This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] See more...

Aliases for ICAM1 Gene

Aliases for ICAM1 Gene

  • Intercellular Adhesion Molecule 1 2 3 4 5
  • Major Group Rhinovirus Receptor 3 4
  • ICAM-1 3 4
  • Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Cell Surface Glycoprotein P3.58 3
  • Human Rhinovirus Receptor 2
  • CD54 Antigen 4
  • P3.58 3
  • CD54 3
  • BB2 3

External Ids for ICAM1 Gene

Previous GeneCards Identifiers for ICAM1 Gene

  • GC19P010503
  • GC19P010604
  • GC19P010226
  • GC19P010243
  • GC19P010244
  • GC19P010247
  • GC19P010381
  • GC19P009965

Summaries for ICAM1 Gene

Entrez Gene Summary for ICAM1 Gene

  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM1 Gene

ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Leukostasis. Among its related pathways are Adhesion and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot Summary for ICAM1 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
  • (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
  • (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
  • (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

Tocris Summary for ICAM1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for ICAM1 Gene

Additional gene information for ICAM1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICAM1 Gene

Genomics for ICAM1 Gene

GeneHancer (GH) Regulatory Elements for ICAM1 Gene

Promoters and enhancers for ICAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010267 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 500.7 -0.5 -503 5.6 ZBTB40 CTCF SIN3A MYC ZNF300 USF1 POLR2G SP1 EP300 POLR2A ICAM1 lnc-ZGLP1-5 ILF3 LOC100419831 ZNF559 ZNF699 KRI1 DNMT1 ZNF266 RAVER1
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 18.2 +133.4 133376 6.5 ZBTB40 EP300 CTCF NRF1 POLR2G USF1 SP1 PHF8 JUND ZIC2 PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 MRPL4 ICAM5 ICAM4 RAVER1
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 13.9 +150.1 150075 10.6 RXRA EP300 HNRNPK ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 MYC PDE4A CDC37 LOC100419831 ZNF266 RAVER1 DNMT1 KRI1 ZNF561 EIF3G ILF3
GH19J010427 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 12.7 +159.7 159724 6.5 HNRNPK CTCF POLR2G BCLAF1 GTF2E2 PHB2 ZBTB5 ZBTB11 ZNF623 DNMT1 PDE4A piR-56480-029 EIF3G ICAM1 C19orf38 TYK2 DNM2 ICAM3 NONHSAG024793.2 lnc-TIMM29-1
GH19J010834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 +565.3 565268 2.6 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 POLR2G C19orf38 TMED1 ILF3 KRI1 ZNF627 DNMT1 ZNF491 ZNF441 RAVER1 PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICAM1

Top Transcription factor binding sites by QIAGEN in the ICAM1 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • CREB
  • deltaCREB

Genomic Locations for ICAM1 Gene

Genomic Locations for ICAM1 Gene
chr19:10,270,841-10,286,615
(GRCh38/hg38)
Size:
15,775 bases
Orientation:
Plus strand
chr19:10,381,511-10,397,291
(GRCh37/hg19)
Size:
15,781 bases
Orientation:
Plus strand

Genomic View for ICAM1 Gene

Genes around ICAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM1 Gene

Proteins for ICAM1 Gene

  • Protein details for ICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05362-ICAM1_HUMAN
    Recommended name:
    Intercellular adhesion molecule 1
    Protein Accession:
    P05362
    Secondary Accessions:
    • B2R6M3
    • Q5NKV7
    • Q96B50

    Protein attributes for ICAM1 Gene

    Size:
    532 amino acids
    Molecular mass:
    57825 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
    • (Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243).
    • (Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).

    Three dimensional structures from OCA and Proteopedia for ICAM1 Gene

neXtProt entry for ICAM1 Gene

Post-translational modifications for ICAM1 Gene

  • Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
  • Glycosylation at Thr62, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385, and Asn406
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICAM1_HUMAN (1423)

Other Protein References for ICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ICAM1

Assay Products

  • Abcam assays for ICAM1

No data available for DME Specific Peptides for ICAM1 Gene

Domains & Families for ICAM1 Gene

Gene Families for ICAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICAM1 Gene

Blocks:
  • Immunoglobulin subtype
  • Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
  • Intercellular adhesion molecule (ICAM) family signature
  • Intercellular adhesion molecule, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICAM1 Gene

GenScript: Design optimal peptide antigens:
  • Major group rhinovirus receptor (ICAM1_HUMAN)
  • Intercelular adhesion molecule 1 (O00177_HUMAN)
  • Intercellular adhesion molecule-1 (Q14601_HUMAN)
  • Cell surface glycoprotein (Q15462_HUMAN)
  • Cell surface glycoprotein (Q15463_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05362

UniProtKB/Swiss-Prot:

ICAM1_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM1: view

Function for ICAM1 Gene

Molecular function for ICAM1 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
GENATLAS Biochemistry:
adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium and leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also interacting with ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation,human rhinovirus receptor with some allele(s) predisposing to cerebral malaria,also contributing to multiple sclerosis susceptibility

Phenotypes From GWAS Catalog for ICAM1 Gene

Gene Ontology (GO) - Molecular Function for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 2538243
GO:0005178 integrin binding IPI,IDA 1448173
GO:0005515 protein binding IPI 7822297
GO:0038023 signaling receptor activity TAS 2538243
genes like me logo Genes that share ontologies with ICAM1: view
genes like me logo Genes that share phenotypes with ICAM1: view

Animal Models for ICAM1 Gene

MGI Knock Outs for ICAM1:

Animal Model Products

Clone Products

  • Addgene plasmids for ICAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM1 Gene

Localization for ICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005615 extracellular space IDA,IEA 9290466
GO:0005623 cell IEA --
GO:0005886 plasma membrane NAS,TAS --
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
genes like me logo Genes that share ontologies with ICAM1: view

Pathways & Interactions for ICAM1 Gene

genes like me logo Genes that share pathways with ICAM1: view

Pathways by source for ICAM1 Gene

6 GeneGo (Thomson Reuters) pathways for ICAM1 Gene
  • Cytokine production by Th17 cells in CF
  • Development VEGF signaling and activation
  • Immune response IFN gamma signaling pathway
  • Immune response MIF-mediated glucocorticoid regulation
  • Immune response_Role of integrins in NK cells cytotoxicity
2 Qiagen pathways for ICAM1 Gene
  • LDL Oxidation in Atherogenesis
  • Transendothelial Migration of Leukocytes
1 Cell Signaling Technology pathway for ICAM1 Gene

SIGNOR curated interactions for ICAM1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia IEA --
GO:0001910 regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0001975 response to amphetamine IEA --
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
genes like me logo Genes that share ontologies with ICAM1: view

Drugs & Compounds for ICAM1 Gene

(80) Drugs for ICAM1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 730
Methimazole Approved Pharma ICAM-1 inhibitor 19
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 574
Natalizumab Approved, Investigational Pharma Target 114
Alicaforsen Investigational Pharma antisense 6

(65) Additional Compounds for ICAM1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
Heparin sodium salt
9041-08-1
KF 38789
257292-29-8
PM 102
1234564-95-4

(5) Tocris Compounds for ICAM1 Gene

Compound Action Cas Number
Ac2-12 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 256447-08-2
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
Heparin sodium salt Anticoagulant 9041-08-1
KF 38789 Selective inhibitor of P-selectin-mediated cell adhesion 257292-29-8
PM 102 Antagonist of heparin (Cat. No. 2812) 1234564-95-4

(3) ApexBio Compounds for ICAM1 Gene

Compound Action Cas Number
A 205804 E-selectin/ICAM-1 expression inhibitor 251992-66-2
A 286982 LFA-1/ICAM-1 interaction inhibitor 280749-17-9
Methimazole ICAM-1 inhibitor 60-56-0
genes like me logo Genes that share compounds with ICAM1: view

Transcripts for ICAM1 Gene

mRNA/cDNA for ICAM1 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for ICAM1

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ICAM1 Gene

GeneLoc Exon Structure for
ICAM1

Expression for ICAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery