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Aliases for HYOU1 Gene

Aliases for HYOU1 Gene

  • Hypoxia Up-Regulated 1 2 3 5
  • 170 KDa Glucose-Regulated Protein 3 4
  • 150 KDa Oxygen-Regulated Protein 3 4
  • GRP-170 3 4
  • ORP-150 3 4
  • ORP150 3 4
  • Oxygen Regulated Protein (150kD) 3
  • Hypoxia Up-Regulated Protein 1 3
  • Glucose-Regulated Protein 170 2
  • Grp170 3
  • HSP12A 3
  • GRP170 4

External Ids for HYOU1 Gene

Previous GeneCards Identifiers for HYOU1 Gene

  • GC11P135580
  • GC11M120426
  • GC11M118948
  • GC11M118452
  • GC11M118420
  • GC11M114854
  • GC11M118914

Summaries for HYOU1 Gene

Entrez Gene Summary for HYOU1 Gene

  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for HYOU1 Gene

HYOU1 (Hypoxia Up-Regulated 1) is a Protein Coding gene. Diseases associated with HYOU1 include Hypoxia and Ischemia. Among its related pathways are Protein processing in endoplasmic reticulum and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include chaperone binding. An important paralog of this gene is HSPA4L.

UniProtKB/Swiss-Prot for HYOU1 Gene

  • Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Gene Wiki entry for HYOU1 Gene

Additional gene information for HYOU1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYOU1 Gene

Genomics for HYOU1 Gene

GeneHancer (GH) Regulatory Elements for HYOU1 Gene

Promoters and enhancers for HYOU1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J119066 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 -10.4 -10440 2.2 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 VPS11 ENSG00000272186 HYOU1 DPAGT1 HMBS ARCN1 H2AFX C2CD2L KMT2A ENSG00000254909
GH11J119055 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 109 3 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 VPS11 GC11P119057 HYOU1 RPL5P30 KMT2A HINFP UBE4A HMBS PIR44546
GH11J118906 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 +138.5 138453 24.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 BCL9L UPK2 ARCN1 DPAGT1 CCDC84 RNF26 UBE4A ENSG00000254909 VPS11 KMT2A
GH11J119741 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.1 -685.0 -685025 2.2 HDGF CTCF RB1 ZSCAN4 KLF14 ZNF48 RBPJ RAD21 ZFHX2 GLIS2 LOC102724301 HYOU1 GC11P119746
GH11J119076 Enhancer 0.2 ENCODE 12.7 -20.7 -20683 2.5 VPS11 HMBS C2CD2L DPAGT1 HYOU1 ENSG00000255114 SLC37A4 RPS25 TRAPPC4 HINFP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HYOU1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYOU1 gene promoter:
  • p53
  • MyoD

Genomic Locations for HYOU1 Gene

Genomic Locations for HYOU1 Gene
13,062 bases
Minus strand
13,030 bases
Minus strand

Genomic View for HYOU1 Gene

Genes around HYOU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYOU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYOU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYOU1 Gene

Proteins for HYOU1 Gene

  • Protein details for HYOU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypoxia up-regulated protein 1
    Protein Accession:
    Secondary Accessions:
    • A8C1Z0
    • B7Z909
    • Q2I204
    • Q53H25

    Protein attributes for HYOU1 Gene

    999 amino acids
    Molecular mass:
    111335 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Alternative splice isoforms for HYOU1 Gene


neXtProt entry for HYOU1 Gene

Post-translational modifications for HYOU1 Gene

  • Glycosylation at Asn931, isoforms=922, Asn869, isoforms=862, Asn830, isoforms=2596, isoforms=2580, Asn515, Asn222, and isoforms=2155
  • Ubiquitination at Lys398
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HYOU1 Gene

Domains & Families for HYOU1 Gene

Gene Families for HYOU1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for HYOU1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HYOU1: view

Function for HYOU1 Gene

Molecular function for HYOU1 Gene

UniProtKB/Swiss-Prot Function:
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
UniProtKB/Swiss-Prot Induction:
By hypoxia and also by 2-deoxyglucose or tunicamycin.

Phenotypes From GWAS Catalog for HYOU1 Gene

Gene Ontology (GO) - Molecular Function for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
GO:0031072 heat shock protein binding IBA --
GO:0042623 ATPase activity, coupled IBA --
GO:0044183 protein binding involved in protein folding IBA --
genes like me logo Genes that share ontologies with HYOU1: view
genes like me logo Genes that share phenotypes with HYOU1: view

Animal Models for HYOU1 Gene

MGI Knock Outs for HYOU1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HYOU1 Gene

Localization for HYOU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYOU1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYOU1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum NAS 9020069
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with HYOU1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HYOU1 Gene

Pathways & Interactions for HYOU1 Gene

genes like me logo Genes that share pathways with HYOU1: view

Interacting Proteins for HYOU1 Gene

Gene Ontology (GO) - Biological Process for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA,ISS --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 10837345
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006986 response to unfolded protein IBA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with HYOU1: view

No data available for SIGNOR curated interactions for HYOU1 Gene

Drugs & Compounds for HYOU1 Gene

(8) Drugs for HYOU1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for HYOU1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HYOU1: view

Transcripts for HYOU1 Gene

Unigene Clusters for HYOU1 Gene

Hypoxia up-regulated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -

Relevant External Links for HYOU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYOU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYOU1 Gene

mRNA differential expression in normal tissues according to GTEx for HYOU1 Gene

This gene is overexpressed in Liver (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HYOU1 Gene

Protein tissue co-expression partners for HYOU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HYOU1 Gene:


SOURCE GeneReport for Unigene cluster for HYOU1 Gene:


mRNA Expression by UniProt/SwissProt for HYOU1 Gene:

Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

Evidence on tissue expression from TISSUES for HYOU1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.4)
  • Heart(4.4)
  • Bone marrow(4.3)
  • Kidney(3.9)
  • Lung(3.9)
  • Intestine(3.3)
  • Pancreas(2.6)
  • Spleen(2.3)
  • Lymph node(2.2)
  • Skin(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with HYOU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYOU1 Gene

Orthologs for HYOU1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HYOU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYOU1 34 33
  • 99.14 (n)
(Canis familiaris)
Mammalia HYOU1 34 33
  • 89.46 (n)
(Bos Taurus)
Mammalia HYOU1 34 33
  • 89.31 (n)
(Rattus norvegicus)
Mammalia Hyou1 33
  • 88.21 (n)
(Mus musculus)
Mammalia Hyou1 16 34 33
  • 87.55 (n)
(Monodelphis domestica)
Mammalia HYOU1 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
(Gallus gallus)
Aves HYOU1 34 33
  • 69.35 (n)
(Anolis carolinensis)
Reptilia HYOU1 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hyou1 33
  • 67.8 (n)
Str.3875 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398531 33
(Danio rerio)
Actinopterygii hyou1 34 33
  • 67.31 (n)
Dr.17462 33
fruit fly
(Drosophila melanogaster)
Insecta CG2918 34 33
  • 54.34 (n)
EG:25E8.1 35
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001827 33
  • 54.22 (n)
(Caenorhabditis elegans)
Secernentea T14G8.3 34 35 33
  • 49.73 (n)
T24H7.2 34 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 34
  • 27 (a)
SSE2 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16660 33
  • 47.8 (n)
(Oryza sativa)
Liliopsida Os02g0710900 33
  • 47.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9387 34
  • 43 (a)
Cin.4458 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4458 33
Species where no ortholog for HYOU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYOU1 Gene

Gene Tree for HYOU1 (if available)
Gene Tree for HYOU1 (if available)
Evolutionary constrained regions (ECRs) for HYOU1: view image

Paralogs for HYOU1 Gene

Paralogs for HYOU1 Gene

(10) SIMAP similar genes for HYOU1 Gene using alignment to 14 proteins:

  • B7Z909_HUMAN
  • E9PJ21_HUMAN
  • E9PL22_HUMAN
  • J3KT27_HUMAN
  • J3QL06_HUMAN
  • Q05D91_HUMAN
  • Q6IN67_HUMAN
genes like me logo Genes that share paralogs with HYOU1: view

Variants for HYOU1 Gene

Sequence variations from dbSNP and Humsavar for HYOU1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010527 -- 119,058,378(-) A/T upstream_transcript_variant
rs1000069607 -- 119,045,393(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000239980 -- 119,053,387(-) T/G intron_variant
rs1000253955 -- 119,058,710(-) A/G upstream_transcript_variant
rs1000373735 -- 119,047,352(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HYOU1 Gene

Variant ID Type Subtype PubMed ID
nsv819696 CNV loss 19587683
nsv952745 CNV deletion 24416366

Variation tolerance for HYOU1 Gene

Residual Variation Intolerance Score: 6.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYOU1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYOU1 Gene

Disorders for HYOU1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HYOU1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HYOU1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HYOU1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HYOU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYOU1 Gene

Publications for HYOU1 Gene

  1. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PMID: 10037731) Ozawa K … Tohyama M (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. (PMID: 9020069) Ikeda J … Yanagi H (Biochemical and biophysical research communications 1997) 2 3 4 22 58
  3. Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. (PMID: 17131193) Takeuchi S (The protein journal 2006) 3 4 22 58
  4. Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. (PMID: 10965054) Kaneda S … Yanagi H (Journal of biochemistry 2000) 3 4 22 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for HYOU1 Gene

Sources for HYOU1 Gene

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