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Aliases for HYMAI Gene

Subcategory (RNA class) for HYMAI Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for HYMAI Gene

  • Hydatidiform Mole Associated And Imprinted (Non-Protein Coding) 2 3 5
  • Non-Protein Coding RNA 20 2
  • NCRNA00020 3

External Ids for HYMAI Gene

Previous GeneCards Identifiers for HYMAI Gene

  • GC06U990239
  • GC06M144365
  • GC06M141887

Summaries for HYMAI Gene

Entrez Gene Summary for HYMAI Gene

  • This gene, which encodes a non-protein coding transcript, exhibits differential DNA methylation between the two parental alleles at an adjacent CpG island, and is expressed only from the paternal allele. It is believed to be one of the causative genes for transient neonatal diabetes mellitus (TNDM), which is a rare disease characterized by intrauterine growth retardation, dehydration, and failure to thrive due to a lack of normal insulin secretion. [provided by RefSeq, Oct 2010]

GeneCards Summary for HYMAI Gene

HYMAI (Hydatidiform Mole Associated And Imprinted (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HYMAI include Diabetes Mellitus, Transient Neonatal, 1 and Paternal Uniparental Disomy Of Chromosome 6.

Additional gene information for HYMAI Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYMAI Gene

Genomics for HYMAI Gene

GeneHancer (GH) Regulatory Elements for HYMAI Gene

Promoters and enhancers for HYMAI Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I144005 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +1.3 1310 3.2 HDGF PKNOX1 ATF1 ARNT EGR1 FOS CREM SMAD5 ZBTB11 IKZF1 PLAGL1 ENSG00000276680 HYMAI SF3B5 PHACTR2 PHACTR2-AS1 GC06P143999
GH06I144013 Enhancer 0.8 ENCODE 0.8 -4.9 -4879 0.2 PKNOX1 NFIB ZNF2 RAD21 RFX5 ZNF155 ARID2 ZNF143 RCOR1 RUNX3 VDAC1P8 ADAT2 ENSG00000270890 LTV1 PLAGL1 HYMAI LOC100131041
GH06I144034 Enhancer 0.8 Ensembl ENCODE 0.3 -25.7 -25679 0.8 HLF CEBPB BACH1 MAFG CEBPG ZNF316 NFIC VEZF1 HMBOX1 NFE2 PHACTR2 PLAGL1 LOC100131041 HYMAI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYMAI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYMAI gene promoter:

Genomic Locations for HYMAI Gene

Genomic Locations for HYMAI Gene
5,845 bases
Minus strand

Genomic View for HYMAI Gene

Genes around HYMAI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYMAI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYMAI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYMAI Gene

Proteins for HYMAI Gene

Post-translational modifications for HYMAI Gene

No Post-translational modifications

No data available for DME Specific Peptides for HYMAI Gene

Domains & Families for HYMAI Gene

Gene Families for HYMAI Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HYMAI: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HYMAI Gene

Function for HYMAI Gene

Human Phenotype Ontology for HYMAI Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HYMAI Gene

Localization for HYMAI Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HYMAI Gene

Pathways & Interactions for HYMAI Gene

SuperPathways for HYMAI Gene

No Data Available

Interacting Proteins for HYMAI Gene

Gene Ontology (GO) - Biological Process for HYMAI Gene


No data available for Pathways by source and SIGNOR curated interactions for HYMAI Gene

Drugs & Compounds for HYMAI Gene

No Compound Related Data Available

Transcripts for HYMAI Gene

mRNA/cDNA for HYMAI Gene

(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HYMAI Gene

Hydatidiform mole associated and imprinted (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYMAI Gene

No ASD Table

Relevant External Links for HYMAI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYMAI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYMAI Gene

NURSA nuclear receptor signaling pathways regulating expression of HYMAI Gene:


SOURCE GeneReport for Unigene cluster for HYMAI Gene:


Phenotype-based relationships between genes and organs from Gene ORGANizer for HYMAI Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • endocrine
  • nervous
  • reproductive
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • head
  • heart
  • kidney
  • pancreas
  • penis
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with HYMAI: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for HYMAI Gene

Orthologs for HYMAI Gene

Evolution for HYMAI Gene

Gene Tree for HYMAI (if available)
Gene Tree for HYMAI (if available)

No data available for Orthologs for HYMAI Gene

Paralogs for HYMAI Gene

No data available for Paralogs for HYMAI Gene

Variants for HYMAI Gene

Sequence variations from dbSNP and Humsavar for HYMAI Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000000069 -- 144,007,285(-) G/A non_coding_transcript_variant
rs1000325418 -- 144,009,387(-) T/C upstream_transcript_variant
rs1000518458 -- 144,007,441(-) A/ non_coding_transcript_variant
rs1001119952 -- 144,008,354(-) C/T non_coding_transcript_variant
rs1001407355 -- 144,008,183(-) C/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HYMAI Gene

Variant ID Type Subtype PubMed ID
nsv830830 CNV gain 17160897
nsv5516 CNV deletion 18451855

Additional Variant Information for HYMAI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HYMAI Gene

Disorders for HYMAI Gene

MalaCards: The human disease database

(4) MalaCards diseases for HYMAI Gene - From: GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, transient neonatal, 1
  • tndm1
paternal uniparental disomy of chromosome 6
  • upd(6)pat
neonatal diabetes mellitus
  • diabetes mellitus syndrome in newborn infant
gestational trophoblastic neoplasm
  • hydatidiform mole, recurrent, 1
- elite association - COSMIC cancer census association via MalaCards
Search HYMAI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HYMAI

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HYMAI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYMAI Gene

Publications for HYMAI Gene

  1. Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. (PMID: 16873690) Gloyn AL … Frayling TM (Diabetes 2006) 3 44 58
  2. A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. (PMID: 10936046) Arima T … Surani MA (Genomics 2000) 2 3 58
  3. Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop. (PMID: 23295672) Iglesias-Platas I … Monk D (Nucleic acids research 2013) 3 58
  4. Prenatal diagnosis of trisomy 6 rescue resulting in paternal UPD6 with novel placental findings. (PMID: 21739591) Cajaiba MM … Surti U (American journal of medical genetics. Part A 2011) 3 58
  5. Transient neonatal diabetes mellitus type 1. (PMID: 20803656) Mackay DJ … Temple IK (American journal of medical genetics. Part C, Seminars in medical genetics 2010) 3 58

Products for HYMAI Gene

Sources for HYMAI Gene

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