources for ICOSLG Gene

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