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Aliases for HYPK Gene

Aliases for HYPK Gene

  • Huntingtin Interacting Protein K 2 3 5
  • Huntingtin Yeast Partner K 2 3 4
  • C15orf63 3 4
  • Chromosome 15 Open Reading Frame 63 2
  • Huntingtin-Interacting Protein K 3
  • HSPC136 3

External Ids for HYPK Gene

Previous HGNC Symbols for HYPK Gene

  • C15orf63

Previous GeneCards Identifiers for HYPK Gene

  • GC15P039459
  • GC15P036988
  • GC15P041671
  • GC15P041808
  • GC15P041879
  • GC15P044070
  • GC15P044092
  • GC15P044095

Summaries for HYPK Gene

GeneCards Summary for HYPK Gene

HYPK (Huntingtin Interacting Protein K) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HYPK Gene

  • Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Additional gene information for HYPK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYPK Gene

Genomics for HYPK Gene

GeneHancer (GH) Regulatory Elements for HYPK Gene

Promoters and enhancers for HYPK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J043791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 650.7 +0.4 373 10.6 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D GC15M043788 HYPK GC15P043795 PIR54305 SERINC4 SERF2 ELL3 SPG11 CTDSPL2 ENSG00000259563
GH15J043132 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 -662.4 -662353 2.2 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B TMEM62 HYPK ADAL CATSPER2 GANC SPCS2P1 FDPSP10 ENSG00000285080
GH15J043769 Enhancer 0.6 ENCODE 12 -26.3 -26344 0.2 CTCF FOXA2 TEAD1 FOXA3 TEAD4 TRIM22 ERF ZNF384 RAD21 RFX5 MIR1282 HYPK SERF2 PDIA3 CATSPER2P1
GH15J043749 Enhancer 0.6 ENCODE 11.8 -45.9 -45937 1.7 PKNOX1 ELF1 ZNF384 ZNF121 PRDM10 ATF7 CREM PRDM1 ZNF18 STRC SERF2 MIR1282 HYPK CATSPER2P1 PDIA3
GH15J043434 Enhancer 0.5 ENCODE 10.2 -361.5 -361494 0.4 ZNF639 ZNF766 ZBTB11 GABPA ZSCAN29 TUBGCP4 HYPK MIR1282 SERF2 PIR48108 PIR42778 TP53BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HYPK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYPK gene promoter:
  • Pax-4a
  • PPAR-alpha
  • AREB6
  • Msx-1
  • ITF-2
  • Tal-1beta
  • GATA-1
  • NF-1
  • AML1a

Genomic Locations for HYPK Gene

Genomic Locations for HYPK Gene
6,902 bases
Plus strand
6,902 bases
Plus strand

Genomic View for HYPK Gene

Genes around HYPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYPK Gene

Proteins for HYPK Gene

  • Protein details for HYPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Huntingtin-interacting protein K
    Protein Accession:
    Secondary Accessions:
    • C9JKJ0
    • O75408
    • Q8WUW8
    • Q9P024

    Protein attributes for HYPK Gene

    129 amino acids
    Molecular mass:
    14665 Da
    Quaternary structure:
    • Interacts with HTT (via N-terminus). Associates with the NAA10-NAA15 complex and with the ribosome; the NAA10-NAA15 complex is required for HYPK stability and for reducing polyQ aggregation of HTT. Interacts with NAA15.
    • Sequence=AAF29100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91165.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript SERF2-HYPK/C15orf63.; Evidence={ECO:0000305};

    Alternative splice isoforms for HYPK Gene


neXtProt entry for HYPK Gene

Post-translational modifications for HYPK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HYPK Gene

No data available for DME Specific Peptides for HYPK Gene

Domains & Families for HYPK Gene

Gene Families for HYPK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HYPK Gene


Suggested Antigen Peptide Sequences for HYPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HYPK: view

No data available for UniProtKB/Swiss-Prot for HYPK Gene

Function for HYPK Gene

Molecular function for HYPK Gene

UniProtKB/Swiss-Prot Function:
Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Gene Ontology (GO) - Molecular Function for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0047485 protein N-terminus binding IPI 17947297
genes like me logo Genes that share ontologies with HYPK: view
genes like me logo Genes that share phenotypes with HYPK: view

Animal Model Products

miRNA for HYPK Gene

miRTarBase miRNAs that target HYPK

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYPK Gene

Localization for HYPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYPK Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYPK gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17947297
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 17947297
GO:0015630 microtubule cytoskeleton IDA --
GO:0032991 protein-containing complex IDA 17947297
genes like me logo Genes that share ontologies with HYPK: view

Pathways & Interactions for HYPK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IDA 17947297
GO:0050821 protein stabilization IDA 17947297
genes like me logo Genes that share ontologies with HYPK: view

No data available for Pathways by source and SIGNOR curated interactions for HYPK Gene

Drugs & Compounds for HYPK Gene

No Compound Related Data Available

Transcripts for HYPK Gene

mRNA/cDNA for HYPK Gene

Unigene Clusters for HYPK Gene

Huntingtin interacting protein K:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYPK Gene

No ASD Table

Relevant External Links for HYPK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYPK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYPK Gene

This gene is overexpressed in Blymphocyte (15.1), Peripheral blood mononuclear cells (13.2), and CD4 Tcells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HYPK Gene

NURSA nuclear receptor signaling pathways regulating expression of HYPK Gene:


SOURCE GeneReport for Unigene cluster for HYPK Gene:


Evidence on tissue expression from TISSUES for HYPK Gene

  • Liver(4.4)
  • Blood(4.1)
  • Nervous system(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with HYPK: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYPK Gene

Orthologs for HYPK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYPK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYPK 34
  • 100 (a)
LOC745332 33
  • 93.8 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
-- 34
  • 93 (a)
(Canis familiaris)
Mammalia HYPK 33
  • 92.29 (n)
(Bos Taurus)
Mammalia C21H15orf63 34 33
  • 91.18 (n)
(Rattus norvegicus)
Mammalia Hypk 33
  • 88.15 (n)
(Mus musculus)
Mammalia Hypk 16 34 33
  • 87.34 (n)
(Gallus gallus)
Aves HYPK 34 33
  • 82.09 (n)
(Anolis carolinensis)
Reptilia HYPK 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hypk 33
  • 78.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6406 33
(Danio rerio)
Actinopterygii hypk 34 33
  • 73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13793 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004606 33
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9922 34 33
  • 50.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2928 34
  • 55 (a)
Species where no ortholog for HYPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYPK Gene

Gene Tree for HYPK (if available)
Gene Tree for HYPK (if available)
Evolutionary constrained regions (ECRs) for HYPK: view image

Paralogs for HYPK Gene Pseudogenes for HYPK Gene

genes like me logo Genes that share paralogs with HYPK: view

No data available for Paralogs for HYPK Gene

Variants for HYPK Gene

Sequence variations from dbSNP and Humsavar for HYPK Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000068099 -- 43,802,476(+) C/T 3_prime_UTR_variant
rs1000288190 -- 43,802,217(+) G/A/C 3_prime_UTR_variant
rs1005404826 -- 43,802,751(+) A/G downstream_transcript_variant
rs1005493589 -- 43,802,555(+) G/A 3_prime_UTR_variant
rs1005966945 -- 43,798,848(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HYPK Gene

Variant ID Type Subtype PubMed ID
esv2760028 CNV gain+loss 17122850
nsv1036318 CNV gain 25217958
nsv1050263 CNV loss 25217958

Variation tolerance for HYPK Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYPK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYPK Gene

Disorders for HYPK Gene

Additional Disease Information for HYPK

No disorders were found for HYPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYPK Gene

Publications for HYPK Gene

  1. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. (PMID: 20154145) Arnesen T … Anderson D (Molecular and cellular biology 2010) 2 3 4 22 58
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber PW … MacDonald ME (Human molecular genetics 1998) 2 3 4 58
  3. HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity. (PMID: 17947297) Raychaudhuri S … Bhattacharyya NP (Human molecular genetics 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for HYPK Gene

Sources for HYPK Gene

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