Aliases for ICOSLG Gene
External Ids for ICOSLG Gene
Previous HGNC Symbols for ICOSLG Gene
Previous GeneCards Identifiers for ICOSLG Gene
GeneCards Summary for ICOSLG Gene
ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Immunodeficiency With Hyper-Igm, Type 2 and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immune response NFAT in immune response and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is LOC102723996.
UniProtKB/Swiss-Prot for ICOSLG Gene
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).