Aliases for ICAM3 Gene
External Ids for ICAM3 Gene
Previous GeneCards Identifiers for ICAM3 Gene
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for ICAM3 Gene
ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include Tick-Borne Encephalitis and Severe Acute Respiratory Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and integrin binding. An important paralog of this gene is ICAM5.
UniProtKB/Swiss-Prot Summary for ICAM3 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).