Aliases for ICAM4 Gene
External Ids for ICAM4 Gene
Previous HGNC Symbols for ICAM4 Gene
Previous GeneCards Identifiers for ICAM4 Gene
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICAM4 Gene
ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include Blood Group System, Landsteiner-Wiener and Anemia, Congenital Dyserythropoietic, Type Iv. Among its related pathways are Degradation of the extracellular matrix and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.
UniProtKB/Swiss-Prot Summary for ICAM4 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.