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The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
ICAM5 (Intercellular Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with ICAM5 include Acute Hemorrhagic Conjunctivitis and Holoprosencephaly. Among its related pathways are Degradation of the extracellular matrix and Innate Immune System. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16820411 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006909 | phagocytosis | IEA | -- |
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0030198 | extracellular matrix organization | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
GO:0098609 | cell-cell adhesion | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ICAM5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ICAM5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ICAM5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Icam5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Icam5 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | icam5 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_035515 | A breast cancer sample | p.Leu140Val | |||
VAR_035516 | A breast cancer sample | p.Arg188Trp | |||
VAR_035517 | A breast cancer sample | p.Glu488Gln | |||
rs1056538 | - | p.Val301Ile | |||
rs2228615 | - | p.Ala348Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute hemorrhagic conjunctivitis |
|
|
holoprosencephaly |
|
|
breast cancer |
|
|