Aliases for IAPP Gene
External Ids for IAPP Gene
Previous GeneCards Identifiers for IAPP Gene
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
GeneCards Summary for IAPP Gene
IAPP (Islet Amyloid Polypeptide) is a Protein Coding gene. Diseases associated with IAPP include Insulinoma and Hyperglycemia. Among its related pathways are Signaling by GPCR and Regulation of beta-cell development. Gene Ontology (GO) annotations related to this gene include identical protein binding and hormone activity. An important paralog of this gene is CALCB.
UniProtKB/Swiss-Prot Summary for IAPP Gene
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.