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The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include Intestine Carcinoma In Situ and Colon Carcinoma In Situ. Among its related pathways are Innate Immune System and Cell adhesion molecules. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and integrin binding. An important paralog of this gene is ICAM5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 8459213 |
GO:0005178 | integrin binding | IPI | 1448173 |
GO:0005515 | protein binding | IPI | 12082081 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | NAS,TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
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2 | Cell adhesion molecules | ||
3 | Class I MHC mediated antigen processing and presentation | ||
4 | CD209 (DC-SIGN) signaling | ||
5 | CLEC7A (Dectin-1) signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0006909 | phagocytosis | IEA | -- |
GO:0007155 | cell adhesion | IEA,IBA | 21873635 |
GO:0030198 | extracellular matrix organization | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ICAM3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ICAM3 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | ICAM3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Tcam1 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17697947 | Benign: not provided. - | 10,338,838(-) |
T/Cp.Ile63Val NM_002162.5(ICAM3):c.187A>G (p.Ile63Val) |
MISSENSE_VARIANT,FIVE_PRIME_UTR | |
rs2304239 | Benign: not provided | 10,338,674(-) |
C/T NM_002162.5(ICAM3):c.343+8G>A |
INTRON | |
rs3181047 | Benign: not provided | 10,335,130(-) |
C/T NM_002162.5(ICAM3):c.873G>A (p.Glu291=) |
SYNONYMOUS_VARIANT,INTRON | |
rs2230399 | - |
p.Ser525Thr |
|||
rs2304237 | - |
p.Asp143Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
intestine carcinoma in situ |
|
|
colon carcinoma in situ |
|
|
membranoproliferative glomerulonephritis |
|
|
tick-borne encephalitis |
|
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actinic prurigo |
|
|