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The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
ICOS (Inducible T Cell Costimulator) is a Protein Coding gene. Diseases associated with ICOS include Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Signaling by GPCR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11956294 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | T cell receptor signaling pathway | ||
4 | HIV Life Cycle |
.45
|
|
5 | Downstream signaling events of B Cell Receptor (BCR) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002517 | T cell tolerance induction | IBA | 21873635 |
GO:0006955 | immune response | NAS | 9930702 |
GO:0031295 | T cell costimulation | TAS | -- |
GO:0051897 | positive regulation of protein kinase B signaling | TAS | -- |
GO:0098609 | cell-cell adhesion | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ipilimumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies, Immunomodulatory agents | 676 | ||
nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 1165 | ||
Pembrolizumab | Approved | Pharma | 1266 | |||
Antibodies | Pharma | 7499 | ||||
Antibodies, Monoclonal | Pharma | 3764 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ICOS 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ICOS 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ICOS 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Icos 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Icos 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ICOS 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ICOS 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ICOS 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ICOS 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
648199 | Uncertain Significance: Common variable immunodeficiency 1 | 203,957,799(+) | A/C | MISSENSE_VARIANT | |
663980 | Likely Pathogenic: Common variable immunodeficiency 1; Inherited Immunodeficiency Diseases | 203,936,873(+) | G/A | ||
666015 | Uncertain Significance: Common variable immunodeficiency 1 | 203,959,588(+) | G/A | MISSENSE_VARIANT | |
666602 | Uncertain Significance: not specified | 203,955,766(+) | C/A | NONSENSE | |
779693 | Likely Benign: not provided | 203,955,740(+) | T/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1001799 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency, common variable, 1 |
|
|
common variable immunodeficiency |
|
|
immunodeficiency, common variable, 2 |
|
|
angioimmunoblastic t-cell lymphoma |
|
|
diffuse cutaneous systemic sclerosis |
|
|