Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICMT Gene

Aliases for ICMT Gene

  • Isoprenylcysteine Carboxyl Methyltransferase 2 3 5
  • Protein-S-Isoprenylcysteine O-Methyltransferase 2 3
  • Prenylated Protein Carboxyl Methyltransferase 3 4
  • Prenylcysteine Carboxyl Methyltransferase 3 4
  • EC 4 56
  • PCCMT 3 4
  • PPMT 3 4
  • Isoprenylcysteine Carboxylmethyltransferase 4
  • MSTP098 3
  • HSTE14 3
  • MST098 3
  • PCMT 3

External Ids for ICMT Gene

Previous GeneCards Identifiers for ICMT Gene

  • GC01M005857
  • GC01M006090
  • GC01M005990
  • GC01M006215
  • GC01M005429

Summaries for ICMT Gene

Entrez Gene Summary for ICMT Gene

  • This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICMT Gene

ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Hallermann-Streiff Syndrome. Among its related pathways are G-protein signaling N-RAS regulation pathway and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ICMT Gene

  • Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Gene Wiki entry for ICMT Gene

Additional gene information for ICMT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICMT Gene

Genomics for ICMT Gene

GeneHancer (GH) Regulatory Elements for ICMT Gene

Promoters and enhancers for ICMT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I006233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569 +1.0 993 3.4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B E2F8 SP3 ICMT LINC00337 ZBTB48 RPL22 THAP3 NOL9 GPR153 RNF207
GH01I006259 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.7 -26.0 -26014 4.6 PKNOX1 ATF1 ARID4B SIN3A BRCA1 GLIS2 KLF7 ATF7 ZNF263 SP3 GPR153 GC01P006262 ICMT LINC00337 RPL22 LOC102724450 RNF207 CHD5 NOL9 THAP3
GH01I006357 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.9 -123.5 -123498 4.2 HDGF PKNOX1 FOXA2 ARID4B DMAP1 YY1 SLC30A9 ZNF143 SP5 REST ACOT7 ESPN ICMT LINC00337 ENSG00000271746 GC01P006262
GH01I006218 Enhancer 0.9 ENCODE dbSUPER 20.2 +15.5 15545 2.9 SIX4 PKNOX1 NEUROD1 SIN3A EBF1 CTBP1 ZNF316 GATA3 POLR2A FOSL2 ICMT HES3 CHD5 LINC00337 RNF207 RPL22
GH01I006352 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 -118.1 -118120 2.3 TFAP4 PKNOX1 MXI1 SAP130 ARID4B MAX THRB RFX5 TEAD3 GLIS2 ESPN ICMT LINC00337 ENSG00000271746 ACOT7 GC01P006262
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ICMT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ICMT gene promoter:

Genomic Locations for ICMT Gene

Genomic Locations for ICMT Gene
14,792 bases
Minus strand

Genomic View for ICMT Gene

Genes around ICMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICMT Gene

Proteins for ICMT Gene

  • Protein details for ICMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q6FHT0

    Protein attributes for ICMT Gene

    284 amino acids
    Molecular mass:
    31938 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ICMT Gene

Selected DME Specific Peptides for ICMT Gene


Post-translational modifications for ICMT Gene

Other Protein References for ICMT Gene

Domains & Families for ICMT Gene

Gene Families for ICMT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
genes like me logo Genes that share domains with ICMT: view

Function for ICMT Gene

Molecular function for ICMT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
UniProtKB/Swiss-Prot Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Enzyme Numbers (IUBMB) for ICMT Gene

Phenotypes From GWAS Catalog for ICMT Gene

Gene Ontology (GO) - Molecular Function for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity TAS 9614111
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity TAS --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ICMT: view
genes like me logo Genes that share phenotypes with ICMT: view

Animal Models for ICMT Gene

MGI Knock Outs for ICMT:

Animal Model Products

CRISPR Products

miRNA for ICMT Gene

miRTarBase miRNAs that target ICMT

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICMT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene

Localization for ICMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICMT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 9614111
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane TAS,IEA 10441503
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICMT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICMT Gene

Pathways & Interactions for ICMT Gene

genes like me logo Genes that share pathways with ICMT: view

Gene Ontology (GO) - Biological Process for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9614111
GO:0006481 C-terminal protein methylation TAS,IEA --
GO:0006612 protein targeting to membrane TAS 9614111
GO:0032259 methylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ICMT: view

No data available for SIGNOR curated interactions for ICMT Gene

Drugs & Compounds for ICMT Gene

(3) Drugs for ICMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(4) Additional Compounds for ICMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
genes like me logo Genes that share compounds with ICMT: view

Transcripts for ICMT Gene

Unigene Clusters for ICMT Gene

Isoprenylcysteine carboxyl methyltransferase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICMT

Alternative Splicing Database (ASD) splice patterns (SP) for ICMT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP2: -
SP3: -
SP4: - -

Relevant External Links for ICMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICMT Gene

This gene is overexpressed in Lung (25.4) and Placenta (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ICMT Gene

Protein tissue co-expression partners for ICMT Gene

NURSA nuclear receptor signaling pathways regulating expression of ICMT Gene:


SOURCE GeneReport for Unigene cluster for ICMT Gene:


mRNA Expression by UniProt/SwissProt for ICMT Gene:

Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Evidence on tissue expression from TISSUES for ICMT Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Blood(4.2)
  • Lymph node(4.2)
  • Lung(3.3)
  • Skin(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ICMT: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICMT Gene

Orthologs for ICMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICMT 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia ICMT 33
  • 92.61 (n)
(Mus musculus)
Mammalia Icmt 33 16 34
  • 89.08 (n)
(Rattus norvegicus)
Mammalia Icmt 33
  • 88.03 (n)
(Bos Taurus)
Mammalia ICMT 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ICMT 34
  • 88 (a)
(Monodelphis domestica)
Mammalia ICMT 34
  • 78 (a)
(Gallus gallus)
Aves ICMT 33 34
  • 75.15 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia icmt 33
  • 70.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397717 33
(Danio rerio)
Actinopterygii icmt 33 34
  • 63.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta ste14 33 34
  • 54.74 (n)
CG11268 35
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001310 33
  • 52.52 (n)
(Caenorhabditis elegans)
Secernentea M01E11.1 35 33 34
  • 51.58 (n)
F21F3.3 35 34
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE14 33 34 36
  • 50.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR122C 33
  • 50.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02167g 33
  • 50.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons STE14A 33
  • 51.22 (n)
(Oryza sativa)
Liliopsida Os04g0602900 33
  • 52.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00034 33
  • 48.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mam4 33
  • 45.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10934 34
  • 39 (a)
Species where no ortholog for ICMT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICMT Gene

Gene Tree for ICMT (if available)
Gene Tree for ICMT (if available)

Paralogs for ICMT Gene

No data available for Paralogs for ICMT Gene

Variants for ICMT Gene

Sequence variations from dbSNP and Humsavar for ICMT Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032691 -- 6,230,081(-) G/C intron_variant
rs1000138378 -- 6,233,094(-) T/C intron_variant
rs1000430267 -- 6,232,982(-) C/T intron_variant
rs1000521636 -- 6,235,958(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000763311 -- 6,234,166(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ICMT Gene

Variant ID Type Subtype PubMed ID
nsv831425 CNV loss 17160897
nsv545236 CNV loss 21841781
nsv508825 CNV insertion 20534489
nsv1119660 CNV deletion 24896259
nsv1119659 CNV deletion 24896259
nsv1076987 CNV deletion 25765185
dgv8n67 CNV gain 20364138
dgv28n106 CNV deletion 24896259

Variation tolerance for ICMT Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene

Disorders for ICMT Gene

MalaCards: The human disease database

(1) MalaCards diseases for ICMT Gene - From: DISEASES

Disorder Aliases PubMed IDs
hallermann-streiff syndrome
  • hss
- elite association - COSMIC cancer census association via MalaCards
Search ICMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICMT

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene

Publications for ICMT Gene

  1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q … Philips MR (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright LP … Philips MR (Molecular and cellular biology 2009) 3 4 22 58
  3. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 44 58
  4. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I … Casey PJ (The Journal of biological chemistry 2009) 3 22 58
  5. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 44 58

Products for ICMT Gene

Sources for ICMT Gene

Loading form....