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Aliases for ICAM4 Gene

Aliases for ICAM4 Gene

  • Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group) 2 3 5
  • Intercellular Adhesion Molecule 4 (LW Blood Group) 2 3
  • Landsteiner-Wiener Blood Group Glycoprotein 3 4
  • CD242 Antigen 3 4
  • LW 3 4
  • Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group 2
  • Landsteiner-Wiener Blood Group Antigen A 3
  • Intercellular Adhesion Molecule 4 3
  • Landsteiner-Wiener Blood Group 2
  • LW Blood Group Protein 4
  • LW Antigen A 3
  • ICAM-4 4
  • CD242 3

External Ids for ICAM4 Gene

Previous HGNC Symbols for ICAM4 Gene

  • LW

Previous GeneCards Identifiers for ICAM4 Gene

  • GC19P010519
  • GC19P010620
  • GC19P010242
  • GC19P010258
  • GC19P010397
  • GC19P009977

Summaries for ICAM4 Gene

Entrez Gene Summary for ICAM4 Gene

  • This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM4 Gene

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include Blood Group System, Landsteiner-Wiener. Among its related pathways are Innate Immune System and ECM-receptor interaction. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot for ICAM4 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Additional gene information for ICAM4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM4 Gene

Genomics for ICAM4 Gene

GeneHancer (GH) Regulatory Elements for ICAM4 Gene

Promoters and enhancers for ICAM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010285 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.7 2725 7.6 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ICAM5 ENSG00000267607 GC19P010288 GC19P010291 ICAM4 ILF3 ZNF266 ZNF699 KRI1 FBXL12
GH19I010400 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 12.4 +117.3 117250 6.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 MIR1181 CDC37 ICAM1 MRPL4 ICAM5 ICAM4 RAVER1 PDE4A TYK2 C19orf38
GH19I010338 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 12.5 +52.4 52377 2.3 HDGF BCOR BACH1 ZNF384 EBF1 ZNF48 YY1 RELA ZNF121 POLR2A ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM5 ICAM4 ICAM1 MRPL4 PIR48013
GH19I010250 Enhancer 1.1 Ensembl ENCODE 12 -36.8 -36766 0.4 HDAC1 RB1 ARNT ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF335 ZNF121 MRPL4 ICAM4 ICAM5 EIF3G TYK2 C19orf66 S1PR2
GH19I010388 Enhancer 0.8 ENCODE 12.4 +102.1 102093 0.2 PKNOX1 ARID4B SIN3A RAD21 ARID2 ZNF207 ZNF143 BCLAF1 IKZF2 DEK ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G GC19P010382 MIR1181
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ICAM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ICAM4 gene promoter:

Genomic Locations for ICAM4 Gene

Genomic Locations for ICAM4 Gene
chr19:10,286,967-10,288,584
(GRCh38/hg38)
Size:
1,618 bases
Orientation:
Plus strand
chr19:10,397,643-10,399,198
(GRCh37/hg19)

Genomic View for ICAM4 Gene

Genes around ICAM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM4 Gene

Proteins for ICAM4 Gene

  • Protein details for ICAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14773-ICAM4_HUMAN
    Recommended name:
    Intercellular adhesion molecule 4
    Protein Accession:
    Q14773
    Secondary Accessions:
    • A0M8X2
    • Q14771
    • Q14772
    • Q16375
    • Q9BWR0

    Protein attributes for ICAM4 Gene

    Size:
    271 amino acids
    Molecular mass:
    29265 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICAM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICAM4 Gene

Post-translational modifications for ICAM4 Gene

  • N- and O-glycosylated.
  • Glycosylation at isoforms=3, 268, isoforms=3, 278, posLast=190190, and posLast=223223

Other Protein References for ICAM4 Gene

No data available for DME Specific Peptides for ICAM4 Gene

Domains & Families for ICAM4 Gene

Gene Families for ICAM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ICAM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14773

UniProtKB/Swiss-Prot:

ICAM4_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM4: view

Function for ICAM4 Gene

Molecular function for ICAM4 Gene

GENATLAS Biochemistry:
adhesion molecule,intercellular 4
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Phenotypes From GWAS Catalog for ICAM4 Gene

