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This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Homocysteinemia and Hallermann-Streiff Syndrome. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity | TAS | 9614111 |
GO:0004671 | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | IBA | 21873635 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IDA | 9614111 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA,TAS | 10441503 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Terpenoid backbone biosynthesis | ||
3 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
4 | G-protein signaling N-RAS regulation pathway |
G-protein signaling N-RAS regulation pathway
.52
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|
5 | G-protein signaling_H-RAS regulation pathway |
G-protein signaling_H-RAS regulation pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006464 | cellular protein modification process | TAS | 9614111 |
GO:0006481 | C-terminal protein methylation | IBA | 21873635 |
GO:0006612 | protein targeting to membrane | TAS | 9614111 |
GO:0032259 | methylation | IEA | -- |
GO:0043687 | post-translational protein modification | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
s-adenosylhomocysteine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ICMT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ICMT 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Icmt 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Icmt 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ICMT 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ICMT 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ICMT 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ICMT 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | icmt 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397717 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | icmt 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | ste14 30 31 |
|
OneToOne | |
CG11268 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001310 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | M01E11.1 30 31 32 |
|
OneToMany | |
F21F3.3 31 32 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE14 30 31 33 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAR122C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A02167g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | STE14A 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0602900 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00034 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mam4 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10934 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
775494 | Benign: not provided | 6,232,010(-) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
homocysteinemia |
|
|
hallermann-streiff syndrome |
|
|
restrictive dermopathy, lethal |
|
|
charcot-marie-tooth disease and deafness |
|
|
hutchinson-gilford progeria syndrome |
|
|