This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is ... See more...

Aliases for ICAM4 Gene

Aliases for ICAM4 Gene

  • Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group) 2 3 5
  • Intercellular Adhesion Molecule 4 (LW Blood Group) 2 3
  • Landsteiner-Wiener Blood Group Glycoprotein 3 4
  • Intercellular Adhesion Molecule 4 3 4
  • CD242 Antigen 3 4
  • CD242 2 3
  • LW 3 4
  • Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group 2
  • Landsteiner-Wiener Blood Group Antigen A 3
  • Landsteiner-Wiener Blood Group 2
  • LW Blood Group Protein 4
  • LW Antigen A 3
  • ICAM-4 4
  • ICAM4 5

External Ids for ICAM4 Gene

Previous HGNC Symbols for ICAM4 Gene

  • LW

Previous GeneCards Identifiers for ICAM4 Gene

  • GC19P010519
  • GC19P010620
  • GC19P010242
  • GC19P010258
  • GC19P010397
  • GC19P009977

Summaries for ICAM4 Gene

Entrez Gene Summary for ICAM4 Gene

  • This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM4 Gene

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include Blood Group System, Landsteiner-Wiener and Anemia, Congenital Dyserythropoietic, Type Iv. Among its related pathways are Degradation of the extracellular matrix and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot Summary for ICAM4 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Additional gene information for ICAM4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICAM4 Gene

Genomics for ICAM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ICAM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010285 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 600.7 +2.7 2700 7.5 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ ICAM5 ENSG00000267607 ICAM4 ILF3 ZNF266 ZNF699 KRI1 FBXL12 RAVER1 ZNF561
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.4 +117.3 117262 6.5 SP1 HNRNPL CREB1 CTCF ATF7 PRDM10 ZNF629 RFX1 IKZF1 NFKBIZ PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 KANK2 MRPL4 ICAM5 ICAM4
GH19J010338 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 12.6 +52.6 52588 1.9 POLR2A BACH1 LARP7 RELA SMAD5 YY1 SIN3A ELK1 DPF2 RELB ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM4 ICAM5 ICAM1 MRPL4 ENSG00000274425 RAVER1
GH19J010388 Enhancer 1 Ensembl ENCODE 12.4 +102.0 102046 1.2 CTCF TEAD4 IKZF1 POLR2A JUND DDX20 ZNF143 RELA REST SMAD5 ICAM1 ZGLP1 ICAM5 MRPL4 ICAM4 EIF3G TMEM205 TYK2 lnc-TIMM29-1 MIR1181
GH19J010390 Enhancer 0.9 Ensembl ENCODE 12.4 +103.6 103622 0.8 CTCF ZBTB33 TEAD4 IKZF1 POLR2A PATZ1 REST RAD21 IKZF2 TRIM22 ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G lnc-TIMM29-1 MIR1181 TYK2 PDE4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICAM4

Top Transcription factor binding sites by QIAGEN in the ICAM4 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • GR
  • GR-alpha
  • STAT1
  • STAT1alpha

Genomic Locations for ICAM4 Gene

Genomic Locations for ICAM4 Gene
chr19:10,286,955-10,288,522
(GRCh38/hg38)
Size:
1,568 bases
Orientation:
Plus strand
chr19:10,397,643-10,399,198
(GRCh37/hg19)
Size:
1,556 bases
Orientation:
Plus strand

Genomic View for ICAM4 Gene

Genes around ICAM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM4 Gene

Proteins for ICAM4 Gene

  • Protein details for ICAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14773-ICAM4_HUMAN
    Recommended name:
    Intercellular adhesion molecule 4
    Protein Accession:
    Q14773
    Secondary Accessions:
    • A0M8X2
    • Q14771
    • Q14772
    • Q16375
    • Q9BWR0

    Protein attributes for ICAM4 Gene

    Size:
    271 amino acids
    Molecular mass:
    29265 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICAM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICAM4 Gene

Post-translational modifications for ICAM4 Gene

Other Protein References for ICAM4 Gene

No data available for DME Specific Peptides for ICAM4 Gene

Domains & Families for ICAM4 Gene

Gene Families for ICAM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICAM4 Gene

