ICAM1 Gene (Protein Coding)

Intercellular Adhesion Molecule 1

GC19P010270
GIFtS:
50
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] See more...

Aliases for ICAM1 Gene

Aliases for ICAM1 Gene

  • Intercellular Adhesion Molecule 1 2 3 4 5
  • Major Group Rhinovirus Receptor 3 4
  • ICAM-1 3 4
  • CD54 2 3
  • BB2 2 3
  • Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Cell Surface Glycoprotein P3.58 3
  • Human Rhinovirus Receptor 2
  • CD54 Antigen 4
  • P3.58 3
  • ICAM1 5

External Ids for ICAM1 Gene

Previous GeneCards Identifiers for ICAM1 Gene

  • GC19P010503
  • GC19P010604
  • GC19P010226
  • GC19P010243
  • GC19P010244
  • GC19P010247
  • GC19P010381
  • GC19P009965

Summaries for ICAM1 Gene

Entrez Gene Summary for ICAM1 Gene

  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM1 Gene

ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Hepatocellular Carcinoma. Among its related pathways are Interleukin-11 Signaling Pathway and Folate Metabolism. An important paralog of this gene is ICAM3.

UniProtKB/Swiss-Prot Summary for ICAM1 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
  • (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
  • (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
  • (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

Tocris Summary for ICAM1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for ICAM1 Gene

Additional gene information for ICAM1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ICAM1 Gene

Genomics for ICAM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ICAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J010267 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.8 -755 5.6 SP1 HNRNPL GATAD2A CTCF REST TFE3 RFX1 IKZF1 NFKBIZ KDM1A ICAM1 LOC105372272 lnc-ZGLP1-5 LOC100419831 ZNF559 ZNF699 ZNF846 ILF3 ZNF426 ZNF562
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 18.2 +133.1 133124 6.5 SP1 HNRNPL CREB1 CTCF ATF7 PRDM10 ZNF629 RFX1 IKZF1 NFKBIZ PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 KANK2 MRPL4 ICAM5 ICAM4
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 13.9 +149.8 149823 10.6 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PDE4A CDC37 ILF3 ZNF266 KRI1 LOC100419831 DNMT1 RAVER1 FBXL12 PPAN
GH19J010427 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 12.7 +159.5 159472 6.5 ARHGAP35 CREB1 ZNF512 RFX1 LEF1 IKZF1 KDM1A RCOR2 BACH1 LARP7 PDE4A piR-56480-029 ZNF266 TYK2 ILF3 FBXL12 RAVER1 EIF3G KRI1 ZNF561
GH19J010338 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 12.2 +68.5 68450 1.9 POLR2A BACH1 LARP7 RELA SMAD5 YY1 SIN3A ELK1 DPF2 RELB ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM4 ICAM5 ICAM1 MRPL4 ENSG00000274425 RAVER1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ICAM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ICAM1

Top Transcription factor binding sites by QIAGEN in the ICAM1 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • CREB
  • deltaCREB

Genomic Locations for ICAM1 Gene

Genomic Locations for ICAM1 Gene
chr19:10,271,093-10,286,615
(GRCh38/hg38)
Size:
15,523 bases
Orientation:
Plus strand
chr19:10,381,511-10,397,291
(GRCh37/hg19)
Size:
15,781 bases
Orientation:
Plus strand

Genomic View for ICAM1 Gene

Genes around ICAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ICAM1 Gene

Proteins for ICAM1 Gene

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  • Protein details for ICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05362-ICAM1_HUMAN
    Recommended name:
    Intercellular adhesion molecule 1
    Protein Accession:
    P05362
    Secondary Accessions:
    • B2R6M3
    • Q5NKV7
    • Q96B50

    Protein attributes for ICAM1 Gene

    Size:
    532 amino acids
    Molecular mass:
    57825 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
    • (Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243).
    • (Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).

    Three dimensional structures from OCA and Proteopedia for ICAM1 Gene

neXtProt entry for ICAM1 Gene

Protein Expression for ICAM1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ICAM1 Gene

  • Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
  • Glycosylation at Thr62, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385, and Asn406
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ICAM1_HUMAN (1423)

Other Protein References for ICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ICAM1

No data available for DME Specific Peptides for ICAM1 Gene

Domains & Families for ICAM1 Gene

Gene Families for ICAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ICAM1 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
  • Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
  • Intercellular adhesion molecule (ICAM) family signature
  • Intercellular adhesion molecule, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ICAM1 Gene

GenScript: Design optimal peptide antigens:
  • Major group rhinovirus receptor (ICAM1_HUMAN)
  • Intercelular adhesion molecule 1 (O00177_HUMAN)
  • Intercellular adhesion molecule-1 (Q14601_HUMAN)
  • Cell surface glycoprotein (Q15462_HUMAN)
  • Cell surface glycoprotein (Q15463_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05362

UniProtKB/Swiss-Prot:

ICAM1_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM1: view

Function for ICAM1 Gene

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Molecular function for ICAM1 Gene

UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
GENATLAS Biochemistry:
adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium and leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also interacting with ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation,human rhinovirus receptor with some allele(s) predisposing to cerebral malaria,also contributing to multiple sclerosis susceptibility

Phenotypes From GWAS Catalog for ICAM1 Gene

Gene Ontology (GO) - Molecular Function for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 2538243
GO:0005178 integrin binding IDA,IPI 1448173
GO:0005515 protein binding IPI 7822297
GO:0038023 signaling receptor activity TAS 2538243
genes like me logo Genes that share ontologies with ICAM1: view
genes like me logo Genes that share phenotypes with ICAM1: view

Animal Models for ICAM1 Gene

MGI Knock Outs for ICAM1:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM1 Gene

Localization for ICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM1 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005615 extracellular space IEA,IDA 9290466
GO:0005623 cell IEA --
GO:0005886 plasma membrane NAS,TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
genes like me logo Genes that share ontologies with ICAM1: view

Pathways & Interactions for ICAM1 Gene

genes like me logo Genes that share pathways with ICAM1: view

Pathways by source for ICAM1 Gene

6 GeneGo (Thomson Reuters) pathways for ICAM1 Gene
  • Cytokine production by Th17 cells in CF
  • Development VEGF signaling and activation
  • Immune response IFN gamma signaling pathway
  • Immune response MIF-mediated glucocorticoid regulation
  • Immune response_Role of integrins in NK cells cytotoxicity
2 Qiagen pathways for ICAM1 Gene
  • LDL Oxidation in Atherogenesis
  • Transendothelial Migration of Leukocytes
1 Cell Signaling Technology pathway for ICAM1 Gene

SIGNOR curated interactions for ICAM1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia IEA --
GO:0001910 regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0001975 response to amphetamine IEA --
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
genes like me logo Genes that share ontologies with ICAM1: view

Drugs & Compounds for ICAM1 Gene

Products:

  1. Drug

(80) Drugs for ICAM1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 717
Methimazole Approved Pharma ICAM-1 inhibitor 23
Simvastatin Approved Pharma Inhibitor, Competitive HMG-CoA reductase inhibitor 582
Natalizumab Approved, Investigational Pharma Target 115
Alicaforsen Investigational Pharma antisense 6

(65) Additional Compounds for ICAM1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
Heparin sodium salt
9041-08-1
KF 38789
257292-29-8
PM 102
1234564-95-4

(5) Tocris Compounds for ICAM1 Gene

Compound Action Cas Number
Ac2-12 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 256447-08-2
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
Heparin sodium salt Anticoagulant 9041-08-1
KF 38789 Selective inhibitor of P-selectin-mediated cell adhesion 257292-29-8
PM 102 Antagonist of heparin (Cat. No. 2812) 1234564-95-4

(3) ApexBio Compounds for ICAM1 Gene

Compound Action Cas Number
A 205804 E-selectin/ICAM-1 expression inhibitor 251992-66-2
A 286982 LFA-1/ICAM-1 interaction inhibitor 280749-17-9
Methimazole ICAM-1 inhibitor 60-56-0
genes like me logo Genes that share compounds with ICAM1: view

Transcripts for ICAM1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for ICAM1 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ICAM1

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ICAM1 Gene

GeneLoc Exon Structure for
ICAM1

Expression for ICAM1 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ICAM1 Gene

mRNA expression in normal human tissues for ICAM1 Gene
mRNA expression by GTEx for ICAM1 GenemRNA expression by BioGPS for ICAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM1 Gene

This gene is overexpressed in Lung (x7.6).

Protein differential expression in normal tissues from HIPED for ICAM1 Gene

This gene is overexpressed in Spleen (11.4), Lymph node (10.0), and Lung (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ICAM1 Gene



Protein tissue co-expression partners for ICAM1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ICAM1

SOURCE GeneReport for Unigene cluster for ICAM1 Gene:

Hs.643447

Evidence on tissue expression from TISSUES for ICAM1 Gene

  • Lung(5)
  • Blood(4.8)
  • Liver(4.7)
  • Bone marrow(4.7)
  • Kidney(4.7)
  • Spleen(4)
  • Heart(4)
  • Nervous system(3.9)
  • Lymph node(3.6)
  • Intestine(3.5)
  • Muscle(3.4)
  • Eye(3.3)
  • Skin(3.2)
  • Pancreas(2.8)
  • Stomach(2.7)
  • Bone(2.5)
  • Adrenal gland(2.5)
  • Thyroid gland(2.5)
  • Urine(2.4)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with ICAM1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM1 Gene

Orthologs for ICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ICAM1 30 31
  • 98.5 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ICAM1 30 31
  • 72.96 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ICAM1 30 31
  • 68.91 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Icam1 30 17 31
  • 64.77 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Icam1 30
  • 63.46 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 40 (a)
 ManyToMany
-- 31
  • 37 (a)
 ManyToMany
-- 31
  • 34 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 29 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 29 (a)
 ManyToMany
-- 31
  • 23 (a)
 ManyToMany
Species where no ortholog for ICAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ICAM1 Gene

ENSEMBL:
Gene Tree for ICAM1 (if available)
TreeFam:
Gene Tree for ICAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ICAM1: view image

Paralogs for ICAM1 Gene

Paralogs for ICAM1 Gene

(5) SIMAP similar genes for ICAM1 Gene using alignment to 5 proteins:

  • ICAM1_HUMAN
  • E7ESS4_HUMAN
  • K7EKL8_HUMAN
  • Q14601_HUMAN
  • Q5NKV8_HUMAN

Pseudogenes.org Pseudogenes for ICAM1 Gene

genes like me logo Genes that share paralogs with ICAM1: view

Variants for ICAM1 Gene

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  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM1 Gene

ICAM1_HUMAN-P05362
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ICAM1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710376 Benign: not provided 10,284,572(+) C/T SYNONYMOUS_VARIANT
713658 Likely Benign: not provided 10,284,465(+) G/A MISSENSE_VARIANT
717372 Benign: not provided 10,284,974(+) C/T MISSENSE_VARIANT
717487 Benign: not provided 10,284,232(+) C/T SYNONYMOUS_VARIANT
721158 Likely Benign: not provided 10,274,844(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ICAM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ICAM1 Gene

Variant ID Type Subtype PubMed ID
esv3643651 CNV loss 21293372
nsv578612 CNV gain 21841781

Variation tolerance for ICAM1 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ICAM1 Gene

Human Gene Mutation Database (HGMD)
ICAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM1

SNP Genotyping and Copy Number Assay Products

Disorders for ICAM1 Gene

MalaCards: The human disease database

(194) MalaCards diseases for ICAM1 Gene - From: LncRNADisease, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, susceptibility to
hepatocellular carcinoma
  • hcc
leukostasis
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
acute hemorrhagic conjunctivitis
  • apollo disease
- elite association - COSMIC cancer census association via MalaCards
Search ICAM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ICAM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ICAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM1 Gene

Publications for ICAM1 Gene

  1. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PMID: 20167578) Barbalic M … Benjamin EJ (Human molecular genetics 2010) 3 23 41
  2. Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from the Women's Genome Health Study. (PMID: 19332210) Albert MA … Zee RY (American heart journal 2009) 3 23 41
  3. ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. (PMID: 19306055) Burim RV … Carlotti-Júnior CG (Clinical and experimental medicine 2009) 3 23 41
  4. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. (PMID: 19212205) Khazen D … Ayed K (European journal of gastroenterology & hepatology 2009) 3 23 41
  5. Role of non-HLA genetic variants in end-stage renal disease. (PMID: 19497039) Ranganath P … Agrawal S (Tissue antigens 2009) 3 23 41

ExternalLinks

View latest publications for ICAM1 gene in Mastermind

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