Aliases for IAPP Gene
External Ids for IAPP Gene
Previous GeneCards Identifiers for IAPP Gene
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
GeneCards Summary for IAPP Gene
IAPP (Islet Amyloid Polypeptide) is a Protein Coding gene. Diseases associated with IAPP include Insulinoma and Hyperglycemia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include identical protein binding and hormone activity.
UniProtKB/Swiss-Prot for IAPP Gene
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.