Aliases for ICMT Gene
External Ids for ICMT Gene
Previous GeneCards Identifiers for ICMT Gene
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICMT Gene
ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Hallermann-Streiff Syndrome and Legionnaire Disease. Among its related pathways are G-protein signaling_K-RAS regulation pathway and G-protein signaling_H-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for ICMT Gene
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.