The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic bi... See more...

Aliases for ICAM5 Gene

Aliases for ICAM5 Gene

  • Intercellular Adhesion Molecule 5 2 3 4 5
  • Telencephalin 2 3 4
  • TLN 2 3 4
  • ICAM-5 3 4
  • TLCN 3 4
  • Intercellular Adhesion Molecule 5, Telencephalin 3
  • ICAM5 5

External Ids for ICAM5 Gene

Previous HGNC Symbols for ICAM5 Gene

  • TLCN

Previous GeneCards Identifiers for ICAM5 Gene

  • GC19P010522
  • GC19P010623
  • GC19P010246
  • GC19P010261
  • GC19P010400
  • GC19P009980

Summaries for ICAM5 Gene

Entrez Gene Summary for ICAM5 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM5 Gene

ICAM5 (Intercellular Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with ICAM5 include Acute Hemorrhagic Conjunctivitis and Holoprosencephaly. Among its related pathways are Degradation of the extracellular matrix and Innate Immune System. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM3.

UniProtKB/Swiss-Prot Summary for ICAM5 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Gene Wiki entry for ICAM5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICAM5 Gene

Genomics for ICAM5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ICAM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010285 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 611.4 +0.3 304 7.5 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ ICAM5 ENSG00000267607 ICAM4 ILF3 ZNF266 ZNF699 KRI1 FBXL12 RAVER1 ZNF561
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.4 +114.9 114866 6.5 SP1 HNRNPL CREB1 CTCF ATF7 PRDM10 ZNF629 RFX1 IKZF1 NFKBIZ PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 KANK2 MRPL4 ICAM5 ICAM4
GH19J010338 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 12.6 +50.2 50192 1.9 POLR2A BACH1 LARP7 RELA SMAD5 YY1 SIN3A ELK1 DPF2 RELB ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM4 ICAM5 ICAM1 MRPL4 ENSG00000274425 RAVER1
GH19J010304 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 7.9 +16.1 16081 1.3 IKZF1 JUND MTA2 PHF21A MTA1 NR2C1 EGR1 ZBTB2 HDAC2 E2F5 ZGLP1 lnc-ZGLP1-1 ICAM5 ENSG00000167807
GH19J010388 Enhancer 1 Ensembl ENCODE 13 +99.7 99650 1.2 CTCF TEAD4 IKZF1 POLR2A JUND DDX20 ZNF143 RELA REST SMAD5 ICAM1 ZGLP1 ICAM5 MRPL4 ICAM4 EIF3G TMEM205 TYK2 lnc-TIMM29-1 MIR1181
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICAM5

Top Transcription factor binding sites by QIAGEN in the ICAM5 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • GR
  • GR-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ICAM5 Gene

Genomic Locations for ICAM5 Gene
chr19:10,289,351-10,296,778
(GRCh38/hg38)
Size:
7,428 bases
Orientation:
Plus strand
chr19:10,400,655-10,407,454
(GRCh37/hg19)
Size:
6,800 bases
Orientation:
Plus strand

Genomic View for ICAM5 Gene

Genes around ICAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM5 Gene

Proteins for ICAM5 Gene

  • Protein details for ICAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMF0-ICAM5_HUMAN
    Recommended name:
    Intercellular adhesion molecule 5
    Protein Accession:
    Q9UMF0
    Secondary Accessions:
    • Q9Y6F3

    Protein attributes for ICAM5 Gene

    Size:
    924 amino acids
    Molecular mass:
    97116 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM5 Gene

neXtProt entry for ICAM5 Gene

Post-translational modifications for ICAM5 Gene

  • Glycosylation at Asn-54 is critical for functional folding.
  • Glycosylation at Asn54, Asn74, Asn137, Asn195, Asn214, Asn303, Asn316, Asn371, Asn397, Asn583, Asn646, Asn764, Asn795, and Asn796
  • Modification sites at PhosphoSitePlus

Other Protein References for ICAM5 Gene

No data available for DME Specific Peptides for ICAM5 Gene

Domains & Families for ICAM5 Gene

Gene Families for ICAM5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICAM5 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin I-set
  • Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
  • Intercellular adhesion molecule (ICAM) family signature
  • Intercellular adhesion molecule, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ICAM5 Gene

GenScript: Design optimal peptide antigens:
  • Telencephalin (ICAM5_HUMAN)
  • ICAM5 protein (Q8N6I2_HUMAN)
  • Intercellular adhesion molecule 5, telencephalin (Q8TAM9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UMF0

UniProtKB/Swiss-Prot:

ICAM5_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM5: view

Function for ICAM5 Gene

Molecular function for ICAM5 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
GENATLAS Biochemistry:
intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the telencephalin from birth and throughout life

Phenotypes From GWAS Catalog for ICAM5 Gene

Gene Ontology (GO) - Molecular Function for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA 21873635
GO:0005515 protein binding IPI 16820411
genes like me logo Genes that share ontologies with ICAM5: view
genes like me logo Genes that share phenotypes with ICAM5: view

Animal Model Products

CRISPR Products

miRNA for ICAM5 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM5 Gene

Localization for ICAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM5 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICAM5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICAM5 Gene

Pathways & Interactions for ICAM5 Gene

genes like me logo Genes that share pathways with ICAM5: view

Gene Ontology (GO) - Biological Process for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0007155 cell adhesion IBA 21873635
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ICAM5: view

No data available for SIGNOR curated interactions for ICAM5 Gene

Drugs & Compounds for ICAM5 Gene

No Compound Related Data Available

Transcripts for ICAM5 Gene

mRNA/cDNA for ICAM5 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM5

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3:

Relevant External Links for ICAM5 Gene

GeneLoc Exon Structure for
ICAM5

Expression for ICAM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICAM5 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.8), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Frontal Cortex (BA9) (x5.5), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ICAM5 Gene

This gene is overexpressed in Brain (39.9) and Frontal cortex (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ICAM5 Gene



Protein tissue co-expression partners for ICAM5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICAM5

SOURCE GeneReport for Unigene cluster for ICAM5 Gene:

Hs.465862

mRNA Expression by UniProt/SwissProt for ICAM5 Gene:

Q9UMF0-ICAM5_HUMAN
Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Evidence on tissue expression from TISSUES for ICAM5 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ICAM5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM5 Gene

Orthologs for ICAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ICAM5 30 31
  • 94.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ICAM5 30 31
  • 87.2 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ICAM5 30 31
  • 86.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Icam5 30 17 31
  • 82.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Icam5 30
  • 81.79 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 29 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia icam5 30
  • 45.4 (n)
Species where no ortholog for ICAM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ICAM5 Gene

ENSEMBL:
Gene Tree for ICAM5 (if available)
TreeFam:
Gene Tree for ICAM5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICAM5: view image

Paralogs for ICAM5 Gene

Paralogs for ICAM5 Gene

(4) SIMAP similar genes for ICAM5 Gene using alignment to 4 proteins:

  • ICAM5_HUMAN
  • K7EIL3_HUMAN
  • Q8N6I2_HUMAN
  • Q8TAM9_HUMAN
genes like me logo Genes that share paralogs with ICAM5: view

Variants for ICAM5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICAM5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_035515 A breast cancer sample p.Leu140Val
VAR_035516 A breast cancer sample p.Arg188Trp
VAR_035517 A breast cancer sample p.Glu488Gln
rs1056538 - p.Val301Ile
rs2228615 - p.Ala348Thr

Additional dbSNP identifiers (rs#s) for ICAM5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ICAM5 Gene

Variant ID Type Subtype PubMed ID
nsv470124 CNV gain 18288195
nsv953974 CNV deletion 24416366

Variation tolerance for ICAM5 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.33; 96.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM5 Gene

Human Gene Mutation Database (HGMD)
ICAM5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM5 Gene

Disorders for ICAM5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ICAM5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute hemorrhagic conjunctivitis
  • apollo disease
holoprosencephaly
  • holoprosencephaly sequence
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ICAM5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ICAM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM5 Gene

Publications for ICAM5 Gene

  1. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PMID: 9828136) Kilgannon P … Gallatin WM (Genomics 1998) 2 3 4 23
  2. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PMID: 8995416) Mizuno T … Mori K (The Journal of biological chemistry 1997) 2 3 4 23
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for ICAM5 Gene

  • Boster Bio Antibodies for ICAM5
  • Boster Bio ELISA Kits for ICAM5

Sources for ICAM5 Gene