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This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [pro... See more...
Aliases for ICMT Gene
Aliases for ICMT Gene
External Ids for ICMT Gene
- HGNC: 5350
- Entrez Gene: 23463
- Ensembl: ENSG00000116237
- OMIM: 605851
- UniProtKB: O60725
Previous GeneCards Identifiers for ICMT Gene
- GC01M005857
- GC01M006090
- GC01M005990
- GC01M006215
- GC01M006282
- GC01M005429
Summaries for ICMT Gene
-
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICMT Gene
ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Homocysteinemia and Hallermann-Streiff Syndrome. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for ICMT Gene
-
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Additional gene information for ICMT Gene
- HGNC(5350)
- Entrez Gene(23463)
- Ensembl(ENSG00000116237)
- OMIM(605851)
- UniProtKB(O60725)
- Open Targets Platform(ENSG00000116237)
- Search for ICMT at DataMed
- Search for ICMT at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICMT Gene
Genomics for ICMT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ICMT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ICMT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICMT
- Top Transcription factor binding sites by QIAGEN in the ICMT gene promoter:
-
- ARP-1
- Bach2
- c-Myc
- COMP1
- Max1
- NRSF form 1
- NRSF form 2
- STAT3
Genomic Locations for ICMT Gene
Genomic Locations for ICMT Gene
- chr1:6,221,193-6,235,972
- (GRCh38/hg38)
- Size:
- 14,780 bases
- Orientation:
- Minus strand
- chr1:6,281,253-6,296,044
- (GRCh37/hg19)
- Size:
- 14,792 bases
- Orientation:
- Minus strand
Genomic View for ICMT Gene
Genes around ICMT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.31 by HGNC
- 1p36.31 by Entrez Gene
- 1p36.31 by Ensembl
ICMT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICMT Gene
Proteins for ICMT Gene
-
Protein details for ICMT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60725-ICMT_HUMAN
- Recommended name:
- Protein-S-isoprenylcysteine O-methyltransferase
- Protein Accession:
- O60725
- Q6FHT0
Protein attributes for ICMT Gene
- Size:
- 284 amino acids
- Molecular mass:
- 31938 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ICMT Gene
Selected DME Specific Peptides for ICMT Gene
- O60725:
-
- SLIHFFGE
- RHPSYVG
- HTLVTSGVY
- GTQVMLCNP
- VPTGLPFIKGVK
- SFLLNHS
Post-translational modifications for ICMT Gene
Other Protein References for ICMT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ICMT monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for ICMT
- Novus Biologicals Antibodies for ICMT
- Invitrogen Antibodies for ICMT (AFLGC-Icmt)
-
Biorbyt antibodies for ICMT
-
Boster Bio Antibodies for ICMT
- Sino Biological Antibodies for ICMT
Protein Products
-
OriGene Purified Proteins for ICMT
- Search Origene for MassSpec and Protein Over-expression Lysates for ICMT
- Origene Custom Protein Services for ICMT
- antibodies-online: Show 6 available ICMT Proteins ranked by validation data
- Compare Top ICMT Proteins
-
Quality Products:
-
Abcam proteins for ICMT
Assay Products
- antibodies-online: Show 6 available ICMT Elisa Kits ranked by validation data
- Compare Top ICMT Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for ICMT
Domains & Families for ICMT Gene
Gene Families for ICMT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ICMT Gene
- InterPro:
- Blocks:
-
- Isoprenylcysteine carboxyl methyltransferase
- Gamma-crystallin related
- ProtoNet:
Suggested Antigen Peptide Sequences for ICMT Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ35571 fis, clone SPLEN2005806, highly similar to Protein-S-isoprenylcysteineO-methyltransferase (EC 2.1.1.100) (B3KS61_HUMAN)
- Prenylcysteine carboxyl methyltransferase (ICMT_HUMAN)
- Isoprenylcysteine carboxyl methyltransferase, isoform CRA_a (Q6FHT0_HUMAN)
- MSTP098 (Q9NRT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60725UniProtKB/Swiss-Prot:
ICMT_HUMAN :- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
- Family:
-
- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Function for ICMT Gene
Molecular function for ICMT Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100; Evidence={ECO:0000255|PROSITE-ProRule:PRU00897};.
