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This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [pro... See more...
Aliases for ICMT Gene
Aliases for ICMT Gene
External Ids for ICMT Gene
- HGNC: 5350
- Entrez Gene: 23463
- Ensembl: ENSG00000116237
- OMIM: 605851
- UniProtKB: O60725
Previous GeneCards Identifiers for ICMT Gene
- GC01M005857
- GC01M006090
- GC01M005990
- GC01M006215
- GC01M006282
- GC01M005429
Summaries for ICMT Gene
-
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICMT Gene
ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Hallermann-Streiff Syndrome and Legionnaire Disease. Among its related pathways are G-protein signaling_K-RAS regulation pathway and G-protein signaling_H-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for ICMT Gene
-
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICMT Gene
Genomics for ICMT Gene
GeneHancer (GH) Regulatory Elements for ICMT Gene
Promoters and enhancers for ICMT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ICMT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ICMT gene promoter:
-
- ARP-1
- Bach2
- c-Myc
- COMP1
- Max1
- NRSF form 1
- NRSF form 2
- STAT3
Genomic Locations for ICMT Gene
Genomic Locations for ICMT Gene
- chr1:6,221,193-6,235,984
- (GRCh38/hg38)
- Size:
- 14,792 bases
- Orientation:
- Minus strand
- chr1:6,281,253-6,296,044
- (GRCh37/hg19)
- Size:
- 14,792 bases
- Orientation:
- Minus strand
Genomic View for ICMT Gene
Genes around ICMT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.31 by HGNC
- 1p36.31 by Entrez Gene
- 1p36.31 by Ensembl
ICMT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICMT Gene
Proteins for ICMT Gene
-
Protein details for ICMT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60725-ICMT_HUMAN
- Recommended name:
- Protein-S-isoprenylcysteine O-methyltransferase
- Protein Accession:
- O60725
- Q6FHT0
Protein attributes for ICMT Gene
- Size:
- 284 amino acids
- Molecular mass:
- 31938 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ICMT Gene
Selected DME Specific Peptides for ICMT Gene
- O60725:
-
- SLIHFFGE
- RHPSYVG
- HTLVTSGVY
- GTQVMLCNP
- VPTGLPFIKGVK
- SFLLNHS
Post-translational modifications for ICMT Gene
Other Protein References for ICMT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-ICMT Antibody (HPA032025) and Anti-ICMT Antibody (HPA032024)
- Creative Diagnostics Anti-ICMT monoclonal antibody and Rabbit Anti-Human ICMT Polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for ICMT
- Novus Biologicals Antibodies for ICMT
- Invitrogen Antibodies for ICMT (AFLGC-ICMT)
-
Biorbyt antibodies for ICMT
Protein Products
-
OriGene Purified Proteins for ICMT
- Search Origene for MassSpec and Protein Over-expression Lysates for ICMT
- Origene Custom Protein Services for ICMT
- antibodies-online: Show 6 available ICMT Proteins ranked by validation data
- Compare Top ICMT Proteins
-
Quality Products:
-
Abcam proteins for ICMT
Assay Products
- antibodies-online: Show 6 available ICMT Elisa Kits ranked by validation data
- Compare Top ICMT Elisa Kits
-
Quality Products:
Domains & Families for ICMT Gene
Gene Families for ICMT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ICMT Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ICMT Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ35571 fis, clone SPLEN2005806, highly similar to Protein-S-isoprenylcysteineO-methyltransferase (EC 2.1.1.100) (B3KS61_HUMAN)
- Prenylcysteine carboxyl methyltransferase (ICMT_HUMAN)
- Isoprenylcysteine carboxyl methyltransferase, isoform CRA_a (Q6FHT0_HUMAN)
- MSTP098 (Q9NRT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60725UniProtKB/Swiss-Prot:
ICMT_HUMAN :- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
- Family:
-
- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Function for ICMT Gene
Molecular function for ICMT Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100; Evidence=. ;.
