The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive int... See more...

Aliases for ICAM2 Gene

Aliases for ICAM2 Gene

  • Intercellular Adhesion Molecule 2 2 3 4 5
  • ICAM-2 3 4
  • CD102 2 3
  • CD102 Antigen 4
  • ICAM2 5

External Ids for ICAM2 Gene

Previous GeneCards Identifiers for ICAM2 Gene

  • GC17M061717
  • GC17M064506
  • GC17M062420
  • GC17M062553
  • GC17M059433
  • GC17M062079
  • GC17M057447

Summaries for ICAM2 Gene

Entrez Gene Summary for ICAM2 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM2 Gene

ICAM2 (Intercellular Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with ICAM2 include Leukocyte Adhesion Deficiency, Type I and Intestine Carcinoma In Situ. Among its related pathways are Degradation of the extracellular matrix and CD209 (DC-SIGN) signaling. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot Summary for ICAM2 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Gene Wiki entry for ICAM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICAM2 Gene

Genomics for ICAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ICAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J064013 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 252.3 +0.6 607 12.9 BCLAF1 SP1 ZNF654 NCOR1 MYC IKZF1 ZNF592 ZMYM3 ATF2 POLR2A ICAM2 lnc-ERN1-4 PRR29 DDX5 CEP95 POLG2 FTSJ3 PLEKHM1P1 SMARCD2 ENSG00000265982
GH17J064005 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 250.4 +12.8 12835 5.1 NCOR1 MYC IKZF1 ZNF592 ZMYM3 CEBPA NFIC ZIC2 CHD4 NONO ICAM2 PRR29 SCN4A CSHL1 GH1 RF00017-2252 lnc-ICAM2-2 lnc-ERN1-4
GH17J063982 Enhancer 1 ENCODE dbSUPER 12 +36.0 36048 3.3 JUND ZBTB10 BHLHE40 ZNF148 MCM3 ZBTB7B HES1 GABPA FOXA2 CTBP1 FTSJ3 CEP95 POLG2 DDX42 DDX5 ENSG00000265982 PLEKHM1P1 MAP3K3 ARHGAP27P1-BPTFP1-KPNA2P3 CD79B
GH17J064259 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 4.9 -242.0 -241987 6.3 SP1 ZNF207 MYC NCOR1 IKZF1 CEBPA NFIC POLR2A YY1 MXD4 TEX2 CEP95 POLG2 FTSJ3 ENSG00000265982 SLC16A6P1 DDX42 PLEKHM1P1 SMARCD2 DDX5
GH17J064041 Enhancer 0.6 ENCODE dbSUPER 11.5 -22.2 -22188 1.8 SIX4 MAFF ZNF316 MAFK MAFG EMSY HSALNG0118067 lnc-ICAM2-1 ERN1 CSHL1 GH1 ICAM2 SNORD104 CD79B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICAM2

Top Transcription factor binding sites by QIAGEN in the ICAM2 gene promoter:
  • AREB6
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MRF-2
  • Sox5

Genomic Locations for ICAM2 Gene

Latest Assembly
chr17:64,002,594-64,020,634
(GRCh38/hg38)
Size:
18,041 bases
Orientation:
Minus strand

Previous Assembly
chr17:62,079,955-62,097,993
(GRCh37/hg19 by Entrez Gene)
Size:
18,039 bases
Orientation:
Minus strand

chr17:62,079,954-62,097,994
(GRCh37/hg19 by Ensembl)
Size:
18,041 bases
Orientation:
Minus strand

Genomic View for ICAM2 Gene

Genes around ICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM2 Gene

Proteins for ICAM2 Gene

  • Protein details for ICAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13598-ICAM2_HUMAN
    Recommended name:
    Intercellular adhesion molecule 2
    Protein Accession:
    P13598
    Secondary Accessions:
    • Q14600

    Protein attributes for ICAM2 Gene

    Size:
    275 amino acids
    Molecular mass:
    30654 Da
    Quaternary structure:
    • Interacts with RDX, EZR and MSN.

    Three dimensional structures from OCA and Proteopedia for ICAM2 Gene

neXtProt entry for ICAM2 Gene

Post-translational modifications for ICAM2 Gene

  • Glycosylation at Asn47, Asn82, Asn105, Asn153, Asn176, and Asn187
  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICAM2_HUMAN (682)

Antibodies for research

  • Abcam antibodies for ICAM2

No data available for DME Specific Peptides for ICAM2 Gene

Domains & Families for ICAM2 Gene

Gene Families for ICAM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICAM2 Gene

InterPro:
Blocks:
  • Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
  • Intercellular adhesion molecule (ICAM) family signature
  • Intercellular adhesion molecule, N-terminal

Suggested Antigen Peptide Sequences for ICAM2 Gene

GenScript: Design optimal peptide antigens:
  • Intercellular adhesion molecule 2, isoform CRA_b (D3DU30_HUMAN)
  • Intercellular adhesion molecule 2 (ICAM2_HUMAN)
  • Intercellular adhesion molecule 2, isoform CRA_a (Q6FHE2_HUMAN)
  • Intercellular adhesion molecule 2 (Q9NZC6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13598

UniProtKB/Swiss-Prot:

ICAM2_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM2: view

Function for ICAM2 Gene

Molecular function for ICAM2 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
GENATLAS Biochemistry:
adhesion molecule,intercellular 2,ligand for (LFA1,CD11A/CD18),expressed in resting lymphocyte,monocyte,platelet,vascular endothelium,redistributed by ezrin (VIL2) as a target for killer cells,also interacting with ICAM1 and VIL2 in microvillar projections,under phosphatidylinositol-4,5 biphosphate regulation,Ig superfamily

Phenotypes From GWAS Catalog for ICAM2 Gene

Gene Ontology (GO) - Molecular Function for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 1448173
genes like me logo Genes that share ontologies with ICAM2: view
genes like me logo Genes that share phenotypes with ICAM2: view

Animal Models for ICAM2 Gene

MGI Knock Outs for ICAM2:

miRNA for ICAM2 Gene

miRTarBase miRNAs that target ICAM2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM2

Clone products for research

  • Addgene plasmids for ICAM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM2 Gene

Localization for ICAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM2 Gene

Membrane. Single-pass type I membrane protein. Cell projection, microvillus. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250 UniProtKB:P35330}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0005902 microvillus ISS --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with ICAM2: view

Pathways & Interactions for ICAM2 Gene

genes like me logo Genes that share pathways with ICAM2: view

Pathways by source for ICAM2 Gene

1 GeneGo (Thomson Reuters) pathway for ICAM2 Gene
  • Immune response_Role of integrins in NK cells cytotoxicity
1 Qiagen pathway for ICAM2 Gene
  • Transendothelial Migration of Leukocytes
3 Cell Signaling Technology pathways for ICAM2 Gene

SIGNOR curated interactions for ICAM2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007155 cell adhesion IEA,IBA 21873635
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ICAM2: view

Drugs & Compounds for ICAM2 Gene

(3) Drugs for ICAM2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for ICAM2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ICAM2: view

Transcripts for ICAM2 Gene

mRNA/cDNA for ICAM2 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM2

Clone products for research

  • Addgene plasmids for ICAM2

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for ICAM2 Gene

GeneLoc Exon Structure for
ICAM2

Expression for ICAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM2 Gene

This gene is overexpressed in Whole Blood (x5.8) and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for ICAM2 Gene

This gene is overexpressed in Serum (35.4), Peripheral blood mononuclear cells (6.6), and Plasma (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICAM2 Gene



Protein tissue co-expression partners for ICAM2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICAM2

SOURCE GeneReport for Unigene cluster for ICAM2 Gene:

Hs.431460

Evidence on tissue expression from TISSUES for ICAM2 Gene

  • Heart(4.6)
  • Nervous system(4.6)
  • Bone marrow(4.5)
  • Spleen(3.2)
  • Lymph node(3)
  • Blood(2.8)
  • Lung(2.7)
  • Muscle(2.6)
  • Intestine(2.4)
  • Kidney(2.3)
  • Liver(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with ICAM2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM2 Gene

Orthologs for ICAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ICAM2 29 30
  • 99.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Icam2 29 16 30
  • 71.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ICAM2 29 30
  • 70.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Icam2 29
  • 68.74 (n)
Cow
(Bos Taurus)
Mammalia LOC616254 29
  • 65.56 (n)
ICAM2 30
  • 52 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ICAM2 30
  • 42 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 11 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
Species where no ortholog for ICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ICAM2 Gene

ENSEMBL:
Gene Tree for ICAM2 (if available)
TreeFam:
Gene Tree for ICAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICAM2: view image
Alliance of Genome Resources:
Additional Orthologs for ICAM2

Paralogs for ICAM2 Gene

Paralogs for ICAM2 Gene

(3) SIMAP similar genes for ICAM2 Gene using alignment to 10 proteins:

  • ICAM2_HUMAN
  • D3DU30_HUMAN
  • J3KSR9_HUMAN
  • J3QKR4_HUMAN
  • J3QQR8_HUMAN
  • J3QQX6_HUMAN
  • J3QRQ1_HUMAN
  • J3QRT5_HUMAN
  • Q6FHE2_HUMAN
  • Q9NZC6_HUMAN

Pseudogenes.org Pseudogenes for ICAM2 Gene

genes like me logo Genes that share paralogs with ICAM2: view

Variants for ICAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICAM2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs3764867 -- p.Arg256Gln
rs5503 -- p.Ala37Thr
rs5504 -- p.Arg199His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ICAM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv473576 CNV novel sequence insertion 20440878
nsv517272 CNV gain+loss 19592680
nsv833511 CNV loss 17160897
nsv952357 CNV deletion 24416366

Variation tolerance for ICAM2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM2
Leiden Open Variation Database (LOVD)
ICAM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM2 Gene

Disorders for ICAM2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ICAM2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
leukocyte adhesion deficiency, type i
  • lad
intestine carcinoma in situ
colon carcinoma in situ
  • carcinoma in situ of colon
polyarteritis nodosa
  • pan
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ICAM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ICAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM2 Gene

Publications for ICAM2 Gene

  1. The human ICAM2 gene maps to 17q23-25. (PMID: 1769660) Sansom D … Trowsdale J (Genomics 1991) 2 3 22
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 40
  4. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. (PMID: 18842965) Porter JC … Hall A (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 22
  5. Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer. (PMID: 19175829) Liu Z … Lopez RD (Journal of gastroenterology and hepatology 2009) 3 22

Products for ICAM2 Gene

Sources for ICAM2 Gene