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Aliases for ICAM3 Gene

Aliases for ICAM3 Gene

  • Intercellular Adhesion Molecule 3 2 3 3 5
  • ICAM-3 3 4
  • ICAM-R 3 4
  • CD50 Antigen 4
  • CDW50 3
  • CDw50 4
  • CD50 3

External Ids for ICAM3 Gene

Previous GeneCards Identifiers for ICAM3 Gene

  • GC19M010565
  • GC19M010667
  • GC19M010289
  • GC19M010305
  • GC19M010444
  • GC19M010024

Summaries for ICAM3 Gene

Entrez Gene Summary for ICAM3 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for ICAM3 Gene

ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include Actinic Prurigo and Trichosporonosis. Among its related pathways are CD209 (DC-SIGN) signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot for ICAM3 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Gene Wiki entry for ICAM3 Gene

Additional gene information for ICAM3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM3 Gene

Genomics for ICAM3 Gene

GeneHancer (GH) Regulatory Elements for ICAM3 Gene

Promoters and enhancers for ICAM3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010338 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 664.4 +0.5 485 2.3 HDGF BCOR BACH1 EBF1 ZNF384 ZNF48 RELA YY1 ZNF121 POLR2A ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM5 ICAM4 ICAM1 MRPL4 PIR48013
GH19J010601 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 -264.3 -264294 4.4 ARID4B DMAP1 ZNF2 YY1 TCF12 ZNF121 ZNF766 GLIS2 ZNF213 ZNF143 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 ZNF627 PRKCSH TYK2 DNM2 S1PR5
GH19J010345 Enhancer 1.3 FANTOM5 Ensembl ENCODE 28 -6.7 -6749 1.7 HDAC1 PKNOX1 ATF1 FOXA2 ARID4B RFX5 YY1 ZNF614 EGR1 ATF7 CDKN2D ICAM3 SLC44A2 TYK2 RAVER1 DNM2 ICAM1 ATG4D GC19M010353
GH19J010595 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -256.4 -256372 2 NFATC3 ZSCAN4 MAX EBF1 BATF IRF4 ADNP VEZF1 ATF7 IKZF2 KRI1 CDKN2D SLC44A2 ICAM3 ATG4D ILF3 TYK2 DNM2 C19orf38 S1PR5
GH19J010331 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 +6.2 6152 3.7 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 RAVER1 PIR48013 ENSG00000274425 ILF3 LOC100419831 ZNF266 KRI1 FBXL12 DNMT1 PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ICAM3 gene promoter:
  • Sp1
  • Bach2
  • Pax-3
  • Tal-1beta

Genomic Locations for ICAM3 Gene

Genomic Locations for ICAM3 Gene
6,054 bases
Minus strand
6,048 bases
Minus strand

Genomic View for ICAM3 Gene

Genes around ICAM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM3 Gene

Proteins for ICAM3 Gene

  • Protein details for ICAM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intercellular adhesion molecule 3
    Protein Accession:
    Secondary Accessions:
    • Q6PD68

    Protein attributes for ICAM3 Gene

    547 amino acids
    Molecular mass:
    59541 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM3 Gene

neXtProt entry for ICAM3 Gene

Post-translational modifications for ICAM3 Gene

  • Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
  • N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
  • Glycosylation at isoforms=457, Asn453, Asn389, Asn363, isoforms=320, Asn308, Asn295, isoforms=264, Asn206, isoforms=134, Asn110, Asn101, Asn91, Asn87, Asn84, and Asn52
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICAM3_HUMAN (286)

Antibody Products

  • Abcam antibodies for ICAM3

No data available for DME Specific Peptides for ICAM3 Gene

Domains & Families for ICAM3 Gene

Gene Families for ICAM3 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ICAM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. ICAM family.
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM3: view

Function for ICAM3 Gene

Molecular function for ICAM3 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
GENATLAS Biochemistry:
adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig superfamily

Phenotypes From GWAS Catalog for ICAM3 Gene

Gene Ontology (GO) - Molecular Function for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8459213
GO:0005178 integrin binding IPI 1448173
GO:0005515 protein binding IPI 12082081
genes like me logo Genes that share ontologies with ICAM3: view
genes like me logo Genes that share phenotypes with ICAM3: view

Animal Model Products

CRISPR Products

miRNA for ICAM3 Gene

miRTarBase miRNAs that target ICAM3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM3 Gene

Localization for ICAM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,NAS --
GO:0005887 integral component of plasma membrane TAS 8459213
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with ICAM3: view

Pathways & Interactions for ICAM3 Gene

genes like me logo Genes that share pathways with ICAM3: view

Pathways by source for ICAM3 Gene

Gene Ontology (GO) - Biological Process for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006909 phagocytosis IEA --
GO:0007155 cell adhesion IBA --
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ICAM3: view

No data available for SIGNOR curated interactions for ICAM3 Gene

Drugs & Compounds for ICAM3 Gene

(4) Drugs for ICAM3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for ICAM3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ICAM3: view

Transcripts for ICAM3 Gene

mRNA/cDNA for ICAM3 Gene

Unigene Clusters for ICAM3 Gene

Intercellular adhesion molecule 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM3

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -

Relevant External Links for ICAM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICAM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICAM3 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM3 Gene

This gene is overexpressed in Whole Blood (x35.3).

Protein differential expression in normal tissues from HIPED for ICAM3 Gene

This gene is overexpressed in Nasal epithelium (18.4) and Neutrophil (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICAM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ICAM3 Gene:


SOURCE GeneReport for Unigene cluster for ICAM3 Gene:


mRNA Expression by UniProt/SwissProt for ICAM3 Gene:

Tissue specificity: Leukocytes.

Evidence on tissue expression from TISSUES for ICAM3 Gene

  • Bone marrow(4.5)
  • Liver(4.5)
  • Lung(4.3)
  • Blood(3.6)
  • Lymph node(3.5)
  • Spleen(3.5)
  • Heart(2.5)
  • Intestine(2.2)
  • Skin(2.2)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ICAM3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM3 Gene

Orthologs for ICAM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICAM3 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia ICAM3 33
  • 76.2 (n)
-- 34
  • 32 (a)
(Bos Taurus)
Mammalia ICAM3 34 33
  • 71.6 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
-- 34
  • 38 (a)
-- 34
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 32 (a)
(Mus musculus)
Mammalia Tcam1 34
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
-- 34
  • 24 (a)
Species where no ortholog for ICAM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM3 Gene

Gene Tree for ICAM3 (if available)
Gene Tree for ICAM3 (if available)
Evolutionary constrained regions (ECRs) for ICAM3: view image

Paralogs for ICAM3 Gene

Paralogs for ICAM3 Gene

(5) SIMAP similar genes for ICAM3 Gene using alignment to 9 proteins:

  • K7EP52_HUMAN
genes like me logo Genes that share paralogs with ICAM3: view

Variants for ICAM3 Gene

Sequence variations from dbSNP and Humsavar for ICAM3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000033187 -- 10,338,127(-) G/A intron_variant
rs1000639468 -- 10,333,738(-) GGG/GG downstream_transcript_variant
rs1000818991 -- 10,337,382(-) A/C intron_variant
rs1000850149 -- 10,335,514(-) G/C 5_prime_UTR_variant, intron_variant
rs1001900897 -- 10,340,875(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ICAM3 Gene

Variant ID Type Subtype PubMed ID
nsv470124 CNV gain 18288195
nsv470125 CNV loss 18288195
nsv518008 CNV gain 19592680

Variation tolerance for ICAM3 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM3 Gene

Disorders for ICAM3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ICAM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
actinic prurigo
  • polymorphic light eruption, hereditary; hple
marburg hemorrhagic fever
  • marburg disease
colon carcinoma in situ
  • carcinoma in situ of colon
griscelli syndrome, type 1
  • gs1
- elite association - COSMIC cancer census association via MalaCards
Search ICAM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ICAM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM3 Gene

Publications for ICAM3 Gene

  1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PMID: 1448174) Vazeux R … Gallatin WM (Nature 1992) 2 3 4 22 58
  2. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PMID: 11179968) Funatsu O … Furukawa K (European journal of biochemistry 2001) 3 4 22 58
  3. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PMID: 1448173) Fawcett J … Simmons DL (Nature 1992) 3 4 22 58
  4. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. (PMID: 23775590) Kristóf E … Fésüs L (Apoptosis : an international journal on programmed cell death 2013) 3 4 58
  5. No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients. (PMID: 20086017) Reuss R … Oschmann P (Multiple sclerosis (Houndmills, Basingstoke, England) 2010) 3 22 58

Products for ICAM3 Gene

Sources for ICAM3 Gene

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