Aliases for ICAM3 Gene
Aliases for ICAM3 Gene
External Ids for ICAM3 Gene
- HGNC: 5346
- Entrez Gene: 3385
- Ensembl: ENSG00000076662
- OMIM: 146631
- UniProtKB: P32942
Previous GeneCards Identifiers for ICAM3 Gene
- GC19M010565
- GC19M010667
- GC19M010289
- GC19M010305
- GC19M010444
- GC19M010024
Summaries for ICAM3 Gene
-
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for ICAM3 Gene
ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include Actinic Prurigo and Trichosporonosis. Among its related pathways are CD209 (DC-SIGN) signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and integrin binding. An important paralog of this gene is ICAM5.
UniProtKB/Swiss-Prot for ICAM3 Gene
-
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Additional gene information for ICAM3 Gene
- Monarch Initiative
- Search for ICAM3 at DataMed
- Search for ICAM3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM3 Gene
Genomics for ICAM3 Gene
GeneHancer (GH) Regulatory Elements for ICAM3 Gene
Promoters and enhancers for ICAM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ICAM3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ICAM3 gene promoter:
-
- Sp1
- Bach2
- Pax-3
- Tal-1beta
Regulatory Element Products
Genomic Locations for ICAM3 Gene
Genomic Locations for ICAM3 Gene
- chr19:10,333,776-10,339,829
- (GRCh38/hg38)
- Size:
- 6,054 bases
- Orientation:
- Minus strand
- chr19:10,444,452-10,450,499
- (GRCh37/hg19)
- Size:
- 6,048 bases
- Orientation:
- Minus strand
Genomic View for ICAM3 Gene
Genes around ICAM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
- 19p13.2 by Ensembl
ICAM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICAM3 Gene
Proteins for ICAM3 Gene
-
Protein details for ICAM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32942-ICAM3_HUMAN
- Recommended name:
- Intercellular adhesion molecule 3
- Protein Accession:
- P32942
- Q6PD68
Protein attributes for ICAM3 Gene
- Size:
- 547 amino acids
- Molecular mass:
- 59541 Da
- Quaternary structure:
- No Data Available
Protein Expression for ICAM3 Gene
Post-translational modifications for ICAM3 Gene
- Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
- N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
- Glycosylation at isoforms=457, Asn453, Asn389, Asn363, isoforms=320, Asn308, Asn295, isoforms=264, Asn206, isoforms=134, Asn110, Asn101, Asn91, Asn87, Asn84, and Asn52
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- ICAM3_HUMAN (286)
Other Protein References for ICAM3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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- CF507134
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- TA507168
- TA507170
- TA507174
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-
Abcam antibodies for ICAM3
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-
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Protein Products
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-
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-
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Assay Products
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-
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-
Abcam assays for ICAM3
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No data available for DME Specific Peptides for ICAM3 Gene
Domains & Families for ICAM3 Gene
Gene Families for ICAM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ICAM3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ICAM3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P32942- Family:
-
- Belongs to the immunoglobulin superfamily. ICAM family.
Function for ICAM3 Gene
Molecular function for ICAM3 Gene
- UniProtKB/Swiss-Prot Function:
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
- GENATLAS Biochemistry:
- adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig superfamily
Phenotypes From GWAS Catalog for ICAM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 8459213 |
| GO:0005178 | integrin binding | IPI | 1448173 |
| GO:0005515 | protein binding | IPI | 12082081 |
Phenotypes for ICAM3 Gene
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-
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-
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miRNA for ICAM3 Gene
- miRTarBase miRNAs that target ICAM3
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
-
Horizon Cell Lines for ICAM3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM3 Gene
Localization for ICAM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICAM3 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 1 |
| lysosome | 1 |
| endosome | 1 |
- Mitochondria (2)
- Nuclear membrane (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,NAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8459213 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
Pathways & Interactions for ICAM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Cell adhesion molecules (CAMs) | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | CD209 (DC-SIGN) signaling | ||
| 5 | CLEC7A (Dectin-1) signaling | ||
Pathways by source for ICAM3 Gene
8 Reactome pathways for ICAM3 Gene
1 KEGG pathway for ICAM3 Gene
1 GeneGo (Thomson Reuters) pathway for ICAM3 Gene
Interacting Proteins for ICAM3 Gene
GPS-Prot Interaction Network for ICAM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0006909 | phagocytosis | IEA | -- |
| GO:0007155 | cell adhesion | IBA | -- |
| GO:0030198 | extracellular matrix organization | TAS | -- |
| GO:0050776 | regulation of immune response | TAS | -- |
No data available for SIGNOR curated interactions for ICAM3 Gene
Transcripts for ICAM3 Gene
mRNA/cDNA for ICAM3 Gene
- (4) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (529) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000589900 2057 bps (uc060thb.1)
- ENST00000587992 2491 bps (uc060thc.1)
- ENST00000160262 1934 bps (uc002mob.3)
- ENST00000592945 658 bps (uc060thd.1)
- ENST00000589261 2024 bps (uc010dxd.2)
Unigene Clusters for ICAM3 Gene
CRISPR Products
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-
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-
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ICAM3 (ICAM-3/CD50)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: |
Expression for ICAM3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for ICAM3 Gene
This gene is overexpressed in Whole Blood (x35.3).
This gene is overexpressed in Nasal epithelium (18.4) and Neutrophil (14.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICAM3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ICAM3 Gene:
ICAM3SOURCE GeneReport for Unigene cluster for ICAM3 Gene:
Hs.654563mRNA Expression by UniProt/SwissProt for ICAM3 Gene:
P32942-ICAM3_HUMAN
Tissue specificity:
Leukocytes.
Evidence on tissue expression from TISSUES for ICAM3 Gene
- Bone marrow(4.5)
- Liver(4.5)
- Lung(4.3)
- Blood(3.6)
- Lymph node(3.5)
- Spleen(3.5)
- Heart(2.5)
- Intestine(2.2)
- Skin(2.2)
- Nervous system(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for ICAM3
-
OriGene qPCR primer pairs and template standards for ICAM3
- genomics-online: primer clones - Search results for available ICAM3 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM3 Gene
Orthologs for ICAM3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ICAM3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ICAM3 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | ICAM3 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Tcam1 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ICAM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ICAM3 Gene
- ENSEMBL:
- Gene Tree for ICAM3 (if available)
- TreeFam:
- Gene Tree for ICAM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ICAM3: view image
Paralogs for ICAM3 Gene
(5) SIMAP similar genes for ICAM3 Gene using alignment to 9 proteins:
- ICAM3_HUMAN
- K7ELH4_HUMAN
- K7EMH0_HUMAN
- K7EP52_HUMAN
- K7EQC7_HUMAN
- K7ERF0_HUMAN
- K7ERJ4_HUMAN
- K7ERN2_HUMAN
- Q5NKU1_HUMAN
Variants for ICAM3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033187 | -- | 10,338,127(-) | G/A | intron_variant | |
| rs1000639468 | -- | 10,333,738(-) | GGG/GG | downstream_transcript_variant | |
| rs1000818991 | -- | 10,337,382(-) | A/C | intron_variant | |
| rs1000850149 | -- | 10,335,514(-) | G/C | 5_prime_UTR_variant, intron_variant | |
| rs1001900897 | -- | 10,340,875(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.58;
78.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ICAM3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ICAM3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM3 Gene
Disorders for ICAM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| actinic prurigo |
|
|
| trichosporonosis |
|
|
| marburg hemorrhagic fever |
|
|
| colon carcinoma in situ |
|
|
| griscelli syndrome, type 1 |
|
|
Search ICAM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ICAM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM3 Gene
Publications for ICAM3 Gene
- Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PMID: 1448174) Vazeux R … Gallatin WM (Nature 1992) 2 3 4 22 58
- Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PMID: 11179968) Funatsu O … Furukawa K (European journal of biochemistry 2001) 3 4 22 58
- Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PMID: 1448173) Fawcett J … Simmons DL (Nature 1992) 3 4 22 58
- Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. (PMID: 23775590) Kristóf E … Fésüs L (Apoptosis : an international journal on programmed cell death 2013) 3 4 58
- No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients. (PMID: 20086017) Reuss R … Oschmann P (Multiple sclerosis (Houndmills, Basingstoke, England) 2010) 3 22 58
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- Invitrogen Antibodies for ICAM3 (AFLGC-ICAM3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for ICAM3
- Addgene plasmids for ICAM3
- antibodies-online: Search results for 411 available ICAM3 Antibodies ranked by validation data
- Compare Top ICAM3 Antibodies
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- antibodies-online: Search results for 45 available ICAM3 Elisa Kits ranked by validation data
- Compare Top ICAM3 Elisa Kits
- antibodies-online: Search results for 12 available ICAM3 Proteins ranked by validation data
- Compare Top ICAM3 Proteins
- GeneTex ICAM3 Antibody for ICAM3
- Search GeneTex for Proteins for ICAM3
- Santa Cruz Biotechnology (SCBT) Antibodies for ICAM3
- Search Santa Cruz Biotechnology (SCBT) for ICAM3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ICAM3
- Horizon Cell Lines for ICAM3
- genomics-online: cdna clones - Search results for available ICAM3 gene related products
- orf clones - Search results for available ICAM3 gene related products
- genomics-online: gRNA clones - Search results for available ICAM3 gene related products
- genomics-online: primer clones - Search results for available ICAM3 gene related products
- genomics-online: shRNA clones - Search results for available ICAM3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ICAM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ICAM3
- GeneCopoeia miRNA 3'UTR Target clone products for ICAM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM3
Sources for ICAM3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (24) DrugBank
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
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- (96) Addgene
- (97) antibodies-online
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- (135) Horizon
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- (164) LncRNADisease
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