Enzyme Numbers (IUBMB) for ICMT Gene
Phenotypes From GWAS Catalog for ICMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity | TAS | 9614111 |
| GO:0004671 | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | IBA | 21873635 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for ICMT Gene
- MGI mutant phenotypes for ICMT:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ICMT:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Decreased viability
- Synthetic lethal with Ras
- Decreased shRNA abundance
- Decreased viability after Maraba virus infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased ionizing radiation sensitivity
Animal Model Products
-
Taconic Biosciences Mouse Models for ICMT
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ICMT - Select products 50% OFF >
- * ICMT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ICMT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICMT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
miRNA for ICMT Gene
- miRTarBase miRNAs that target ICMT
-
- mmu-miR-340-5p (MIRT010250)
- hsa-miR-130b-3p (MIRT020175)
- hsa-miR-124-3p (MIRT022702)
- hsa-miR-93-5p (MIRT028069)
- hsa-miR-26b-5p (MIRT029560)
- hsa-miR-331-3p (MIRT043333)
- hsa-miR-1260b (MIRT052699)
- hsa-miR-4433b-5p (MIRT074491)
- hsa-miR-4475 (MIRT283557)
- hsa-miR-6504-3p (MIRT343357)
- hsa-miR-210-3p (MIRT440033)
- hsa-miR-218-5p (MIRT440471)
- hsa-miR-4436b-3p (MIRT475394)
- hsa-miR-6864-5p (MIRT475395)
- hsa-miR-3650 (MIRT475396)
- hsa-miR-6499-3p (MIRT475397)
- hsa-miR-873-5p (MIRT475398)
- hsa-miR-3179 (MIRT475399)
- hsa-miR-7515 (MIRT475400)
- hsa-miR-7845-5p (MIRT475401)
- hsa-miR-940 (MIRT475402)
- hsa-miR-6893-5p (MIRT475403)
- hsa-miR-6808-5p (MIRT475404)
- hsa-miR-3910 (MIRT475405)
- hsa-miR-3714 (MIRT475406)
- hsa-miR-506-3p (MIRT475407)
- hsa-miR-106b-5p (MIRT475408)
- hsa-miR-17-5p (MIRT475409)
- hsa-miR-20a-5p (MIRT475410)
- hsa-miR-20b-5p (MIRT475411)
- hsa-miR-519d-3p (MIRT475412)
- hsa-miR-526b-3p (MIRT475413)
- hsa-miR-106a-5p (MIRT475414)
- hsa-miR-6807-5p (MIRT523047)
- hsa-miR-6888-3p (MIRT523048)
- hsa-miR-7151-3p (MIRT523049)
- hsa-miR-5095 (MIRT523050)
- hsa-miR-3120-5p (MIRT523051)
- hsa-miR-1292-3p (MIRT523052)
- hsa-miR-6850-3p (MIRT523053)
- hsa-miR-4438 (MIRT523054)
- hsa-miR-1260a (MIRT529513)
- hsa-miR-4433a-5p (MIRT529514)
- hsa-miR-219b-5p (MIRT529515)
- hsa-miR-5009-3p (MIRT529516)
- hsa-miR-1224-3p (MIRT529517)
- hsa-miR-6834-3p (MIRT529518)
- hsa-miR-501-5p (MIRT529519)
- hsa-miR-508-5p (MIRT529520)
- hsa-miR-3145-5p (MIRT529521)
- hsa-miR-4797-5p (MIRT529522)
- hsa-miR-520e (MIRT529523)
- hsa-miR-520d-3p (MIRT529524)
- hsa-miR-520c-3p (MIRT529525)
- hsa-miR-520b (MIRT529526)
- hsa-miR-520a-3p (MIRT529527)
- hsa-miR-373-3p (MIRT529528)
- hsa-miR-372-3p (MIRT529529)
- hsa-miR-302e (MIRT529530)
- hsa-miR-302d-3p (MIRT529531)
- hsa-miR-302c-3p (MIRT529532)
- hsa-miR-302b-3p (MIRT529533)
- hsa-miR-302a-3p (MIRT529534)
- hsa-miR-519c-3p (MIRT529535)
- hsa-miR-519b-3p (MIRT529536)
- hsa-miR-519a-3p (MIRT529537)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICMT
- Browse OriGene Inhibitory RNA Products For ICMT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT
Clone Products
- Applied Biological Materials (abm): Clones for ICMT - Select products 50% OFF >
- * ICMT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ICMT
- Addgene plasmids for ICMT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICMT
Cell Line Products
-
Horizon Cell Lines for ICMT
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene
Localization for ICMT Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 9614111 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA,TAS | 10441503 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICMT Gene
Pathways & Interactions for ICMT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Terpenoid backbone biosynthesis | ||
| 3 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
| 4 | G-protein signaling N-RAS regulation pathway |
G-protein signaling N-RAS regulation pathway
.52
|
|
| 5 | G-protein signaling_H-RAS regulation pathway |
G-protein signaling_H-RAS regulation pathway
-
|
|
Pathways by source for ICMT Gene
3 Reactome pathways for ICMT Gene
1 KEGG pathway for ICMT Gene
3 GeneGo (Thomson Reuters) pathways for ICMT Gene
- G-protein signaling N-RAS regulation pathway
- G-protein signaling_H-RAS regulation pathway
- G-protein signaling_K-RAS regulation pathway
Interacting Proteins for ICMT Gene
Selected Interacting proteins:
O60725-ICMT_HUMAN
ENSP00000343552
for ICMT Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ICMT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | TAS | 9614111 |
| GO:0006481 | C-terminal protein methylation | IBA | 21873635 |
| GO:0006612 | protein targeting to membrane | TAS | 9614111 |
| GO:0032259 | methylation | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ICMT Gene
Drugs & Compounds for ICMT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