Enzyme Numbers (IUBMB) for ICMT Gene
Phenotypes From GWAS Catalog for ICMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity | TAS | 9614111 |
| GO:0004671 | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | IEA | -- |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for ICMT Gene
- MGI mutant phenotypes for ICMT:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ICMT:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with Ras
- Decreased viability after Maraba virus infection
Animal Model Products
-
Taconic Biosciences Mouse Models for ICMT
CRISPR Products
-
OriGene CRISPR knockouts for ICMT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICMT
- genomics-online: gRNA clones - Search results for available ICMT gene related products
- Applied Biological Materials (abm): CRISPR Clones for ICMT - Select products 50% OFF >
- * ICMT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ICMT CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
miRNA for ICMT Gene
- miRTarBase miRNAs that target ICMT
-
- hsa-mir-130b-3p (MIRT020175)
- hsa-mir-124-3p (MIRT022702)
- hsa-mir-93-5p (MIRT028069)
- hsa-mir-26b-5p (MIRT029560)
- hsa-mir-331-3p (MIRT043333)
- hsa-mir-1260b (MIRT052699)
- hsa-mir-4433b-5p (MIRT074491)
- hsa-mir-4475 (MIRT283557)
- hsa-mir-6504-3p (MIRT343357)
- hsa-mir-210-3p (MIRT440033)
- hsa-mir-218-5p (MIRT440471)
- hsa-mir-4436b-3p (MIRT475394)
- hsa-mir-6864-5p (MIRT475395)
- hsa-mir-3650 (MIRT475396)
- hsa-mir-6499-3p (MIRT475397)
- hsa-mir-873-5p (MIRT475398)
- hsa-mir-3179 (MIRT475399)
- hsa-mir-7515 (MIRT475400)
- hsa-mir-7845-5p (MIRT475401)
- hsa-mir-940 (MIRT475402)
- hsa-mir-6893-5p (MIRT475403)
- hsa-mir-6808-5p (MIRT475404)
- hsa-mir-3910 (MIRT475405)
- hsa-mir-3714 (MIRT475406)
- hsa-mir-506-3p (MIRT475407)
- hsa-mir-106b-5p (MIRT475408)
- hsa-mir-17-5p (MIRT475409)
- hsa-mir-20a-5p (MIRT475410)
- hsa-mir-20b-5p (MIRT475411)
- hsa-mir-519d-3p (MIRT475412)
- hsa-mir-526b-3p (MIRT475413)
- hsa-mir-106a-5p (MIRT475414)
- hsa-mir-6807-5p (MIRT523047)
- hsa-mir-6888-3p (MIRT523048)
- hsa-mir-7151-3p (MIRT523049)
- hsa-mir-5095 (MIRT523050)
- hsa-mir-3120-5p (MIRT523051)
- hsa-mir-1292-3p (MIRT523052)
- hsa-mir-6850-3p (MIRT523053)
- hsa-mir-4438 (MIRT523054)
- hsa-mir-1260a (MIRT529513)
- hsa-mir-4433a-5p (MIRT529514)
- hsa-mir-219b-5p (MIRT529515)
- hsa-mir-5009-3p (MIRT529516)
- hsa-mir-1224-3p (MIRT529517)
- hsa-mir-6834-3p (MIRT529518)
- hsa-mir-501-5p (MIRT529519)
- hsa-mir-508-5p (MIRT529520)
- hsa-mir-3145-5p (MIRT529521)
- hsa-mir-4797-5p (MIRT529522)
- hsa-mir-520e (MIRT529523)
- hsa-mir-520d-3p (MIRT529524)
- hsa-mir-520c-3p (MIRT529525)
- hsa-mir-520b (MIRT529526)
- hsa-mir-520a-3p (MIRT529527)
- hsa-mir-373-3p (MIRT529528)
- hsa-mir-372-3p (MIRT529529)
- hsa-mir-302e (MIRT529530)
- hsa-mir-302d-3p (MIRT529531)
- hsa-mir-302c-3p (MIRT529532)
- hsa-mir-302b-3p (MIRT529533)
- hsa-mir-302a-3p (MIRT529534)
- hsa-mir-519c-3p (MIRT529535)
- hsa-mir-519b-3p (MIRT529536)
- hsa-mir-519a-3p (MIRT529537)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ICMT
- Browse OriGene Inhibitory RNA Products For ICMT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT
- genomics-online: shRNA clones - Search results for available ICMT gene related products
Clone Products
- Sino Biological Human cDNA Clone for ICMT
- Addgene plasmids for ICMT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICMT
- genomics-online: cdna clones - Search results for available ICMT gene related products
- orf clones - Search results for available ICMT gene related products
- Applied Biological Materials (abm): Clones for ICMT - Select products 50% OFF >
- * ICMT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ICMT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for ICMT
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene
Localization for ICMT Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 2 |
| extracellular | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 9614111 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA,TAS | 10441503 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICMT Gene
Pathways & Interactions for ICMT Gene
Pathways by source for ICMT Gene
3 Reactome pathways for ICMT Gene
1 KEGG pathway for ICMT Gene
3 GeneGo (Thomson Reuters) pathways for ICMT Gene
Interacting Proteins for ICMT Gene
GPS-Prot Interaction Network for ICMT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | TAS | 9614111 |
| GO:0006481 | C-terminal protein methylation | TAS,IEA | -- |
| GO:0006612 | protein targeting to membrane | TAS | 9614111 |
| GO:0032259 | methylation | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ICMT Gene
Drugs & Compounds for ICMT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
Transcripts for ICMT Gene
mRNA/cDNA for ICMT Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (374) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343813 4795 bps (ENST00000343813.9)
- ENST00000495791 328 bps (ENST00000495791.1)
- ENST00000489498 2612 bps (ENST00000489498.5)
- ENST00000474756 1227 bps (ENST00000474756.1)
CRISPR Products
-
OriGene CRISPR knockouts for ICMT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICMT
- genomics-online: gRNA clones - Search results for available ICMT gene related products
- Applied Biological Materials (abm): CRISPR Clones for ICMT - Select products 50% OFF >
- * ICMT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ICMT CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ICMT
- Browse OriGene Inhibitory RNA Products For ICMT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT
- genomics-online: shRNA clones - Search results for available ICMT gene related products
Clone Products
- Sino Biological Human cDNA Clone for ICMT
- Addgene plasmids for ICMT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICMT
- genomics-online: cdna clones - Search results for available ICMT gene related products
- orf clones - Search results for available ICMT gene related products
- Applied Biological Materials (abm): Clones for ICMT - Select products 50% OFF >
- * ICMT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ICMT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - |
Expression for ICMT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Eye (Sensory Organs)
-
Fibroblasts (Uncategorized)
This gene is overexpressed in Lung (25.4) and Placenta (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICMT Gene
NURSA nuclear receptor signaling pathways regulating expression of ICMT Gene:
ICMTSOURCE GeneReport for Unigene cluster for ICMT Gene:
Hs.515688mRNA Expression by UniProt/SwissProt for ICMT Gene:
O60725-ICMT_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Evidence on tissue expression from TISSUES for ICMT Gene
- Nervous system(4.6)
- Spleen(4.3)
- Blood(4.2)
- Lymph node(4.2)
- Lung(3.3)
- Skin(2.3)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for ICMT
-
OriGene qPCR primer pairs and template standards for ICMT
- genomics-online: primer clones - Search results for available ICMT gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICMT Gene
Orthologs for ICMT Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ICMT 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ICMT 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Icmt 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Icmt 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ICMT 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ICMT 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ICMT 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ICMT 33 32 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | icmt 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397717 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | icmt 33 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | ste14 33 32 |
|
OneToOne | |
| CG11268 34 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001310 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | M01E11.1 33 34 32 |
|
OneToMany | |
| F21F3.3 33 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE14 35 33 32 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAR122C 32 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A02167g 32 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | STE14A 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0602900 32 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00034 32 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mam4 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10934 33 |
|
OneToOne |
- Species where no ortholog for ICMT was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ICMT Gene
- ENSEMBL:
- Gene Tree for ICMT (if available)
- TreeFam:
- Gene Tree for ICMT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ICMT: view image
Paralogs for ICMT Gene
No data available for Paralogs for ICMT Gene
Variants for ICMT Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000032691 | -- | 6,230,081(-) | G/C | intron_variant | |
| rs1000138378 | -- | 6,233,094(-) | T/C | intron_variant | |
| rs1000430267 | -- | 6,232,982(-) | C/T | intron_variant | |
| rs1000521636 | -- | 6,235,958(-) | G/A/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000763311 | -- | 6,234,166(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ICMT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ICMT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene
Disorders for ICMT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hallermann-streiff syndrome |
|
|
| legionnaire disease |
|
|
Search ICMT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ICMT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene
Publications for ICMT Gene
- Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q … Philips MR (The Journal of biological chemistry 1998) 2 3 4 23 56
- Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright LP … Philips MR (Molecular and cellular biology 2009) 3 4 23 56
- Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 43 56
- An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 43 56
- Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I … Casey PJ (The Journal of biological chemistry 2009) 3 23 56
ExternalLinks
Products for ICMT Gene
- Custom Antibody ServicesOriGene Antibodies for ICMT
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ICMT
- Search Origene for MassSpec and Protein Over-expression Lysates for ICMT
- Origene Custom Protein Services for ICMT
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ICMT
- Browse OriGene Inhibitory RNA Products For ICMT
- OriGene qPCR primer pairs for ICMT
- OriGene qPCR primer pairs and template standards for ICMT
- OriGene CRISPR knockouts for ICMT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ICMT
- Sino Biological Human cDNA Clone for ICMT
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for ICMT
- Novus Biologicals proteins and lysates for ICMT
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- Abcam proteins for ICMT
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for ICMT
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ICMT (AFLGC-ICMT)
- Addgene plasmids for ICMT
- antibodies-online: Show 14 available ICMT Antibodies ranked by validation data
- Compare Top ICMT Antibodies
- antibodies-online: Show 6 available ICMT Elisa Kits ranked by validation data
- Compare Top ICMT Elisa Kits
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- antibodies-online: Show 6 available ICMT Proteins ranked by validation data
- Compare Top ICMT Proteins
- Quality Products:
- Horizon Cell Lines for ICMT
- genomics-online: cdna clones - Search results for available ICMT gene related products
- orf clones - Search results for available ICMT gene related products
- genomics-online: gRNA clones - Search results for available ICMT gene related products
- genomics-online: primer clones - Search results for available ICMT gene related products
- genomics-online: shRNA clones - Search results for available ICMT gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICMT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICMT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ICMT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT
- Biorbyt antibodies for ICMT
Sources for ICMT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource