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The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] See more...
Aliases for ICOS Gene
Aliases for ICOS Gene
External Ids for ICOS Gene
- HGNC: 5351
- Entrez Gene: 29851
- Ensembl: ENSG00000163600
- OMIM: 604558
- UniProtKB: Q9Y6W8
Previous GeneCards Identifiers for ICOS Gene
- GC02P203018
- GC02P203526
- GC02P204765
- GC02P205004
- GC02P204626
- GC02P204509
- GC02P196648
Summaries for ICOS Gene
-
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICOS Gene
ICOS (Inducible T Cell Costimulator) is a Protein Coding gene. Diseases associated with ICOS include Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and GAB1 signalosome.
UniProtKB/Swiss-Prot Summary for ICOS Gene
-
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Additional gene information for ICOS Gene
- Monarch Initiative
- Search for ICOS at DataMed
- Search for ICOS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICOS Gene
Genomics for ICOS Gene
GeneHancer (GH) Regulatory Elements for ICOS Gene
Promoters and enhancers for ICOS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ICOS on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICOS
- Top Transcription factor binding sites by QIAGEN in the ICOS gene promoter:
-
- AML1a
- AP-1
- ATF-2
- c-Jun
- Chx10
- HOXA3
- IRF-7A
- LCR-F1
- Pax-4a
- Sp1
Genomic Locations for ICOS Gene
Genomic Locations for ICOS Gene
- chr2:203,936,731-203,961,579
- (GRCh38/hg38)
- Size:
- 24,849 bases
- Orientation:
- Plus strand
- chr2:204,801,471-204,826,300
- (GRCh37/hg19)
- Size:
- 24,830 bases
- Orientation:
- Plus strand
Genomic View for ICOS Gene
Genes around ICOS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.2 by HGNC
- 2q33.2 by Entrez Gene
- 2q33.2 by Ensembl
ICOS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICOS Gene
Proteins for ICOS Gene
-
Protein details for ICOS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6W8-ICOS_HUMAN
- Recommended name:
- Inducible T-cell costimulator
- Protein Accession:
- Q9Y6W8
- Q8N6W8
Protein attributes for ICOS Gene
- Size:
- 199 amino acids
- Molecular mass:
- 22625 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Post-translational modifications for ICOS Gene
- N-glycosylated.
-
Glycosylation at Asn23, Asn89, and Asn110
- NX_Q9Y6W8 (NX_Q9Y6W8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ICOS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ICOS / CD278 Antibody (LS-B11916) and ICOS / CD278 Antibody (LS-B4395)
- NSJ Bioreagents ICOS Antibody
- Creative Diagnostics Anti-ICOS monoclonal antibody, clone JTB-4
-
Custom Antibody ServicesOriGene Antibodies for ICOS
- AP13108PU-N
- CF813208
- CF813209
- CF813212
- CF813215
- CF813216
- CF813217
- CF813218
- CF813219
- CF813222
- CF813223
- CF813299
- CF813300
- CF813303
- TA320352
- TA320353
- TA321805
- TA327185
- TA813208
- TA813208S
- TA813209
- TA813209S
- TA813212
- TA813212S
- TA813215
- TA813215S
- TA813216
- TA813216S
- TA813217
- TA813217S
- TA813218
- TA813218S
- TA813219
- TA813219S
- TA813222
- TA813222S
- TA813223
- TA813223S
- TA813299
- TA813299S
- TA813300
- TA813300S
- TA813303
- TA813303S
- Novus Biologicals Antibodies for ICOS
-
Abcam antibodies for ICOS
- Invitrogen Antibodies for ICOS (AFLGC-ICOS)
- antibodies-online: Show 92 available ICOS Antibodies ranked by validation data
- Compare Top ICOS Antibodies
-
Recommended
- 45 FACS Antibodies (anti-mouse)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 5 IP Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 94 FACS Antibodies (anti-human)
- 66 WB Antibodies (anti-human)
- 17 IHC (fro) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 29 WB Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 ICFC Antibodies (anti-rat)
-
Boster Bio Antibodies for ICOS
-
Santa Cruz Biotechnology (SCBT) Antibodies for ICOS
Protein Products
-
OriGene Purified Proteins for ICOS
- Search Origene for MassSpec and Protein Over-expression Lysates for ICOS
- Origene Custom Protein Services for ICOS
- Novus Biologicals lysates for ICOS
- Sino Biological Cell Lysates for ICOS
- Sino Biological Recombinant Proteins for ICOS
- ProSpec Recombinant Proteins for ICOS
-
ProSci Proteins for ICOS
- inducible T-cell co-stimulator [91-826]
- inducible T-cell costimulator precursor [96-888]
- inducible T-cell co-stimulator [90-441]
- inducible T-cell co-stimulator [90-442]
- inducible T-cell co-stimulator [90-443]
- inducible T-cell co-stimulator [90-444]
- inducible T-cell co-stimulator [90-445]
- inducible T cell co-stimulator [90-446]
-
Abcam proteins for ICOS
Assay Products
- RayBiotech Human ICOS ELISA
- Aviva Systems Biology ICOS ELISA Kit (Human) (OKCD00111)
-
Custom Assay ServicesOriGene ELISA Kits for ICOS
-
Boster Bio ELISA Kits for ICOS
-
Signalway ELISA kits for ICOS
No data available for DME Specific Peptides for ICOS Gene
Domains & Families for ICOS Gene
Gene Families for ICOS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Predicted membrane proteins
Protein Domains for ICOS Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ICOS Gene
- GenScript: Design optimal peptide antigens:
-
- Activation-inducible lymphocyte immunomediatory molecule (ICOS_HUMAN)
- cDNA, FLJ95906, Homo sapiens inducible T-cell co-stimulator (ICOS), mRNA (Q53QY6_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ICOS Gene
Function for ICOS Gene
Molecular function for ICOS Gene
- UniProtKB/Swiss-Prot Function:
- Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.
Phenotypes From GWAS Catalog for ICOS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11956294 |
Phenotypes for ICOS Gene
- MGI mutant phenotypes for ICOS:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for ICOS:
Animal Models for ICOS Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ICOS
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ICOS - Select products 50% OFF >
- * ICOS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ICOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- genomics-online: gRNA clones - Search for available ICOS gRNA products
- Overview of 145 available ICOS gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
miRNA for ICOS Gene
- miRTarBase miRNAs that target ICOS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICOS
- Browse OriGene Inhibitory RNA Products For ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- genomics-online: shRNA clones - Search for available ICOS shRNA products
- Overview of 145 available ICOS gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ICOS - Select products 50% OFF >
- * ICOS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- genomics-online: cdna clones - Search for available ICOS CDNA products
- Overview of 145 available ICOS gene related products
- orf clones - Search for available ICOS ORF products
- Overview of 145 available ICOS gene related products
Cell Line Products
-
Horizon Cell Lines for ICOS
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ICOS Gene
Localization for ICOS Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICOS Gene
- [Isoform 1]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Plasma membrane (2)
- Actin filaments (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ICOS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | T cell receptor signaling pathway | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Downstream signaling events of B Cell Receptor (BCR) | ||
Pathways by source for ICOS Gene
2 BioSystems pathways for ICOS Gene
26 Reactome pathways for ICOS Gene
4 KEGG pathways for ICOS Gene
1 GeneGo (Thomson Reuters) pathway for ICOS Gene
- Immune response ICOS pathway in T-helper cell
3 R&D Systems pathways for ICOS Gene
1 Qiagen pathway for ICOS Gene
- ICos-ICosL Pathway in T-Helper Cell
1 Cell Signaling Technology pathway for ICOS Gene
Interacting Proteins for ICOS Gene
Selected Interacting proteins:
Q9Y6W8-ICOS_HUMAN
ENSP00000319476
for ICOS Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ICOS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002517 | T cell tolerance induction | IBA | 21873635 |
| GO:0006955 | immune response | NAS | 9930702 |
| GO:0031295 | T cell costimulation | TAS | -- |
| GO:0051897 | positive regulation of protein kinase B signaling | TAS | -- |
| GO:0098609 | cell-cell adhesion | IBA | 21873635 |
No data available for SIGNOR curated interactions for ICOS Gene
Drugs & Compounds for ICOS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ipilimumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies, Immunomodulatory agents | 648 | ||
| nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 1080 | ||
| Pembrolizumab | Approved | Pharma | 1134 | |||
| Antibodies | Pharma | 8750 | ||||
| Antibodies, Monoclonal | Pharma | 5379 |
Transcripts for ICOS Gene
mRNA/cDNA for ICOS Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316386 2645 bps (ENST00000316386.10)
- ENST00000435193 2528 bps (ENST00000435193.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ICOS - Select products 50% OFF >
- * ICOS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ICOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- genomics-online: gRNA clones - Search for available ICOS gRNA products
- Overview of 145 available ICOS gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICOS
- Browse OriGene Inhibitory RNA Products For ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- genomics-online: shRNA clones - Search for available ICOS shRNA products
- Overview of 145 available ICOS gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ICOS - Select products 50% OFF >
- * ICOS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- genomics-online: cdna clones - Search for available ICOS CDNA products
- Overview of 145 available ICOS gene related products
- orf clones - Search for available ICOS ORF products
- Overview of 145 available ICOS gene related products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - |
Relevant External Links for ICOS Gene
- GeneLoc Exon Structure for
- ICOS
Expression for ICOS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ICOS Gene
This gene is overexpressed in Whole Blood (x15.2), Small Intestine - Terminal Ileum (x7.1), Spleen (x6.0), and Lung (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICOS
SOURCE GeneReport for Unigene cluster for ICOS Gene:
Hs.56247mRNA Expression by UniProt/SwissProt for ICOS Gene:
Q9Y6W8-ICOS_HUMAN
Tissue specificity:
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Evidence on tissue expression from TISSUES for ICOS Gene
- Blood(4.5)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ICOS Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- ear
- eye
- head
- hypothalamus
- meninges
- middle ear
- neck
- pituitary gland
- sinus
- skull
- thyroid
Thorax:
- bronchus
- heart
- lung
Abdomen:
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- anus
- rectum
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ICOS
-
OriGene qPCR primer pairs and template standards for ICOS
- genomics-online: primer clones - Search for available ICOS Primer products
- Overview of 145 available ICOS gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ICOS Gene
Orthologs for ICOS Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ICOS 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ICOS 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ICOS 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Icos 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Icos 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ICOS 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ICOS 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ICOS 31 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ICOS 31 |
|
OneToOne |
- Species where no ortholog for ICOS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ICOS Gene
- ENSEMBL:
- Gene Tree for ICOS (if available)
- TreeFam:
- Gene Tree for ICOS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ICOS: view image
Paralogs for ICOS Gene
No data available for Paralogs for ICOS Gene
Variants for ICOS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICOS Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 648199 | Uncertain Significance: Common variable immunodeficiency 1 | 203,957,799(+) | A/C | MISSENSE_VARIANT | |
| 663980 | Likely Pathogenic: Common variable immunodeficiency 1 | 203,936,873(+) | G/A | SPLICE_DONOR_VARIANT | |
| 666015 | Uncertain Significance: Common variable immunodeficiency 1 | 203,959,588(+) | G/A | MISSENSE_VARIANT | |
| 666602 | Uncertain Significance: not specified | 203,955,766(+) | C/A | NONSENSE | |
| 779693 | Likely Benign: not provided | 203,955,740(+) | T/C | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1001799 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.51;
29.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ICOS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOS Gene
Disorders for ICOS Gene
(8) MalaCards diseases for ICOS Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency, common variable, 1 |
|
|
| common variable immunodeficiency |
|
|
| immunodeficiency, common variable, 2 |
|
|
| angioimmunoblastic t-cell lymphoma |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
Search ICOS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ICOS_HUMAN- Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ICOS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ICOS Gene
Publications for ICOS Gene
- Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PMID: 20113255) Kim YO … Hong SJ (Clinical chemistry and laboratory medicine 2010) 3 23 41 54
- Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. (PMID: 19202444) Haimila K … Partanen J (Transplantation 2009) 3 23 41 54
- Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. (PMID: 19332044) Wu J … Yang YC (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 41 54
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 23 41 54
- Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (PMID: 18396212) Suwalska K … Frydecka I (Human immunology 2008) 3 23 41 54
ExternalLinks
Products for ICOS Gene
- View all 51 R&D Systems ICOS (ICOS) Products
- View all 4 R&D Systems ICOS (ICOS) Proteins and Enzymes
- View all 45 R&D Systems ICOS (ICOS) Primary Antibodies
- View all R&D Systems ICOS (ICOS) ELISAs
- View all R&D Systems ICOS (ICOS) cDNA Clones
- Learn more about R&D Systems custom ICOS antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ICOS
- AP13108PU-N
- CF813208
- CF813209
- CF813212
- CF813215
- CF813216
- CF813217
- CF813218
- CF813219
- CF813222
- CF813223
- CF813299
- CF813300
- CF813303
- TA320352
- TA320353
- TA321805
- TA327185
- TA813208
- TA813208S
- TA813209
- TA813209S
- TA813212
- TA813212S
- TA813215
- TA813215S
- TA813216
- TA813216S
- TA813217
- TA813217S
- TA813218
- TA813218S
- TA813219
- TA813219S
- TA813222
- TA813222S
- TA813223
- TA813223S
- TA813299
- TA813299S
- TA813300
- TA813300S
- TA813303
- TA813303S
- Custom Assay ServicesOriGene ELISA Kits for ICOS
- OriGene Purified Proteins for ICOS
- Search Origene for MassSpec and Protein Over-expression Lysates for ICOS
- Origene Custom Protein Services for ICOS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICOS
- Browse OriGene Inhibitory RNA Products For ICOS
- OriGene qPCR primer pairs for ICOS
- OriGene qPCR primer pairs and template standards for ICOS
- OriGene CRISPR knockouts for ICOS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ICOS
- Sino Biological Human cDNA Clone for ICOS
- Sino Biological Cell Lysates for ICOS
- Sino Biological Recombinant Proteins for ICOS
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ICOS
- Novus Biologicals lysates for ICOS
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ICOS
- Abcam proteins for ICOS
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for ICOS
- Taconic Biosciences Mouse Models for ICOS
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ICOS (AFLGC-ICOS)
- VectorBuilder Custom and pre-made DNA vectors for ICOS (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ICOS (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ICOS (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ICOS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ICOS
- antibodies-online: Show 92 available ICOS Antibodies ranked by validation data
- Compare Top ICOS Antibodies
- Recommended
- 45 FACS Antibodies (anti-mouse)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 5 IP Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 94 FACS Antibodies (anti-human)
- 66 WB Antibodies (anti-human)
- 17 IHC (fro) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 29 WB Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 ICFC Antibodies (anti-rat)
- antibodies-online: Show 30 available ICOS Elisa Kits ranked by validation data
- Compare Top ICOS Elisa Kits
- antibodies-online: Show 42 available ICOS Proteins ranked by validation data
- Compare Top ICOS Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ICOS
- Search Santa Cruz Biotechnology (SCBT) for ICOS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
- Search for ICOS Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ICOS
- inducible T-cell co-stimulator [91-826]
- inducible T-cell costimulator precursor [96-888]
- inducible T-cell co-stimulator [90-441]
- inducible T-cell co-stimulator [90-442]
- inducible T-cell co-stimulator [90-443]
- inducible T-cell co-stimulator [90-444]
- inducible T-cell co-stimulator [90-445]
- inducible T cell co-stimulator [90-446]
- Horizon Cell Lines for ICOS
- genomics-online: cdna clones - Search for available ICOS CDNA products
- Overview of 145 available ICOS gene related products
- orf clones - Search for available ICOS ORF products
- Overview of 145 available ICOS gene related products
- genomics-online: gRNA clones - Search for available ICOS gRNA products
- Overview of 145 available ICOS gene related products
- genomics-online: primer clones - Search for available ICOS Primer products
- Overview of 145 available ICOS gene related products
- genomics-online: shRNA clones - Search for available ICOS shRNA products
- Overview of 145 available ICOS gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- Boster Bio Antibodies for ICOS
- Boster Bio ELISA Kits for ICOS
Sources for ICOS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody