This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [pro... See more...

Aliases for ICMT Gene

Aliases for ICMT Gene

  • Isoprenylcysteine Carboxyl Methyltransferase 2 3 5
  • Protein-S-Isoprenylcysteine O-Methyltransferase 2 3 4
  • Prenylated Protein Carboxyl Methyltransferase 3 4
  • Prenylcysteine Carboxyl Methyltransferase 3 4
  • EC 2.1.1.100 4 52
  • PCCMT 3 4
  • PPMT 3 4
  • Isoprenylcysteine Carboxylmethyltransferase 4
  • MSTP098 3
  • HSTE14 3
  • MST098 3
  • PcCMT 4
  • PCMT 3

External Ids for ICMT Gene

Previous GeneCards Identifiers for ICMT Gene

  • GC01M005857
  • GC01M006090
  • GC01M005990
  • GC01M006215
  • GC01M006282
  • GC01M005429

Summaries for ICMT Gene

Entrez Gene Summary for ICMT Gene

  • This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICMT Gene

ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Homocysteinemia and Hallermann-Streiff Syndrome. Among its related pathways are Metabolism of proteins and G-protein signaling_H-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot Summary for ICMT Gene

  • Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Gene Wiki entry for ICMT Gene

Additional gene information for ICMT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICMT Gene

Genomics for ICMT Gene

GeneHancer (GH) Regulatory Elements for ICMT Gene

Promoters and enhancers for ICMT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J006233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 518.9 +0.8 846 3.7 RXRA SIN3A NRF1 MYC POLR2G PHF8 ZFX ZNF639 SIX5 POLR2A ICMT LINC00337 GPR153 RNF207
GH01J006259 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.7 -26.0 -25974 4.7 HNRNPK MYC ZIC2 ZBTB10 ZNF263 ZBTB26 KLF7 ZNF740 CTBP1 EZH2 GPR153 ICMT LINC00337 RPL22 LOC102724450 RNF207 CHD5 NOL9 THAP3 lnc-GPR153-1
GH01J006357 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 -123.5 -123498 4.2 CTCF POLR2G KDM6A ZBTB11 GABPA TARDBP RFX1 RELA ZNF740 MYC ACOT7 ESPN ICMT LINC00337 ENSG00000271746 RF00017-019
GH01J006218 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.2 +15.6 15583 3.2 ZNF217 ZNF10 CTBP1 SIN3A MYC ZNF316 MBD2 POLR2A FOS NR3C1 ICMT HES3 CHD5 LINC00337 NONHSAG000233.2 lnc-RPL22-2 RNF207
GH01J006222 Enhancer 0.8 Ensembl ENCODE dbSUPER 20.2 +12.0 12035 3.8 POLR2A ZBTB33 TCF7L2 JUND GLIS2 ZFX lnc-RPL22-2 ICMT HES3 CHD5 LINC00337 NONHSAG000233.2 piR-57460-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICMT on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICMT

Top Transcription factor binding sites by QIAGEN in the ICMT gene promoter:
  • ARP-1
  • Bach2
  • c-Myc
  • COMP1
  • Max1
  • NRSF form 1
  • NRSF form 2
  • STAT3

Genomic Locations for ICMT Gene

Genomic Locations for ICMT Gene
chr1:6,221,193-6,235,984
(GRCh38/hg38)
Size:
14,792 bases
Orientation:
Minus strand
chr1:6,281,253-6,296,044
(GRCh37/hg19)
Size:
14,792 bases
Orientation:
Minus strand

Genomic View for ICMT Gene

Genes around ICMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICMT Gene

Proteins for ICMT Gene

  • Protein details for ICMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60725-ICMT_HUMAN
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase
    Protein Accession:
    O60725
    Secondary Accessions:
    • Q6FHT0

    Protein attributes for ICMT Gene

    Size:
    284 amino acids
    Molecular mass:
    31938 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ICMT Gene

Selected DME Specific Peptides for ICMT Gene

O60725:
  • SLIHFFGE
  • RHPSYVG
  • HTLVTSGVY
  • GTQVMLCNP
  • VPTGLPFIKGVK
  • SFLLNHS

Post-translational modifications for ICMT Gene

  • Ubiquitination at Lys278
  • Modification sites at PhosphoSitePlus

Other Protein References for ICMT Gene

Domains & Families for ICMT Gene

Gene Families for ICMT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ICMT Gene

Blocks:
  • Gamma-crystallin related
  • Isoprenylcysteine carboxyl methyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICMT Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35571 fis, clone SPLEN2005806, highly similar to Protein-S-isoprenylcysteineO-methyltransferase (EC 2.1.1.100) (B3KS61_HUMAN)
  • Prenylcysteine carboxyl methyltransferase (ICMT_HUMAN)
  • Isoprenylcysteine carboxyl methyltransferase, isoform CRA_a (Q6FHT0_HUMAN)
  • MSTP098 (Q9NRT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60725

UniProtKB/Swiss-Prot:

ICMT_HUMAN :
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Family:
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
genes like me logo Genes that share domains with ICMT: view

Function for ICMT Gene

Molecular function for ICMT Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100; Evidence=. ;.

Enzyme Numbers (IUBMB) for ICMT Gene

Phenotypes From GWAS Catalog for ICMT Gene

Gene Ontology (GO) - Molecular Function for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity TAS 9614111
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ICMT: view
genes like me logo Genes that share phenotypes with ICMT: view

Animal Models for ICMT Gene

MGI Knock Outs for ICMT:

Animal Model Products

  • Taconic Biosciences Mouse Models for ICMT

CRISPR Products

miRNA for ICMT Gene

miRTarBase miRNAs that target ICMT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene

Localization for ICMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICMT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
golgi apparatus 2
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 9614111
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,TAS 10441503
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICMT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICMT Gene

Pathways & Interactions for ICMT Gene

genes like me logo Genes that share pathways with ICMT: view

Pathways by source for ICMT Gene

3 GeneGo (Thomson Reuters) pathways for ICMT Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_H-RAS regulation pathway
  • G-protein signaling_K-RAS regulation pathway

Gene Ontology (GO) - Biological Process for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9614111
GO:0006481 C-terminal protein methylation TAS,IEA --
GO:0006612 protein targeting to membrane TAS 9614111
GO:0032259 methylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ICMT: view

No data available for SIGNOR curated interactions for ICMT Gene

Drugs & Compounds for ICMT Gene

(3) Drugs for ICMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(4) Additional Compounds for ICMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with ICMT: view

Transcripts for ICMT Gene

mRNA/cDNA for ICMT Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICMT

Alternative Splicing Database (ASD) splice patterns (SP) for ICMT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ICMT Gene

GeneLoc Exon Structure for
ICMT

Expression for ICMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICMT Gene

This gene is overexpressed in Lung (25.4) and Placenta (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICMT Gene



Protein tissue co-expression partners for ICMT Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICMT

SOURCE GeneReport for Unigene cluster for ICMT Gene:

Hs.515688

mRNA Expression by UniProt/SwissProt for ICMT Gene:

O60725-ICMT_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Evidence on tissue expression from TISSUES for ICMT Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Blood(4.2)
  • Lymph node(4.2)
  • Lung(3.3)
  • Skin(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ICMT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICMT Gene

Orthologs for ICMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICMT 31 30
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ICMT 30
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Icmt 17 31 30
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Icmt 30
  • 88.03 (n)
cow
(Bos Taurus)
Mammalia ICMT 31
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICMT 31
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICMT 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICMT 31 30
  • 75.15 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia icmt 30
  • 70.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397717 30
zebrafish
(Danio rerio)
Actinopterygii icmt 31 30
  • 63.71 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ste14 31 30
  • 54.74 (n)
OneToOne
CG11268 32
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001310 30
  • 52.52 (n)
worm
(Caenorhabditis elegans)
Secernentea M01E11.1 31 32 30
  • 51.58 (n)
OneToMany
F21F3.3 31 32
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE14 33 31 30
  • 50.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR122C 30
  • 50.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02167g 30
  • 50.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons STE14A 30
  • 51.22 (n)
rice
(Oryza sativa)
Liliopsida Os04g0602900 30
  • 52.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00034 30
  • 48.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mam4 30
  • 45.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10934 31
  • 39 (a)
OneToOne
Species where no ortholog for ICMT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICMT Gene

ENSEMBL:
Gene Tree for ICMT (if available)
TreeFam:
Gene Tree for ICMT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICMT: view image

Paralogs for ICMT Gene

No data available for Paralogs for ICMT Gene

Variants for ICMT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICMT Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
775494 Benign: not provided 6,232,010(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ICMT Gene

Structural Variations from Database of Genomic Variants (DGV) for ICMT Gene

Variant ID Type Subtype PubMed ID
dgv28n106 CNV deletion 24896259
dgv8n67 CNV gain 20364138
nsv1076987 CNV deletion 25765185
nsv1119659 CNV deletion 24896259
nsv1119660 CNV deletion 24896259
nsv508825 CNV insertion 20534489
nsv545236 CNV loss 21841781
nsv831425 CNV loss 17160897

Variation tolerance for ICMT Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene

Disorders for ICMT Gene

MalaCards: The human disease database

(4) MalaCards diseases for ICMT Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
homocysteinemia
  • hyperhomocysteinemia
hallermann-streiff syndrome
  • hss
hutchinson-gilford progeria syndrome
  • hgps
legionnaire disease
  • legionnaire disease, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ICMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene

Publications for ICMT Gene

  1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q … Philips MR (The Journal of biological chemistry 1998) 2 3 4 23 54
  2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright LP … Philips MR (Molecular and cellular biology 2009) 3 4 23 54
  3. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 41 54
  4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 41 54
  5. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I … Casey PJ (The Journal of biological chemistry 2009) 3 23 54

Products for ICMT Gene

  • Biorbyt antibodies for ICMT

Sources for ICMT Gene