Gene Ontology (GO) - Molecular Function for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 8566017
genes like me logo Genes that share ontologies with ICAM4: view
genes like me logo Genes that share phenotypes with ICAM4: view

Animal Models for ICAM4 Gene

MGI Knock Outs for ICAM4:

miRNA for ICAM4 Gene

miRTarBase miRNAs that target ICAM4

Clone Products

  • Addgene plasmids for ICAM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM4 Gene

Localization for ICAM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM4 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein.
Isoform Short: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 6431896
genes like me logo Genes that share ontologies with ICAM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICAM4 Gene

Pathways & Interactions for ICAM4 Gene

genes like me logo Genes that share pathways with ICAM4: view

Gene Ontology (GO) - Biological Process for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA --
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ICAM4: view

No data available for SIGNOR curated interactions for ICAM4 Gene

Drugs & Compounds for ICAM4 Gene

No Compound Related Data Available

Transcripts for ICAM4 Gene

Unigene Clusters for ICAM4 Gene

Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group):
Representative Sequences:

Clone Products

  • Addgene plasmids for ICAM4

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ICAM4 Gene

GeneLoc Exon Structure for
ICAM4
ECgene alternative splicing isoforms for
ICAM4

Expression for ICAM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICAM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM4 Gene

This gene is overexpressed in Whole Blood (x15.1) and Lung (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of ICAM4 Gene:

ICAM4

SOURCE GeneReport for Unigene cluster for ICAM4 Gene:

Hs.706750

mRNA Expression by UniProt/SwissProt for ICAM4 Gene:

Q14773-ICAM4_HUMAN
Tissue specificity: Erythrocytes.

Evidence on tissue expression from TISSUES for ICAM4 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ICAM4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM4 Gene

Orthologs for ICAM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ICAM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICAM4 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia ICAM4 33 34
  • 79.39 (n)
cow
(Bos Taurus)
Mammalia ICAM4 33 34
  • 76.87 (n)
rat
(Rattus norvegicus)
Mammalia Icam4 33
  • 75.21 (n)
mouse
(Mus musculus)
Mammalia Icam4 33 16 34
  • 74.33 (n)
Species where no ortholog for ICAM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM4 Gene

ENSEMBL:
Gene Tree for ICAM4 (if available)
TreeFam:
Gene Tree for ICAM4 (if available)

Paralogs for ICAM4 Gene

Paralogs for ICAM4 Gene

genes like me logo Genes that share paralogs with ICAM4: view

Variants for ICAM4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM4 Gene

ICAM4_HUMAN-Q14773
Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).

Sequence variations from dbSNP and Humsavar for ICAM4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs77493670 affects, Landsteiner-Wiener phenotype 10,287,311(+) A/G coding_sequence_variant, missense_variant
rs1000675984 -- 10,285,576(+) G/A/C upstream_transcript_variant
rs1001130557 -- 10,285,254(+) C/T upstream_transcript_variant
rs1002288516 -- 10,285,542(+) T/C upstream_transcript_variant
rs1002582178 -- 10,285,907(+) C/T upstream_transcript_variant

Variation tolerance for ICAM4 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM4 Gene

Human Gene Mutation Database (HGMD)
ICAM4
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM4

SNP Genotyping and Copy Number Assay Products

No data available for Structural Variations from Database of Genomic Variants (DGV) for ICAM4 Gene

Disorders for ICAM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ICAM4 Gene - From: OMIM

Disorder Aliases PubMed IDs
blood group system, landsteiner-wiener
  • lw
- elite association - COSMIC cancer census association via MalaCards
Search ICAM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICAM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM4 Gene

Publications for ICAM4 Gene

  1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PMID: 8639917) Hermand P … Bailly P (Blood 1996) 2 3 4 22 58
  2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PMID: 8202485) Bailly P … Cartron JP (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 58
  3. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PMID: 21533024) Paré G … Chasman DI (PLoS genetics 2011) 3 44 58
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for ICAM4 Gene

  • Addgene plasmids for ICAM4

Sources for ICAM4 Gene

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