Aliases for ICOS Gene
Aliases for ICOS Gene
External Ids for ICOS Gene
- HGNC: 5351
- Entrez Gene: 29851
- Ensembl: ENSG00000163600
- OMIM: 604558
- UniProtKB: Q9Y6W8
Previous GeneCards Identifiers for ICOS Gene
- GC02P203018
- GC02P203526
- GC02P204765
- GC02P205004
- GC02P204626
- GC02P204509
- GC02P196648
Summaries for ICOS Gene
-
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICOS Gene
ICOS (Inducible T Cell Costimulator) is a Protein Coding gene. Diseases associated with ICOS include Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency. Among its related pathways are T cell receptor signaling pathway and HIV Life Cycle.
UniProtKB/Swiss-Prot for ICOS Gene
-
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Additional gene information for ICOS Gene
- Monarch Initiative
- Search for ICOS at DataMed
- Search for ICOS at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOS Gene
Genomics for ICOS Gene
GeneHancer (GH) Regulatory Elements for ICOS Gene
Promoters and enhancers for ICOS Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J203936 | Promoter/Enhancer | 1.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 675.8 | +1.8 | 1792 | 4.6 | POLR2A MLLT1 | ICOS CD28 CTLA4 LOC101927840 | |
| GH02J203704 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 38.6 | -228.7 | -228668 | 7.8 | FOXA2 BACH1 STAT5A EBF1 CEBPG BMI1 BATF KLF5 IRF4 RELA | CD28 ICOS CTLA4 RNU6-474P NBEAL1 KRT18P39 LOC100419679 | |
| GH02J203717 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 12.4 | -216.5 | -216494 | 6.2 | ELF3 SOX13 FOXA2 MAX ERF RARA FOS RUNX3 GATAD2A NANOG | CD28 ICOS RAPH1 RNU6-474P KRT18P39 CTLA4 CARF CYP20A1 | |
| GH02J203737 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 14.4 | -195.3 | -195315 | 7.2 | GATA3 SOX6 ZSCAN4 CEBPB | CD28 KRT18P39 ICOS RNU6-474P RAPH1 CTLA4 | |
| GH02J204015 | Enhancer | 0.5 | FANTOM5 | 20.4 | +79.0 | 78958 | 0.2 | CREB1 ATF2 | ICOS CTLA4 CD28 GC02P204020 LOC101927840 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ICOS on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ICOS gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- Sp1
- Chx10
- AML1a
- LCR-F1
- Pax-4a
- HOXA3
- IRF-7A
Regulatory Element Products
Genomic Locations for ICOS Gene
Genomic Locations for ICOS Gene
- chr2:203,936,731-203,961,579
- (GRCh38/hg38)
- Size:
- 24,849 bases
- Orientation:
- Plus strand
- chr2:204,801,471-204,826,300
- (GRCh37/hg19)
- Size:
- 24,830 bases
- Orientation:
- Plus strand
Genomic View for ICOS Gene
Genes around ICOS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.2 by Entrez Gene
- 2q33.2 by HGNC
- 2q33.2 by Ensembl
ICOS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICOS Gene
Proteins for ICOS Gene
-
Protein details for ICOS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6W8-ICOS_HUMAN
- Recommended name:
- Inducible T-cell costimulator
- Protein Accession:
- Q9Y6W8
- Q8N6W8
Protein attributes for ICOS Gene
- Size:
- 199 amino acids
- Molecular mass:
- 22625 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Post-translational modifications for ICOS Gene
- N-glycosylated.