Transcripts for ICMT Gene
mRNA/cDNA for ICMT Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343813 4795 nts (view in UCSC)
- ENST00000474756 1227 nts (view in UCSC)
- ENST00000489498 2612 nts (view in UCSC)
- ENST00000495791 328 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ICMT - Select products 50% OFF >
- * ICMT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ICMT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICMT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ICMT
- Browse OriGene Inhibitory RNA Products For ICMT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT
Clone Products
- Applied Biological Materials (abm): Clones for ICMT - Select products 50% OFF >
- * ICMT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ICMT
- Addgene plasmids for ICMT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICMT
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - |
Relevant External Links for ICMT Gene
- GeneLoc Exon Structure for
- ICMT
Expression for ICMT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Eye (Sensory Organs)
-
Fibroblasts (Uncategorized)
This gene is overexpressed in Lung (25.4) and Placenta (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICMT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICMT
SOURCE GeneReport for Unigene cluster for ICMT Gene:
Hs.515688mRNA Expression by UniProt/SwissProt for ICMT Gene:
O60725-ICMT_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Evidence on tissue expression from TISSUES for ICMT Gene
- Nervous system(4.7)
- Spleen(4.4)
- Blood(4.3)
- Lymph node(4.3)
- Lung(3.4)
- Skin(3.2)
- Eye(2.6)
- Kidney(2.6)
- Intestine(2.5)
- Heart(2.5)
- Muscle(2.5)
- Liver(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for ICMT
-
OriGene qPCR primer pairs and template standards for ICMT
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICMT Gene
Orthologs for ICMT Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ICMT 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ICMT 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Icmt 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Icmt 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ICMT 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ICMT 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ICMT 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ICMT 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | icmt 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397717 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | icmt 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | ste14 30 31 |
|
OneToOne | |
| CG11268 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001310 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | M01E11.1 30 31 32 |
|
OneToMany | |
| F21F3.3 31 32 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE14 30 31 33 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAR122C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A02167g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | STE14A 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0602900 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00034 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mam4 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10934 31 |
|
OneToOne |
- Species where no ortholog for ICMT was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ICMT Gene
- ENSEMBL:
- Gene Tree for ICMT (if available)
- TreeFam:
- Gene Tree for ICMT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ICMT: view image
Paralogs for ICMT Gene
No data available for Paralogs for ICMT Gene
Variants for ICMT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICMT Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 775494 | Benign: not provided | 6,232,010(-) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ICMT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ICMT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene
Disorders for ICMT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| homocysteinemia |
|
|
| hallermann-streiff syndrome |
|
|
| restrictive dermopathy, lethal |
|
|
| charcot-marie-tooth disease and deafness |
|
|
| hutchinson-gilford progeria syndrome |
|
|
Search ICMT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ICMT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene
Publications for ICMT Gene
- Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q … Philips MR (The Journal of biological chemistry 1998) 2 3 4 23
- Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright LP … Philips MR (Molecular and cellular biology 2009) 3 4 23
- Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 41
- An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 41
- Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I … Casey PJ (The Journal of biological chemistry 2009) 3 23
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