Aliases for ICA1 Gene
External Ids for ICA1 Gene
Previous GeneCards Identifiers for ICA1 Gene
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
GeneCards Summary for ICA1 Gene
ICA1 (Islet Cell Autoantigen 1) is a Protein Coding gene. Diseases associated with ICA1 include Diabetes Mellitus and Insulinoma. Among its related pathways are Allograft rejection. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is ICA1L.
UniProtKB/Swiss-Prot Summary for ICA1 Gene
May play a role in neurotransmitter secretion.