- Glycosylation at isoforms=2110, Asn89, and isoforms=223
- Modification sites at PhosphoSitePlus
Other Protein References for ICOS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ICOS (ICOS)
-
Custom Antibody ServicesOriGene Antibodies for ICOS
- Novus Biologicals Antibodies for ICOS
-
Abcam antibodies for ICOS
- Invitrogen Antibodies for ICOS (AFLGC-ICOS)
- GeneTex ICOS Antibody for ICOS
-
CrownBio Antibodies for ICOS
-
Boster Bio Antibodies for ICOS
-
Santa Cruz Biotechnology (SCBT) Antibodies for ICOS
Protein Products
- R&D Systems Proteins and Enzymes for ICOS
-
OriGene Purified Proteins for ICOS
- Search Origene for MassSpec and Protein Over-expression Lysates for ICOS
- Origene Custom Protein Services for ICOS
- Sino Biological Recombinant Proteins for ICOS
- Sino Biological Cell Lysates for ICOS
- GeneTex Proteins for ICOS
-
ProSci Proteins for ICOS
- inducible T-cell costimulator precursor [96-888]
- inducible T-cell co-stimulator [90-441]
- inducible T-cell co-stimulator [90-442]
- inducible T-cell co-stimulator [90-443]
- inducible T-cell co-stimulator [90-444]
- inducible T-cell co-stimulator [90-445]
- inducible T cell co-stimulator [90-446]
- inducible T-cell co-stimulator [91-826]
-
Abcam proteins for ICOS
Assay Products
- R&D Systems ELISAs and other biochemical assays for ICOS (ICOS)
-
Boster Bio ELISA Kits for ICOS
No data available for DME Specific Peptides for ICOS Gene
Domains & Families for ICOS Gene
Gene Families for ICOS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Predicted membrane proteins
Protein Domains for ICOS Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ICOS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ICOS Gene
Function for ICOS Gene
Molecular function for ICOS Gene
- UniProtKB/Swiss-Prot Function:
- Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.
Phenotypes From GWAS Catalog for ICOS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11956294 |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for ICOS Gene
- MGI mutant phenotypes for ICOS:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for ICOS:
Animal Models for ICOS Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ICOS
- Cyagen custom Knockout/knockin (KOKI) mouse models for ICOS
-
CRISPR Products
-
OriGene CRISPR knockouts for ICOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- genomics-online: gRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- Applied Biological Materials CRISPR for ICOS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
- GenScript: Design CRISPR guide RNA sequences for ICOS
miRNA for ICOS Gene
- miRTarBase miRNAs that target ICOS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICOS
- Browse OriGene Inhibitory RNA Products For ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- genomics-online: shRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
Clone Products
- Sino Biological Human cDNA Clone for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- Applied Biological Materials Clones for ICOS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ICOS
Cell Line Products
-
Horizon Cell Lines for ICOS
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ICOS Gene
Localization for ICOS Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICOS Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICOS Gene
Pathways & Interactions for ICOS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | T cell receptor signaling pathway | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Downstream signaling events of B Cell Receptor (BCR) | ||
Pathways by source for ICOS Gene
2 BioSystems pathways for ICOS Gene
26 Reactome pathways for ICOS Gene
4 KEGG pathways for ICOS Gene
1 GeneGo (Thomson Reuters) pathway for ICOS Gene
3 R&D Systems pathways for ICOS Gene
1 Qiagen pathway for ICOS Gene
1 Cell Signaling Technology pathway for ICOS Gene
Interacting Proteins for ICOS Gene
Selected Interacting proteins:
ENSP00000319476
Q9Y6W8-ICOS_HUMAN
for ICOS Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for ICOS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002517 | T cell tolerance induction | IEA | -- |
| GO:0006955 | immune response | NAS | 9930702 |
| GO:0031295 | T cell costimulation | TAS | -- |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | -- |
| GO:0051897 | positive regulation of protein kinase B signaling | TAS | -- |
No data available for SIGNOR curated interactions for ICOS Gene
Transcripts for ICOS Gene
mRNA/cDNA for ICOS Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (16) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000316386 2645 bps (uc002vam.4)
- ENST00000435193 2528 bps (uc010fua.4)
Unigene Clusters for ICOS Gene
CRISPR Products
-
OriGene CRISPR knockouts for ICOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- genomics-online: gRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- Applied Biological Materials CRISPR for ICOS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
- GenScript: Design CRISPR guide RNA sequences for ICOS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICOS
- Browse OriGene Inhibitory RNA Products For ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- genomics-online: shRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
Clone Products
- Sino Biological Human cDNA Clone for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- Applied Biological Materials Clones for ICOS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ICOS
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - |
Expression for ICOS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ICOS Gene
This gene is overexpressed in Whole Blood (x15.2), Small Intestine - Terminal Ileum (x7.1), Spleen (x6.0), and Lung (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of ICOS Gene:
ICOSSOURCE GeneReport for Unigene cluster for ICOS Gene:
Hs.56247mRNA Expression by UniProt/SwissProt for ICOS Gene:
Q9Y6W8-ICOS_HUMAN
Tissue specificity:
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Evidence on tissue expression from TISSUES for ICOS Gene
- Blood(4.5)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ICOS Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- ear
- eye
- head
- hypothalamus
- meninges
- middle ear
- neck
- pituitary gland
- sinus
- skull
- thyroid
Thorax:
- bronchus
- heart
- lung
Abdomen:
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- anus
- rectum
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ICOS
-
OriGene qPCR primer pairs and template standards for ICOS
- genomics-online: primer clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ICOS Gene
Orthologs for ICOS Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ICOS 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ICOS 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ICOS 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Icos 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Icos 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ICOS 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ICOS 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ICOS 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ICOS 34 |
|
OneToOne |
- Species where no ortholog for ICOS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ICOS Gene
- ENSEMBL:
- Gene Tree for ICOS (if available)
- TreeFam:
- Gene Tree for ICOS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ICOS: view image
Paralogs for ICOS Gene
No data available for Paralogs for ICOS Gene
Variants for ICOS Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10183087 | likely-benign, benign, Common Variable Immune Deficiency, Recessive, not specified | 203,959,601(+) | A/C/G | 3_prime_UTR_variant | |
| rs10932035 | likely-benign, Common Variable Immune Deficiency, Recessive | 203,959,929(+) | G/A | 3_prime_UTR_variant | |
| rs10932036 | likely-benign, Common Variable Immune Deficiency, Recessive | 203,960,458(+) | A/T | 3_prime_UTR_variant | |
| rs10932037 | likely-benign, Common Variable Immune Deficiency, Recessive | 203,960,623(+) | C/T | 3_prime_UTR_variant | |
| rs10932038 | likely-benign, Common Variable Immune Deficiency, Recessive | 203,960,861(+) | A/G | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1001799 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.51;
29.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ICOS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOS Gene
Disorders for ICOS Gene
(5) MalaCards diseases for ICOS Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency, common variable, 1 |
|
|
| common variable immunodeficiency |
|
|
| immunodeficiency, common variable, 2 |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
| good syndrome |
|
|
Search ICOS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ICOS_HUMAN- Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ICOS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ICOS Gene
Publications for ICOS Gene
- Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PMID: 20113255) Kim YO … Hong SJ (Clinical chemistry and laboratory medicine 2010) 3 22 44 58
- Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. (PMID: 19202444) Haimila K … Partanen J (Transplantation 2009) 3 22 44 58
- Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. (PMID: 19332044) Wu J … Yang YC (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 44 58
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 22 44 58
- Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (PMID: 18396212) Suwalska K … Frydecka I (Human immunology 2008) 3 22 44 58
Products for ICOS Gene
- R&D Systems Antibodies for ICOS (ICOS)
- R&D Systems Proteins and Enzymes for ICOS
- R&D Systems ELISAs and other biochemical assays for ICOS (ICOS)
- R&D Systems cDNA Clones for ICOS
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- Taconic Biosciences Mouse Models for ICOS
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ICOS (AFLGC-ICOS)
- Cyagen custom Knockout/knockin (KOKI) mouse models for ICOS
- antibodies-online: Search results for 123 available Icos Antibodies ranked by validation data
- Compare Top Icos Antibodies
- antibodies-online: Search results for 16 available Icos Elisa Kits ranked by validation data
- Compare Top Icos Elisa Kits
- antibodies-online: Search results for 14 available Icos Proteins ranked by validation data
- Compare Top Icos Proteins
- GeneTex ICOS Antibody for ICOS
- GeneTex Proteins for ICOS
- Santa Cruz Biotechnology (SCBT) Antibodies for ICOS
- Search Santa Cruz Biotechnology (SCBT) for ICOS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ICOS
- Search for ICOS Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ICOS
- inducible T-cell costimulator precursor [96-888]
- inducible T-cell co-stimulator [90-441]
- inducible T-cell co-stimulator [90-442]
- inducible T-cell co-stimulator [90-443]
- inducible T-cell co-stimulator [90-444]
- inducible T-cell co-stimulator [90-445]
- inducible T cell co-stimulator [90-446]
- inducible T-cell co-stimulator [91-826]
- Horizon Cell Lines for ICOS
- genomics-online: cdna clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- orf clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- genomics-online: gRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- genomics-online: primer clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- genomics-online: shRNA clones - Search results for 22 available Icos gene related products
- Overview of 22 available Icos gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICOS
- GeneCopoeia miRNA 3'UTR Target clone products for ICOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICOS
- Boster Bio Antibodies for ICOS
- Boster Bio ELISA Kits for ICOS
Sources for ICOS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt