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ICOS Gene(Protein Coding)

Inducible T Cell Costimulator

GCID:
GC02P203937
GIFtS:
52
Genes Participants
UDN Logo

Aliases for ICOS Gene

Aliases for ICOS Gene

  • Inducible T Cell Costimulator 2 3
  • Activation-Inducible Lymphocyte Immunomediatory Molecule 2 3 4
  • Inducible T-Cell Costimulator 2 3 5
  • AILIM 3 4
  • Inducible T-Cell Co-Stimulator 3
  • Inducible Costimulator 3
  • CD278 Antigen 4
  • CD278 3
  • CVID1 3

External Ids for ICOS Gene

Previous GeneCards Identifiers for ICOS Gene

  • GC02P203018
  • GC02P203526
  • GC02P204765
  • GC02P205004
  • GC02P204626
  • GC02P204509
  • GC02P196648

Summaries for ICOS Gene

Entrez Gene Summary for ICOS Gene

  • The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICOS Gene

ICOS (Inducible T Cell Costimulator) is a Protein Coding gene. Diseases associated with ICOS include Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Allograft rejection.

UniProtKB/Swiss-Prot for ICOS Gene

  • Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Gene Wiki entry for ICOS Gene

Additional gene information for ICOS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOS Gene

Genomics for ICOS Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ICOS Gene

Promoters and enhancers for ICOS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I203936 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 575.9 +1.8 1792 4.6 POLR2A MLLT1 ICOS CD28 CTLA4 LOC101927840
GH02I203704 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.6 -228.7 -228668 7.8 FOXA2 BACH1 EBF1 CEBPG BMI1 BATF KLF5 IRF4 RELA POLR2A CD28 ICOS CTLA4 RNU6-474P NBEAL1 KRT18P39 LOC100419679
GH02I203737 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -195.3 -195315 7.2 GATA3 SOX6 ZSCAN4 CEBPB CD28 KRT18P39 ICOS RNU6-474P RAPH1 CTLA4
GH02I203717 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -216.5 -216494 6.2 ELF3 SOX13 FOXA2 MAX RARA FOS RUNX3 GATAD2A RXRA FOXA3 CD28 ICOS RAPH1 RNU6-474P KRT18P39 CTLA4 CARF CYP20A1
GH02I204015 Enhancer 0.5 FANTOM5 20.4 +79.0 78958 0.2 CREB1 ATF2 ICOS CTLA4 CD28 GC02P204020 LOC101927840
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ICOS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ICOS gene promoter:

Genomic Locations for ICOS Gene

Genomic Locations for ICOS Gene
chr2:203,936,731-203,961,579
(GRCh38/hg38)
Size:
24,849 bases
Orientation:
Plus strand
chr2:204,801,471-204,826,300
(GRCh37/hg19)

Genomic View for ICOS Gene

Genes around ICOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICOS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ICOS Gene

Proteins for ICOS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ICOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W8-ICOS_HUMAN
    Recommended name:
    Inducible T-cell costimulator
    Protein Accession:
    Q9Y6W8
    Secondary Accessions:
    • Q8N6W8

    Protein attributes for ICOS Gene

    Size:
    199 amino acids
    Molecular mass:
    22625 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for ICOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOS Gene

Post-translational modifications for ICOS Gene

Other Protein References for ICOS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ICOS Gene

Domains & Families for ICOS Gene

Gene Families for ICOS Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for ICOS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ICOS: view

No data available for UniProtKB/Swiss-Prot for ICOS Gene

Function for ICOS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ICOS Gene

UniProtKB/Swiss-Prot Function:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.

Phenotypes From GWAS Catalog for ICOS Gene

Gene Ontology (GO) - Molecular Function for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with ICOS: view
genes like me logo Genes that share phenotypes with ICOS: view

Human Phenotype Ontology for ICOS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ICOS Gene

MGI Knock Outs for ICOS:

Animal Model Products

miRNA for ICOS Gene

miRTarBase miRNAs that target ICOS

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ICOS Gene

Localization for ICOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOS Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICOS gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ICOS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICOS Gene

Pathways & Interactions for ICOS Gene

genes like me logo Genes that share pathways with ICOS: view

Gene Ontology (GO) - Biological Process for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002517 T cell tolerance induction IEA --
GO:0006955 immune response NAS 9930702
GO:0031295 T cell costimulation TAS --
GO:0046854 phosphatidylinositol phosphorylation IEA --
GO:0051897 positive regulation of protein kinase B signaling TAS --
genes like me logo Genes that share ontologies with ICOS: view

No data available for SIGNOR curated interactions for ICOS Gene

Drugs & Compounds for ICOS Gene

Products:

  1. Drug

(5) Drugs for ICOS Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
nivolumab Approved Pharma Therapeutic Antibodies, Immunotherapies 604
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
Immunoglobulins Pharma 7224
genes like me logo Genes that share compounds with ICOS: view

Transcripts for ICOS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ICOS Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ICOS Gene

Inducible T-cell co-stimulator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICOS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for ICOS Gene

GeneLoc Exon Structure for
ICOS
ECgene alternative splicing isoforms for
ICOS

Expression for ICOS Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICOS Gene

mRNA expression in normal human tissues for ICOS Gene
mRNA expression by GTEx for ICOS GenemRNA expression by BioGPS for ICOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICOS Gene

This gene is overexpressed in Whole Blood (x15.2), Small Intestine - Terminal Ileum (x7.1), Spleen (x6.0), and Lung (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of ICOS Gene:

ICOS

SOURCE GeneReport for Unigene cluster for ICOS Gene:

Hs.56247

mRNA Expression by UniProt/SwissProt for ICOS Gene:

Q9Y6W8-ICOS_HUMAN
Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

Evidence on tissue expression from TISSUES for ICOS Gene

  • Blood(4.5)
  • Lymph node(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ICOS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • meninges
  • middle ear
  • neck
  • pituitary gland
  • sinus
  • skull
  • thyroid
Thorax:
  • bronchus
  • heart
  • lung
Abdomen:
  • adrenal gland
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with ICOS: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ICOS Gene

Orthologs for ICOS Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ICOS 33 34
  • 99.16 (n)
dog
(Canis familiaris)
 Mammalia ICOS 33 34
  • 84.26 (n)
cow
(Bos Taurus)
 Mammalia ICOS 33 34
  • 83.67 (n)
rat
(Rattus norvegicus)
 Mammalia Icos 33
  • 77.54 (n)
mouse
(Mus musculus)
 Mammalia Icos 33 16 34
  • 77.44 (n)
oppossum
(Monodelphis domestica)
 Mammalia ICOS 34
  • 43 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ICOS 34
  • 42 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ICOS 34
  • 29 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ICOS 34
  • 22 (a)
 OneToOne
Species where no ortholog for ICOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOS Gene

ENSEMBL:
Gene Tree for ICOS (if available)
TreeFam:
Gene Tree for ICOS (if available)

Paralogs for ICOS Gene

No data available for Paralogs for ICOS Gene

Variants for ICOS Gene

Sequence variations from dbSNP and Humsavar for ICOS Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10183087 likely-benign, benign, Common Variable Immune Deficiency, Recessive, not specified 203,959,601(+) A/C/G 3_prime_UTR_variant
rs10932035 likely-benign, Common Variable Immune Deficiency, Recessive 203,959,929(+) G/A 3_prime_UTR_variant
rs10932036 likely-benign, Common Variable Immune Deficiency, Recessive 203,960,458(+) A/T 3_prime_UTR_variant
rs10932037 likely-benign, Common Variable Immune Deficiency, Recessive 203,960,623(+) C/T 3_prime_UTR_variant
rs10932038 likely-benign, Common Variable Immune Deficiency, Recessive 203,960,861(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ICOS Gene

Variant ID Type Subtype PubMed ID
nsv1001799 CNV gain 25217958

Variation tolerance for ICOS Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICOS Gene

Human Gene Mutation Database (HGMD)
ICOS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOS Gene

Disorders for ICOS Gene

MalaCards: The human disease database

(5) MalaCards diseases for ICOS Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 1
  • cvid1
common variable immunodeficiency
  • acquired agammaglobulinemia
immunodeficiency, common variable, 2
  • cvid2
good syndrome
  • thymoma with hypogammaglobulinemia
diffuse cutaneous systemic sclerosis
  • dcssc
- elite association - COSMIC cancer census association via MalaCards
Search ICOS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ICOS_HUMAN
  • Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ICOS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICOS: view

No data available for Genatlas for ICOS Gene

Publications for ICOS Gene

  1. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PMID: 20113255) Kim YO … Hong SJ (Clinical chemistry and laboratory medicine 2010) 3 22 44 58
  2. Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. (PMID: 19332044) Wu J … Yang YC (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 44 58
  3. Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. (PMID: 19202444) Haimila K … Partanen J (Transplantation 2009) 3 22 44 58
  4. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (PMID: 18396212) Suwalska K … Frydecka I (Human immunology 2008) 3 22 44 58
  5. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 22 44 58

Products for ICOS Gene

Sources for ICOS Gene

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