InterPro:
Blocks:
  • Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
  • Intercellular adhesion molecule, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ICAM4 Gene

GenScript: Design optimal peptide antigens:
  • Landsteiner-Wiener blood group glycoprotein (ICAM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14773

UniProtKB/Swiss-Prot:

ICAM4_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM4: view

Function for ICAM4 Gene

Molecular function for ICAM4 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
GENATLAS Biochemistry:
adhesion molecule,intercellular 4

Phenotypes From GWAS Catalog for ICAM4 Gene

Gene Ontology (GO) - Molecular Function for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS,IBA 21873635
genes like me logo Genes that share ontologies with ICAM4: view
genes like me logo Genes that share phenotypes with ICAM4: view

Animal Models for ICAM4 Gene

MGI Knock Outs for ICAM4:

Animal Model Products

CRISPR Products

miRNA for ICAM4 Gene

miRTarBase miRNAs that target ICAM4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM4

Clone Products

  • Addgene plasmids for ICAM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM4 Gene

Localization for ICAM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM4 Gene

[Isoform Long]: Cell membrane. Single-pass type I membrane protein.
[Isoform Short]: Secreted.
Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 6431896
genes like me logo Genes that share ontologies with ICAM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICAM4 Gene

Pathways & Interactions for ICAM4 Gene

genes like me logo Genes that share pathways with ICAM4: view

Gene Ontology (GO) - Biological Process for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ICAM4: view

No data available for SIGNOR curated interactions for ICAM4 Gene

Drugs & Compounds for ICAM4 Gene

No Compound Related Data Available

Transcripts for ICAM4 Gene

mRNA/cDNA for ICAM4 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM4

Clone Products

  • Addgene plasmids for ICAM4

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ICAM4 Gene

GeneLoc Exon Structure for
ICAM4

Expression for ICAM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICAM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM4 Gene

This gene is overexpressed in Whole Blood (x15.1) and Lung (x9.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICAM4

SOURCE GeneReport for Unigene cluster for ICAM4 Gene:

Hs.706750

mRNA Expression by UniProt/SwissProt for ICAM4 Gene:

Q14773-ICAM4_HUMAN
Tissue specificity: Erythrocytes.

Evidence on tissue expression from TISSUES for ICAM4 Gene

  • Lung(4.2)
  • Blood(2.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with ICAM4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM4 Gene

Orthologs for ICAM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ICAM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ICAM4 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ICAM4 30 31
  • 79.39 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ICAM4 30 31
  • 76.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Icam4 30
  • 75.21 (n)
Mouse
(Mus musculus)
Mammalia Icam4 30 17 31
  • 74.33 (n)
OneToOne
Species where no ortholog for ICAM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ICAM4 Gene

ENSEMBL:
Gene Tree for ICAM4 (if available)
TreeFam:
Gene Tree for ICAM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICAM4: view image

Paralogs for ICAM4 Gene

Paralogs for ICAM4 Gene

genes like me logo Genes that share paralogs with ICAM4: view

Variants for ICAM4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM4 Gene

ICAM4_HUMAN-Q14773
Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICAM4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs77493670 Affects: Landsteiner-Wiener phenotype. - 10,287,311(+) A/Gp.Gln100Arg MISSENSE_VARIANT
rs36023325 - p.Val208Leu

Additional dbSNP identifiers (rs#s) for ICAM4 Gene

Variation tolerance for ICAM4 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM4 Gene

Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
Human Gene Mutation Database (HGMD)
ICAM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM4

SNP Genotyping and Copy Number Assay Products

No data available for Structural Variations from Database of Genomic Variants (DGV) for ICAM4 Gene

Disorders for ICAM4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ICAM4 Gene - From: OMIM and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ICAM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ICAM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM4 Gene

Publications for ICAM4 Gene

  1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PMID: 8639917) Hermand P … Bailly P (Blood 1996) 2 3 4 23
  2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PMID: 8202485) Bailly P … Cartron JP (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 23
  3. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PMID: 21533024) Paré G … Chasman DI (PLoS genetics 2011) 3 41
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41

Products for ICAM4 Gene

Sources for ICAM4 Gene